GREMLIN Database
YEBC - Probable transcriptional regulatory protein YebC
UniProt: P0A8A0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11137
Length: 246 (235)
Sequences: 3265 (1682)
Seq/√Len: 109.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_S203_S4.4621.00
67_N71_A3.5951.00
112_E226_C3.5901.00
209_D212_T3.5641.00
13_R17_Q3.2291.00
99_I117_F2.9381.00
43_P53_V2.9121.00
146_D149_T2.7041.00
125_G129_S2.5561.00
207_D237_E2.4911.00
184_D188_A2.4491.00
41_G74_V2.4021.00
16_A20_K2.3071.00
208_M216_L2.2411.00
149_T152_E2.1931.00
8_A11_R2.1121.00
116_A226_C2.1081.00
138_G174_T2.1061.00
178_E181_K2.1051.00
2_A9_N2.0641.00
89_G117_F2.0051.00
143_E194_D2.0021.00
205_K237_E1.9851.00
179_M196_A1.8971.00
154_A159_A1.8631.00
139_V199_S1.8051.00
11_R15_A1.7861.00
5_S8_A1.7801.00
28_I59_N1.7761.00
83_E106_R1.7441.00
31_E48_R1.7341.00
101_C109_T1.7251.00
160_E178_E1.7121.00
174_T182_V1.6891.00
120_C222_M1.6851.00
86_I100_E1.6841.00
175_A178_E1.6761.00
65_T68_R1.6531.00
152_E156_E1.6031.00
5_S9_N1.5881.00
219_L223_L1.5791.00
62_T65_T1.5531.00
97_I219_L1.5501.00
208_M212_T1.5181.00
71_A76_G1.5121.00
180_G184_D1.5011.00
157_A185_A1.4961.00
163_V173_Y1.4711.00
140_I179_M1.4551.00
116_A222_M1.4531.00
220_I224_E1.4491.00
86_I98_M1.4471.00
183_R187_E1.4311.00
140_I174_T1.4201.00
115_H118_S1.4181.00
9_N13_R1.4131.00
153_A189_A1.4091.00
154_A162_V1.4041.00
69_A73_G1.4001.00
36_A74_V1.3981.00
63_R67_N1.3821.00
211_E215_K1.3771.00
160_E175_A1.3731.00
176_W198_V1.3641.00
100_E231_E1.3611.00
89_G99_I1.3601.00
202_P205_K1.3601.00
120_C218_R1.3511.00
142_F172_V1.3361.00
157_A182_V1.3311.00
212_T215_K1.3311.00
51_A55_K1.3281.00
53_V66_L1.3271.00
97_I117_F1.3050.99
25_F61_M1.3020.99
9_N17_Q1.2970.99
86_I200_M1.2970.99
153_A191_L1.2880.99
211_E214_P1.2870.99
210_A214_P1.2830.99
137_K160_E1.2570.99
34_T102_L1.2520.99
141_S171_D1.2500.99
93_G212_T1.2450.99
144_K164_T1.2410.99
216_L236_G1.2230.99
90_Y96_A1.2230.99
7_W11_R1.2170.99
85_I101_C1.2090.99
42_D45_A1.2080.99
139_V171_D1.2070.99
8_A12_H1.1910.99
91_G216_L1.1780.99
85_I106_R1.1770.99
97_I216_L1.1720.99
220_I234_H1.1710.99
187_E193_A1.1670.99
147_E151_M1.1570.99
137_K201_I1.1540.99
53_V70_I1.1250.98
2_A13_R1.1220.98
164_T170_I1.1200.98
124_L127_D1.1160.98
151_M155_L1.1100.98
71_A77_D1.1010.98
53_V57_L1.1010.98
70_I73_G1.0970.98
184_D187_E1.0880.98
113_V226_C1.0830.98
185_A188_A1.0820.98
57_L63_R1.0810.98
132_Y204_T1.0770.98
77_D80_A1.0710.98
24_I59_N1.0600.98
12_H16_A1.0520.97
9_N12_H1.0470.97
185_A189_A1.0410.97
