GREMLIN Database
TALB - Transaldolase B
UniProt: P0A870 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11556
Length: 317 (302)
Sequences: 2361 (1394)
Seq/√Len: 80.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_K149_E5.7581.00
108_S133_L5.3831.00
141_R144_E4.6321.00
103_Y138_Q3.6601.00
183_L232_E3.5671.00
37_S305_D3.4161.00
109_I145_Q3.3721.00
106_E110_A3.3131.00
194_E197_P3.3081.00
80_N84_E2.9881.00
84_E87_K2.8101.00
104_D107_A2.7451.00
135_S158_L2.6971.00
133_L146_L2.6861.00
194_E198_A2.6111.00
234_L259_I2.5511.00
145_Q149_E2.5071.00
292_V296_A2.4261.00
235_E262_K2.3461.00
168_A212_Y2.3091.00
3_D6_T2.2851.00
113_K151_I2.2601.00
250_K254_E2.2321.00
163_Q295_L2.2311.00
27_Y250_K2.2161.00
116_I129_I2.1991.00
277_T280_E2.1321.00
105_T141_R2.1291.00
278_E282_L2.1141.00
261_R265_Y2.1111.00
307_E311_K2.0981.00
82_G86_L1.9541.00
195_Y198_A1.9501.00
113_K145_Q1.9071.00
152_N173_F1.8831.00
144_E148_K1.8781.00
61_Q64_N1.8671.00
4_K257_G1.8351.00
100_R310_E1.8341.00
221_V241_R1.8191.00
137_W166_A1.8071.00
289_P293_D1.7601.00
165_R212_Y1.7591.00
6_T10_Q1.7501.00
161_F165_R1.7491.00
4_K255_S1.7341.00
105_T145_Q1.7311.00
261_R264_S1.7201.00
68_Q72_D1.7061.00
54_D58_W1.7041.00
300_R304_I1.6921.00
83_L87_K1.6911.00
285_H292_V1.6881.00
101_L107_A1.6841.00
297_E301_K1.6831.00
296_A300_R1.6731.00
4_K234_L1.6691.00
143_A155_L1.6651.00
304_I308_K1.6311.00
109_I113_K1.6101.00
23_A246_P1.6011.00
234_L255_S1.5811.00
3_D253_A1.5420.99
265_Y268_E1.4630.99
81_I85_I1.4380.99
283_W303_A1.4150.99
69_Q73_A1.4130.99
293_D297_E1.4020.99
73_A77_L1.3860.99
74_T77_L1.3670.99
111_K114_R1.3660.99
185_W293_D1.3530.99
234_L257_G1.3500.99
266_T269_V1.3470.99
230_I234_L1.3180.98
280_E284_Q1.3170.98
203_V235_E1.3130.98
37_S41_N1.3060.98
96_E178_F1.2990.98
41_N247_A1.2980.98
252_L258_A1.2910.98
286_N289_P1.2900.98
203_V231_G1.2650.98
114_R118_L1.2630.98
106_E145_Q1.2590.98
83_L86_L1.2530.98
58_W62_Q1.2520.98
109_I146_L1.2470.98
80_N83_L1.2300.97
11_Y237_A1.2180.97
68_Q71_V1.2170.97
25_K72_D1.2030.97
155_L172_V1.1970.97
289_P296_A1.1900.97
81_I84_E1.1870.97
135_S155_L1.1840.97
54_D80_N1.1820.97
5_L28_Q1.1800.97
112_A133_L1.1650.96
173_F221_V1.1630.96
26_L250_K1.1630.96
114_R117_K1.1610.96
138_Q282_L1.1540.96
281_F286_N1.1530.96
301_K304_I1.1520.96
193_K199_E1.1500.96
311_K314_G1.1460.96
14_V244_I1.1450.96
72_D114_R1.1450.96
161_F208_E1.1410.96
177_P209_I1.1400.96
