TYSY - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

TYSY - Thymidylate synthase

UniProt:	P0A884	Sequences: MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11002
Length:	264 (262)
Sequences:	3013 (1319)
Seq/√Len:	81.5

ECOLI - TYSY
BACSU - TYSY2 TYSY1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
11_V	170_V	3.844	1.00
225_R	254_P	3.676	1.00
10_K	14_E	3.606	1.00
63_L	112_I	3.353	1.00
10_K	32_H	3.096	1.00
238_S	241_D	3.030	1.00
225_R	253_D	2.942	1.00
17_Q	27_L	2.840	1.00
118_Q	128_I	2.798	1.00
208_L	216_T	2.678	1.00
117_N	121_N	2.631	1.00
203_G	206_T	2.579	1.00
51_H	54_S	2.565	1.00
218_L	221_S	2.506	1.00
9_Q	13_D	2.495	1.00
115_V	128_I	2.458	1.00
161_C	185_V	2.455	1.00
78_T	81_D	2.434	1.00
186_H	196_V	2.350	1.00
10_K	29_I	2.313	1.00
52_L	56_I	2.232	1.00
231_I	248_E	2.191	1.00
231_I	250_E	2.136	1.00
70_A	74_E	2.133	1.00
17_Q	210_S	2.099	1.00
116_L	188_M	2.099	1.00
69_I	73_H	2.081	1.00
186_H	230_L	2.057	1.00
225_R	255_H	1.995	1.00
12_L	217_H	1.995	1.00
116_L	239_I	1.962	1.00
67_T	96_K	1.952	1.00
99_R	110_D	1.944	1.00
27_L	213_M	1.934	1.00
96_K	102_P	1.929	1.00
191_Q	242_Y	1.921	1.00
37_N	40_D	1.827	1.00
20_D	25_G	1.823	1.00
233_K	246_D	1.807	1.00
19_N	124_D	1.806	1.00
168_C	174_L	1.798	1.00
57_H	75_N	1.779	1.00
18_K	124_D	1.759	1.00
103_T	107_R	1.753	1.00
119_L	192_C	1.723	1.00
50_C	55_I	1.701	1.00
56_I	247_F	1.690	1.00
57_H	71_Y	1.676	1.00
35_R	198_D	1.660	1.00
73_H	78_T	1.631	1.00
39_Q	158_K	1.627	1.00
229_K	251_G	1.617	1.00
232_I	247_F	1.597	1.00
100_A	108_H	1.571	1.00
27_L	210_S	1.569	1.00
71_Y	75_N	1.543	1.00
236_P	242_Y	1.529	0.99
44_L	50_C	1.513	0.99
8_M	216_T	1.496	0.99
57_H	77_V	1.489	0.99
73_H	81_D	1.467	0.99
130_V	150_F	1.466	0.99
16_T	156_D	1.450	0.99
16_T	155_A	1.439	0.99
233_K	248_E	1.434	0.99
8_M	170_V	1.427	0.99
158_K	195_E	1.427	0.99
29_I	32_H	1.423	0.99
28_S	153_Y	1.410	0.99
223_E	255_H	1.405	0.99
116_L	192_C	1.392	0.99
119_L	128_I	1.390	0.99
170_V	206_T	1.389	0.99
201_W	206_T	1.388	0.99
17_Q	213_M	1.383	0.99
157_G	194_L	1.381	0.99
152_F	188_M	1.380	0.99
53_R	76_N	1.355	0.99
102_P	108_H	1.354	0.99
191_Q	236_P	1.334	0.99
118_Q	122_D	1.327	0.98
115_V	188_M	1.315	0.98
163_L	199_F	1.301	0.98
115_V	118_Q	1.293	0.98
229_K	250_E	1.283	0.98
230_L	247_F	1.269	0.98
114_T	118_Q	1.269	0.98
113_T	117_N	1.266	0.98
138_L	144_A	1.261	0.98
44_L	249_I	1.249	0.98
186_H	249_I	1.240	0.98
230_L	249_I	1.234	0.98
57_H	244_F	1.228	0.97
