GREMLIN Database
YEEN - Probable transcriptional regulatory protein YeeN
UniProt: P0A8A2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13382
Length: 238 (231)
Sequences: 3263 (1692)
Seq/√Len: 111.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_D202_Q4.5691.00
109_N225_D3.6461.00
65_D69_D3.6231.00
11_K15_K3.3181.00
143_D146_H2.9401.00
96_A114_F2.8871.00
41_P51_I2.8701.00
39_P72_K2.7761.00
208_S211_D2.7741.00
182_A186_A2.5121.00
206_E236_A2.4351.00
122_G126_S2.4201.00
14_A18_A2.3021.00
146_H149_E2.2341.00
207_L215_F2.1811.00
6_A9_V2.1651.00
135_G172_T2.1531.00
176_D179_K2.1521.00
113_I225_D2.1111.00
151_L156_V1.9901.00
3_R6_A1.9891.00
86_G114_F1.9801.00
177_L195_T1.9361.00
136_V198_E1.8721.00
9_V13_T1.7941.00
26_F57_A1.7941.00
80_V103_V1.7811.00
29_E46_S1.7801.00
3_R7_N1.7771.00
204_E236_A1.7501.00
117_K221_A1.7261.00
98_T106_T1.7171.00
172_T180_G1.7151.00
173_E176_D1.7081.00
140_K193_S1.7011.00
83_R97_E1.6811.00
63_V66_K1.6511.00
149_E153_E1.6131.00
60_P63_V1.5851.00
207_L211_D1.5831.00
218_L222_L1.5781.00
94_I218_L1.5601.00
7_N11_K1.5591.00
150_I187_A1.5431.00
5_W9_V1.5101.00
178_H182_A1.5011.00
113_I221_A1.4691.00
83_R95_I1.4641.00
154_A183_A1.4471.00
69_D74_G1.4451.00
137_I177_L1.4431.00
219_V223_E1.4261.00
181_I185_K1.4221.00
137_I172_T1.4211.00
211_D214_I1.4131.00
97_E230_K1.4041.00
201_A204_E1.4031.00
7_N15_K1.4011.00
67_A71_A1.3781.00
61_K65_D1.3771.00
112_T115_N1.3761.00
34_A72_K1.3731.00
144_P148_F1.3511.00
174_P197_L1.3401.00
117_K217_G1.3401.00
49_F53_R1.3391.00
154_A180_G1.3271.00
83_R199_M1.2860.99
90_N211_D1.2820.99
86_G96_A1.2790.99
6_A10_A1.2740.99
94_I114_F1.2660.99
40_D43_L1.2660.99
210_E214_I1.2630.99
51_I68_I1.2600.99
150_I189_I1.2580.99
32_A99_L1.2560.99
139_F170_I1.2560.99
51_I64_I1.2550.99
210_E213_E1.2530.99
87_F93_M1.2490.99
138_V169_V1.2450.99
82_G98_T1.2420.99
23_Y59_V1.2400.99
136_V169_V1.2310.99
215_F235_V1.2130.99
219_V233_H1.2080.99
88_G215_F1.2060.99
134_T200_I1.1870.99
185_K192_F1.1720.99
82_G103_V1.1700.99
7_N10_A1.1630.99
94_I215_F1.1580.99
148_F152_L1.1480.99
209_P212_L1.1300.98
121_I124_A1.1270.98
182_A185_K1.1140.98
51_I55_K1.1130.98
68_I71_A1.0970.98
22_I57_A1.0880.98
55_K61_K1.0710.98
183_A187_A1.0650.98
183_A186_A1.0520.98
141_G163_E1.0500.98
110_V225_D1.0460.97
209_P213_E1.0450.97
10_A14_A1.0440.97
62_H66_K1.0310.97
147_I168_I1.0230.97
139_F192_F1.0190.97
31_Y71_A1.0170.97
90_N215_F1.0130.97
38_E43_L1.0080.97
12_K16_D1.0020.97
108_A112_T0.9980.97