142_F193_A1.0220.97
147_E164_T1.0210.97
33_V73_G1.0180.97
133_L203_S1.0070.97
111_A115_H1.0010.97
57_L62_T0.9990.97
2_A8_A0.9930.96
150_I170_I0.9890.96
93_G216_L0.9830.96
139_V201_I0.9800.96
27_K225_D0.9690.96
100_E136_K0.9660.96
169_A194_D0.9630.96
141_S169_A0.9550.95
14_K18_D0.9470.95
115_H119_K0.9460.95
64_D68_R0.9460.95
149_T153_A0.9420.95
115_H120_C0.9420.95
218_R221_D0.9420.95
217_M238_I0.9310.95
210_A213_A0.9280.95
140_I183_R0.9180.94
91_G97_I0.9030.94
180_G183_R0.9000.94
162_V172_V0.8990.94
163_V171_D0.8980.94
21_R25_F0.8940.94
87_Y106_R0.8920.94
36_A41_G0.8900.93
95_T236_G0.8890.93
9_N21_R0.8810.93
33_V72_R0.8790.93
153_A157_A0.8750.93
24_I28_I0.8740.93
147_E170_I0.8710.93
224_E232_V0.8670.93
61_M65_T0.8670.93
95_T208_M0.8620.92
55_K197_E0.8610.92
208_M213_A0.8580.92
159_A172_V0.8580.92
213_A236_G0.8530.92
137_K175_A0.8530.92
95_T216_L0.8520.92
15_A21_R0.8500.92
132_Y203_S0.8490.92
136_K200_M0.8410.91
133_L204_T0.8370.91
89_G125_G0.8340.91
116_A120_C0.8300.91
181_K184_D0.8250.91
11_R17_Q0.8240.91
41_G76_G0.8230.90
126_T132_Y0.8230.90
93_G208_M0.8220.90
98_M131_A0.8150.90
187_E192_K0.8120.90
68_R71_A0.8110.90
38_L48_R0.8110.90
179_M198_V0.8100.90
139_V173_Y0.8030.89
206_A235_N0.8020.89
141_S195_S0.8010.89
85_I103_S0.8000.89
162_V170_I0.7990.89
132_Y206_A0.7970.89
54_D183_R0.7910.89
10_T18_D0.7870.88
173_Y201_I0.7870.88
99_I229_V0.7870.88
10_T13_R0.7830.88
116_A223_L0.7810.88
48_R51_A0.7790.88
91_G95_T0.7770.88
10_T15_A0.7730.87
140_I193_A0.7730.87
6_K11_R0.7720.87
12_H15_A0.7710.87
216_L234_H0.7680.87
62_T68_R0.7660.87
6_K9_N0.7620.87
144_K170_I0.7600.87
19_A22_G0.7600.87
17_Q20_K0.7590.87
217_M236_G0.7590.87
51_A54_D0.7570.86
124_L223_L0.7570.86
32_L66_L0.7470.86
29_I33_V0.7450.86
214_P218_R0.7420.85
28_I66_L0.7360.85
165_Y169_A0.7330.85
15_A19_A0.7310.84
218_R222_M0.7260.84
183_R196_A0.7250.84
208_M236_G0.7230.84
152_E155_L0.7200.84
10_T14_K0.7120.83
117_F124_L0.7120.83
29_I65_T0.7070.82
36_A73_G0.7060.82
82_M102_L0.7040.82
97_I220_I0.7030.82
101_C126_T0.7030.82
110_V124_L0.6950.81
28_I31_E0.6930.81
142_F170_I0.6920.81
150_I162_V0.6910.81
23_K225_D0.6890.81
213_A238_I0.6890.81
74_V77_D0.6860.80
87_Y110_V0.6840.80
48_R52_A0.6770.80
137_K173_Y0.6770.80
31_E50_R0.6760.80
18_D22_G0.6660.79
90_Y130_V0.6660.79
149_T191_L0.6650.78
119_K222_M0.6630.78
217_M221_D0.6620.78
29_I61_M0.6620.78
28_I52_A0.6570.78
90_Y129_S0.6540.77
18_D21_R0.6540.77
7_W18_D0.6530.77
140_I186_L0.6530.77
40_G46_N0.6500.77
179_M193_A0.6490.77
12_H17_Q0.6480.77
