GREMLIN Database
TRPR - Trp operon repressor
UniProt: P0A881 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11029
Length: 108 (93)
Sequences: 193 (101)
Seq/√Len: 10.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_M55_V3.6720.98
60_E63_R2.5020.85
14_Q77_A2.3750.82
51_L55_V2.1890.76
46_D81_T2.1890.76
35_H39_L2.0870.72
70_E103_V1.8100.61
24_D27_K1.7850.60
38_L95_E1.7550.58
27_K35_H1.7180.57
31_Q66_M1.6840.55
38_L96_L1.6480.54
41_L82_I1.6170.52
42_M96_L1.5880.51
98_Q102_E1.5520.49
29_A85_G1.5480.49
72_K88_S1.5070.47
48_R82_I1.5040.47
76_G97_R1.4950.46
46_D75_L1.4730.45
25_L100_L1.4380.44
22_F59_E1.4100.42
33_D49_E1.3880.41
35_H42_M1.3820.41
48_R81_T1.3750.41
52_G70_E1.3090.38
72_K78_G1.3000.37
37_P96_L1.2800.37
24_D28_N1.2700.36
70_E73_N1.2670.36
52_G56_R1.2100.34
59_E74_E1.1730.32
65_E82_I1.1710.32
24_D98_Q1.1590.31
40_N103_V1.1510.31
36_L94_V1.1370.31
25_L64_G1.1330.30
25_L60_E1.1320.30
75_L85_G1.1260.30
48_R80_A1.1110.30
15_R97_R1.0900.29
22_F70_E1.0770.28
24_D91_A1.0660.28
38_L42_M1.0540.27
33_D105_L1.0500.27
23_V62_L1.0490.27
85_G104_L1.0410.27
37_P100_L1.0380.27
75_L104_L1.0330.27
63_R66_M1.0330.27
20_L31_Q1.0240.26
15_R31_Q1.0070.26
31_Q102_E0.9940.25
56_R60_E0.9910.25
99_W104_L0.9870.25
26_L81_T0.9810.25
41_L73_N0.9770.25
64_G100_L0.9760.25
79_I87_N0.9700.24
22_F42_M0.9470.24
72_K79_I0.9420.23
72_K76_G0.9220.23
75_L80_A0.9030.22
29_A75_L0.9020.22
28_N32_N0.8900.22
20_L102_E0.8890.22
23_V94_V0.8880.22
27_K100_L0.8840.22
66_M74_E0.8830.22
79_I88_S0.8770.21
55_V102_E0.8760.21
48_R64_G0.8680.21
39_L91_A0.8630.21
22_F67_S0.8550.21
24_D94_V0.8420.20
13_E35_H0.8380.20
67_S81_T0.8370.20
50_A105_L0.8370.20
15_R28_N0.8350.20
28_N31_Q0.8290.20
20_L101_E0.8280.20
35_H78_G0.8230.20
29_A57_I0.7980.19
41_L63_R0.7890.19
60_E100_L0.7870.19
18_E93_P0.7850.19
28_N95_E0.7770.18
35_H105_L0.7760.18
17_Q62_L0.7750.18
53_T76_G0.7570.18
78_G88_S0.7460.17
58_V85_G0.7370.17
29_A87_N0.7320.17
26_L103_V0.7310.17
52_G79_I0.7240.17
53_T78_G0.7200.17
32_N91_A0.7150.17
18_E46_D0.7140.17
56_R72_K0.7130.17
15_R30_Y0.7090.17
56_R73_N0.7030.16
43_L70_E0.7030.16
64_G97_R0.7010.16
45_P94_V0.7000.16
35_H91_A0.7000.16
23_V43_L0.6950.16
22_F58_V0.6830.16
62_L103_V0.6630.15
56_R74_E0.6610.15
13_E17_Q0.6570.15
52_G74_E0.6520.15
15_R62_L0.6480.15
26_L99_W0.6430.15
53_T72_K0.6260.14
70_E77_A0.6250.14
32_N66_M0.6240.14
29_A43_L0.6230.14
13_E38_L0.6210.14
93_P96_L0.6150.14
14_Q38_L0.6120.14
33_D101_E0.6100.14
95_E102_E0.6040.14
67_S74_E0.6030.14
39_L76_G0.5980.14
85_G88_S0.5930.14
30_Y62_L0.5900.14
25_L45_P0.5780.13
20_L32_N0.5770.13
55_V104_L0.5610.13
18_E97_R0.5560.13
35_H65_E0.5550.13
24_D100_L0.5540.13
67_S76_G0.5460.13
13_E79_I0.5450.13
27_K33_D0.5420.13
33_D36_L0.5370.13
29_A34_L0.5360.13
40_N60_E0.5350.12
59_E71_L0.5270.12
56_R88_S0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3frwA 2 0.8981 99.6 0.618 Contact Map
1jhgA 2 0.9352 99.3 0.677 Contact Map
3korA 2 0.9259 97.7 0.811 Contact Map
3h5oA 2 0 96.2 0.847 Contact Map
3bilA 2 0 95.8 0.853 Contact Map
1jyeA 2 0 95.5 0.855 Contact Map
1qpzA 2 0.3981 95.4 0.857 Contact Map
2o20A 2 0 95.3 0.857 Contact Map
3ctpA 2 0.0093 94.8 0.862 Contact Map
1uxcA 1 0.3981 94.7 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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