234_R	237_E	1.211	0.97
24_T	263_A	1.197	0.97
103_T	109_I	1.181	0.97
190_Q	234_R	1.169	0.97
52_L	249_I	1.168	0.97
131_S	135_V	1.165	0.97
113_T	240_F	1.162	0.96
33_Q	202_T	1.160	0.96
137_E	140_K	1.150	0.96
83_W	262_V	1.148	0.96
216_T	260_A	1.143	0.96
213_M	217_H	1.132	0.96
12_L	213_M	1.120	0.96
96_K	108_H	1.119	0.96
214_D	217_H	1.116	0.96
171_F	260_A	1.108	0.95
208_L	260_A	1.107	0.95
168_C	203_G	1.102	0.95
96_K	137_E	1.095	0.95
32_H	170_V	1.089	0.95
114_T	117_N	1.084	0.95
152_F	161_C	1.077	0.95
226_P	253_D	1.071	0.94
153_Y	160_S	1.069	0.94
66_D	71_Y	1.059	0.94
5_L	224_P	1.050	0.94
162_Q	202_T	1.045	0.94
170_V	174_L	1.035	0.93
115_V	152_F	1.033	0.93
7_L	170_V	1.030	0.93
12_L	208_L	1.027	0.93
253_D	256_P	1.024	0.93
165_Q	168_C	1.009	0.92
154_V	194_L	1.007	0.92
114_T	139_D	1.006	0.92
70_A	73_H	1.004	0.92
257_G	262_V	0.991	0.92
8_M	208_L	0.988	0.92
211_N	263_A	0.980	0.91
115_V	130_V	0.971	0.91
101_W	135_V	0.967	0.91
168_C	201_W	0.965	0.91
171_F	216_T	0.964	0.91
171_F	215_Q	0.959	0.90
164_Y	204_G	0.951	0.90
119_L	188_M	0.941	0.90
187_M	191_Q	0.931	0.89
73_H	84_A	0.931	0.89
119_L	194_L	0.929	0.89
50_C	257_G	0.928	0.89
215_Q	260_A	0.925	0.89
190_Q	233_K	0.923	0.89
20_D	24_T	0.922	0.89
39_Q	197_G	0.920	0.89
97_Q	134_N	0.916	0.88
47_T	219_Q	0.911	0.88
186_H	247_F	0.910	0.88
238_S	242_Y	0.907	0.88
174_L	203_G	0.905	0.88
214_D	218_L	0.903	0.88
14_E	29_I	0.901	0.87
160_S	198_D	0.898	0.87
25_G	210_S	0.891	0.87
118_Q	121_N	0.889	0.87
118_Q	125_S	0.888	0.87
14_E	32_H	0.887	0.87
102_P	107_R	0.886	0.87
84_A	87_N	0.884	0.86
57_H	243_R	0.881	0.86
49_R	257_G	0.877	0.86
149_F	164_Y	0.870	0.86
5_L	219_Q	0.869	0.86
35_R	200_V	0.863	0.85
104_P	136_G	0.861	0.85
218_L	257_G	0.858	0.85
39_Q	195_E	0.853	0.84
56_I	249_I	0.849	0.84
73_H	85_D	0.849	0.84
155_A	160_S	0.849	0.84
210_S	263_A	0.847	0.84
187_M	247_F	0.847	0.84
96_K	100_A	0.845	0.84
7_L	32_H	0.834	0.83
56_I	183_L	0.834	0.83
64_Q	243_R	0.830	0.83
210_S	213_M	0.828	0.83
12_L	27_L	0.827	0.83
103_T	108_H	0.827	0.83
101_W	109_I	0.825	0.82
232_I	242_Y	0.824	0.82
92_P	96_K	0.823	0.82
233_K	237_E	0.823	0.82
157_G	195_E	0.822	0.82
18_K	28_S	0.822	0.82
6_E	9_Q	0.821	0.82
49_R	254_P	0.820	0.82
71_Y	74_E	0.820	0.82
73_H	87_N	0.818	0.82
52_L	230_L	0.818	0.82
233_K	236_P	0.817	0.82
9_Q	217_H	0.815	0.82
73_H	76_N	0.812	0.81
182_A	199_F	0.809	0.81
102_P	137_E	0.807	0.81
158_K	197_G	0.802	0.81
237_E	242_Y	0.800	0.80
