GREMLIN Database
TALA - Transaldolase A
UniProt: P0A867 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11797
Length: 316 (302)
Sequences: 2355 (1392)
Seq/√Len: 80.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_R148_E5.8251.00
107_S132_L5.3951.00
140_R143_E4.6871.00
102_F137_E3.7281.00
79_N83_E3.7021.00
182_Y231_Q3.6281.00
108_I144_E3.4951.00
105_E109_E3.4251.00
36_S304_D3.3171.00
132_L145_L2.7821.00
103_D106_K2.7631.00
134_S157_L2.7511.00
83_E86_K2.5921.00
233_L258_V2.5401.00
144_E148_E2.4771.00
260_R263_I2.3731.00
234_A261_K2.3661.00
167_A211_Y2.3421.00
291_V295_S2.3231.00
228_R254_K2.2791.00
115_V128_I2.2741.00
162_Q294_L2.2661.00
249_K253_E2.2371.00
276_S279_E2.2071.00
112_R150_I2.1861.00
190_P197_E2.1611.00
277_E281_R2.1271.00
190_P194_Y2.1271.00
306_R310_D2.0601.00
112_R144_E2.0391.00
104_K140_R2.0301.00
228_R253_E1.9281.00
67_Q71_A1.9161.00
198_E226_F1.9101.00
260_R264_P1.9091.00
143_E147_K1.8881.00
151_N172_F1.8841.00
3_E256_S1.8761.00
99_R309_E1.8741.00
223_G226_F1.8681.00
60_K63_K1.8431.00
3_E254_K1.8421.00
136_W165_A1.8361.00
21_E46_Q1.8331.00
160_F164_R1.7751.00
3_E233_L1.7751.00
299_R303_V1.7401.00
220_I240_R1.7371.00
5_D9_Q1.7341.00
295_S299_R1.7341.00
164_R211_Y1.7281.00
265_P268_T1.7221.00
104_K144_E1.7101.00
142_A154_L1.7071.00
53_D57_W1.6981.00
288_A292_E1.6841.00
284_H291_V1.6791.00
296_E300_L1.6791.00
100_L106_K1.6731.00
310_D314_A1.6421.00
233_L254_K1.6411.00
108_I112_R1.6291.00
303_V307_K1.6031.00
24_R71_A1.5130.99
22_S245_P1.4520.99
292_E296_E1.4490.99
282_W302_A1.4330.99
189_K193_P1.4290.99
184_W292_E1.4010.99
81_G85_L1.3900.99
74_D125_K1.3890.99
202_V234_A1.3660.99
110_K113_H1.3550.99
113_H117_L1.3540.99
285_N288_A1.3450.99
57_W61_N1.3390.98
45_S48_E1.3360.98
33_T69_V1.3340.98
279_E283_E1.3220.98
40_K246_N1.3170.98
88_V171_V1.3060.98
210_D270_P1.3040.98
95_E177_F1.3000.98
233_L256_S1.2930.98
108_I145_L1.2860.98
154_L171_V1.2830.98
13_V243_I1.2760.98
265_P269_F1.2550.98
211_Y214_Q1.2470.98
10_F236_T1.2410.98
36_S40_K1.2380.97
288_A295_S1.2310.97
229_T233_L1.2270.97
67_Q70_V1.2220.97
280_F285_N1.2210.97
71_A113_H1.2160.97
111_A132_L1.2090.97
164_R214_Q1.2080.97
113_H116_D1.2040.97
53_D79_N1.1980.97
104_K108_I1.1970.97
242_T301_F1.1890.97
192_D198_E1.1890.97
160_F207_N1.1880.97
134_S154_L1.1860.97
137_E281_R1.1840.97
19_D46_Q1.1800.97
300_L303_V1.1750.97
228_R232_I1.1740.97
105_E144_E1.1730.96
