GREMLIN Database
TRPA - Tryptophan synthase alpha chain
UniProt: P0A877 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11024
Length: 268 (256)
Sequences: 3775 (2487)
Seq/√Len: 155.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_G32_Q3.6191.00
38_D91_K3.5011.00
27_D70_R3.1421.00
109_K117_Q2.9101.00
66_N242_E2.7751.00
144_L171_R2.6341.00
160_D199_K2.5391.00
34_L87_L2.4931.00
209_L230_G2.3541.00
42_E256_K2.3301.00
89_R124_D2.3031.00
24_T68_T2.2971.00
43_A256_K2.2121.00
21_P45_A2.1421.00
115_Y143_A2.1321.00
117_Q120_K2.1231.00
154_C163_L2.0921.00
87_L90_Q2.0761.00
5_E149_A1.9861.00
149_A171_R1.9781.00
77_T80_Q1.9751.00
3_R124_D1.9651.00
39_T43_A1.9351.00
233_S262_M1.9301.00
7_L10_Q1.9201.00
112_D142_A1.9121.00
71_A76_V1.9011.00
7_L11_L1.9011.00
116_A146_H1.8651.00
37_I88_I1.8591.00
256_K260_Q1.8431.00
37_I48_L1.8221.00
80_Q83_E1.8081.00
41_I95_I1.8041.00
86_A120_K1.7991.00
217_P221_K1.7321.00
10_Q14_R1.7301.00
79_A117_Q1.7211.00
52_I78_P1.7131.00
106_V128_V1.7091.00
20_V209_L1.7071.00
18_A230_G1.7041.00
216_A219_Q1.6361.00
116_A120_K1.6321.00
4_Y47_A1.6241.00
83_E86_A1.6111.00
119_E146_H1.6061.00
201_K208_P1.5961.00
101_M106_V1.5941.00
22_F68_T1.5681.00
178_S210_Q1.5651.00
41_I94_T1.5491.00
101_M105_L1.5481.00
128_V139_F1.5421.00
164_R168_S1.5411.00
86_A117_Q1.5201.00
201_K229_A1.5101.00
198_A202_E1.4991.00
176_L208_P1.4851.00
76_V80_Q1.4751.00
113_E116_A1.4521.00
239_K243_Q1.4511.00
36_I241_I1.4261.00
37_I97_I1.4251.00
112_D145_R1.4181.00
158_A163_L1.4161.00
117_Q121_V1.3951.00
143_A150_P1.3911.00
39_T256_K1.3891.00
118_C148_V1.3891.00
113_E117_Q1.3881.00
39_T42_E1.3751.00
69_L73_A1.3561.00
76_V81_C1.3551.00
47_A98_G1.3541.00
164_R203_Y1.3511.00
34_L38_D1.3271.00
79_A109_K1.3261.00
103_A131_V1.3241.00
140_R144_L1.3191.00
35_K38_D1.2741.00
210_Q228_A1.2681.00
27_D242_E1.2571.00
6_S9_A1.2571.00
214_I231_A1.2561.00
209_L232_I1.2521.00
36_I255_L1.2481.00
257_V261_P1.2471.00
9_A13_E1.2421.00
32_Q35_K1.2301.00
23_V36_I1.2291.00
176_L196_L1.2171.00
118_C123_V1.2121.00
160_D202_E1.2031.00
83_E87_L1.2001.00
163_L200_L1.1921.00
217_P261_P1.1901.00
82_F118_C1.1831.00
30_I34_L1.1781.00
136_S152_F1.1761.00
5_E9_A1.1761.00
103_A111_I1.1681.00
25_L50_L1.1621.00
106_V114_F1.1601.00
39_T252_L1.1491.00
253_A257_V1.1391.00
6_S10_Q1.1381.00
98_G151_I1.1381.00
141_Q145_R1.1361.00
52_I99_L1.1341.00
215_S239_K1.1191.00
48_L95_I1.1151.00
115_Y142_A1.1131.00
179_R186_E1.1131.00
170_G206_A1.1091.00
30_I80_Q1.0990.99
165_Q168_S1.0980.99
250_K254_A1.0930.99
239_K242_E1.0840.99
66_N69_L1.0800.99
103_A139_F1.0770.99
100_L127_L1.0750.99
195_H198_A1.0690.99
17_G225_D1.0680.99
27_D238_V1.0670.99
174_T204_N1.0560.99
192_P195_H1.0550.99
194_N198_A1.0540.99
7_L47_A1.0320.99
