GREMLIN Database
TNAA - Tryptophanase
UniProt: P0A853 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11005
Length: 471 (451)
Sequences: 478 (278)
Seq/√Len: 13.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
453_T469_K6.4551.00
191_I217_A6.1321.00
214_Y218_K5.7491.00
66_A320_V5.3731.00
389_A438_A4.1721.00
177_E219_K4.0671.00
180_I184_G3.8410.99
11_F333_Y3.8160.99
225_V263_M3.7790.99
94_Q283_K3.7470.99
208_A212_A3.7110.99
207_L245_Y3.6220.99
443_K446_A3.5040.99
118_E189_P3.3870.98
180_I222_I3.3300.98
367_L446_A3.1460.98
31_I387_K3.1060.97
31_I383_C3.0860.97
155_I165_Y3.0790.97
177_E181_E3.0470.97
131_F189_P3.0080.97
38_P382_A2.9100.96
86_S323_Y2.8680.96
195_I257_T2.7720.95
240_Q339_Q2.7620.95
248_W252_Q2.7090.94
193_A210_L2.6960.94
13_I428_T2.6080.93
24_R28_E2.6030.93
89_N323_Y2.5920.92
173_L216_I2.5670.92
341_L436_I2.5410.92
244_E248_W2.5080.91
156_K175_G2.4900.91
115_K118_E2.4830.91
384_E445_N2.4020.89
164_R353_Q2.4010.89
207_L238_I2.3990.89
342_V355_A2.3530.88
367_L443_K2.3470.88
245_Y248_W2.3150.87
130_A189_P2.3120.87
239_K328_L2.2770.86
144_Q150_V2.2650.86
243_A246_K2.2610.86
346_E353_Q2.2470.86
43_S73_A2.2300.85
107_Q146_N2.1700.84
33_K45_D2.1060.82
346_E351_V2.0710.80
66_A79_S2.0690.80
35_G467_K2.0280.79
276_M311_E2.0250.79
14_R17_E2.0040.78
339_Q343_D1.9930.78
212_A215_S1.9550.76
376_F410_Q1.9360.76
239_K253_I1.9130.75
211_K256_E1.9100.75
8_P434_F1.8900.74
245_Y256_E1.8640.73
62_S69_R1.8580.72
221_D350_V1.8580.72
398_S416_E1.8210.71
399_F468_L1.8200.71
42_D45_D1.7880.69
362_V439_F1.7600.68
396_I400_L1.7500.68
344_G433_D1.7240.67
140_Q152_N1.6900.65
256_E259_K1.6730.64
228_S258_Y1.6650.64
348_I440_K1.6560.63
310_L315_M1.6430.63
95_Y285_D1.6010.61
64_Q275_P1.5970.60
79_S320_V1.5910.60
355_A360_A1.5900.60
9_E13_I1.5850.60
131_F179_G1.5800.60
79_S82_A1.5750.59
137_D463_H1.5690.59
59_V275_P1.5630.59
173_L212_A1.5460.58
180_I188_V1.5450.58
237_F357_G1.5400.57
118_E187_N1.5320.57
235_A257_T1.5290.57
66_A274_V1.5290.57
238_I257_T1.5240.57
440_K444_E1.5220.57
157_E170_N1.5190.56
23_T26_Y1.5140.56
59_V317_R1.5060.56
30_A41_L1.4830.55
178_R182_E1.4700.54
87_V96_T1.4680.54
184_G222_I1.4590.53
36_M470_E1.4540.53
210_L214_Y1.4380.52
110_I190_Y1.4330.52
82_A316_E1.4080.51
232_A254_T1.3950.50
171_F216_I1.3930.50
232_A331_L1.3900.50
141_G300_V1.3620.48
275_P317_R1.3610.48
66_A82_A1.3600.48
93_Y261_A1.3490.48
284_D287_F1.3480.47
275_P314_A1.3390.47
180_I185_P1.3370.47
38_P393_A1.3330.47
112_V294_C1.3300.47
39_F51_L1.3160.46
30_A45_D1.3120.46
161_T366_K1.3060.45
129_V151_R1.2850.44
140_Q197_S1.2670.43
368_L380_A1.2660.43
90_I180_I1.2620.43
57_G426_T1.2540.43