227_R233_L1.1700.96
237_G262_L1.1690.96
22_S27_H1.1620.96
190_P193_P1.1600.96
74_D110_K1.1550.96
209_Y264_P1.1540.96
66_E70_V1.1510.96
303_V306_R1.1410.96
82_A86_K1.1360.96
184_W188_R1.1330.96
206_R210_D1.1320.96
251_L257_P1.1310.96
176_P208_I1.1200.95
153_N156_L1.1180.95
310_D313_A1.1140.95
251_L255_V1.1130.95
10_F260_R1.0970.95
164_R168_E1.0900.95
131_K242_T1.0800.94
8_K29_Q1.0760.94
21_E24_R1.0700.94
59_K63_K1.0620.94
157_L212_Y1.0600.94
112_R145_L1.0490.94
146_E151_N1.0370.93
49_H53_D1.0360.93
246_N250_E1.0350.93
296_E299_R1.0340.93
197_E206_R1.0240.93
58_G72_A1.0230.93
57_W75_K1.0220.93
145_L148_E1.0210.93
161_A284_H1.0160.92
72_A312_L1.0120.92
285_N291_V1.0030.92
202_V230_E1.0000.92
25_H249_K0.9920.91
172_F220_I0.9910.91
181_I204_S0.9910.91
286_Q306_R0.9900.91
286_Q290_A0.9880.91
4_L13_V0.9830.91
11_T237_G0.9770.91
261_K269_F0.9770.91
281_R299_R0.9650.90
197_E234_A0.9560.90
34_N242_T0.9530.90
199_D230_E0.9470.89
191_M198_E0.9470.89
54_A57_W0.9470.89
210_D214_Q0.9440.89
305_Q309_E0.9420.89
184_W296_E0.9400.89
39_L307_K0.9330.89
209_Y263_I0.9320.89
190_P195_V0.9320.89
144_E147_K0.9220.88
293_K296_E0.9110.88
282_W285_N0.9090.87
112_R116_D0.9060.87
212_Y239_D0.8970.87
285_N295_S0.8970.87
93_S153_N0.8960.87
177_F242_T0.8920.86
107_S141_A0.8920.86
40_K300_L0.8900.86
18_G33_T0.8860.86
280_F287_D0.8820.86
75_K79_N0.8820.86
32_T131_K0.8810.86
80_F83_E0.8800.86
177_F297_G0.8800.86
50_L54_A0.8780.86
91_R151_N0.8740.85
275_M283_E0.8730.85
167_A181_I0.8710.85
158_F301_F0.8680.85
306_R313_A0.8620.85
99_R306_R0.8620.85
300_L304_D0.8590.84
187_A296_E0.8570.84
32_T242_T0.8540.84
21_E25_H0.8520.84
6_G9_Q0.8510.84
139_I165_A0.8490.84
146_E172_F0.8460.83
23_I75_K0.8390.83
64_T67_Q0.8370.83
195_V198_E0.8350.83
54_A58_G0.8310.82
70_V124_E0.8280.82
62_G71_A0.8230.82
236_T258_V0.8230.82
191_M195_V0.8220.82
287_D291_V0.8190.81
264_P268_T0.8170.81
63_K71_A0.8160.81
38_L80_F0.8120.81
102_F285_N0.8050.80
6_G10_F0.8040.80
249_K252_Q0.8030.80
266_S269_F0.8030.80
188_R192_D0.8000.80
156_L177_F0.7990.80
236_T251_L0.7940.79
130_I152_C0.7910.79
91_R240_R0.7890.79
40_K44_L0.7890.79
96_V107_S0.7880.79
43_G307_K0.7870.79
76_L80_F0.7840.78
299_R302_A0.7810.78
31_A84_I0.7810.78
155_T158_F0.7780.78
23_I71_A0.7780.78
302_A306_R0.7750.78
79_N82_A0.7740.78
115_V151_N0.7720.77
153_N177_F0.7680.77
172_F240_R0.7660.77
91_R146_E0.7640.77
209_Y237_G0.7640.77