129_Y203_S0.9970.97
4_K7_N0.9950.97
130_M202_Q0.9860.96
34_A38_E0.9860.96
167_N193_S0.9840.96
146_H150_I0.9830.96
55_K60_P0.9820.96
136_V200_I0.9670.96
97_E133_N0.9660.96
138_V167_N0.9630.96
69_D75_G0.9620.96
217_G220_D0.9520.96
112_T116_K0.9400.95
4_K16_D0.9400.95
159_R176_D0.9350.95
90_N207_L0.9340.95
112_T117_K0.9290.95
7_N19_T0.9270.95
137_I181_I0.9210.95
88_G94_I0.9200.95
144_P163_E0.9170.95
3_R10_A0.9150.95
4_K9_V0.9140.94
150_I154_A0.9050.94
19_T23_Y0.9020.94
84_Y103_V0.9010.94
31_Y70_K0.8990.94
123_A129_Y0.8930.94
92_S235_V0.8900.94
39_P68_I0.8890.94
4_K8_I0.8880.94
178_H181_I0.8830.93
134_T173_E0.8740.93
13_T19_T0.8730.93
59_V63_V0.8720.93
163_E168_I0.8700.93
212_L235_V0.8700.93
179_K182_A0.8640.93
52_E181_I0.8580.92
25_K224_D0.8550.92
8_I11_K0.8540.92
130_M203_S0.8540.92
86_G122_G0.8540.92
92_S215_F0.8480.92
223_E231_V0.8470.92
156_V170_I0.8460.92
53_R196_E0.8420.92
10_A13_T0.8400.92
8_I12_K0.8400.92
8_I16_D0.8370.91
141_G166_G0.8340.91
66_K69_D0.8340.91
22_I26_F0.8320.91
113_I117_K0.8310.91
133_N199_M0.8290.91
88_G92_S0.8210.91
162_T171_Y0.8160.90
177_L197_L0.8160.90
151_L161_V0.8150.90
49_F52_E0.8140.90
82_G100_T0.8130.90
136_V171_Y0.8120.90
46_S49_F0.8080.90
144_P168_I0.8060.90
149_E152_L0.8020.90
36_Q46_S0.8010.90
216_E235_V0.8010.90
171_Y200_I0.8000.90
95_I128_S0.7970.89
92_S207_L0.7950.89
13_T17_G0.7920.89
96_A228_V0.7880.89
138_V194_T0.7870.89
129_Y202_Q0.7870.89
185_K191_E0.7860.89
30_I64_I0.7780.88
159_R173_E0.7780.88
98_T123_A0.7770.88
3_R8_I0.7750.88
9_V15_K0.7730.88
17_G20_S0.7730.88
60_P66_K0.7720.88
137_I192_F0.7640.87
27_G31_Y0.7630.87
34_A71_A0.7600.87
113_I222_L0.7590.87
205_V234_N0.7590.87
207_L212_L0.7570.87
114_F121_I0.7530.87
213_E216_E0.7490.86
121_I222_L0.7480.86
94_I219_V0.7410.86
26_F64_I0.7410.86
215_F233_H0.7410.86
129_Y205_V0.7330.85
161_V170_I0.7320.85
15_K18_A0.7270.85
8_I13_T0.7270.85
162_T169_V0.7230.84
26_F29_E0.7210.84
5_W16_D0.7180.84
213_E217_G0.7170.84
217_G221_A0.7140.83
38_E41_P0.7130.83
107_I121_I0.7030.83
84_Y107_I0.7020.82
34_A39_P0.7010.82
181_I195_T0.7000.82
137_I184_L0.6990.82
87_F127_V0.6980.82
212_L216_E0.6960.82
164_E169_V0.6940.82
34_A67_A0.6920.82
3_R16_D0.6900.81
21_K224_D0.6890.81
13_T16_D0.6890.81
146_H153_E0.6870.81
16_D19_T0.6840.81
29_E48_K0.6770.80
24_A31_Y0.6770.80
27_G63_V0.6750.80
72_K75_G0.6700.79
45_T48_K0.6690.79
37_G44_N0.6680.79
143_D149_E0.6670.79
159_R162_T0.6660.79
134_T171_Y0.6620.79
79_F99_L0.6620.79
134_T159_R0.6600.78
