GREMLIN Database
TOLB - Protein TolB
UniProt: P0A855 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11008
Length: 430 (358)
Sequences: 586 (489)
Seq/√Len: 25.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_F260_F4.4691.00
297_P343_G3.8721.00
96_I103_Q3.7371.00
215_A258_L3.5921.00
216_Y229_Q3.4491.00
198_S229_Q3.2791.00
348_M361_Q3.2011.00
242_F246_N3.1971.00
347_V382_L3.1421.00
270_L304_F3.0821.00
184_V187_Y2.8091.00
198_S216_Y2.7460.99
259_A262_L2.6620.99
304_F315_Y2.6360.99
286_G309_A2.5200.99
53_D84_Q2.4950.99
257_K260_F2.3170.98
207_W295_W2.3030.98
215_A251_F2.2640.98
349_V377_D2.1950.97
34_G40_V2.1520.97
94_L104_V2.1110.97
313_Q326_R2.0690.96
236_V240_A2.0410.96
390_I395_Q2.0160.96
182_L187_Y1.9910.95
257_K261_A1.9880.95
218_T223_R1.9440.95
110_G120_D1.9410.95
83_A87_Q1.9190.94
293_P304_F1.9090.94
58_V66_G1.8970.94
76_L79_Q1.8720.93
228_I251_F1.8640.93
242_F269_N1.8630.93
182_L188_D1.8530.93
348_M359_A1.8480.93
61_D64_N1.8340.93
96_I99_V1.8240.92
259_A302_L1.8190.92
351_S358_I1.8080.92
218_T225_A1.7860.92
172_Q175_G1.7810.92
385_N391_Y1.7610.91
54_I68_F1.7600.91
294_T303_A1.7590.91
55_G60_A1.7380.90
292_E305_T1.7300.90
257_K262_L1.7280.90
77_P80_P1.7260.90
208_S248_A1.7150.90
239_V273_M1.7100.90
330_E348_M1.6770.89
26_V33_S1.6630.88
86_V100_V1.6520.88
25_I28_D1.6300.87
223_R229_Q1.6300.87
154_E160_K1.6160.87
38_G42_F1.6150.87
95_G99_V1.6140.87
273_M315_Y1.6030.86
103_Q107_N1.6000.86
191_N310_G1.5990.86
23_V27_I1.5980.86
158_G161_G1.5970.86
95_G98_A1.5890.86
248_A261_A1.5830.86
136_V156_L1.5610.85
267_S286_G1.5580.85
296_F340_S1.5240.84
285_D315_Y1.5120.83
202_L292_E1.5070.83
103_Q109_D1.5030.83
259_A263_S1.4950.82
182_L186_D1.4950.82
100_V107_N1.4910.82
25_I30_G1.4830.82
51_P55_G1.4600.81
127_T139_Q1.4500.80
267_S271_Y1.4450.80
262_L269_N1.4350.80
261_A293_P1.4290.79
181_E185_S1.4250.79
225_A251_F1.4220.79
61_D72_D1.4210.79
238_Q243_P1.4140.79
167_I170_V1.4140.79
77_P81_G1.4090.78
115_A120_D1.4090.78
61_D70_P1.4020.78
79_Q113_N1.3990.78
28_D32_D1.3970.78
112_Y116_Y1.3860.77
183_R187_Y1.3840.77
303_A339_V1.3800.77
35_R42_F1.3780.77
198_S223_R1.3720.76
211_G271_Y1.3720.76
85_E90_A1.3640.76
128_V131_Q1.3600.76
50_A75_R1.3530.75
283_V303_A1.3290.74
61_D66_G1.3240.74
76_L81_G1.3210.74
34_G38_G1.3150.73
369_Q372_S1.3080.73
90_A95_G1.3020.72
261_A309_A1.3010.72
254_D342_D1.2990.72
150_D163_F1.2940.72
316_K364_A1.2910.72
91_W102_G1.2850.71
58_V61_D1.2830.71
226_L260_F1.2820.71
90_A100_V1.2720.71
146_H149_S1.2710.71
223_R260_F1.2660.70
75_R78_Q1.2390.69
106_P118_L1.2360.68
40_V43_Q1.2340.68
137_N140_W1.2310.68
62_L65_S1.2290.68
306_S326_R1.2230.68
54_I58_V1.2200.67
138_K272_V1.2130.67
79_Q83_A1.2060.66
85_E106_P1.2040.66
335_Q350_S1.2030.66
381_S388_M1.2000.66
30_G36_P1.1950.66
270_L293_P1.1950.66
202_L205_P1.1940.66