48_E52_D0.7630.77
275_M278_A0.7610.76
140_R298_I0.7600.76
196_V230_E0.7560.76
95_E297_G0.7540.76
102_F281_R0.7520.76
66_E313_A0.7490.75
176_P201_G0.7480.75
219_T222_M0.7470.75
33_T94_T0.7450.75
184_W288_A0.7430.75
102_F295_S0.7400.74
192_D282_W0.7380.74
93_S180_R0.7350.74
213_K266_S0.7340.74
50_L67_Q0.7340.74
204_S208_I0.7340.74
82_A85_L0.7330.74
198_E203_K0.7330.74
248_L251_L0.7320.74
187_A191_M0.7300.73
153_N175_S0.7280.73
3_E6_G0.7280.73
131_K301_F0.7280.73
210_D266_S0.7250.73
34_N131_K0.7220.73
229_T254_K0.7190.72
258_V262_L0.7180.72
21_E44_L0.7100.71
109_E113_H0.7090.71
155_T242_T0.7080.71
60_K64_T0.7070.71
258_V261_K0.7060.71
161_A283_E0.7020.70
52_D55_I0.7020.70
156_L297_G0.7000.70
192_D195_V0.6980.70
88_V92_V0.6950.70
34_N301_F0.6900.69
177_F301_F0.6900.69
27_H245_P0.6880.69
80_F84_I0.6870.69
154_L166_C0.6850.69
32_T301_F0.6750.67
159_S284_H0.6730.67
285_N299_R0.6720.67
161_A275_M0.6710.67
107_S133_A0.6680.67
262_L265_P0.6670.67
264_P267_Q0.6600.66
50_L53_D0.6590.66
281_R285_N0.6580.65
17_S22_S0.6560.65
20_I80_F0.6540.65
229_T250_E0.6520.65
160_F211_Y0.6520.65
134_S139_I0.6520.65
243_I248_L0.6510.65
232_I247_L0.6480.64
3_E258_V0.6480.64
43_G311_L0.6480.64
282_W286_Q0.6480.64
109_E112_R0.6460.64
164_R278_A0.6450.64
167_A217_Y0.6440.64
282_W299_R0.6430.64
158_F242_T0.6420.64
12_T29_Q0.6390.63
131_K177_F0.6390.63
116_D148_E0.6390.63
189_K196_V0.6370.63
223_G241_L0.6370.63
139_I162_Q0.6340.63
140_R147_K0.6310.62
115_V129_L0.6310.62
80_F305_Q0.6300.62
167_A212_Y0.6300.62
276_S286_Q0.6300.62
155_T301_F0.6270.62
110_K117_L0.6260.62
41_A47_Y0.6250.61
153_N301_F0.6250.61
161_A287_D0.6230.61
131_K155_T0.6210.61
108_I141_A0.6200.61
12_T89_P0.6180.61
178_V204_S0.6170.60
108_I148_E0.6150.60
131_K158_F0.6150.60
93_S156_L0.6140.60
47_Y80_F0.6140.60
189_K192_D0.6140.60
81_G84_I0.6130.60
68_Q72_A0.6120.60
153_N180_R0.6120.60
262_L266_S0.6120.60
34_N155_T0.6110.60
270_P277_E0.6110.60
10_F257_P0.6100.60
4_L248_L0.6070.59
175_S297_G0.6060.59
153_N158_F0.6060.59
254_K258_V0.6030.59
18_G69_V0.6020.59
261_K265_P0.6010.58
282_W288_A0.6010.58
11_T223_G0.6010.58
129_L171_V0.5990.58
58_G64_T0.5980.58
56_A249_K0.5970.58
188_R191_M0.5960.58
94_T128_I0.5950.58
104_K107_S0.5940.58
66_E69_V0.5930.57
158_F177_F0.5930.57
7_I236_T0.5910.57
281_R291_V0.5900.57
34_N153_N0.5880.57
153_N242_T0.5880.57
166_C171_V0.5880.57
110_K114_L0.5870.57