40_G45_A0.6470.76
47_P50_R0.6460.76
89_G122_G0.6430.76
84_T100_E0.6420.76
54_D58_S0.6400.76
26_T33_V0.6400.76
15_A18_D0.6400.76
142_F191_L0.6370.75
30_R38_L0.6310.75
15_A57_L0.6300.75
36_A69_A0.6300.75
72_R82_M0.6290.74
165_Y171_D0.6260.74
30_R109_T0.6250.74
20_K23_K0.6240.74
214_P217_M0.6220.74
102_L230_Q0.6200.73
35_A52_A0.6200.73
136_K198_V0.6130.73
144_K150_I0.6130.73
199_S233_Y0.6110.72
220_I236_G0.6100.72
27_K30_R0.6070.72
54_D195_S0.6070.72
4_H7_W0.6060.72
93_G209_D0.6060.72
109_T113_V0.6050.72
3_G7_W0.6040.71
149_T156_E0.6020.71
98_M127_D0.6010.71
154_A158_G0.5990.71
46_N49_L0.5990.71
146_D181_K0.5990.71
155_L159_A0.5980.71
2_A17_Q0.5970.71
115_H222_M0.5970.71
110_V114_R0.5940.70
107_N111_A0.5910.70
213_A217_M0.5900.70
112_E115_H0.5900.70
113_V116_A0.5880.69
87_Y228_D0.5870.69
109_T226_C0.5830.69
117_F219_L0.5790.68
130_V133_L0.5760.68
234_H238_I0.5730.67
50_R61_M0.5730.67
3_G12_H0.5710.67
110_V127_D0.5690.67
41_G77_D0.5670.67
23_K47_P0.5620.66
75_G230_Q0.5580.65
4_H12_H0.5580.65
182_V185_A0.5540.65
99_I113_V0.5540.65
142_F186_L0.5530.65
73_G132_Y0.5530.65
86_I136_K0.5520.65
179_M197_E0.5470.64
146_D152_E0.5450.64
107_N110_V0.5440.64
20_K24_I0.5430.63
95_T206_A0.5400.63
152_E158_G0.5380.63
147_E155_L0.5380.63
44_D47_P0.5370.63
101_C110_V0.5330.62
41_G70_I0.5320.62
181_K185_A0.5310.62
35_A39_G0.5310.62
61_M140_I0.5280.61
29_I72_R0.5270.61
10_T21_R0.5260.61
48_R84_T0.5260.61
90_Y125_G0.5260.61
97_I234_H0.5230.61
180_G198_V0.5230.61
2_A10_T0.5220.60
111_A118_S0.5210.60
106_R110_V0.5170.60
98_M200_M0.5170.60
62_T82_M0.5160.59
141_S163_V0.5160.59
140_I182_V0.5150.59
8_A13_R0.5150.59
209_D213_A0.5140.59
6_K18_D0.5130.59
55_K231_E0.5130.59
51_A62_T0.5110.59
84_T102_L0.5110.59
24_I31_E0.5100.59
28_I61_M0.5090.58
220_I232_V0.5080.58
5_S10_T0.5060.58
17_Q21_R0.5060.58
2_A16_A0.5060.58
151_M162_V0.5050.58
106_R126_T0.5050.58
2_A5_S0.5050.58
96_A125_G0.5030.58
109_T114_R0.5020.57
15_A59_N0.5020.57
60_N71_A0.5020.57
7_W10_T0.5000.57
143_E188_A0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1konA 1 0.9431 100 -0.008 Contact Map
1lfpA 1 0.9756 100 0.001 Contact Map
4f3qA 1 0.9472 100 0.014 Contact Map
1mw7A 1 0.8618 100 0.082 Contact Map
4ptaD 3 0.4106 43.7 0.959 Contact Map
2q02A 2 0.4756 38.3 0.96 Contact Map
2ra5A 2 0.4065 36.7 0.96 Contact Map
4pt7A 3 0.4472 36.3 0.961 Contact Map
3tvaA 1 0.4634 33.9 0.961 Contact Map
2yr1A 2 0.7195 29.2 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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