GREMLIN Database
YFBV - UPF0208 membrane protein YfbV
UniProt: P0A8D9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14106
Length: 151 (140)
Sequences: 204 (129)
Seq/√Len: 10.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_P132_L3.2110.96
40_V47_A3.1520.96
18_G21_Y2.9950.94
15_F54_I2.5480.87
139_A143_L2.4630.85
69_L72_A2.4170.84
20_H134_D2.3760.83
57_F61_W2.2780.80
15_F120_L2.2490.80
51_M76_A2.2190.79
48_I82_L2.2090.78
106_F127_P2.1290.76
127_P132_L2.0990.74
17_R95_V2.0870.74
57_F130_Q2.0450.72
78_F82_L2.0420.72
79_A88_W1.9760.70
81_S105_W1.9550.69
47_A80_L1.8630.65
137_K141_K1.8120.63
72_A76_A1.7890.62
51_M87_L1.7860.62
39_R43_M1.7490.60
44_T90_L1.6880.57
89_W93_R1.6690.56
100_P145_K1.6070.53
29_K119_V1.4870.47
29_K131_A1.4830.47
35_F44_T1.4810.47
132_L147_F1.4630.46
25_W44_T1.4420.45
86_G93_R1.4100.44
32_A76_A1.4030.44
82_L97_P1.3840.43
63_I67_G1.3520.41
43_M117_G1.3430.41
49_R53_P1.3240.40
31_L35_F1.3230.40
95_V130_Q1.3200.40
40_V68_Q1.2890.38
55_A69_L1.2850.38
21_Y26_P1.2700.37
113_L147_F1.2680.37
41_I90_L1.2630.37
139_A142_Q1.2620.37
62_Q77_L1.2590.37
40_V84_M1.2390.36
39_R127_P1.1830.34
54_I144_D1.1830.34
80_L149_D1.1770.33
74_A78_F1.1740.33
56_V80_L1.1700.33
102_I140_F1.1680.33
90_L93_R1.1620.33
30_R113_L1.1560.32
105_W133_A1.1490.32
38_N147_F1.1320.31
86_G89_W1.1290.31
87_L130_Q1.1250.31
77_L146_T1.1220.31
29_K73_V1.1170.31
18_G26_P1.1120.31
107_Y131_A1.0980.30
55_A133_A1.0820.29
58_T80_L1.0720.29
77_L82_L1.0570.28
45_R108_E1.0520.28
109_V143_L1.0400.28
70_G74_A1.0390.28
10_N113_L1.0330.27
16_R120_L1.0290.27
57_F121_A1.0190.27
49_R73_V1.0120.27
75_T79_A1.0040.26
34_V148_L1.0040.26
63_I94_S0.9930.26
37_E143_L0.9920.26
105_W136_L0.9880.26
129_Y139_A0.9850.26
105_W109_V0.9770.25
22_S99_P0.9730.25
32_A96_T0.9650.25
106_F132_L0.9410.24
46_Y60_C0.9340.24
13_S94_S0.9260.24
10_N36_V0.9250.24
49_R99_P0.9230.24
113_L142_Q0.9090.23
62_Q85_Q0.9060.23
29_K88_W0.9060.23
109_V113_L0.9030.23
92_K127_P0.8950.23
44_T117_G0.8940.23
47_A121_A0.8810.22
55_A72_A0.8760.22
51_M79_A0.8680.22
39_R51_M0.8660.22
28_E32_A0.8630.21
59_L97_P0.8590.21
96_T132_L0.8590.21
99_P129_Y0.8550.21
112_K137_K0.8470.21
36_V102_I0.8470.21
40_V86_G0.8470.21
28_E37_E0.8390.21
80_L101_A0.8370.21
26_P52_P0.8290.20
57_F75_T0.8260.20
64_A137_K0.8230.20
46_Y53_P0.8190.20
20_H97_P0.8150.20
29_K63_I0.8030.20
