GREMLIN Database
TYSY - Thymidylate synthase
UniProt: P0A884 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11002
Length: 264 (262)
Sequences: 3013 (1319)
Seq/√Len: 81.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_V170_V3.8441.00
225_R254_P3.6761.00
10_K14_E3.6061.00
63_L112_I3.3531.00
10_K32_H3.0961.00
238_S241_D3.0301.00
225_R253_D2.9421.00
17_Q27_L2.8401.00
118_Q128_I2.7981.00
208_L216_T2.6781.00
117_N121_N2.6311.00
203_G206_T2.5791.00
51_H54_S2.5651.00
218_L221_S2.5061.00
9_Q13_D2.4951.00
115_V128_I2.4581.00
161_C185_V2.4551.00
78_T81_D2.4341.00
186_H196_V2.3501.00
10_K29_I2.3131.00
52_L56_I2.2321.00
231_I248_E2.1911.00
231_I250_E2.1361.00
70_A74_E2.1331.00
17_Q210_S2.0991.00
116_L188_M2.0991.00
69_I73_H2.0811.00
186_H230_L2.0571.00
225_R255_H1.9951.00
12_L217_H1.9951.00
116_L239_I1.9621.00
67_T96_K1.9521.00
99_R110_D1.9441.00
27_L213_M1.9341.00
96_K102_P1.9291.00
191_Q242_Y1.9211.00
37_N40_D1.8271.00
20_D25_G1.8231.00
233_K246_D1.8071.00
19_N124_D1.8061.00
168_C174_L1.7981.00
57_H75_N1.7791.00
18_K124_D1.7591.00
103_T107_R1.7531.00
119_L192_C1.7231.00
50_C55_I1.7011.00
56_I247_F1.6901.00
57_H71_Y1.6761.00
35_R198_D1.6601.00
73_H78_T1.6311.00
39_Q158_K1.6271.00
229_K251_G1.6171.00
232_I247_F1.5971.00
100_A108_H1.5711.00
27_L210_S1.5691.00
71_Y75_N1.5431.00
236_P242_Y1.5290.99
44_L50_C1.5130.99
8_M216_T1.4960.99
57_H77_V1.4890.99
73_H81_D1.4670.99
130_V150_F1.4660.99
16_T156_D1.4500.99
16_T155_A1.4390.99
233_K248_E1.4340.99
8_M170_V1.4270.99
158_K195_E1.4270.99
29_I32_H1.4230.99
28_S153_Y1.4100.99
223_E255_H1.4050.99
116_L192_C1.3920.99
119_L128_I1.3900.99
170_V206_T1.3890.99
201_W206_T1.3880.99
17_Q213_M1.3830.99
157_G194_L1.3810.99
152_F188_M1.3800.99
53_R76_N1.3550.99
102_P108_H1.3540.99
191_Q236_P1.3340.99
118_Q122_D1.3270.98
115_V188_M1.3150.98
163_L199_F1.3010.98
115_V118_Q1.2930.98
229_K250_E1.2830.98
230_L247_F1.2690.98
114_T118_Q1.2690.98
113_T117_N1.2660.98
138_L144_A1.2610.98
44_L249_I1.2490.98
186_H249_I1.2400.98
230_L249_I1.2340.98
57_H244_F1.2280.97
234_R237_E1.2110.97
24_T263_A1.1970.97
103_T109_I1.1810.97
190_Q234_R1.1690.97
52_L249_I1.1680.97
131_S135_V1.1650.97
113_T240_F1.1620.96
33_Q202_T1.1600.96
137_E140_K1.1500.96
83_W262_V1.1480.96
216_T260_A1.1430.96
213_M217_H1.1320.96
12_L213_M1.1200.96
96_K108_H1.1190.96
214_D217_H1.1160.96
171_F260_A1.1080.95
208_L260_A1.1070.95
168_C203_G1.1020.95
96_K137_E1.0950.95
32_H170_V1.0890.95
114_T117_N1.0840.95
152_F161_C1.0770.95
226_P253_D1.0710.94
153_Y160_S1.0690.94
66_D71_Y1.0590.94
5_L224_P1.0500.94
162_Q202_T1.0450.94
170_V174_L1.0350.93
115_V152_F1.0330.93
7_L170_V1.0300.93
12_L208_L1.0270.93
253_D256_P1.0240.93
165_Q168_C1.0090.92
154_V194_L1.0070.92
114_T139_D1.0060.92
70_A73_H1.0040.92
257_G262_V0.9910.92
