GREMLIN Database
YMDB - O-acetyl-ADP-ribose deacetylase
UniProt: P0A8D6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13874
Length: 177 (162)
Sequences: 3928 (2816)
Seq/√Len: 221.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_V156_F3.0261.00
6_H153_Q2.9481.00
49_A71_G2.5571.00
15_L155_Y2.4641.00
94_D132_A2.4231.00
160_D163_N2.4011.00
114_T152_E2.3951.00
49_A69_L2.2941.00
42_A46_L2.1691.00
67_I111_N2.0961.00
67_I107_L2.0921.00
99_D103_N2.0311.00
45_A72_D2.0141.00
64_H103_N1.9631.00
89_G93_E1.9371.00
164_A168_E1.9351.00
62_T96_L1.8941.00
103_N106_R1.8841.00
102_L140_T1.8511.00
9_Q161_E1.8341.00
14_K41_A1.7891.00
130_R163_N1.7811.00
30_G35_D1.6981.00
9_Q164_A1.6621.00
77_A113_Y1.6441.00
109_A144_F1.6341.00
140_T143_E1.6191.00
47_L51_L1.6011.00
128_Y132_A1.5761.00
105_L144_F1.5631.00
130_R166_L1.5441.00
128_Y136_I1.5151.00
81_T104_S1.4821.00
19_V113_Y1.4691.00
42_A71_G1.4641.00
107_L110_A1.4401.00
161_E165_H1.4381.00
98_Q140_T1.4151.00
17_V117_A1.4121.00
8_V15_L1.4001.00
141_V154_V1.3991.00
65_A79_V1.3781.00
120_A123_T1.3371.00
7_V164_A1.3281.00
120_A167_Y1.3211.00
144_F148_H1.3011.00
53_V66_V1.2981.00
86_W93_E1.2891.00
45_A71_G1.2651.00
106_R144_F1.2651.00
20_I38_I1.2591.00
130_R162_E1.2491.00
166_L170_L1.2451.00
70_A75_A1.2401.00
60_C66_V1.2211.00
81_T100_A1.2161.00
109_A151_P1.2091.00
158_C164_A1.2051.00
15_L157_V1.1981.00
68_T80_H1.1981.00
158_C167_Y1.1951.00
61_P66_V1.1881.00
94_D128_Y1.1881.00
18_D76_K1.1851.00
86_W89_G1.1801.00
46_L71_G1.1721.00
104_S118_F1.1721.00
120_A163_N1.1671.00
107_L111_N1.1641.00
130_R160_D1.1551.00
134_A166_L1.1521.00
98_Q139_K1.1511.00
83_G122_S1.1481.00
131_A169_R1.1431.00
77_A111_N1.1331.00
109_A148_H1.1281.00
101_Y137_A1.1081.00
123_T163_N1.1071.00
108_V116_V1.1061.00
18_D113_Y1.1051.00
79_V104_S1.0571.00
19_V79_V1.0461.00
35_D39_H1.0291.00
48_D52_K1.0251.00
120_A134_A1.0241.00
106_R110_A1.0161.00
98_Q102_L1.0151.00
65_A103_N1.0111.00
45_A69_L1.0001.00
120_A130_R0.9871.00
88_G93_E0.9821.00
10_G15_L0.9791.00
67_I113_Y0.9751.00
36_G40_R0.9751.00
139_K143_E0.9671.00
10_G157_V0.9621.00
10_G14_K0.9531.00
163_N167_Y0.9461.00
104_S116_V0.9431.00
62_T85_V0.9411.00
165_H169_R0.9331.00
61_P64_H0.9291.00
135_E170_L0.9200.99
7_V171_L0.9040.99
98_Q143_E0.9040.99
26_P82_V0.9000.99
45_A48_D0.8960.99
138_V171_L0.8960.99
29_M51_L0.8900.99
88_G91_Q0.8900.99
17_V155_Y0.8840.99
142_S146_T0.8830.99
69_L77_A0.8790.99
87_R91_Q0.8690.99
26_P61_P0.8660.99
37_A41_A0.8650.99
92_N95_Q0.8640.99
29_M47_L0.8580.99
16_A74_P0.8530.99
86_W132_A0.8460.99
123_T133_A0.8450.99
102_L106_R0.8410.99
98_Q136_I0.8410.99
89_G92_N0.8400.99
7_V158_C0.8350.99
132_A135_E0.8320.99
65_A107_L0.8260.99
130_R134_A0.8250.99