95_E175_S0.5820.56
201_G208_I0.5810.56
66_E117_L0.5800.56
35_P180_R0.5790.56
186_Q198_E0.5780.56
99_R302_A0.5750.55
151_N240_R0.5730.55
168_E211_Y0.5720.55
181_I200_P0.5720.55
35_P156_L0.5720.55
153_N297_G0.5710.55
24_R46_Q0.5710.55
288_A291_V0.5700.55
95_E153_N0.5700.55
162_Q165_A0.5680.54
91_R220_I0.5680.54
58_G71_A0.5680.54
201_G227_R0.5670.54
164_R279_E0.5660.54
22_S25_H0.5650.54
219_T242_T0.5640.54
213_K262_L0.5640.54
157_L162_Q0.5640.54
241_L244_A0.5640.54
75_K82_A0.5610.53
111_A128_I0.5610.53
61_N65_Q0.5590.53
35_P153_N0.5580.53
3_E257_P0.5570.53
274_P283_E0.5560.53
59_K64_T0.5560.53
162_Q176_P0.5550.53
178_V201_G0.5550.53
65_Q68_Q0.5540.52
209_Y213_K0.5540.52
9_Q113_H0.5530.52
188_R292_E0.5530.52
33_T37_L0.5520.52
93_S177_F0.5520.52
85_L127_R0.5520.52
53_D75_K0.5500.52
123_V151_N0.5500.52
274_P278_A0.5490.52
227_R230_E0.5480.52
165_A183_D0.5480.52
52_D56_A0.5460.51
115_V145_L0.5440.51
254_K257_P0.5440.51
95_E156_L0.5440.51
302_A309_E0.5430.51
102_F136_W0.5430.51
250_E253_E0.5410.51
95_E242_T0.5410.51
30_D127_R0.5390.51
64_T68_Q0.5370.50
3_E229_T0.5370.50
294_L298_I0.5370.50
93_S175_S0.5360.50
279_E282_W0.5360.50
213_K263_I0.5340.50
143_E169_A0.5340.50
115_V126_S0.5330.50
281_R284_H0.5310.49
85_L88_V0.5310.49
221_V227_R0.5300.49
25_H46_Q0.5280.49
262_L268_T0.5280.49
185_Y200_P0.5260.49
267_Q270_P0.5260.49
182_Y300_L0.5260.49
218_E222_M0.5250.49
16_D158_F0.5230.48
174_I208_I0.5230.48
20_I92_V0.5220.48
51_I58_G0.5210.48
20_I87_I0.5210.48
8_K13_V0.5210.48
215_H222_M0.5200.48
130_I242_T0.5180.48
104_K132_L0.5180.48
190_P223_G0.5170.48
194_Y197_E0.5150.47
36_S99_R0.5140.47
186_Q193_P0.5130.47
92_V172_F0.5120.47
55_I59_K0.5090.47
275_M279_E0.5090.47
177_F180_R0.5090.47
39_L304_D0.5080.47
35_P93_S0.5080.47
42_A138_G0.5060.46
226_F230_E0.5060.46
3_E10_F0.5060.46
102_F298_I0.5050.46
11_T17_S0.5040.46
167_A176_P0.5040.46
184_W187_A0.5010.46
20_I26_Y0.5010.46
49_H52_D0.5010.46
216_H222_M0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cwnA 2 1 100 0.082 Contact Map
3tkfA 2 0.9747 100 0.086 Contact Map
3m16A 2 0.9968 100 0.087 Contact Map
3cq0A 2 0.9873 100 0.09 Contact Map
3hjzA 1 1 100 0.091 Contact Map
2e1dA 2 1 100 0.098 Contact Map
3r5eA 1 0.9684 100 0.185 Contact Map
3clmA 1 0.9462 100 0.195 Contact Map
1wx0A 6 0.6424 100 0.387 Contact Map
3s1xA 6 0.6867 100 0.397 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.