15_F56_V0.7990.20
20_H94_S0.7930.19
15_F64_A0.7920.19
77_L142_Q0.7890.19
69_L135_T0.7790.19
24_T87_L0.7740.19
22_S36_V0.7710.19
45_R49_R0.7490.18
124_E130_Q0.7490.18
132_L148_L0.7470.18
13_S141_K0.7400.18
86_G90_L0.7380.18
41_I62_Q0.7370.18
64_A88_W0.7360.18
31_L140_F0.7290.17
20_H68_Q0.7260.17
44_T89_W0.7240.17
61_W130_Q0.7170.17
22_S131_A0.7160.17
50_F70_G0.7160.17
54_I122_P0.7080.17
64_A113_L0.7020.17
61_W70_G0.6990.17
94_S138_R0.6930.17
51_M86_G0.6880.16
19_Q130_Q0.6870.16
120_L145_K0.6810.16
20_H111_G0.6790.16
99_P142_Q0.6780.16
103_L127_P0.6760.16
59_L145_K0.6750.16
24_T129_Y0.6740.16
39_R76_A0.6740.16
74_A147_F0.6720.16
133_A136_L0.6710.16
57_F87_L0.6680.16
27_L43_M0.6660.16
129_Y133_A0.6620.16
36_V39_R0.6590.16
33_P96_T0.6540.16
59_L103_L0.6410.15
76_A92_K0.6380.15
118_Q146_T0.6370.15
61_W69_L0.6330.15
23_K125_G0.6300.15
63_I101_A0.6250.15
55_A71_P0.6240.15
31_L76_A0.6230.15
61_W97_P0.6200.15
49_R138_R0.6150.15
55_A136_L0.6140.15
39_R72_A0.6130.15
79_A148_L0.6110.14
76_A113_L0.6110.14
44_T136_L0.6060.14
47_A72_A0.6060.14
117_G140_F0.6040.14
42_K62_Q0.6030.14
55_A76_A0.6010.14
105_W144_D0.5880.14
117_G144_D0.5860.14
50_F140_F0.5820.14
65_L102_I0.5800.14
92_K96_T0.5790.14
37_E53_P0.5780.14
39_R57_F0.5780.14
118_Q145_K0.5740.14
116_S121_A0.5720.14
53_P127_P0.5690.13
20_H73_V0.5660.13
78_F119_V0.5600.13
142_Q149_D0.5570.13
76_A87_L0.5560.13
19_Q51_M0.5550.13
10_N121_A0.5510.13
50_F64_A0.5440.13
34_V42_K0.5430.13
62_Q72_A0.5370.13
70_G73_V0.5340.13
19_Q46_Y0.5320.13
15_F19_Q0.5300.13
142_Q148_L0.5300.13
15_F18_G0.5300.13
19_Q22_S0.5250.13
37_E54_I0.5240.13
86_G139_A0.5190.12
12_F73_V0.5190.12
51_M55_A0.5140.12
53_P131_A0.5140.12
38_N96_T0.5130.12
28_E92_K0.5120.12
10_N45_R0.5110.12
30_R140_F0.5110.12
41_I107_Y0.5100.12
54_I116_S0.5080.12
31_L42_K0.5080.12
81_S125_G0.5040.12
33_P48_I0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3racA 2 0.2252 7.1 0.962 Contact Map
1oeyJ 1 0.3245 6.7 0.962 Contact Map
3efoB 1 0.9139 6.5 0.963 Contact Map
3sv0A 1 0.9603 6.2 0.963 Contact Map
1m2vB 1 0.894 5.1 0.964 Contact Map
3eh2A 1 0.9139 4.8 0.965 Contact Map
3mn2A 1 0.2848 4.2 0.966 Contact Map
2f6mB 1 0.3179 4.1 0.966 Contact Map
1k8bA 1 0.2384 3.8 0.967 Contact Map
2wyoA 2 0.4305 3.6 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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