67_A71_V1.1400.96
22_A47_E1.1380.96
165_R169_E1.1380.96
77_L81_I1.1360.96
229_N233_I1.1340.96
216_H219_E1.1340.96
304_I307_E1.1300.96
81_I86_L1.1270.96
243_T302_F1.1210.95
146_L149_E1.1160.95
50_K54_D1.1120.95
252_L256_E1.1070.95
113_K146_L1.1030.95
69_Q75_D1.1020.95
27_Y253_A1.0970.95
207_S211_Q1.0970.95
9_R30_Q1.0930.95
191_D198_A1.0930.95
297_E300_R1.0800.94
154_N157_L1.0740.94
190_T193_K1.0660.94
287_Q291_A1.0650.94
185_W189_N1.0630.94
76_K80_N1.0520.94
182_I205_S1.0380.93
60_K64_N1.0360.93
105_T109_I1.0360.93
86_L89_V1.0340.93
200_D231_G1.0300.93
89_V172_V1.0270.93
275_R279_S1.0270.93
12_T238_G1.0270.93
247_A251_E1.0200.93
145_Q148_K1.0160.92
132_K243_T1.0140.92
147_E152_N1.0050.92
5_L14_V1.0000.92
29_P249_L0.9970.92
73_A313_I0.9960.92
22_A25_K0.9950.92
75_D111_K0.9880.91
162_A285_H0.9820.91
287_Q307_E0.9810.91
70_I74_T0.9780.91
81_I88_L0.9780.91
210_Y265_Y0.9770.91
77_L82_G0.9650.90
172_V218_Y0.9590.90
282_L300_R0.9590.90
40_L308_K0.9540.90
59_A73_A0.9510.90
238_G263_L0.9510.90
69_Q77_L0.9510.90
192_K199_E0.9510.90
276_I284_Q0.9490.90
286_N292_V0.9370.89
158_L213_Y0.9330.89
34_T70_I0.9300.89
19_G34_T0.9270.88
65_D68_Q0.9220.88
55_A58_W0.9220.88
58_W76_K0.9040.87
69_Q74_T0.9010.87
11_Y261_R0.9000.87
185_W297_E0.9000.87
190_T195_Y0.9000.87
211_Q274_A0.9000.87
94_S154_N0.8940.87
35_N243_T0.8870.86
198_A207_S0.8860.86
294_K297_E0.8830.86
226_S243_T0.8830.86
113_K117_K0.8820.86
83_L88_L0.8800.86
75_D126_N0.8800.86
194_E283_W0.8770.86
108_S142_A0.8750.85
286_N296_A0.8750.85
140_I166_A0.8730.85
132_K225_A0.8670.85
178_F298_G0.8670.85
74_T81_I0.8610.85
196_A199_E0.8610.85
67_A70_I0.8580.84
301_K305_D0.8580.84
92_R152_N0.8570.84
178_F243_T0.8530.84
281_F288_D0.8530.84
306_Q310_E0.8510.84
100_R307_E0.8500.84
51_L55_A0.8470.84
82_G85_I0.8410.83
190_T194_E0.8390.83
225_A302_F0.8360.83
71_V75_D0.8360.83
41_N301_K0.8350.83
197_P231_G0.8310.82
33_T132_K0.8310.82
7_S11_Y0.8270.82
147_E173_F0.8210.82
157_L178_F0.8210.82
188_A297_E0.8180.81
97_V108_S0.8140.81
46_P49_R0.8110.81
168_A182_I0.8080.81
3_D28_Q0.8050.80
274_A284_Q0.8000.80
283_W286_N0.7990.80
85_I88_L0.7940.79
103_Y296_A0.7920.79
55_A59_A0.7900.79
66_R69_Q0.7900.79
5_L249_L0.7850.79
34_T95_T0.7840.79
12_T224_G0.7820.78
191_D197_P0.7760.78
185_W289_P0.7750.78
235_E259_I0.7740.78
11_Y258_A0.7720.77
44_Q308_K0.7700.77
300_R303_A0.7680.77
154_N178_F0.7650.77
288_D292_V0.7640.77