97_D104_V1.1940.66
255_G306_S1.1900.65
121_T166_R1.1850.65
98_A105_T1.1760.64
305_T348_M1.1750.64
103_Q106_P1.1750.64
27_I30_G1.1740.64
71_L75_R1.1700.64
39_V226_L1.1680.64
51_P65_S1.1680.64
382_L392_S1.1600.63
259_A295_W1.1570.63
97_D100_V1.1510.63
374_T382_L1.1490.63
240_A246_N1.1480.63
177_Q180_Y1.1480.63
78_Q81_G1.1470.62
136_V143_Y1.1450.62
126_G129_L1.1440.62
56_G59_A1.1430.62
380_P391_Y1.1420.62
66_G69_N1.1410.62
146_H161_G1.1380.62
261_A290_N1.1290.61
251_F275_L1.1280.61
339_V346_M1.1260.61
360_K383_A1.1250.61
334_N350_S1.1170.60
226_L249_P1.1090.60
134_Y141_L1.0960.59
72_D75_R1.0960.59
142_R145_G1.0950.59
216_Y307_D1.0880.58
390_I393_S1.0860.58
97_D105_T1.0790.58
343_G346_M1.0750.57
312_P337_A1.0740.57
93_A97_D1.0700.57
99_V104_V1.0690.57
386_G389_V1.0680.57
114_V117_Q1.0510.56
164_R167_I1.0500.56
144_A155_K1.0390.55
215_A259_A1.0360.55
305_T334_N1.0320.54
96_I100_V1.0270.54
246_N260_F1.0240.54
184_V190_Y1.0230.54
129_L137_N1.0210.53
186_D189_G1.0200.53
242_F271_Y1.0120.53
116_Y120_D1.0090.53
285_D311_R1.0020.52
141_L152_V0.9960.52
28_D38_G0.9940.51
71_L80_P0.9930.51
258_L261_A0.9930.51
55_G62_L0.9840.51
179_P183_R0.9830.51
65_S68_F0.9760.50
370_V373_S0.9750.50
111_S114_V0.9750.50
92_S103_Q0.9730.50
158_G163_F0.9720.50
63_R117_Q0.9710.50
99_V121_T0.9690.50
94_L102_G0.9680.50
129_L239_V0.9660.49
270_L302_L0.9640.49
33_S36_P0.9630.49
231_L291_T0.9570.49
327_I375_F0.9540.49
304_F309_A0.9530.48
310_G335_Q0.9530.48
337_A347_V0.9480.48
205_P216_Y0.9470.48
104_V108_P0.9450.48
178_F182_L0.9440.48
60_A64_N0.9420.48
297_P341_S0.9410.48
140_W144_A0.9410.48
195_V303_A0.9390.47
142_R158_G0.9390.47
60_A63_R0.9340.47
113_N121_T0.9280.47
294_T382_L0.9270.47
380_P390_I0.9250.46
224_S229_Q0.9240.46
58_V65_S0.9230.46
350_S359_A0.9230.46
377_D380_P0.9220.46
102_G158_G0.9210.46
274_D277_S0.9180.46
212_S230_T0.9180.46
134_Y137_N0.9150.46
148_A153_F0.9140.46
138_K142_R0.9130.46
23_V30_G0.9100.45
259_A293_P0.9100.45
56_G60_A0.9100.45
237_R240_A0.9070.45
290_N295_W0.9050.45
360_K364_A0.9030.45
104_V107_N0.9020.45
205_P255_G0.9000.45
203_M247_G0.8980.44
249_P255_G0.8980.44
101_V106_P0.8960.44
104_V115_A0.8870.44
238_Q241_S0.8870.44
145_G149_S0.8860.44
165_T170_V0.8840.43
227_V248_A0.8830.43
32_D47_P0.8820.43
346_M361_Q0.8800.43
60_A74_A0.8800.43
99_V107_N0.8780.43
24_R28_D0.8770.43
330_E361_Q0.8750.43
142_R188_D0.8740.43
332_S349_V0.8680.42
64_N72_D0.8630.42
104_V110_G0.8600.42
146_H182_L0.8600.42
286_G306_S0.8590.42
154_E157_T0.8580.42
253_P299_S0.8540.41
215_A295_W0.8540.41
197_R218_T0.8510.41
61_D65_S0.8510.41
383_A393_S0.8490.41
34_G41_P0.8490.41
180_Y183_R0.8480.41
90_A96_I0.8470.41
272_V295_W0.8460.41
257_K263_S0.8420.40
139_Q179_P0.8400.40
59_A67_K0.8360.40
215_A228_I0.8330.40
90_A102_G0.8330.40
133_S141_L0.8320.40
95_G101_V0.8320.40
142_R163_F0.8320.40
