GREMLIN Database
YGFB - UPF0149 protein YgfB
UniProt: P0A8C4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11323
Length: 192 (173)
Sequences: 547 (371)
Seq/√Len: 28.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_E164_Y4.8231.00
133_A168_A4.2231.00
14_N26_P3.9971.00
101_R155_E3.6361.00
139_N142_Q3.0941.00
127_T175_T3.0511.00
71_M75_T2.7151.00
105_L165_V2.6741.00
10_Y27_A2.3280.99
130_T172_C2.1570.98
112_F169_A2.1270.98
106_A143_L2.0720.97
96_V100_D2.0700.97
102_A143_L2.0670.97
158_L162_I2.0360.97
8_P74_A2.0200.97
109_V172_C1.9760.96
173_H177_T1.9510.96
116_L137_L1.9460.96
33_I141_A1.8550.95
25_T107_G1.8170.94
131_G135_D1.7780.93
116_L173_H1.7560.93
91_P104_A1.7060.92
163_E166_R1.6670.91
77_D81_D1.5990.89
178_H181_P1.5940.89
20_Q61_G1.5930.88
102_A118_V1.5530.87
86_F160_E1.5430.87
30_H108_W1.5400.87
140_I143_L1.5250.86
126_V176_F1.5170.86
40_G116_L1.5120.86
105_L140_I1.4790.84
136_D140_I1.4490.83
34_S75_T1.4400.83
143_L161_I1.4380.83
107_G164_Y1.4290.82
157_S160_E1.4090.81
106_A141_A1.3980.81
15_Q95_D1.3810.80
46_W117_G1.3810.80
26_P157_S1.3600.79
47_L161_I1.3600.79
157_S164_Y1.3550.79
56_E61_G1.3490.78
56_E111_H1.3420.78
38_C79_L1.3180.77
144_G148_D1.3170.77
14_N18_N1.3040.76
102_A158_L1.3010.76
130_T175_T1.2940.75
32_L143_L1.2750.74
21_G164_Y1.2740.74
34_S78_A1.2530.73
116_L121_P1.2490.73
107_G110_N1.2400.72
138_R141_A1.2250.71
10_Y104_A1.1960.69
105_L117_G1.1900.69
119_T158_L1.1720.68
137_L165_V1.1690.68
103_D149_E1.1540.67
79_L169_A1.1530.66
13_M155_E1.1490.66
34_S143_L1.1360.65
37_I75_T1.1350.65
30_H35_G1.1160.64
42_D148_D1.1060.63
47_L65_A1.0960.62
43_D143_L1.0890.62
76_S156_M1.0690.60
68_L154_L1.0620.60
101_R104_A1.0600.60
37_I158_L1.0590.60
152_E156_M1.0580.60
157_S171_L1.0460.59
16_Y63_E1.0320.58
160_E171_L1.0270.57
97_S100_D1.0210.57
108_W112_F1.0090.56
27_A91_P1.0090.56
60_F68_L1.0020.55
8_P12_E0.9860.54
53_L118_V0.9850.54
46_W50_L0.9800.54
28_E95_D0.9770.54
101_R142_Q0.9710.53
38_C66_Q0.9620.52
81_D166_R0.9570.52
123_L126_V0.9550.52
39_G46_W0.9480.51
100_D124_D0.9440.51
121_P176_F0.9230.49
103_D110_N0.9210.49
36_M139_N0.9120.49
65_A126_V0.9110.48
128_G131_G0.9090.48
65_A175_T0.9080.48
107_G153_E0.9070.48
26_P105_L0.9050.48
38_C152_E0.9040.48
113_L141_A0.9030.48
22_T46_W0.9010.48
94_D149_E0.8980.47
95_D179_P0.8960.47
26_P80_Q0.8950.47
127_T179_P0.8910.47
105_L136_D0.8870.47
84_F174_D0.8860.47
92_D97_S0.8820.46
98_V175_T0.8780.46
16_Y67_A0.8720.46
37_I86_F0.8670.45
39_G173_H0.8650.45
110_N147_E0.8580.44
29_M54_T0.8570.44
39_G165_V0.8550.44
76_S80_Q0.8440.43
20_Q64_L0.8410.43
38_C84_F0.8380.43
27_A111_H0.8360.43
140_I165_V0.8340.43
81_D85_L0.8340.43
117_G163_E0.8250.42
17_L20_Q0.8210.42
94_D115_G0.8190.41
113_L138_R0.8170.41
91_P111_H0.8140.41
22_T153_E0.8110.41
80_Q168_A0.8090.41
13_M17_L0.8060.41
122_K138_R0.7880.39
18_N177_T0.7850.39
130_T141_A0.7800.39