24_M76_K0.7640.77
66_R73_A0.7630.77
265_Y269_V0.7590.76
210_Y238_G0.7580.76
250_K253_A0.7550.76
22_A26_L0.7540.76
92_R241_R0.7540.76
266_T270_K0.7520.76
303_A307_E0.7500.75
18_T23_A0.7500.75
7_S10_Q0.7500.75
103_Y286_N0.7470.75
92_R147_E0.7460.75
33_T243_T0.7450.75
159_F302_F0.7440.75
131_I153_C0.7410.75
63_S72_D0.7350.74
225_A243_T0.7340.74
9_R28_Q0.7320.74
49_R53_D0.7320.74
41_N45_I0.7310.74
168_A213_Y0.7290.73
96_E226_S0.7280.73
230_I251_E0.7280.73
103_Y282_L0.7270.73
96_E298_G0.7240.73
214_K240_D0.7230.73
141_R299_I0.7230.73
3_D7_S0.7190.72
213_Y240_D0.7190.72
154_N176_S0.7180.72
94_S181_R0.7170.72
282_L286_N0.7160.72
51_L54_D0.7150.72
89_V93_I0.7130.72
117_K149_E0.7090.71
173_F241_R0.7060.71
178_F226_S0.7060.71
44_Q312_M0.7030.71
224_G242_L0.7020.70
188_A192_K0.7000.70
193_K196_A0.6990.70
283_W300_R0.6950.70
249_L252_L0.6950.70
283_W287_Q0.6940.70
35_N132_K0.6930.70
116_I152_N0.6890.69
211_Q267_G0.6870.69
205_S209_I0.6870.69
64_N72_D0.6860.69
162_A284_Q0.6830.68
132_K302_F0.6810.68
289_P292_V0.6800.68
190_T199_E0.6790.68
35_N302_F0.6780.68
154_N302_F0.6780.68
53_D56_V0.6780.68
178_F225_A0.6750.67
274_A277_T0.6720.67
286_N300_R0.6720.67
110_A114_R0.6710.67
230_I255_S0.6670.67
14_V28_Q0.6660.66
177_P202_G0.6660.66
262_K270_K0.6660.66
168_A218_Y0.6610.66
4_K7_S0.6610.66
160_S285_H0.6590.66
32_A85_I0.6550.65
188_A191_D0.6550.65
307_E314_G0.6520.65
199_E204_V0.6510.65
43_A46_P0.6500.65
237_A252_L0.6470.64
13_T90_P0.6440.64
210_Y264_S0.6400.63
157_L298_G0.6390.63
261_R270_K0.6370.63
140_I163_Q0.6330.63
192_K196_A0.6330.63
92_R221_V0.6310.62
189_N293_D0.6290.62
155_L167_C0.6280.62
108_S134_A0.6270.62
135_S140_I0.6270.62
56_V60_K0.6220.61
42_A48_Y0.6200.61
96_E176_S0.6200.61
156_T159_F0.6160.60
94_S157_L0.6160.60
33_T302_F0.6140.60
22_A45_I0.6130.60
156_T243_T0.6130.60
141_R148_K0.6090.60
178_F302_F0.6060.59
116_I130_L0.6060.59
154_N159_F0.6040.59
132_K178_F0.6030.59
167_C172_V0.6030.59
233_I248_L0.6020.59
244_I249_L0.5960.58
259_I262_K0.5940.58
4_K230_I0.5940.58
39_I81_I0.5940.58
251_E254_E0.5900.57
59_A72_D0.5880.57
71_V74_T0.5880.57
191_D199_E0.5860.57
35_N156_T0.5850.57
13_T30_Q0.5830.56
179_V205_S0.5820.56
71_V125_S0.5810.56
77_L86_L0.5810.56
282_L296_A0.5810.56
110_A113_K0.5790.56
116_I127_D0.5790.56
237_A259_I0.5770.56
169_E212_Y0.5770.56
161_F212_Y0.5760.55
213_Y222_V0.5740.55
130_L172_V0.5720.55
242_L245_A0.5710.55