8_M208_L0.9880.92
211_N263_A0.9800.91
115_V130_V0.9710.91
101_W135_V0.9670.91
168_C201_W0.9650.91
171_F216_T0.9640.91
171_F215_Q0.9590.90
164_Y204_G0.9510.90
119_L188_M0.9410.90
187_M191_Q0.9310.89
73_H84_A0.9310.89
119_L194_L0.9290.89
50_C257_G0.9280.89
215_Q260_A0.9250.89
190_Q233_K0.9230.89
20_D24_T0.9220.89
39_Q197_G0.9200.89
97_Q134_N0.9160.88
47_T219_Q0.9110.88
186_H247_F0.9100.88
238_S242_Y0.9070.88
174_L203_G0.9050.88
214_D218_L0.9030.88
14_E29_I0.9010.87
160_S198_D0.8980.87
25_G210_S0.8910.87
118_Q121_N0.8890.87
118_Q125_S0.8880.87
14_E32_H0.8870.87
102_P107_R0.8860.87
84_A87_N0.8840.86
57_H243_R0.8810.86
49_R257_G0.8770.86
149_F164_Y0.8700.86
5_L219_Q0.8690.86
35_R200_V0.8630.85
104_P136_G0.8610.85
218_L257_G0.8580.85
39_Q195_E0.8530.84
56_I249_I0.8490.84
73_H85_D0.8490.84
155_A160_S0.8490.84
210_S263_A0.8470.84
187_M247_F0.8470.84
96_K100_A0.8450.84
7_L32_H0.8340.83
56_I183_L0.8340.83
64_Q243_R0.8300.83
210_S213_M0.8280.83
12_L27_L0.8270.83
103_T108_H0.8270.83
101_W109_I0.8250.82
232_I242_Y0.8240.82
92_P96_K0.8230.82
233_K237_E0.8230.82
157_G195_E0.8220.82
18_K28_S0.8220.82
6_E9_Q0.8210.82
49_R254_P0.8200.82
71_Y74_E0.8200.82
73_H87_N0.8180.82
52_L230_L0.8180.82
233_K236_P0.8170.82
9_Q217_H0.8150.82
73_H76_N0.8120.81
182_A199_F0.8090.81
102_P137_E0.8070.81
158_K197_G0.8020.81
237_E242_Y0.8000.80
97_Q141_M0.7990.80
191_Q238_S0.7990.80
8_M260_A0.7970.80
104_P108_H0.7890.80
236_P243_R0.7880.79
151_Q204_G0.7840.79
54_S57_H0.7810.79
131_S148_A0.7770.78
148_A164_Y0.7660.77
124_D157_G0.7650.77
44_L179_A0.7620.77
38_L185_V0.7560.77
163_L201_W0.7530.76
103_T136_G0.7440.75
187_M242_Y0.7390.75
112_I130_V0.7350.75
162_Q204_G0.7220.73
233_K242_Y0.7220.73
26_T126_R0.7220.73
56_I244_F0.7190.73
59_L180_S0.7140.72
181_Y199_F0.7140.72
135_V141_M0.7120.72
104_P107_R0.7110.72
196_V230_L0.7110.72
62_F180_S0.7080.72
121_N128_I0.7070.72
193_D235_K0.7060.72
90_L93_V0.7020.71
51_H78_T0.7000.71
150_F181_Y0.6990.71
148_A163_L0.6940.70
156_D194_L0.6900.70
3_Q6_E0.6880.70
136_G139_D0.6860.69
20_D210_S0.6850.69
187_M190_Q0.6840.69
174_L199_F0.6820.69
223_E226_P0.6810.69
128_I192_C0.6800.69
137_E141_M0.6790.69
45_V254_P0.6780.68
6_E10_K0.6770.68
9_Q221_S0.6770.68
193_D237_E0.6760.68
61_W72_L0.6760.68
164_Y202_T0.6750.68
69_I75_N0.6690.67
231_I234_R0.6670.67
60_L247_F0.6670.67
32_H206_T0.6630.67
101_W136_G0.6600.66
156_D195_E0.6580.66
188_M192_C0.6500.65
141_M145_P0.6490.65
144_A148_A0.6480.65
104_P137_E0.6480.65
56_I230_L0.6460.65
98_W132_A0.6450.65
195_E198_D0.6440.64
41_G227_L0.6430.64
135_V138_L0.6410.64
187_M236_P0.6410.64
69_I84_A0.6390.64
138_L141_M0.6390.64
129_I133_W0.6360.64
5_L220_L0.6360.64
27_L217_H0.6350.63
234_R242_Y0.6350.63
28_S205_D0.6330.63
103_T106_G0.6330.63
254_P257_G0.6280.63
5_L227_L0.6270.62