350_V439_F1.2480.42
249_T252_Q1.2380.42
80_Y84_A1.2370.42
59_V64_Q1.2250.41
250_I254_T1.2170.41
97_I104_G1.2140.41
44_E78_R1.2120.40
77_S426_T1.2120.40
62_S320_V1.2110.40
274_V318_L1.2080.40
258_Y272_A1.2070.40
42_D81_Y1.1950.40
180_I216_I1.1940.40
129_V183_V1.1860.39
142_H301_Q1.1780.39
177_E220_Y1.1710.38
131_F143_S1.1700.38
160_D366_K1.1670.38
272_A325_G1.1630.38
10_P13_I1.1630.38
137_D194_T1.1600.38
60_T425_A1.1590.38
232_A272_A1.1480.37
393_A420_L1.1450.37
441_H444_E1.1440.37
382_A418_L1.1440.37
88_K94_Q1.1400.37
83_L291_Y1.1380.37
207_L257_T1.1370.37
108_I297_L1.1360.37
221_D349_G1.1340.37
167_F280_L1.1310.36
231_F254_T1.1270.36
183_V189_P1.1240.36
226_M261_A1.1220.36
132_S229_A1.1190.36
95_Y291_Y1.1090.35
144_Q402_G1.1080.35
268_A318_L1.1070.35
9_E430_T1.1030.35
29_E33_K1.1010.35
388_V445_N1.1000.35
114_I148_C1.0990.35
250_I326_M1.0980.35
118_E131_F1.0960.35
91_F326_M1.0940.35
11_F465_T1.0910.34
94_Q285_D1.0870.34
66_A316_E1.0830.34
72_E312_G1.0750.34
129_V179_G1.0700.34
64_Q314_A1.0650.33
396_I463_H1.0600.33
210_L213_M1.0580.33
188_V215_S1.0570.33
455_T469_K1.0550.33
403_R457_E1.0530.33
404_D407_T1.0490.33
210_L224_V1.0440.32
32_I246_K1.0360.32
87_V281_C1.0350.32
29_E32_I1.0330.32
445_N448_N1.0310.32
435_I439_F1.0260.31
391_I394_V1.0200.31
22_T30_A1.0140.31
194_T231_F1.0130.31
73_A141_G1.0090.31
429_Q433_D1.0030.30
344_G437_E1.0020.30
276_M310_L0.9950.30
313_G317_R0.9920.30
110_I463_H0.9910.30
135_F192_V0.9900.30
238_I265_A0.9880.30
364_A381_L0.9870.30
200_A401_L0.9840.30
167_F242_E0.9810.29
254_T272_A0.9800.29
191_I222_I0.9730.29
456_Y467_K0.9710.29
271_D334_R0.9700.29
362_V418_L0.9670.29
180_I183_V0.9650.29
109_Y265_A0.9610.29
107_Q301_Q0.9610.29
336_A429_Q0.9580.28
194_T463_H0.9580.28
57_G273_M0.9550.28
132_S143_S0.9530.28
439_F446_A0.9500.28
340_Y433_D0.9490.28
305_P402_G0.9470.28
173_L213_M0.9420.28
222_I433_D0.9420.28
41_L45_D0.9370.28
252_Q329_D0.9360.28
207_L244_E0.9360.28
380_A449_I0.9310.27
228_S264_L0.9290.27
378_A403_R0.9280.27
9_E428_T0.9260.27
363_D366_K0.9230.27
373_A412_P0.9220.27
29_E185_P0.9200.27
344_G436_I0.9190.27
275_P313_G0.9170.27
383_C389_A0.9160.27
243_A339_Q0.9150.27
174_E219_K0.9140.27
400_L463_H0.9130.27
233_E334_R0.9080.26
350_V393_A0.9060.26
170_N208_A0.9050.26
223_P391_I0.9050.26
108_I468_L0.9040.26
372_P375_Q0.9040.26
439_F442_V0.9020.26
255_R323_Y0.9000.26
86_S272_A0.8980.26
385_L418_L0.8960.26
256_E260_Y0.8960.26
187_N249_T0.8920.26
211_K244_E0.8870.26
137_D396_I0.8860.26
214_Y224_V0.8860.26
305_P465_T0.8830.25
214_Y260_Y0.8780.25
207_L259_K0.8750.25
250_I332_A0.8750.25
404_D409_K0.8740.25
207_L256_E0.8730.25
