GREMLIN Database
PSRP - Phosphoenolpyruvate synthase regulatory protein
UniProt: P0A8A4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11132
Length: 277 (251)
Sequences: 1472 (911)
Seq/√Len: 57.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_S178_A5.6091.00
153_V176_I4.6021.00
101_Q108_P4.1311.00
50_R81_I3.9151.00
215_A233_C3.3891.00
46_E77_E2.9471.00
195_A199_P2.8661.00
71_Y89_C2.6131.00
153_V270_M2.6021.00
71_Y83_L2.5751.00
66_R103_E2.5601.00
186_D232_Q2.5601.00
241_E245_R2.5271.00
148_L181_Y2.4991.00
40_L52_V2.4891.00
151_A179_A2.4881.00
79_R94_Q2.4501.00
176_I267_L2.4151.00
139_H147_N2.3751.00
11_Y24_G2.3111.00
240_V244_Y2.2981.00
85_S88_F2.2891.00
209_I255_T2.1971.00
49_A78_I2.1441.00
250_P269_I2.1231.00
8_H38_I2.1011.00
209_I214_L2.0861.00
136_T139_H2.0111.00
44_E48_R1.9741.00
183_F240_V1.8771.00
53_K85_S1.8250.99
208_T241_E1.8220.99
101_Q107_D1.6980.99
154_I200_L1.6900.99
149_D199_P1.6870.99
234_R238_A1.6710.99
130_I259_V1.6660.99
156_L197_L1.6500.99
46_E81_I1.6490.99
12_I82_I1.6450.99
73_I78_I1.6360.99
156_L181_Y1.6220.99
70_F96_L1.6210.99
80_A84_Q1.6150.99
133_I259_V1.5710.98
172_M259_V1.5660.98
24_G70_F1.5390.98
244_Y251_W1.5370.98
206_G244_Y1.5360.98
144_S147_N1.5320.98
167_S176_I1.5290.98
100_L104_M1.5240.98
25_H37_S1.5140.98
198_K246_K1.5120.98
211_P237_V1.5020.98
68_L100_L1.4870.98
185_A232_Q1.4850.98
12_I52_V1.4640.97
50_R85_S1.4580.97
32_P109_T1.4440.97
161_C254_S1.4320.97
14_D19_T1.4310.97
10_F40_L1.4200.97
158_V214_L1.4080.97
155_L168_L1.4070.97
19_T113_H1.3850.96
234_R245_R1.3820.96
49_A82_I1.3740.96
27_V100_L1.3720.96
193_L197_L1.3690.96
135_Y138_A1.3520.96
46_E78_I1.3400.96
139_H144_S1.3280.95
131_A134_D1.3230.95
265_K268_D1.3220.95
99_P103_E1.3180.95
11_Y37_S1.3090.95
91_D94_Q1.2920.95
74_V113_H1.2870.95
158_V240_V1.2860.95
11_Y25_H1.2840.94
150_Q177_R1.2690.94
68_L103_E1.2600.94
11_Y20_A1.2100.93
28_M100_L1.1970.92
205_F269_I1.1920.92
133_I172_M1.1900.92
75_L129_R1.1890.92
216_A256_N1.1880.92
28_M154_I1.1780.91
210_D255_T1.1680.91
72_S116_H1.1590.91
211_P230_L1.1520.91
49_A81_I1.1450.90
156_L204_L1.1340.90
225_S228_A1.1270.90
157_G161_C1.1150.89
231_R235_M1.1120.89
30_Q74_V1.1120.89
139_H169_Y1.1070.89
150_Q266_I1.1030.89
53_K81_I1.0990.88
234_R241_E1.0860.88
71_Y82_I1.0860.88
28_M129_R1.0830.88
38_I116_H1.0790.87
56_I67_P1.0770.87
167_S270_M1.0730.87
38_I55_Q1.0710.87
186_D247_N1.0700.87
209_I217_I1.0570.86
230_L234_R1.0430.86
126_Y130_I1.0350.85
56_I63_T1.0300.85
31_F101_Q1.0300.85
19_T74_V1.0140.84
139_H143_I1.0060.83
136_T148_L1.0060.83
98_A102_Q1.0030.83
17_A30_Q0.9940.83
7_R103_E0.9920.83
13_S19_T0.9880.82
183_F244_Y0.9870.82
133_I186_D0.9830.82
71_Y228_A0.9820.82
204_L247_N0.9800.82