79_A113_E1.0230.99
3_R89_R1.0230.99
119_E147_N1.0190.99
137_A141_Q1.0190.99
109_K113_E1.0070.99
24_T67_A1.0060.99
160_D203_Y1.0060.99
79_A83_E1.0030.99
42_E91_K1.0000.99
114_F126_V0.9910.99
38_D42_E0.9890.99
34_L91_K0.9890.99
115_Y126_V0.9890.99
11_L18_A0.9880.99
236_A240_I0.9750.99
21_P237_I0.9710.99
218_D222_A0.9680.99
41_I93_P0.9680.99
240_I244_H0.9650.99
160_D164_R0.9540.98
150_P171_R0.9480.98
254_A257_V0.9420.98
30_I76_V0.9380.98
34_L84_M0.9370.98
240_I254_A0.9360.98
63_T239_K0.9330.98
186_E219_Q0.9330.98
244_H254_A0.9310.98
258_F261_P0.9310.98
86_A121_V0.9280.98
185_A239_K0.9260.98
258_F262_M0.9210.98
157_N180_A0.9190.98
133_V169_Y0.9080.98
63_T185_A0.9040.98
82_F117_Q0.9040.98
20_V47_A0.9030.98
70_R242_E0.9020.98
112_D116_A0.8950.98
10_Q13_E0.8940.98
255_L258_F0.8910.98
196_L199_K0.8870.98
19_F237_I0.8870.98
38_D41_I0.8840.98
225_D231_A0.8770.97
21_P40_L0.8740.97
176_L200_L0.8680.97
244_H251_M0.8630.97
29_G74_A0.8600.97
220_V231_A0.8600.97
252_L256_K0.8570.97
85_L97_I0.8510.97
115_Y148_V0.8500.97
25_L81_C0.8500.97
50_L85_L0.8490.97
70_R73_A0.8460.97
154_C170_G0.8430.97
251_M254_A0.8380.97
30_I33_S0.8330.96
22_F51_G0.8300.96
98_G125_S0.8290.96
116_A119_E0.8280.96
240_I243_Q0.8260.96
194_N222_A0.8240.96
245_I248_P0.8220.96
25_L84_M0.8220.96
165_Q169_Y0.8190.96
210_Q224_I0.8180.96
115_Y139_F0.8140.96
174_T200_L0.8100.96
153_I177_L0.8080.96
237_I259_V0.8070.96
9_A12_K0.8060.96
138_P142_A0.8040.96
41_I48_L0.8030.96
136_S140_R0.8000.96
152_F170_G0.7900.95
33_S84_M0.7900.95
215_S219_Q0.7890.95
97_I123_V0.7880.95
37_I50_L0.7830.95
34_L37_I0.7810.95
4_Y125_S0.7790.95
86_A90_Q0.7700.95
37_I95_I0.7690.94
88_I97_I0.7680.94
155_P158_A0.7660.94
30_I83_E0.7660.94
32_Q36_I0.7610.94
111_I142_A0.7600.94
64_I238_V0.7580.94
38_D93_P0.7570.94
154_C200_L0.7560.94
11_L16_E0.7550.94
194_N226_A0.7530.94
152_F169_Y0.7500.94
233_S258_F0.7480.94
111_I138_P0.7470.94
19_F259_V0.7460.94
36_I252_L0.7430.93
257_V260_Q0.7430.93
126_V150_P0.7400.93
142_A146_H0.7380.93
152_F166_I0.7340.93
85_L123_V0.7320.93
129_A232_I0.7320.93
30_I84_M0.7320.93
221_K226_A0.7310.93
112_D146_H0.7310.93
111_I139_F0.7300.93
218_D221_K0.7280.93
237_I255_L0.7230.92
243_Q254_A0.7200.92
88_I93_P0.7190.92
154_C158_A0.7180.92
185_A189_A0.7180.92
185_A215_S0.7130.92
137_A169_Y0.7120.92
33_S50_L0.7110.92
176_L227_G0.7100.92
79_A82_F0.7090.92
54_F58_L0.7040.91
138_P141_Q0.7030.91
59_A212_F0.7010.91
167_A206_A0.7000.91
167_A204_N0.6990.91
167_A174_T0.6980.91
250_K253_A0.6960.91
244_H250_K0.6950.91
30_I74_A0.6940.91
200_L204_N0.6940.91
133_V165_Q0.6940.91
252_L255_L0.6930.91
253_A256_K0.6920.91
133_V152_F0.6920.91
167_A203_Y0.6910.91
62_P66_N0.6900.91
93_P97_I0.6880.90
17_G231_A0.6860.90
211_G234_G0.6850.90
214_I220_V0.6810.90