332_A453_T0.8730.25
17_E70_G0.8720.25
238_I245_Y0.8680.25
434_F438_A0.8660.25
236_Y345_L0.8640.25
35_G456_Y0.8630.25
28_E387_K0.8630.25
208_A246_K0.8590.24
362_V385_L0.8570.24
389_A434_F0.8540.24
129_V180_I0.8490.24
135_F143_S0.8470.24
135_F150_V0.8460.24
211_K245_Y0.8460.24
171_F193_A0.8450.24
44_E285_D0.8430.24
299_V421_T0.8410.24
90_I323_Y0.8380.24
83_L96_T0.8360.24
190_Y224_V0.8360.24
422_I435_I0.8360.24
185_P447_A0.8360.24
14_R70_G0.8360.24
22_T390_G0.8310.23
304_F398_S0.8290.23
368_L449_I0.8210.23
184_G188_V0.8180.23
154_Y158_A0.8170.23
331_L335_I0.8160.23
190_Y193_A0.8140.23
82_A86_S0.8130.23
22_T26_Y0.8110.23
15_V160_D0.8100.23
336_A343_D0.8060.22
230_R271_D0.8050.22
254_T258_Y0.8010.22
107_Q142_H0.8010.22
207_L248_W0.8000.22
91_F258_Y0.8000.22
8_P337_Q0.7990.22
208_A243_A0.7990.22
422_I432_M0.7900.22
23_T391_I0.7880.22
28_E32_I0.7880.22
195_I224_V0.7870.22
230_R358_H0.7850.22
84_A295_R0.7840.22
422_I440_K0.7830.22
43_S235_A0.7810.22
239_K252_Q0.7800.22
65_A79_S0.7770.21
311_E314_A0.7770.21
104_G452_L0.7770.21
395_E418_L0.7760.21
108_I434_F0.7720.21
9_E340_Y0.7710.21
129_V188_V0.7670.21
230_R334_R0.7670.21
114_I190_Y0.7660.21
215_S444_E0.7660.21
80_Y391_I0.7650.21
8_P47_F0.7640.21
92_G436_I0.7620.21
268_A396_I0.7590.21
115_K224_V0.7590.21
295_R449_I0.7580.21
360_A391_I0.7570.21
95_Y336_A0.7570.21
235_A254_T0.7570.21
243_A468_L0.7550.21
294_C426_T0.7550.21
59_V313_G0.7510.21
273_M276_M0.7500.20
214_Y217_A0.7490.20
64_Q313_G0.7480.20
253_I357_G0.7470.20
15_V67_M0.7470.20
60_T324_D0.7460.20
291_Y295_R0.7450.20
117_R418_L0.7450.20
384_E387_K0.7430.20
40_L180_I0.7430.20
367_L447_A0.7410.20
57_G217_A0.7400.20
250_I331_L0.7370.20
385_L439_F0.7360.20
188_V223_P0.7360.20
76_G364_A0.7350.20
362_V449_I0.7330.20
199_S463_H0.7310.20
99_T238_I0.7310.20
79_S421_T0.7300.20
135_F153_V0.7300.20
210_L260_Y0.7290.20
259_K283_K0.7270.20
7_L11_F0.7250.20
273_M330_W0.7240.20
199_S396_I0.7230.20
83_L97_I0.7220.20
151_R422_I0.7210.19
229_A318_L0.7200.19
137_D394_V0.7180.19
379_Q399_F0.7180.19
93_Y465_T0.7180.19
364_A370_H0.7180.19
81_Y85_E0.7170.19
90_I326_M0.7160.19
134_Y434_F0.7160.19
264_L281_C0.7140.19
194_T197_S0.7130.19
35_G213_M0.7120.19
13_I17_E0.7110.19
211_K249_T0.7110.19
207_L347_E0.7080.19
137_D199_S0.7080.19
197_S224_V0.7070.19
49_D54_S0.7070.19
24_R388_V0.7050.19
56_T217_A0.7050.19
228_S418_L0.7040.19
224_V261_A0.7040.19
371_I449_I0.7030.19
64_Q68_M0.7020.19
196_T233_E0.7010.19
31_I445_N0.7010.19
110_I396_I0.7010.19
401_L410_Q0.7000.19
285_D449_I0.6990.19
40_L467_K0.6990.19
359_A368_L0.6990.19
12_R21_R0.6980.19
388_V438_A0.6980.19
258_Y330_W0.6980.19
