GREMLIN Database
TRPB - Tryptophan synthase beta chain
UniProt: P0A879 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11025
Length: 397 (310)
Sequences: 14852 (7983)
Seq/√Len: 453.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_S130_C4.2451.00
72_T371_L3.9441.00
212_T373_V3.2701.00
61_K72_T3.2601.00
172_E175_R3.1741.00
331_E360_K3.0721.00
226_A253_I2.9871.00
175_R179_G2.6831.00
133_Y176_D2.6741.00
251_G323_D2.6531.00
140_E147_F2.5681.00
258_G328_T2.5671.00
129_K155_E2.5411.00
97_L200_I2.5291.00
56_P215_Q2.5051.00
99_K102_G2.5041.00
176_D180_S2.4491.00
56_P214_A2.4321.00
131_R155_E2.3921.00
227_V244_F2.3801.00
367_D370_Q2.2631.00
241_F320_G2.1861.00
338_T342_H2.1071.00
264_T272_K2.1001.00
59_L373_V2.0881.00
261_G265_G2.0401.00
131_R157_I2.0391.00
106_I131_R2.0041.00
354_A374_V1.9901.00
224_P373_V1.9871.00
255_V357_H1.9701.00
225_D370_Q1.9261.00
61_K74_Y1.9111.00
304_L353_H1.8511.00
61_K66_T1.8511.00
74_Y371_L1.8401.00
328_T331_E1.8221.00
253_I323_D1.8051.00
209_G240_M1.7771.00
97_L101_M1.7161.00
245_I322_A1.7161.00
225_D371_L1.7081.00
339_L347_P1.6891.00
273_H277_G1.6851.00
227_V240_M1.6721.00
99_K128_L1.6671.00
338_T359_L1.6461.00
68_G338_T1.6441.00
228_I255_V1.6301.00
94_Q198_P1.6271.00
180_S186_Y1.6211.00
237_A321_R1.5791.00
259_G329_D1.5631.00
96_L126_L1.5621.00
209_G244_F1.5591.00
339_L355_L1.5531.00
83_G121_L1.5491.00
173_A177_W1.5481.00
278_I308_S1.5411.00
147_F150_R1.5301.00
174_L178_S1.5201.00
134_M149_M1.5001.00
209_G243_D1.4971.00
170_C174_L1.4921.00
226_A370_Q1.4901.00
347_P376_L1.4861.00
146_V150_R1.4771.00
210_E243_D1.4711.00
146_V158_P1.4561.00
260_H266_E1.4511.00
222_R371_L1.4481.00
228_I361_M1.4461.00
241_F252_L1.4391.00
165_T168_D1.4291.00
213_K247_E1.4251.00
226_A251_G1.4091.00
231_V254_G1.4001.00
70_N368_K1.3951.00
335_A356_A1.3871.00
47_D50_K1.3741.00
63_Q67_A1.3701.00
136_A164_A1.3621.00
172_E176_D1.3581.00
206_R210_E1.3551.00
116_G149_M1.3541.00
265_G273_H1.3491.00
240_M375_N1.3431.00
301_S332_A1.3431.00
265_G272_K1.3391.00
95_A126_L1.3281.00
261_G326_S1.3271.00
74_Y216_I1.3171.00
226_A372_L1.3161.00
58_A80_L1.2831.00
53_A92_L1.2691.00
300_I333_L1.2671.00
228_I358_A1.2571.00
68_G342_H1.2571.00
106_I129_K1.2491.00
254_G324_Y1.2471.00
299_S305_D1.2441.00
205_Q246_N1.2381.00
111_G116_G1.2361.00
253_I325_V1.2351.00
171_N175_R1.2331.00
64_N67_A1.2221.00
60_T77_R1.2121.00
264_T326_S1.2081.00
48_L93_G1.2011.00
73_L358_A1.2001.00
124_A130_C1.1931.00
59_L216_I1.1921.00
325_V357_H1.1921.00
59_L212_T1.1851.00