97_Q	141_M	0.799	0.80
191_Q	238_S	0.799	0.80
8_M	260_A	0.797	0.80
104_P	108_H	0.789	0.80
236_P	243_R	0.788	0.79
151_Q	204_G	0.784	0.79
54_S	57_H	0.781	0.79
131_S	148_A	0.777	0.78
148_A	164_Y	0.766	0.77
124_D	157_G	0.765	0.77
44_L	179_A	0.762	0.77
38_L	185_V	0.756	0.77
163_L	201_W	0.753	0.76
103_T	136_G	0.744	0.75
187_M	242_Y	0.739	0.75
112_I	130_V	0.735	0.75
162_Q	204_G	0.722	0.73
233_K	242_Y	0.722	0.73
26_T	126_R	0.722	0.73
56_I	244_F	0.719	0.73
59_L	180_S	0.714	0.72
181_Y	199_F	0.714	0.72
135_V	141_M	0.712	0.72
104_P	107_R	0.711	0.72
196_V	230_L	0.711	0.72
62_F	180_S	0.708	0.72
121_N	128_I	0.707	0.72
193_D	235_K	0.706	0.72
90_L	93_V	0.702	0.71
51_H	78_T	0.700	0.71
150_F	181_Y	0.699	0.71
148_A	163_L	0.694	0.70
156_D	194_L	0.690	0.70
3_Q	6_E	0.688	0.70
136_G	139_D	0.686	0.69
20_D	210_S	0.685	0.69
187_M	190_Q	0.684	0.69
174_L	199_F	0.682	0.69
223_E	226_P	0.681	0.69
128_I	192_C	0.680	0.69
137_E	141_M	0.679	0.69
45_V	254_P	0.678	0.68
6_E	10_K	0.677	0.68
9_Q	221_S	0.677	0.68
193_D	237_E	0.676	0.68
61_W	72_L	0.676	0.68
164_Y	202_T	0.675	0.68
69_I	75_N	0.669	0.67
231_I	234_R	0.667	0.67
60_L	247_F	0.667	0.67
32_H	206_T	0.663	0.67
101_W	136_G	0.660	0.66
156_D	195_E	0.658	0.66
188_M	192_C	0.650	0.65
141_M	145_P	0.649	0.65
144_A	148_A	0.648	0.65
104_P	137_E	0.648	0.65
56_I	230_L	0.646	0.65
98_W	132_A	0.645	0.65
195_E	198_D	0.644	0.64
41_G	227_L	0.643	0.64
135_V	138_L	0.641	0.64
187_M	236_P	0.641	0.64
69_I	84_A	0.639	0.64
138_L	141_M	0.639	0.64
129_I	133_W	0.636	0.64
5_L	220_L	0.636	0.64
27_L	217_H	0.635	0.63
234_R	242_Y	0.635	0.63
28_S	205_D	0.633	0.63
103_T	106_G	0.633	0.63
254_P	257_G	0.628	0.63
5_L	227_L	0.627	0.62
165_Q	174_L	0.627	0.62
7_L	34_M	0.625	0.62
51_H	76_N	0.624	0.62
225_R	256_P	0.623	0.62
211_N	261_P	0.623	0.62
45_V	50_C	0.622	0.62
165_Q	201_W	0.621	0.62
174_L	201_W	0.621	0.62
77_V	244_F	0.619	0.61
78_T	261_P	0.618	0.61
57_H	64_Q	0.618	0.61
18_K	153_Y	0.617	0.61
54_S	77_V	0.615	0.61
233_K	245_E	0.614	0.61
190_Q	236_P	0.612	0.61
191_Q	234_R	0.611	0.60
168_C	206_T	0.610	0.60
112_I	188_M	0.609	0.60
64_Q	71_Y	0.607	0.60
53_R	57_H	0.604	0.60
208_L	213_M	0.604	0.60
190_Q	242_Y	0.604	0.60
5_L	45_V	0.604	0.60
92_P	97_Q	0.602	0.59
97_Q	137_E	0.601	0.59
235_K	246_D	0.601	0.59
155_A	158_K	0.600	0.59
39_Q	196_V	0.597	0.59
235_K	242_Y	0.596	0.59
120_K	192_C	0.594	0.58
33_Q	162_Q	0.592	0.58
85_D	89_D	0.590	0.58
225_R	251_G	0.585	0.57
75_N	244_F	0.585	0.57