249_P315_Y0.8270.39
280_I283_V0.8250.39
168_A171_V0.8190.39
336_D387_T0.8150.38
60_A80_P0.8120.38
33_S43_Q0.8090.38
23_V31_V0.8090.38
51_P54_I0.8080.38
62_L66_G0.8050.38
166_R170_V0.8030.38
95_G104_V0.8000.37
94_L97_D0.7990.37
306_S313_Q0.7980.37
134_Y140_W0.7970.37
211_G278_G0.7960.37
146_H156_L0.7910.37
334_N337_A0.7910.37
267_S273_M0.7900.37
130_A133_S0.7880.37
83_A93_A0.7840.36
260_F263_S0.7840.36
46_G49_A0.7820.36
290_N334_N0.7800.36
120_D170_V0.7790.36
146_H152_V0.7780.36
211_G286_G0.7770.36
180_Y184_V0.7760.36
149_S186_D0.7720.36
113_N116_Y0.7700.35
109_D112_Y0.7650.35
231_L306_S0.7630.35
260_F281_R0.7590.35
85_E93_A0.7580.35
89_A105_T0.7570.35
106_P115_A0.7550.34
105_T111_S0.7540.34
29_S39_V0.7520.34
230_T235_A0.7500.34
35_R43_Q0.7490.34
101_V111_S0.7490.34
120_D158_G0.7480.34
391_Y395_Q0.7470.34
57_I65_S0.7460.34
85_E88_P0.7460.34
204_S207_W0.7450.34
94_L100_V0.7440.34
349_V380_P0.7440.34
76_L80_P0.7420.34
216_Y224_S0.7390.33
59_A66_G0.7390.33
158_G170_V0.7390.33
228_I292_E0.7380.33
97_D111_S0.7370.33
49_A81_G0.7360.33
104_V112_Y0.7330.33
379_T390_I0.7320.33
348_M352_N0.7320.33
128_V133_S0.7310.33
25_I39_V0.7280.33
388_M395_Q0.7250.32
270_L280_I0.7240.32
24_R35_R0.7230.32
79_Q127_T0.7230.32
45_A48_G0.7170.32
146_H153_F0.7150.32
293_P303_A0.7150.32
57_I61_D0.7130.32
55_G63_R0.7130.32
346_M367_G0.7130.32
214_L248_A0.7120.32
202_L218_T0.7100.31
369_Q376_L0.7070.31
131_Q166_R0.7020.31
381_S390_I0.7000.31
110_G113_N0.6980.31
56_G63_R0.6940.30
53_D59_A0.6910.30
181_E187_Y0.6880.30
29_S50_A0.6840.30
102_G106_P0.6820.30
173_T176_G0.6800.30
92_S100_V0.6790.30
29_S33_S0.6780.29
115_A119_V0.6770.29
346_M358_I0.6770.29
153_F161_G0.6770.29
142_R149_S0.6740.29
224_S315_Y0.6740.29
377_D393_S0.6740.29
58_V77_P0.6670.29
363_L367_G0.6650.29
88_P93_A0.6640.29
275_L283_V0.6640.29
224_S235_A0.6620.28
62_L70_P0.6620.28
43_Q62_L0.6600.28
205_P336_D0.6580.28
93_A96_I0.6570.28
184_V188_D0.6570.28
365_T368_V0.6550.28
121_T130_A0.6540.28
242_F262_L0.6520.28
27_I35_R0.6520.28
152_V186_D0.6510.28
380_P386_G0.6500.28
306_S311_R0.6500.28
216_Y248_A0.6500.28
375_F379_T0.6470.28
316_K362_D0.6460.28
252_S255_G0.6440.27
49_A106_P0.6430.27
263_S358_I0.6410.27
180_Y187_Y0.6400.27
114_V118_L0.6390.27
103_Q125_P0.6360.27
303_A350_S0.6340.27
170_V190_Y0.6310.27
149_S152_V0.6300.27
387_T394_S0.6280.26
290_N305_T0.6250.26
218_T299_S0.6250.26
98_A117_Q0.6220.26
205_P249_P0.6200.26
276_A379_T0.6160.26
298_D343_G0.6160.26
73_R79_Q0.6160.26
143_Y155_K0.6160.26
346_M363_L0.6130.26
95_G181_E0.6060.25
249_P344_K0.6060.25
262_L267_S0.6050.25
365_T393_S0.6030.25
23_V33_S0.6010.25
148_A154_E0.6000.25
72_D80_P0.5960.25
239_V325_Q0.5960.25
90_A103_Q0.5960.25
23_V28_D0.5950.25
47_P75_R0.5950.25
60_A69_N0.5940.25
242_F267_S0.5930.25
117_Q131_Q0.5910.24
377_D395_Q0.5880.24