202_R206_R1.1841.00
340_C346_I1.1831.00
361_M364_E1.1661.00
315_Y319_T1.1591.00
335_A355_L1.1561.00
62_C75_L1.1481.00
244_F250_V1.1461.00
336_F382_K1.1271.00
92_L96_L1.1241.00
164_A168_D1.1221.00
237_A254_G1.1211.00
149_M154_A1.1141.00
323_D364_E1.1131.00
231_V324_Y1.1111.00
180_S185_H1.1041.00
64_N342_H1.1011.00
330_D334_E1.0991.00
47_D51_N1.0991.00
257_P304_L1.0971.00
212_T224_P1.0951.00
337_K341_L1.0811.00
48_L51_N1.0771.00
216_I220_E1.0771.00
75_L376_L1.0751.00
191_A238_I1.0691.00
336_F352_S1.0621.00
258_G326_S1.0601.00
304_L350_E1.0581.00
271_L324_Y1.0561.00
57_T81_L1.0511.00
109_E132_I1.0501.00
274_G318_S1.0431.00
351_S377_S1.0351.00
271_L317_N1.0351.00
173_A176_D1.0311.00
251_G322_A1.0311.00
237_A317_N1.0291.00
168_D171_N1.0291.00
150_R155_E1.0291.00
193_G311_P1.0221.00
176_D179_G1.0201.00
263_E309_V1.0191.00
133_Y172_E1.0161.00
334_E338_T1.0141.00
223_L371_L1.0131.00
333_L390_I1.0081.00
69_T359_L1.0071.00
229_A240_M1.0071.00
358_A374_V1.0021.00
228_I253_I1.0001.00
261_G264_T0.9981.00
216_I224_P0.9961.00
243_D247_E0.9931.00
216_I373_V0.9911.00
208_I236_N0.9911.00
121_L152_M0.9881.00
98_A102_G0.9881.00
335_A359_L0.9871.00
251_G370_Q0.9861.00
134_M158_P0.9811.00
331_E334_E0.9811.00
95_A107_I0.9801.00
166_L169_A0.9721.00
147_F151_L0.9681.00
171_N174_L0.9651.00
119_S130_C0.9641.00
231_V237_A0.9631.00
99_K103_K0.9631.00
146_V156_V0.9611.00
175_R178_S0.9571.00
213_K244_F0.9561.00
327_I356_A0.9561.00
208_I375_N0.9541.00
174_L177_W0.9511.00
46_N214_A0.9491.00
103_K128_L0.9461.00
72_T220_E0.9441.00
199_T312_Q0.9431.00
124_A152_M0.9421.00
264_T324_Y0.9411.00
121_L125_L0.9401.00
190_T198_P0.9391.00
347_P352_S0.9341.00
45_F49_L0.9291.00
77_R376_L0.9231.00
331_E356_A0.9191.00
131_R186_Y0.9171.00
272_K323_D0.9131.00
351_S376_L0.9081.00
66_T72_T0.9081.00
72_T369_E0.9011.00
99_K126_L0.8921.00
312_Q315_Y0.8891.00
263_E317_N0.8861.00
167_K171_N0.8811.00
108_A173_A0.8791.00
105_E129_K0.8761.00
208_I240_M0.8711.00
210_E214_A0.8671.00
100_R104_T0.8671.00
228_I357_H0.8661.00
64_N343_E0.8641.00
317_N321_R0.8591.00
336_F387_V0.8591.00
54_G88_T0.8571.00
169_A172_E0.8561.00
91_V118_A0.8541.00
120_A154_A0.8461.00
55_R82_H0.8381.00
75_L339_L0.8361.00
386_T389_D0.8331.00
96_L100_R0.8311.00
71_T372_L0.8301.00
189_G192_A0.8271.00
332_A353_H0.8261.00
46_N50_K0.8241.00
108_A176_D0.8201.00
242_A246_N0.8191.00
108_A177_W0.8151.00
202_R242_A0.8141.00
237_A252_L0.8131.00
150_R158_P0.8121.00
163_S168_D0.8111.00
59_L74_Y0.8071.00
255_V325_V0.8051.00
