GREMLIN Database
TUSA - Sulfurtransferase TusA
UniProt: P0A890 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12216
Length: 81 (74)
Sequences: 365 (182)
Seq/√Len: 21.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_A47_A3.0911.00
27_R59_M2.6020.98
28_K32_N2.4990.98
41_I52_I2.4400.97
34_Q37_E2.4390.97
62_E78_R2.3500.97
40_L74_R2.2640.96
9_D37_E2.2420.96
30_V77_I1.9880.92
33_M39_L1.9810.92
15_L72_P1.7980.87
38_T76_L1.7970.87
27_R44_D1.7700.86
42_I47_A1.7560.86
44_D59_M1.7490.85
67_E74_R1.7250.85
10_H37_E1.7010.84
15_L42_I1.6770.83
33_M37_E1.6580.82
47_A77_I1.6110.80
8_P76_L1.5850.79
31_R61_H1.5740.79
11_T40_L1.5050.75
29_T32_N1.4940.75
54_G60_E1.3770.69
12_L53_P1.3200.65
57_T76_L1.2090.58
68_T71_L1.1680.56
24_M48_T1.1410.54
44_D72_P1.1310.53
35_P62_E1.1090.52
23_V43_A1.1040.51
23_V26_V1.0000.44
46_P58_F0.9710.43
27_R72_P0.9600.42
59_M72_P0.9530.41
10_H25_M0.9460.41
38_T64_V0.9320.40
30_V33_M0.9310.40
11_T42_I0.9120.39
39_L49_T0.8960.38
10_H41_I0.8910.37
18_R44_D0.8750.36
65_A68_T0.8750.36
26_V60_E0.8710.36
14_A23_V0.8610.36
23_V79_K0.8610.36
7_S41_I0.8510.35
25_M43_A0.8420.34
47_A54_G0.8330.34
65_A76_L0.8290.34
11_T36_G0.8240.33
26_V59_M0.8220.33
26_V44_D0.8150.33
35_P80_G0.8070.32
24_M50_R0.8060.32
50_R58_F0.7970.32
38_T65_A0.7860.31
24_M75_Y0.7780.31
40_L46_P0.7760.31
13_D23_V0.7700.30
62_E69_D0.7630.30
21_E50_R0.7500.29
54_G57_T0.7470.29
41_I68_T0.7470.29
8_P11_T0.7240.28
43_A49_T0.7190.27
60_E80_G0.6880.26
32_N76_L0.6600.24
27_R68_T0.6440.24
59_M68_T0.6340.23
40_L76_L0.6330.23
27_R54_G0.6320.23
54_G59_M0.6250.23
40_L58_F0.6160.22
26_V47_A0.6090.22
49_T78_R0.6070.22
23_V47_A0.6000.22
44_D54_G0.5970.21
67_E71_L0.5860.21
8_P57_T0.5750.20
9_D57_T0.5730.20
70_G74_R0.5700.20
14_A25_M0.5620.20
62_E67_E0.5590.20
18_R72_P0.5560.20
8_P65_A0.5520.19
10_H29_T0.5510.19
8_P74_R0.5510.19
7_S70_G0.5450.19
30_V36_G0.5420.19
30_V75_Y0.5410.19
8_P14_A0.5400.19
18_R47_A0.5370.19
21_E58_F0.5350.19
59_M71_L0.5310.19
15_L47_A0.5290.19
10_H62_E0.5240.18
67_E77_I0.5230.18
28_K76_L0.5210.18
9_D65_A0.5210.18
37_E80_G0.5150.18
29_T64_V0.5120.18
62_E70_G0.5080.18
41_I77_I0.5060.18
38_T77_I0.5060.18
38_T57_T0.5030.18
58_F78_R0.5030.18
27_R71_L0.5010.17
26_V79_K0.5000.17
35_P68_T0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lvjC 1 0.9506 99.8 0.478 Contact Map
1je3A 1 0.9506 99.8 0.484 Contact Map
1jdqA 1 0.963 99.8 0.493 Contact Map
1pavA 1 0.963 99.8 0.509 Contact Map
3hz7A 1 0.9012 99.8 0.514 Contact Map
2lxrA 1 0.8765 99.7 0.568 Contact Map
1okgA 1 0.7407 98.2 0.762 Contact Map
3p2yA 2 1 15.9 0.928 Contact Map
3njrA 4 0.9259 14.3 0.93 Contact Map
4bpyA 1 0.9506 11.1 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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