46_S50_V0.6560.78
151_L155_E0.6540.78
33_A50_V0.6540.78
147_I161_V0.6530.78
28_V106_T0.6510.77
139_F168_I0.6510.77
116_K221_A0.6490.77
216_E220_D0.6480.77
86_G119_G0.6470.77
5_W12_K0.6460.77
16_D20_S0.6460.77
27_G59_V0.6410.76
13_T55_K0.6410.76
26_F50_V0.6370.76
198_E232_Y0.6370.76
5_W8_I0.6320.75
44_N47_L0.6310.75
133_N197_L0.6310.75
146_H189_I0.6240.74
3_R9_V0.6230.74
207_L235_V0.6230.74
52_E194_T0.6230.74
28_V36_Q0.6210.74
177_L192_F0.6180.74
81_Q97_E0.6170.74
160_D163_E0.6140.73
106_T110_V0.6140.73
10_A15_K0.6130.73
139_F189_I0.6120.73
52_E56_Q0.6080.73
18_A21_K0.6030.72
104_N108_A0.5970.71
163_E167_N0.5970.71
109_N112_T0.5960.71
104_N107_I0.5960.71
95_I124_A0.5930.71
219_V235_V0.5930.71
70_K79_F0.5920.71
142_T221_A0.5910.70
114_F218_L0.5880.70
87_F123_A0.5850.70
112_T221_A0.5830.69
84_Y227_D0.5810.69
6_A11_K0.5810.69
6_A16_D0.5810.69
127_V130_M0.5800.69
139_F184_L0.5800.69
180_G183_A0.5790.69
21_K45_T0.5780.69
25_K28_V0.5720.68
179_K183_A0.5710.68
92_S205_V0.5690.68
94_I233_H0.5660.67
107_I111_R0.5620.67
99_L229_Q0.5620.67
83_R133_N0.5610.66
208_S212_L0.5610.66
4_K12_K0.5610.66
189_I192_F0.5590.66
177_L196_E0.5580.66
141_G168_I0.5570.66
48_K59_V0.5550.66
144_P152_L0.5490.65
106_T225_D0.5490.65
110_V113_I0.5470.65
93_M122_G0.5450.64
143_D179_K0.5420.64
107_I124_A0.5400.64
8_I14_A0.5390.63
8_I19_T0.5390.63
108_A115_N0.5380.63
33_A37_G0.5370.63
11_K14_A0.5370.63
206_E209_P0.5360.63
103_V107_I0.5340.63
3_R15_K0.5320.62
50_V53_R0.5310.62
73_G229_Q0.5310.62
5_W11_K0.5250.61
38_E72_K0.5240.61
71_A129_Y0.5240.61
81_Q99_L0.5230.61
53_R57_A0.5200.61
161_V168_I0.5190.61
6_A13_T0.5180.60
148_F161_V0.5170.60
59_V137_I0.5140.60
141_G147_I0.5140.60
82_G107_I0.5130.60
13_T57_A0.5130.60
46_S81_Q0.5110.59
95_I199_M0.5100.59
98_T107_I0.5090.59
18_A22_I0.5080.59
38_E71_A0.5070.59
28_V79_F0.5070.59
27_G70_K0.5060.59
60_P79_F0.5030.58
162_T166_G0.5020.58
95_I129_Y0.5010.58
103_V123_A0.5010.58
58_Q69_D0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mw7A 1 0.8908 100 0.015 Contact Map
1konA 1 0.9412 100 0.03 Contact Map
1lfpA 1 0.9748 100 0.033 Contact Map
4f3qA 1 0.958 100 0.044 Contact Map
2lqjA 1 0.3361 56.1 0.954 Contact Map
2ko1A 2 0.3151 35.4 0.959 Contact Map
4asnA 2 0.3697 35.1 0.959 Contact Map
1y7pA 5 0.3067 34.4 0.959 Contact Map
2jsxA 1 0.3235 29.9 0.961 Contact Map
1yt3A 1 0.2731 29.6 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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