GREMLIN Database
YIDD - Putative membrane protein insertion efficiency factor
UniProt: P0A8C8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11348
Length: 85 (70)
Sequences: 2755 (1744)
Seq/√Len: 208.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_G57_T4.2711.00
12_L50_V2.6991.00
13_I42_I2.3841.00
49_G53_G2.1801.00
27_L30_H2.0821.00
20_Q39_S2.0601.00
47_R77_P1.8771.00
33_F68_H1.8051.00
39_S43_E1.7581.00
55_W59_K1.7111.00
59_K63_K1.6801.00
12_L45_L1.6571.00
33_F69_P1.6371.00
45_L54_S1.6031.00
18_V22_L1.5931.00
56_L76_P1.4771.00
17_R20_Q1.4731.00
34_T72_D1.4201.00
20_Q42_I1.3981.00
42_I46_R1.3771.00
43_E47_R1.3061.00
14_A18_V1.2751.00
59_K65_H1.2601.00
45_L57_T1.2581.00
32_R68_H1.2321.00
17_R42_I1.2181.00
63_K68_H1.1851.00
8_G11_V1.1321.00
16_I41_G1.1111.00
16_I45_L1.1001.00
65_H68_H1.0921.00
9_S50_V1.0901.00
16_I20_Q1.0891.00
58_V62_L1.0811.00
56_L59_K1.0811.00
33_F63_K1.0501.00
45_L50_V1.0241.00
17_R21_R1.0001.00
9_S46_R0.9971.00
41_G54_S0.9871.00
62_L65_H0.9781.00
22_L26_L0.9771.00
22_L25_P0.9540.99
39_S42_I0.9290.99
54_S58_V0.8860.99
48_F75_V0.8840.99
23_I27_L0.8820.99
34_T39_S0.8630.99
13_I17_R0.8220.99
9_S13_I0.8150.98
9_S45_L0.7980.98
48_F52_K0.7950.98
10_R14_A0.7920.98
61_V65_H0.7840.98
13_I46_R0.7840.98
26_L29_P0.7610.98
43_E75_V0.7600.98
48_F76_P0.7590.97
44_A75_V0.7550.97
16_I42_I0.7470.97
48_F77_P0.7460.97
57_T61_V0.7430.97
50_V54_S0.7420.97
11_V14_A0.7370.97
41_G45_L0.7270.97
32_R69_P0.7260.97
14_A17_R0.7140.96
23_I30_H0.7060.96
19_Y23_I0.6870.95
43_E74_P0.6790.95
33_F74_P0.6670.95
24_S28_G0.6560.94
34_T70_G0.6520.94
11_V15_L0.6470.94
8_G50_V0.6390.93
55_W62_L0.6390.93
44_A56_L0.6360.93
9_S15_L0.6330.93
45_L53_G0.6290.93
23_I28_G0.6250.93
23_I29_P0.6110.92
19_Y27_L0.6070.92
16_I61_V0.6060.92
22_L27_L0.6000.91
59_K62_L0.5910.90
12_L15_L0.5910.90
43_E46_R0.5840.90
56_L75_V0.5800.90
12_L54_S0.5730.89
51_I62_L0.5700.89
11_V51_I0.5690.89
9_S53_G0.5680.89
24_S36_T0.5620.88
67_L72_D0.5520.87
16_I19_Y0.5470.87
41_G61_V0.5470.87
21_R27_L0.5410.86
15_L18_V0.5370.86
13_I45_L0.5360.86
23_I26_L0.5170.84
21_R67_L0.5160.84
14_A22_L0.5120.83
59_K68_H0.5100.83
39_S46_R0.5050.82
33_F70_G0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fccA 5 0.8588 29.8 0.912 Contact Map
1gtmA 5 0.8706 10.4 0.929 Contact Map
3mw9A 5 0.8588 10.3 0.929 Contact Map
2tmgA 5 0.9059 10.2 0.929 Contact Map
4xgiA 6 0.8588 8.1 0.932 Contact Map
3aoeE 3 0.8588 8 0.932 Contact Map
3k92A 5 0.8471 7.7 0.933 Contact Map
1v9lA 4 0.8588 7.2 0.933 Contact Map
3qpiA 1 0.4471 6.5 0.935 Contact Map
1bgvA 5 0.9059 6.2 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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