GREMLIN Database
TPX - Thiol peroxidase
UniProt: P0A862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12672
Length: 168 (142)
Sequences: 12495 (7570)
Seq/√Len: 635.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_R140_E3.4461.00
29_T37_D3.0141.00
25_A118_Y2.6341.00
56_I91_Q2.6311.00
46_K79_V2.5691.00
69_N101_N2.5361.00
32_A36_S2.4931.00
139_D145_I2.3711.00
29_T39_T2.3691.00
72_A76_D2.2341.00
24_K143_N2.1971.00
122_I132_A2.0841.00
71_L74_E2.0791.00
27_T41_G2.0211.00
20_Q23_S2.0111.00
110_R113_E1.9491.00
39_T42_Q1.9281.00
113_E117_A1.9101.00
33_K95_C1.8741.00
31_V37_D1.8201.00
139_D143_N1.8091.00
115_L131_A1.7581.00
27_T39_T1.7191.00
72_A101_N1.6621.00
32_A38_V1.6561.00
38_V43_F1.6531.00
67_K71_L1.6521.00
85_A115_L1.5641.00
146_F165_V1.5461.00
48_K142_D1.5021.00
71_L159_Y1.4561.00
65_V100_L1.4481.00
85_A111_N1.4481.00
25_A138_I1.4361.00
57_D98_E1.4311.00
57_D93_R1.3751.00
48_K79_V1.3681.00
49_V137_V1.3661.00
32_A104_I1.3551.00
43_F81_L1.3551.00
30_L106_L1.3461.00
85_A131_A1.2981.00
30_L114_F1.2851.00
44_A48_K1.2831.00
43_F48_K1.2811.00
47_R78_T1.2641.00
160_E164_A1.2511.00
92_S96_G1.2431.00
71_L160_E1.2371.00
76_D79_V1.2291.00
111_N116_Q1.2241.00
69_N103_V1.2101.00
116_Q121_A1.1921.00
48_K81_L1.1791.00
66_R70_Q1.1771.00
78_T166_L1.1701.00
138_I144_V1.1681.00
47_R145_I1.1181.00
44_A142_D1.1061.00
120_V134_A1.0761.00
21_A146_F1.0731.00
67_K70_Q1.0571.00
73_T76_D1.0571.00
79_V104_I1.0541.00
51_N65_V1.0451.00
27_T40_L1.0431.00
52_I83_I1.0401.00
63_A156_E1.0351.00
161_A164_A1.0221.00
41_G44_A1.0061.00
145_I151_D0.9961.00
32_A106_L0.9951.00
57_D97_A0.9851.00
120_V136_V0.9841.00
93_R96_G0.9811.00
132_A149_L0.9761.00
111_N121_A0.9761.00
114_F118_Y0.9741.00
89_F93_R0.9571.00
82_C105_T0.9491.00
34_D92_S0.9481.00
77_N140_E0.9481.00
113_E116_Q0.9481.00
49_V135_V0.9461.00
134_A149_L0.9431.00
66_R69_N0.9411.00
148_Q165_V0.9331.00
62_A98_E0.9271.00
88_P107_S0.9191.00
81_L106_L0.9121.00
74_E163_L0.9031.00
53_F82_C0.9021.00
87_L90_A0.9011.00
48_K138_I0.9001.00
92_S95_C0.8961.00
137_V165_V0.8951.00
25_A144_V0.8921.00
137_V146_F0.8891.00
57_D90_A0.8871.00
19_P144_V0.8841.00
51_N103_V0.8821.00
50_L138_I0.8691.00
47_R77_N0.8651.00
24_K44_A0.8521.00
21_A147_S0.8371.00
157_P160_E0.8301.00
28_F118_Y0.8301.00
65_V82_C0.8231.00
63_A66_R0.8211.00
68_F80_V0.8161.00
66_R98_E0.8121.00
40_L48_K0.8031.00
136_V144_V0.7991.00
28_F114_F0.7931.00