234_R	248_E	0.584	0.57
251_G	254_P	0.583	0.57
171_F	212_H	0.581	0.57
217_H	221_S	0.580	0.57
114_T	138_L	0.579	0.56
178_I	181_Y	0.579	0.56
51_H	244_F	0.577	0.56
163_L	168_C	0.576	0.56
183_L	230_L	0.576	0.56
7_L	36_F	0.574	0.56
82_E	262_V	0.573	0.56
134_N	141_M	0.572	0.55
37_N	198_D	0.571	0.55
69_I	83_W	0.570	0.55
234_R	247_F	0.568	0.55
75_N	243_R	0.567	0.55
127_R	143_L	0.567	0.55
36_F	178_I	0.566	0.55
5_L	9_Q	0.565	0.55
19_N	27_L	0.564	0.54
34_M	203_G	0.564	0.54
78_T	263_A	0.564	0.54
132_A	141_M	0.563	0.54
42_F	179_A	0.563	0.54
91_G	97_Q	0.562	0.54
122_D	125_S	0.561	0.54
185_V	192_C	0.560	0.54
18_K	160_S	0.556	0.53
69_I	93_V	0.555	0.53
33_Q	200_V	0.554	0.53
41_G	186_H	0.554	0.53
27_L	208_L	0.550	0.53
56_I	60_L	0.550	0.53
50_C	254_P	0.550	0.53
187_M	232_I	0.546	0.52
234_R	246_D	0.545	0.52
32_H	36_F	0.545	0.52
109_I	136_G	0.544	0.52
69_I	85_D	0.544	0.52
54_S	76_N	0.543	0.52
22_T	26_T	0.541	0.51
9_Q	12_L	0.540	0.51
150_F	161_C	0.540	0.51
13_D	16_T	0.540	0.51
234_R	241_D	0.538	0.51
101_W	108_H	0.535	0.51
125_S	128_I	0.535	0.51
37_N	41_G	0.535	0.51
185_V	188_M	0.535	0.51
13_D	217_H	0.531	0.50
172_L	219_Q	0.529	0.50
73_H	86_E	0.528	0.50
160_S	197_G	0.527	0.50
237_E	241_D	0.527	0.50
112_I	239_I	0.527	0.50
79_I	176_F	0.525	0.49
115_V	150_F	0.525	0.49
51_H	75_N	0.519	0.49
83_W	88_G	0.519	0.49
38_L	182_A	0.518	0.48
157_G	197_G	0.518	0.48
18_K	155_A	0.518	0.48
119_L	154_V	0.517	0.48
24_T	261_P	0.517	0.48
190_Q	235_K	0.516	0.48
108_H	136_G	0.512	0.48
13_D	223_E	0.511	0.48
69_I	87_N	0.511	0.48
5_L	12_L	0.511	0.48
102_P	136_G	0.510	0.47
37_N	42_F	0.510	0.47
69_I	81_D	0.510	0.47
27_L	216_T	0.508	0.47
45_V	144_A	0.506	0.47
3_Q	227_L	0.505	0.47
166_R	169_D	0.505	0.47
97_Q	111_Q	0.504	0.47
55_I	180_S	0.503	0.46
231_I	243_R	0.503	0.46
160_S	200_V	0.503	0.46
109_I	114_T	0.502	0.46
92_P	140_K	0.501	0.46
168_C	199_F	0.501	0.46
158_K	198_D	0.500	0.46
20_D	26_T	0.500	0.46
24_T	211_N	0.500	0.46
116_L	119_L	0.500	0.46

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3v8hA	2	0.9659	100	-0.036	Contact Map
3uwlA	2	1	100	-0.035	Contact Map
3nrrA	2	1	100	-0.031	Contact Map
1hw4A	2	0.9508	100	-0.029	Contact Map
4iqbA	2	0.9848	100	-0.029	Contact Map
4g9uA	2	0.9886	100	-0.028	Contact Map
3hj3A	2	1	100	-0.028	Contact Map
4eilA	3	1	100	-0.025	Contact Map
3irmA	4	1	100	-0.023	Contact Map
3ix6A	2	0.9356	100	-0.023	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.