220_V225_D0.6790.90
236_A239_K0.6730.90
171_R206_A0.6710.89
40_L259_V0.6710.89
237_I258_F0.6690.89
197_V208_P0.6680.89
21_P47_A0.6670.89
134_E162_L0.6610.89
32_Q252_L0.6600.89
115_Y146_H0.6580.88
52_I81_C0.6580.88
26_G76_V0.6540.88
186_E189_A0.6500.88
224_I227_G0.6430.87
65_Q96_P0.6430.87
240_I258_F0.6420.87
186_E215_S0.6380.87
163_L167_A0.6370.87
160_D163_L0.6360.87
119_E148_V0.6350.87
142_A145_R0.6290.86
159_D199_K0.6280.86
234_G238_V0.6280.86
126_V143_A0.6260.86
99_L123_V0.6230.86
40_L45_A0.6220.86
152_F174_T0.6180.85
248_P252_L0.6160.85
33_S41_I0.6150.85
54_F103_A0.6140.85
164_R202_E0.6130.85
88_I95_I0.6090.84
66_N70_R0.6080.84
111_I115_Y0.6070.84
126_V148_V0.6070.84
22_F67_A0.6070.84
31_E87_L0.6070.84
98_G153_I0.6060.84
85_L99_L0.6020.84
127_L173_Y0.6010.84
233_S236_A0.6000.83
199_K202_E0.5990.83
103_A107_F0.5990.83
217_P220_V0.5980.83
197_V227_G0.5960.83
86_A168_S0.5940.83
195_H199_K0.5930.83
214_I224_I0.5920.83
129_A176_L0.5900.82
100_L232_I0.5900.82
51_G230_G0.5850.82
61_G212_F0.5830.82
194_N227_G0.5830.82
81_C85_L0.5800.81
237_I240_I0.5750.81
97_I124_D0.5750.81
25_L85_L0.5750.81
4_Y8_F0.5740.81
84_M87_L0.5700.80
164_R167_A0.5700.80
50_L97_I0.5640.80
251_M255_L0.5620.79
139_F150_P0.5620.79
52_I101_M0.5610.79
18_A46_D0.5580.79
54_F179_R0.5570.79
60_D127_L0.5560.79
37_I41_I0.5550.78
241_I251_M0.5540.78
4_Y98_G0.5530.78
204_N208_P0.5530.78
222_A226_A0.5510.78
149_A172_G0.5480.78
236_A258_F0.5480.78
47_A209_L0.5460.77
35_K91_K0.5420.77
41_I88_I0.5420.77
238_V242_E0.5400.77
158_A162_L0.5390.76
195_H202_E0.5390.76
126_V139_F0.5380.76
8_F11_L0.5360.76
54_F104_N0.5350.76
31_E34_L0.5350.76
161_D165_Q0.5300.75
35_K248_P0.5300.75
154_C193_L0.5290.75
155_P177_L0.5260.75
132_P135_E0.5260.75
63_T235_S0.5260.75
94_T253_A0.5250.75
58_L103_A0.5240.74
52_I114_F0.5220.74
60_D152_F0.5220.74
139_F143_A0.5200.74
183_T212_F0.5200.74
221_K225_D0.5200.74
72_F105_L0.5190.74
23_V37_I0.5190.74
184_G212_F0.5190.74
59_A177_L0.5180.74
12_K15_K0.5170.73
54_F151_I0.5160.73
3_R94_T0.5140.73
163_L199_K0.5140.73
8_F18_A0.5130.73
28_P36_I0.5120.73
191_L195_H0.5110.73
61_G183_T0.5100.72
134_E165_Q0.5050.72
252_L259_V0.5020.71
216_A258_F0.5010.71
228_A231_A0.5000.71
56_D178_S0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ujpA 1 0.8918 100 0.398 Contact Map
3thaA 2 0.9254 100 0.43 Contact Map
4ht3A 1 1 100 0.451 Contact Map
2ekcA 1 0.9664 100 0.451 Contact Map
3vndA 3 0.9627 100 0.455 Contact Map
3navA 2 0.9701 100 0.462 Contact Map
1rd5A 6 0.9739 100 0.49 Contact Map
1geqA 1 0.9142 100 0.521 Contact Map
3cu2A 2 0.806 100 0.597 Contact Map
2f6uA 2 0.7164 100 0.639 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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