115_L121_A0.7871.00
38_V81_L0.7871.00
151_D155_T0.7861.00
52_I120_V0.7851.00
33_K92_S0.7841.00
148_Q161_A0.7791.00
31_V109_F0.7761.00
132_A150_V0.7751.00
20_Q147_S0.7741.00
47_R166_L0.7731.00
148_Q162_A0.7681.00
49_V78_T0.7601.00
53_F56_I0.7451.00
19_P23_S0.7341.00
64_S135_V0.7331.00
83_I114_F0.7321.00
25_A40_L0.7321.00
111_N115_L0.7221.00
124_D128_K0.7191.00
85_A108_T0.7171.00
34_D95_C0.7111.00
21_A144_V0.7051.00
87_L109_F0.7011.00
146_F161_A0.6991.00
157_P161_A0.6921.00
40_L43_F0.6901.00
69_N72_A0.6841.00
137_V148_Q0.6761.00
68_F162_A0.6751.00
138_I142_D0.6641.00
91_Q94_F0.6631.00
31_V88_P0.6601.00
73_T101_N0.6591.00
43_F79_V0.6541.00
45_G140_E0.6531.00
28_F40_L0.6531.00
64_S68_F0.6511.00
75_I78_T0.6511.00
135_V162_A0.6481.00
122_I128_K0.6461.00
58_T133_R0.6391.00
52_I114_F0.6371.00
50_L118_Y0.6341.00
88_P92_S0.6331.00
101_N104_I0.6331.00
25_A114_F0.6271.00
55_S130_L0.6271.00
51_N64_S0.6251.00
90_A93_R0.6241.00
55_S86_D0.6231.00
38_V106_L0.6111.00
156_E159_Y0.6031.00
154_T157_P0.5951.00
72_A79_V0.5931.00
134_A147_S0.5931.00
89_F92_S0.5901.00
52_I118_Y0.5901.00
63_A67_K0.5871.00
53_F91_Q0.5871.00
95_C105_T0.5861.00
47_R137_V0.5841.00
67_K159_Y0.5811.00
114_F117_A0.5771.00
69_N73_T0.5741.00
94_F98_E0.5701.00
60_V154_T0.5701.00
75_I163_L0.5661.00
148_Q158_D0.5661.00
158_D161_A0.5661.00
33_K104_I0.5591.00
85_A121_A0.5541.00
91_Q105_T0.5531.00
60_V155_T0.5531.00
68_F159_Y0.5461.00
35_L88_P0.5451.00
71_L75_I0.5431.00
115_L120_V0.5431.00
136_V147_S0.5431.00
49_V162_A0.5411.00
49_V68_F0.5380.99
56_I90_A0.5380.99
54_P58_T0.5320.99
80_V103_V0.5300.99
109_F129_G0.5280.99
27_T44_A0.5270.99
51_N82_C0.5170.99
38_V42_Q0.5130.99
67_K156_E0.5130.99
23_S147_S0.5120.99
44_A141_N0.5110.99
55_S87_L0.5100.99
55_S58_T0.5080.99
26_Q117_A0.5070.99
123_A128_K0.5070.99
132_A153_I0.5060.99
33_K88_P0.5060.99
56_I105_T0.5040.99
145_I165_V0.5030.99
53_F94_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zrdA 2 0.9821 100 0.298 Contact Map
1xiyA 1 0.875 100 0.302 Contact Map
2v2gA 2 0.875 100 0.303 Contact Map
3a2vA 5 0.881 100 0.304 Contact Map
3w6gA 6 0.8512 100 0.304 Contact Map
1prxA 2 0.8869 100 0.307 Contact Map
1q98A 2 0.9643 100 0.308 Contact Map
2yzhA 3 0.9821 100 0.31 Contact Map
1xvqA 2 0.9345 100 0.314 Contact Map
1xccA 2 0.875 100 0.314 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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