165_R280_E0.5700.55
111_K118_L0.5700.55
105_T108_S0.5700.55
159_F243_T0.5700.55
165_R279_S0.5690.54
14_V29_P0.5670.54
34_T38_L0.5670.54
255_S258_A0.5660.54
109_I149_E0.5660.54
154_N243_T0.5650.54
100_R303_A0.5640.54
109_I142_A0.5630.54
154_N181_R0.5630.54
198_A235_E0.5590.53
280_E283_W0.5590.53
282_L292_V0.5580.53
43_A139_G0.5560.53
73_A86_L0.5560.53
186_Y201_P0.5550.53
57_A250_K0.5550.53
77_L84_E0.5530.52
116_I146_L0.5530.52
95_T129_I0.5530.52
82_G89_V0.5530.52
154_N298_G0.5520.52
31_D128_R0.5520.52
260_E263_L0.5500.52
86_L128_R0.5500.52
182_I201_P0.5490.52
21_I81_I0.5490.52
191_D195_Y0.5480.52
94_S176_S0.5480.52
283_W289_P0.5480.52
17_D159_F0.5480.52
158_L163_Q0.5470.52
159_F225_A0.5460.52
180_G228_R0.5450.51
163_Q177_P0.5450.51
179_V203_V0.5440.51
61_Q65_D0.5440.51
54_D76_K0.5430.51
277_T287_Q0.5430.51
176_S298_G0.5420.51
48_Y81_I0.5420.51
166_A184_D0.5400.51
96_E154_N0.5400.51
187_K194_E0.5400.51
36_P154_N0.5400.51
259_I263_L0.5380.50
103_Y137_W0.5370.50
189_N193_K0.5370.50
156_T302_F0.5350.50
35_N154_N0.5350.50
8_L237_A0.5350.50
259_I264_S0.5340.50
36_P181_R0.5320.50
176_S243_T0.5310.50
258_A261_R0.5280.49
39_I77_L0.5270.49
23_A26_L0.5270.49
163_Q166_A0.5270.49
21_I93_I0.5260.49
152_N241_R0.5240.49
66_R74_T0.5220.48
234_L258_A0.5210.48
59_A65_D0.5200.48
179_V202_G0.5190.48
53_D57_A0.5190.48
103_Y299_I0.5190.48
65_D69_Q0.5190.48
105_T133_L0.5180.48
132_K159_F0.5180.48
215_E269_V0.5160.48
40_L43_A0.5150.47
40_L312_M0.5150.47
178_F181_R0.5140.47
35_N225_A0.5140.47
161_F287_Q0.5130.47
175_I209_I0.5120.47
260_E264_S0.5110.47
111_K115_L0.5100.47
161_F291_A0.5100.47
94_S178_F0.5100.47
276_I279_S0.5090.47
85_I89_V0.5090.47
207_S266_T0.5060.46
202_G209_I0.5050.46
183_L301_K0.5050.46
226_S302_F0.5050.46
180_G184_D0.5040.46
25_K276_I0.5040.46
9_R14_V0.5030.46
124_I152_N0.5020.46
29_P244_I0.5010.46
52_I59_A0.5010.46
279_S296_A0.5000.46
54_D313_I0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cwnA 2 0.9968 100 0.094 Contact Map
3hjzA 1 1 100 0.094 Contact Map
3cq0A 2 0.9874 100 0.097 Contact Map
3m16A 2 0.9968 100 0.099 Contact Map
3tkfA 2 0.9748 100 0.102 Contact Map
2e1dA 2 1 100 0.103 Contact Map
3clmA 1 0.9464 100 0.196 Contact Map
3r5eA 1 0.9653 100 0.2 Contact Map
1wx0A 6 0.6404 100 0.388 Contact Map
3s1xA 6 0.6814 100 0.405 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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