165_Q174_L0.6270.62
7_L34_M0.6250.62
51_H76_N0.6240.62
225_R256_P0.6230.62
211_N261_P0.6230.62
45_V50_C0.6220.62
165_Q201_W0.6210.62
174_L201_W0.6210.62
77_V244_F0.6190.61
78_T261_P0.6180.61
57_H64_Q0.6180.61
18_K153_Y0.6170.61
54_S77_V0.6150.61
233_K245_E0.6140.61
190_Q236_P0.6120.61
191_Q234_R0.6110.60
168_C206_T0.6100.60
112_I188_M0.6090.60
64_Q71_Y0.6070.60
53_R57_H0.6040.60
208_L213_M0.6040.60
190_Q242_Y0.6040.60
5_L45_V0.6040.60
92_P97_Q0.6020.59
97_Q137_E0.6010.59
235_K246_D0.6010.59
155_A158_K0.6000.59
39_Q196_V0.5970.59
235_K242_Y0.5960.59
120_K192_C0.5940.58
33_Q162_Q0.5920.58
85_D89_D0.5900.58
225_R251_G0.5850.57
75_N244_F0.5850.57
234_R248_E0.5840.57
251_G254_P0.5830.57
171_F212_H0.5810.57
217_H221_S0.5800.57
114_T138_L0.5790.56
178_I181_Y0.5790.56
51_H244_F0.5770.56
163_L168_C0.5760.56
183_L230_L0.5760.56
7_L36_F0.5740.56
82_E262_V0.5730.56
134_N141_M0.5720.55
37_N198_D0.5710.55
69_I83_W0.5700.55
234_R247_F0.5680.55
75_N243_R0.5670.55
127_R143_L0.5670.55
36_F178_I0.5660.55
5_L9_Q0.5650.55
19_N27_L0.5640.54
34_M203_G0.5640.54
78_T263_A0.5640.54
132_A141_M0.5630.54
42_F179_A0.5630.54
91_G97_Q0.5620.54
122_D125_S0.5610.54
185_V192_C0.5600.54
18_K160_S0.5560.53
69_I93_V0.5550.53
33_Q200_V0.5540.53
41_G186_H0.5540.53
27_L208_L0.5500.53
56_I60_L0.5500.53
50_C254_P0.5500.53
187_M232_I0.5460.52
234_R246_D0.5450.52
32_H36_F0.5450.52
109_I136_G0.5440.52
69_I85_D0.5440.52
54_S76_N0.5430.52
22_T26_T0.5410.51
9_Q12_L0.5400.51
150_F161_C0.5400.51
13_D16_T0.5400.51
234_R241_D0.5380.51
101_W108_H0.5350.51
125_S128_I0.5350.51
37_N41_G0.5350.51
185_V188_M0.5350.51
13_D217_H0.5310.50
172_L219_Q0.5290.50
73_H86_E0.5280.50
160_S197_G0.5270.50
237_E241_D0.5270.50
112_I239_I0.5270.50
79_I176_F0.5250.49
115_V150_F0.5250.49
51_H75_N0.5190.49
83_W88_G0.5190.49
38_L182_A0.5180.48
157_G197_G0.5180.48
18_K155_A0.5180.48
119_L154_V0.5170.48
24_T261_P0.5170.48
190_Q235_K0.5160.48
108_H136_G0.5120.48
13_D223_E0.5110.48
69_I87_N0.5110.48
5_L12_L0.5110.48
102_P136_G0.5100.47
37_N42_F0.5100.47
69_I81_D0.5100.47
27_L216_T0.5080.47
45_V144_A0.5060.47
3_Q227_L0.5050.47
166_R169_D0.5050.47
97_Q111_Q0.5040.47
55_I180_S0.5030.46
231_I243_R0.5030.46
160_S200_V0.5030.46
109_I114_T0.5020.46
92_P140_K0.5010.46
168_C199_F0.5010.46
158_K198_D0.5000.46
20_D26_T0.5000.46
24_T211_N0.5000.46
116_L119_L0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v8hA 2 0.9659 100 -0.036 Contact Map
3uwlA 2 1 100 -0.035 Contact Map
3nrrA 2 1 100 -0.031 Contact Map
1hw4A 2 0.9508 100 -0.029 Contact Map
4iqbA 2 0.9848 100 -0.029 Contact Map
4g9uA 2 0.9886 100 -0.028 Contact Map
3hj3A 2 1 100 -0.028 Contact Map
4eilA 3 1 100 -0.025 Contact Map
3irmA 4 1 100 -0.023 Contact Map
3ix6A 2 0.9356 100 -0.023 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.