213_K243_D0.8051.00
263_E324_Y0.8051.00
308_S311_P0.8031.00
259_G298_Y0.7981.00
356_A360_K0.7981.00
210_E247_E0.7971.00
347_P351_S0.7951.00
140_E146_V0.7911.00
48_L96_L0.7821.00
333_L349_L0.7791.00
212_T240_M0.7791.00
95_A122_A0.7781.00
216_I371_L0.7781.00
385_F389_D0.7781.00
138_D302_A0.7771.00
130_C154_A0.7761.00
208_I212_T0.7731.00
315_Y318_S0.7731.00
238_I313_H0.7721.00
325_V360_K0.7711.00
231_V263_E0.7701.00
71_T370_Q0.7691.00
117_V149_M0.7691.00
94_Q201_V0.7681.00
62_C343_E0.7671.00
94_Q200_I0.7651.00
339_L376_L0.7641.00
136_A158_P0.7601.00
226_A367_D0.7591.00
79_D345_I0.7591.00
136_A163_S0.7571.00
157_I172_E0.7561.00
230_C377_S0.7561.00
88_T121_L0.7551.00
131_R176_D0.7541.00
169_A173_A0.7531.00
360_K363_R0.7501.00
93_G96_L0.7471.00
93_G203_E0.7451.00
357_H361_M0.7451.00
93_G97_L0.7391.00
212_T375_N0.7381.00
170_C173_A0.7371.00
276_V311_P0.7361.00
328_T360_K0.7351.00
355_L374_V0.7351.00
159_V164_A0.7341.00
110_T166_L0.7331.00
65_I355_L0.7321.00
203_E206_R0.7301.00
276_V314_A0.7291.00
303_G350_E0.7291.00
119_S132_I0.7261.00
202_R316_L0.7241.00
44_Q47_D0.7231.00
262_I266_E0.7151.00
340_C387_V0.7151.00
365_N370_Q0.7131.00
100_R103_K0.7121.00
229_A237_A0.7121.00
202_R312_Q0.7101.00
216_I222_R0.7071.00
68_G359_L0.7071.00
166_L170_C0.7061.00
107_I128_L0.7061.00
362_M365_N0.7011.00
188_L192_A0.7001.00
43_A46_N0.6981.00
77_R345_I0.6971.00
240_M252_L0.6961.00
325_V364_E0.6951.00
361_M365_N0.6911.00
170_C188_L0.6901.00
49_L53_A0.6861.00
240_M244_F0.6841.00
227_V252_L0.6831.00
329_D332_A0.6821.00
142_Q302_A0.6811.00
199_T203_E0.6691.00
214_A247_E0.6671.00
43_A247_E0.6621.00
45_F48_L0.6601.00
386_T390_I0.6591.00
159_V172_E0.6571.00
256_E262_I0.6561.00
346_I380_G0.6561.00
133_Y159_V0.6541.00
148_R151_L0.6531.00
110_T188_L0.6531.00
102_G187_M0.6521.00
91_V122_A0.6441.00
168_D172_E0.6420.99
102_G105_E0.6420.99
188_L191_A0.6400.99
97_L100_R0.6390.99
273_H276_V0.6380.99
53_A81_L0.6340.99
245_I252_L0.6320.99
112_A303_G0.6310.99
95_A119_S0.6310.99
226_A365_N0.6300.99
105_E176_D0.6300.99
313_H324_Y0.6280.99
224_P250_V0.6260.99
69_T338_T0.6250.99
94_Q189_G0.6240.99
107_I123_S0.6220.99
137_K140_E0.6150.99
314_A318_S0.6140.99
95_A106_I0.6130.99
106_I123_S0.6120.99
46_N51_N0.6120.99
201_V205_Q0.6110.99
43_A47_D0.6110.99
63_Q66_T0.6100.99
77_R80_L0.6090.99
66_T69_T0.6080.99
351_S354_A0.6080.99
129_K186_Y0.6070.99
253_I361_M0.6070.99
385_F388_H0.6070.99
205_Q242_A0.6060.99
99_K104_T0.6020.99
169_A176_D0.6000.99
117_V148_R0.5990.99
59_L215_Q0.5990.99