15_G19_T0.9760.82
138_A144_S0.9750.82
168_L240_V0.9620.81
12_I43_V0.9600.80
152_Q177_R0.9430.79
186_D191_L0.9390.79
31_F97_V0.9330.79
81_I85_S0.9290.78
197_L271_G0.9290.78
135_Y139_H0.9240.78
258_S261_E0.9230.78
254_S262_I0.9220.78
46_E266_I0.9220.78
8_H63_T0.9210.78
156_L244_Y0.9050.76
197_L204_L0.8970.76
135_Y144_S0.8920.75
156_L177_R0.8910.75
76_P110_P0.8900.75
124_N248_Q0.8840.75
17_A113_H0.8840.75
10_F65_V0.8810.74
92_I96_L0.8800.74
158_V244_Y0.8770.74
45_N48_R0.8740.74
9_V259_V0.8710.74
211_P234_R0.8700.74
219_E224_N0.8670.73
7_R24_G0.8620.73
97_V101_Q0.8620.73
229_S241_E0.8600.73
101_Q105_K0.8600.73
148_L193_L0.8600.73
129_R250_P0.8580.72
32_P167_S0.8460.71
136_T143_I0.8450.71
135_Y253_N0.8400.71
239_E243_L0.8370.71
144_S148_L0.8360.71
257_Y262_I0.8360.71
84_Q88_F0.8200.69
168_L171_A0.8190.69
65_V106_L0.8190.69
141_D182_P0.8180.69
128_A238_A0.8160.69
70_F92_I0.8140.68
29_S114_R0.8120.68
53_K69_V0.8120.68
225_S229_S0.8110.68
200_L204_L0.8100.68
156_L183_F0.8090.68
119_N162_G0.8080.68
135_Y175_G0.8060.68
40_L43_V0.7970.67
71_Y92_I0.7960.67
70_F90_Q0.7950.67
220_E223_E0.7940.67
73_I157_G0.7920.66
55_Q99_P0.7910.66
258_S262_I0.7900.66
257_Y265_K0.7870.66
142_G182_P0.7860.66
153_V178_A0.7800.65
49_A73_I0.7790.65
15_G167_S0.7760.65
178_A255_T0.7720.64
45_N130_I0.7720.64
75_L78_I0.7720.64
15_G18_I0.7660.64
167_S184_I0.7660.64
124_N128_A0.7660.64
136_T178_A0.7640.64
99_P102_Q0.7640.64
146_R150_Q0.7640.64
175_G213_R0.7610.63
168_L262_I0.7600.63
161_C217_I0.7560.63
228_A244_Y0.7530.62
45_N85_S0.7520.62
220_E244_Y0.7460.62
90_Q99_P0.7450.62
213_R216_A0.7330.60
80_A106_L0.7320.60
26_A93_V0.7310.60
92_I98_A0.7300.60
23_L94_Q0.7290.60
12_I53_K0.7280.60
133_I237_V0.7280.60
48_R150_Q0.7270.60
135_Y145_L0.7190.59
214_L259_V0.7170.59
10_F272_L0.7160.59
23_L92_I0.7130.58
21_E220_E0.7120.58
203_K243_L0.7110.58
33_V106_L0.7090.58
23_L26_A0.7090.58
88_F93_V0.7080.58
76_P80_A0.7050.57
84_Q87_G0.7040.57
30_Q263_A0.7020.57
156_L249_I0.6960.56
50_R54_D0.6920.56
91_D137_L0.6910.56
77_E81_I0.6880.56
52_V238_A0.6840.55
43_V106_L0.6830.55
158_V209_I0.6800.55
213_R255_T0.6800.55
229_S232_Q0.6790.55
39_T166_T0.6770.54
161_C263_A0.6760.54
134_D147_N0.6750.54
183_F219_E0.6730.54
144_S184_I0.6720.54
137_L166_T0.6710.54
192_V195_A0.6700.54
10_F67_P0.6690.53
162_G233_C0.6680.53
113_H116_H0.6650.53
101_Q104_M0.6650.53
46_E49_A0.6640.53
112_A214_L0.6630.53
19_T72_S0.6560.52
90_Q93_V0.6540.52
49_A85_S0.6530.52
90_Q169_Y0.6500.51
149_D200_L0.6500.51
109_T116_H0.6490.51
159_S227_Y0.6470.51
73_I125_K0.6460.51
244_Y247_N0.6460.51
46_E84_Q0.6450.51
72_S177_R0.6430.51
54_D80_A0.6410.50
66_R107_D0.6370.50
168_L244_Y0.6360.50
181_Y193_L0.6350.50