81_D171_L0.7750.38
99_F135_D0.7710.38
20_Q112_F0.7690.38
9_G37_I0.7660.38
40_G142_Q0.7620.37
25_T29_M0.7610.37
160_E166_R0.7570.37
77_D92_D0.7550.37
40_G173_H0.7530.37
20_Q68_L0.7530.37
10_Y152_E0.7510.37
103_D107_G0.7460.36
29_M60_F0.7460.36
23_G173_H0.7460.36
162_I167_V0.7390.36
111_H144_G0.7370.36
38_C142_Q0.7360.35
81_D161_I0.7330.35
50_L139_N0.7330.35
17_L130_T0.7330.35
51_H94_D0.7320.35
127_T138_R0.7320.35
133_A137_L0.7290.35
85_L155_E0.7270.35
27_A63_E0.7260.35
45_S96_V0.7170.34
45_S134_I0.7170.34
29_M142_Q0.7140.34
114_L120_Q0.7100.34
14_N69_R0.7090.34
154_L160_E0.7090.34
97_S102_A0.7060.33
89_Y101_R0.6980.33
152_E166_R0.6940.33
98_V158_L0.6920.32
134_I156_M0.6880.32
48_P52_D0.6880.32
17_L24_L0.6840.32
153_E158_L0.6730.31
34_S86_F0.6720.31
28_E115_G0.6710.31
9_G12_E0.6670.31
31_G35_G0.6670.31
38_C172_C0.6650.31
94_D125_K0.6640.31
27_A46_W0.6630.30
43_D103_D0.6590.30
22_T79_L0.6580.30
17_L64_L0.6530.30
61_G132_E0.6460.29
104_A113_L0.6460.29
27_A150_D0.6440.29
35_G115_G0.6430.29
161_I165_V0.6430.29
67_A81_D0.6350.29
90_L104_A0.6270.28
131_G164_Y0.6270.28
102_A137_L0.6270.28
21_G92_D0.6250.28
20_Q119_T0.6220.28
157_S165_V0.6150.27
74_A158_L0.6120.27
107_G154_L0.6110.27
96_V143_L0.6020.27
41_N168_A0.6000.27
28_E40_G0.6000.27
161_I164_Y0.6000.27
152_E159_E0.5940.26
71_M155_E0.5920.26
155_E165_V0.5870.26
29_M152_E0.5860.26
74_A169_A0.5830.26
26_P77_D0.5830.26
36_M134_I0.5820.25
134_I138_R0.5810.25
66_Q74_A0.5800.25
116_L178_H0.5780.25
86_F112_F0.5780.25
25_T82_D0.5780.25
29_M40_G0.5740.25
40_G169_A0.5730.25
58_M111_H0.5720.25
33_I118_V0.5720.25
45_S48_P0.5710.25
127_T131_G0.5700.25
13_M77_D0.5690.25
58_M126_V0.5690.25
13_M71_M0.5680.25
85_L110_N0.5660.25
71_M90_L0.5640.24
30_H34_S0.5630.24
91_P155_E0.5580.24
84_F88_L0.5580.24
9_G71_M0.5580.24
118_V130_T0.5560.24
122_K128_G0.5540.24
52_D58_M0.5510.24
79_L178_H0.5500.24
30_H126_V0.5490.24
33_I50_L0.5480.24
67_A73_S0.5450.23
11_N96_V0.5420.23
116_L123_L0.5390.23
51_H175_T0.5380.23
91_P101_R0.5330.23
122_K125_K0.5310.23
32_L152_E0.5310.23
77_D164_Y0.5300.23
119_T175_T0.5270.22
21_G44_S0.5250.22
51_H161_I0.5230.22
146_D150_D0.5210.22
47_L130_T0.5210.22
26_P54_T0.5200.22
66_Q171_L0.5190.22
83_G160_E0.5190.22
147_E154_L0.5170.22
49_L174_D0.5130.22
110_N114_L0.5130.22
84_F141_A0.5130.22
81_D164_Y0.5090.21
11_N66_Q0.5060.21
62_H66_Q0.5050.21
19_Q63_E0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1izmA 2 0.875 100 0.311 Contact Map
4gytA 2 0.8906 100 0.323 Contact Map
2ee7A 1 0.3125 16 0.953 Contact Map
2kmfA 1 0.4271 6.1 0.961 Contact Map
3jrtA 2 0.3906 5.5 0.962 Contact Map
1wlmA 1 0.3802 4.6 0.963 Contact Map
3ip4C 1 0.276 4.3 0.964 Contact Map
3h0lC 1 0.2708 4.1 0.964 Contact Map
4cr2Z 1 0.7969 3.4 0.966 Contact Map
1pulA 1 0.2083 3.3 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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