32_D35_R0.5880.24
92_S105_T0.5860.24
208_S245_H0.5840.24
57_I62_L0.5830.24
91_W106_P0.5800.24
89_A103_Q0.5800.24
89_A96_I0.5800.24
151_E183_R0.5800.24
203_M224_S0.5800.24
146_H154_E0.5770.24
74_A80_P0.5770.24
163_F169_Y0.5760.24
315_Y359_A0.5760.24
105_T108_P0.5760.24
96_I116_Y0.5750.24
382_L386_G0.5740.24
249_P269_N0.5730.23
246_N302_L0.5720.23
24_R29_S0.5710.23
133_S137_N0.5710.23
310_G326_R0.5710.23
218_T247_G0.5710.23
254_D343_G0.5700.23
248_A290_N0.5690.23
130_A144_A0.5680.23
65_S69_N0.5680.23
290_N293_P0.5680.23
171_V180_Y0.5660.23
148_A163_F0.5660.23
103_Q115_A0.5650.23
103_Q126_G0.5650.23
54_I61_D0.5630.23
294_T348_M0.5620.23
55_G75_R0.5610.23
30_G33_S0.5610.23
133_S140_W0.5600.23
375_F394_S0.5580.23
28_D31_V0.5580.23
390_I394_S0.5570.23
45_A89_A0.5550.23
311_R346_M0.5530.22
364_A367_G0.5530.22
379_T389_V0.5510.22
60_A72_D0.5490.22
56_G69_N0.5470.22
62_L67_K0.5470.22
171_V179_P0.5460.22
172_Q180_Y0.5450.22
289_N305_T0.5450.22
27_I43_Q0.5440.22
132_N144_A0.5430.22
281_R316_K0.5420.22
101_V115_A0.5410.22
89_A104_V0.5400.22
55_G72_D0.5400.22
330_E350_S0.5390.22
56_G71_L0.5390.22
285_D309_A0.5380.22
211_G251_F0.5370.22
144_A152_V0.5360.22
232_A237_R0.5360.22
74_A81_G0.5350.22
166_R172_Q0.5350.22
203_M348_M0.5350.22
202_L216_Y0.5330.21
168_A174_N0.5330.21
149_S153_F0.5330.21
91_W186_D0.5320.21
164_R168_A0.5320.21
109_D116_Y0.5310.21
335_Q348_M0.5300.21
117_Q159_I0.5300.21
133_S144_A0.5300.21
300_Q318_N0.5280.21
349_V359_A0.5280.21
85_E108_P0.5280.21
142_R186_D0.5280.21
193_F270_L0.5270.21
33_S40_V0.5240.21
235_A352_N0.5240.21
367_G372_S0.5230.21
135_K160_K0.5230.21
132_N138_K0.5220.21
98_A108_P0.5220.21
33_S85_E0.5200.21
198_S227_V0.5200.21
114_V120_D0.5200.21
91_W94_L0.5200.21
99_V152_V0.5190.21
104_V118_L0.5190.21
125_P129_L0.5180.21
182_L189_G0.5180.21
27_I37_I0.5180.21
210_D226_L0.5180.21
94_L106_P0.5170.21
257_K274_D0.5160.21
217_V352_N0.5160.21
81_G103_Q0.5150.21
165_T168_A0.5150.21
315_Y348_M0.5140.20
58_V71_L0.5140.20
377_D391_Y0.5130.20
202_L362_D0.5130.20
27_I36_P0.5130.20
132_N155_K0.5120.20
67_K83_A0.5120.20
342_D363_L0.5110.20
55_G59_A0.5100.20
64_N74_A0.5100.20
136_V166_R0.5090.20
306_S309_A0.5090.20
23_V40_V0.5070.20
156_L163_F0.5060.20
89_A100_V0.5050.20
113_N117_Q0.5050.20
102_G116_Y0.5030.20
142_R169_Y0.5020.20
349_V353_G0.5010.20
52_E114_V0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hqsA 2 0.9419 100 0.477 Contact Map
1vyhC 1 0.5442 100 0.513 Contact Map
4u1eI 1 0.5302 100 0.516 Contact Map
2ymuA 1 0.5395 100 0.517 Contact Map
5a1uC 1 0.5256 100 0.524 Contact Map
4j87A 1 0.5302 100 0.526 Contact Map
3fm0A 1 0.5302 100 0.526 Contact Map
3j80g 1 0.5349 100 0.527 Contact Map
4j73A 1 0.5349 100 0.527 Contact Map
4bpeR 1 0.5419 100 0.527 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0117 seconds.