35_D47_L0.8240.99
102_L143_E0.8240.99
46_L78_V0.8230.99
64_H99_D0.8200.99
49_A52_K0.8200.99
109_A152_E0.8180.99
7_V138_V0.8140.99
138_V170_L0.8100.99
115_S153_Q0.8090.99
136_I140_T0.7980.99
95_Q99_D0.7950.98
123_T134_A0.7890.98
165_H168_E0.7870.98
109_A149_A0.7860.98
23_A34_V0.7840.98
49_A68_T0.7790.98
11_D14_K0.7760.98
73_L78_V0.7750.98
86_W128_Y0.7740.98
151_P154_V0.7690.98
108_V113_Y0.7690.98
86_W129_P0.7660.98
84_P97_L0.7620.98
30_G50_C0.7530.98
134_A170_L0.7510.98
26_P62_T0.7450.98
31_G36_G0.7420.98
87_R93_E0.7400.98
83_G121_I0.7380.98
101_Y133_A0.7350.97
93_E96_L0.7280.97
131_A166_L0.7270.97
109_A150_L0.7250.97
163_N166_L0.7110.97
94_D98_Q0.7100.97
19_V116_V0.7090.97
123_T167_Y0.7050.97
94_D136_I0.7020.97
120_A158_C0.6980.97
92_N96_L0.6980.97
26_P59_D0.6970.97
134_A167_Y0.6900.96
48_D51_L0.6900.96
9_Q160_D0.6900.96
112_S150_L0.6810.96
46_L69_L0.6740.96
30_G39_H0.6730.96
58_G66_V0.6700.96
30_G47_L0.6670.96
120_A166_L0.6660.95
33_G36_G0.6620.95
44_P48_D0.6600.95
135_E139_K0.6560.95
167_Y170_L0.6540.95
27_S59_D0.6540.95
20_I74_P0.6510.95
105_L154_V0.6470.95
137_A156_F0.6440.95
6_H155_Y0.6440.95
24_A31_G0.6440.95
50_C53_V0.6410.94
65_A81_T0.6310.94
133_A137_A0.6270.94
20_I73_L0.6260.94
120_A156_F0.6220.94
156_F167_Y0.6200.93
7_V168_E0.6170.93
105_L141_V0.6120.93
144_F154_V0.6100.93
131_A135_E0.6090.93
15_L117_A0.6090.93
117_A157_V0.6080.93
28_L50_C0.6060.93
22_N80_H0.6020.92
161_E164_A0.6000.92
17_V115_S0.5930.92
39_H50_C0.5930.92
52_K71_G0.5920.92
12_I34_V0.5910.92
114_T151_P0.5900.92
81_T121_I0.5850.91
22_N38_I0.5800.91
63_G81_T0.5790.91
145_I154_V0.5770.91
122_S126_Y0.5660.90
113_Y116_V0.5660.90
8_V155_Y0.5590.89
123_T130_R0.5590.89
13_T38_I0.5550.89
42_A69_L0.5550.89
128_Y133_A0.5490.89
24_A50_C0.5480.88
106_R109_A0.5470.88
21_V118_F0.5440.88
85_V88_G0.5420.88
24_A126_Y0.5390.88
24_A33_G0.5370.87
28_L53_V0.5370.87
140_T144_F0.5330.87
120_A160_D0.5320.87
87_R92_N0.5280.87
60_C82_V0.5270.86
107_L113_Y0.5270.86
83_G126_Y0.5240.86
39_H46_L0.5240.86
117_A155_Y0.5240.86
76_K115_S0.5190.86
39_H47_L0.5160.85
59_D66_V0.5140.85
88_G92_N0.5130.85
106_R147_R0.5100.85
31_G34_V0.5070.84
26_P60_C0.5060.84
118_F137_A0.5050.84
104_S108_V0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1spvA 1 0.9718 100 0.117 Contact Map
1yd9A 1 0.9887 100 0.135 Contact Map
2xd7A 1 0.9718 100 0.137 Contact Map
3q71A 1 0.9887 100 0.139 Contact Map
3q6zA 1 0.9887 100 0.143 Contact Map
4umlA 1 0.9718 100 0.143 Contact Map
2x47A 1 0.9774 100 0.144 Contact Map
4d86A 1 0.9887 100 0.147 Contact Map
4iqyA 1 0.9718 100 0.156 Contact Map
1vhuA 1 0.9774 100 0.18 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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