135_Y149_D0.6350.50
196_S199_P0.6330.49
92_I110_P0.6300.49
168_L232_Q0.6290.49
146_R196_S0.6240.48
25_H156_L0.6240.48
113_H259_V0.6220.48
54_D235_M0.6220.48
198_K247_N0.6180.48
46_E50_R0.6150.48
117_G155_L0.6110.47
193_L248_Q0.6100.47
97_V203_K0.6090.47
79_R217_I0.6070.47
142_G261_E0.6070.47
76_P84_Q0.6070.47
31_F228_A0.6050.46
117_G128_A0.6040.46
51_A80_A0.6030.46
18_I233_C0.6010.46
144_S233_C0.6010.46
18_I29_S0.6000.46
35_I106_L0.5990.46
134_D237_V0.5980.46
75_L80_A0.5950.45
16_T24_G0.5950.45
210_D253_N0.5940.45
40_L116_H0.5940.45
42_F186_D0.5930.45
14_D26_A0.5900.45
34_T77_E0.5900.45
226_R229_S0.5900.45
175_G195_A0.5880.45
116_H234_R0.5860.44
20_A92_I0.5860.44
47_S64_G0.5850.44
44_E259_V0.5850.44
113_H119_N0.5840.44
52_V78_I0.5830.44
219_E231_R0.5790.44
23_L95_A0.5780.43
175_G208_T0.5760.43
104_M183_F0.5750.43
30_Q113_H0.5740.43
145_L200_L0.5740.43
137_L154_I0.5740.43
73_I158_V0.5730.43
125_K177_R0.5710.43
151_A230_L0.5700.43
19_T116_H0.5690.43
42_F108_P0.5680.42
29_S115_T0.5660.42
7_R104_M0.5630.42
32_P114_R0.5620.42
82_I178_A0.5610.42
107_D128_A0.5580.41
25_H263_A0.5560.41
207_L266_I0.5550.41
93_V137_L0.5530.41
194_P197_L0.5520.41
125_K253_N0.5520.41
210_D237_V0.5520.41
16_T139_H0.5500.40
226_R232_Q0.5500.40
16_T104_M0.5500.40
197_L270_M0.5500.40
136_T201_Q0.5480.40
40_L100_L0.5470.40
96_L104_M0.5460.40
40_L109_T0.5430.40
107_D267_L0.5430.40
158_V161_C0.5400.39
39_T251_W0.5380.39
38_I252_I0.5370.39
244_Y249_I0.5350.39
8_H36_S0.5340.39
19_T126_Y0.5330.39
143_I162_G0.5330.39
87_G103_E0.5320.39
158_V237_V0.5310.38
45_N259_V0.5310.38
39_T133_I0.5300.38
155_L235_M0.5280.38
241_E253_N0.5270.38
42_F264_T0.5260.38
26_A112_A0.5260.38
37_S153_V0.5260.38
215_A255_T0.5260.38
49_A53_K0.5250.38
29_S42_F0.5220.38
243_L250_P0.5220.38
43_V252_I0.5220.38
71_Y79_R0.5210.37
14_D253_N0.5210.37
84_Q226_R0.5200.37
235_M239_E0.5200.37
87_G106_L0.5180.37
161_C191_L0.5160.37
76_P79_R0.5110.36
226_R271_G0.5100.36
111_I114_R0.5100.36
224_N229_S0.5100.36
18_I173_Q0.5090.36
53_K86_E0.5090.36
125_K175_G0.5070.36
213_R258_S0.5070.36
154_I179_A0.5060.36
210_D213_R0.5040.36
19_T26_A0.5040.36
220_E249_I0.5040.36
20_A115_T0.5030.36
83_L235_M0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h92A 1 0.4477 97.7 0.922 Contact Map
1ckeA 1 0.4549 97.5 0.925 Contact Map
1e6cA 1 0.444 97.4 0.927 Contact Map
1zuhA 1 0.4043 97.4 0.927 Contact Map
3fdiA 3 0.444 97.4 0.927 Contact Map
1viaA 2 0.4513 97.3 0.927 Contact Map
2iyvA 1 0.4621 97.3 0.927 Contact Map
3t61A 2 0.4621 97.3 0.928 Contact Map
1kagA 1 0.4007 97.3 0.928 Contact Map
2pt5A 2 0.4513 97.2 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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