94_Q97_L0.5940.99
115_H205_Q0.5930.99
227_V373_V0.5930.99
223_L249_N0.5920.99
212_T227_V0.5910.99
69_T358_A0.5890.99
66_T73_L0.5860.99
359_L363_R0.5850.99
203_E242_A0.5840.99
225_D369_E0.5840.99
118_A122_A0.5810.99
230_C354_A0.5810.99
254_G321_R0.5800.99
245_I320_G0.5790.99
330_D333_L0.5790.99
300_I329_D0.5780.99
331_E362_M0.5770.99
336_F349_L0.5760.99
164_A169_A0.5740.99
55_R81_L0.5740.99
71_T362_M0.5730.99
107_I130_C0.5720.99
262_I309_V0.5700.99
226_A361_M0.5700.99
163_S166_L0.5690.99
301_S304_L0.5690.99
350_E353_H0.5660.99
138_D146_V0.5660.99
133_Y157_I0.5660.99
255_V353_H0.5660.99
327_I357_H0.5660.99
253_I357_H0.5650.99
255_V327_I0.5640.99
157_I176_D0.5640.99
227_V375_N0.5630.99
141_R384_I0.5630.99
73_L374_V0.5610.99
54_G92_L0.5570.99
223_L250_V0.5560.99
46_N49_L0.5530.99
75_L347_P0.5530.99
311_P315_Y0.5530.99
355_L376_L0.5510.98
46_N210_E0.5500.98
364_E367_D0.5490.98
104_T129_K0.5480.98
131_R180_S0.5480.98
209_G213_K0.5470.98
265_G277_G0.5460.98
358_A362_M0.5450.98
229_A252_L0.5450.98
155_E180_S0.5430.98
66_T71_T0.5430.98
332_A352_S0.5420.98
275_R314_A0.5420.98
266_E276_V0.5410.98
245_I249_N0.5410.98
316_L320_G0.5400.98
266_E314_A0.5400.98
192_A311_P0.5390.98
258_G261_G0.5380.98
186_Y189_G0.5380.98
238_I312_Q0.5380.98
259_G297_S0.5350.98
335_A338_T0.5320.98
106_I186_Y0.5300.98
43_A210_E0.5290.98
148_R342_H0.5290.98
82_H121_L0.5280.98
93_G206_R0.5270.98
71_T369_E0.5270.98
339_L345_I0.5270.98
177_W180_S0.5270.98
108_A133_Y0.5260.98
65_I338_T0.5240.98
335_A352_S0.5220.98
278_I281_G0.5220.98
65_I359_L0.5210.98
245_I319_T0.5180.98
333_L337_K0.5180.98
95_A128_L0.5170.98
210_E246_N0.5160.98
71_T368_K0.5150.98
65_I68_G0.5150.98
62_C65_I0.5140.98
224_P371_L0.5140.98
220_E371_L0.5120.98
62_C66_T0.5110.98
110_T173_A0.5110.98
221_G224_P0.5090.97
360_K364_E0.5060.97
261_G266_E0.5060.97
134_M146_V0.5050.97
108_A186_Y0.5050.97
243_D246_N0.5040.97
53_A96_L0.5040.97
115_H189_G0.5030.97
76_K211_E0.5020.97
116_G132_I0.5010.97
67_A70_N0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ht3B 2 0.9723 100 0.263 Contact Map
1tdjA 2 0.8262 100 0.276 Contact Map
4negA 2 0.8136 100 0.281 Contact Map
3ss7X 1 0.9244 100 0.283 Contact Map
2o2eA 2 0.7909 100 0.285 Contact Map
1x1qA 2 0.9521 100 0.287 Contact Map
1v8zA 2 0.9597 100 0.293 Contact Map
1v71A 2 0.7985 100 0.298 Contact Map
2gn0A 2 0.8262 100 0.299 Contact Map
3l6bA 2 0.8035 100 0.316 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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