244_E366_K0.6970.19
413_C454_F0.6970.19
369_P447_A0.6960.19
436_I440_K0.6950.19
342_V360_A0.6950.19
49_D53_D0.6940.19
66_A365_G0.6940.19
200_A361_F0.6940.19
97_I291_Y0.6910.19
143_S190_Y0.6890.18
9_E14_R0.6880.18
43_S382_A0.6870.18
157_E165_Y0.6870.18
311_E386_Y0.6870.18
229_A394_V0.6870.18
32_I453_T0.6870.18
135_F304_F0.6860.18
254_T326_M0.6850.18
380_A411_L0.6840.18
148_C173_L0.6830.18
205_V330_W0.6790.18
86_S90_I0.6780.18
137_D197_S0.6770.18
197_S229_A0.6770.18
247_D453_T0.6750.18
359_A465_T0.6740.18
178_R187_N0.6740.18
57_G359_A0.6710.18
247_D459_K0.6700.18
50_L310_L0.6690.18
429_Q432_M0.6680.18
295_R305_P0.6670.18
402_G468_L0.6640.18
131_F171_F0.6620.18
338_V429_Q0.6600.18
137_D400_L0.6600.18
64_Q317_R0.6590.18
385_L438_A0.6570.17
317_R363_D0.6560.17
29_E187_N0.6560.17
59_V63_M0.6560.17
148_C366_K0.6560.17
85_E216_I0.6540.17
160_D163_V0.6530.17
65_A445_N0.6530.17
391_I396_I0.6510.17
48_I459_K0.6510.17
180_I440_K0.6480.17
345_L363_D0.6470.17
364_A416_E0.6450.17
196_T359_A0.6450.17
421_T432_M0.6450.17
393_A418_L0.6440.17
338_V422_I0.6410.17
13_I18_P0.6410.17
324_D425_A0.6400.17
195_I205_V0.6400.17
108_I456_Y0.6400.17
150_V396_I0.6380.17
79_S233_E0.6380.17
181_E211_K0.6370.17
100_H302_E0.6370.17
43_S156_K0.6360.17
164_R249_T0.6360.17
236_Y240_Q0.6360.17
247_D406_K0.6350.17
64_Q72_E0.6350.17
247_D469_K0.6340.17
149_T406_K0.6330.17
205_V258_Y0.6320.17
371_I447_A0.6320.17
344_G347_E0.6320.17
207_L439_F0.6310.17
211_K260_Y0.6310.17
110_I137_D0.6300.17
104_G421_T0.6290.17
249_T255_R0.6280.17
236_Y256_E0.6260.17
340_Y429_Q0.6260.17
327_N382_A0.6250.17
171_F224_V0.6250.17
350_V444_E0.6250.17
382_A393_A0.6240.16
196_T431_H0.6230.16
69_R320_V0.6220.16
373_A398_S0.6210.16
280_L448_N0.6200.16
404_D411_L0.6190.16
157_E167_F0.6180.16
179_G183_V0.6160.16
192_V229_A0.6130.16
25_A28_E0.6120.16
32_I36_M0.6120.16
80_Y388_V0.6120.16
130_A143_S0.6120.16
264_L468_L0.6120.16
67_M275_P0.6120.16
363_D389_A0.6110.16
394_V463_H0.6110.16
183_V222_I0.6090.16
52_T363_D0.6090.16
243_A332_A0.6080.16
96_T152_N0.6080.16
193_A213_M0.6080.16
197_S396_I0.6070.16
220_Y260_Y0.6060.16
111_P145_I0.6050.16
166_D241_R0.6040.16
21_R225_V0.6040.16
217_A224_V0.6040.16
32_I459_K0.6030.16
229_A401_L0.6030.16
65_A77_S0.6030.16
351_V398_S0.6020.16
215_S219_K0.6020.16
287_F320_V0.6020.16
162_G366_K0.6020.16
72_E269_K0.6010.16
348_I435_I0.6010.16
80_Y148_C0.5980.16
369_P461_L0.5970.16
231_F325_G0.5970.16
331_L463_H0.5960.16
97_I295_R0.5960.16
48_I422_I0.5960.16
145_I458_P0.5960.16
197_S400_L0.5950.16
110_I422_I0.5950.16
171_F251_E0.5950.16
216_I387_K0.5940.16
92_G264_L0.5930.16
159_F197_S0.5920.16
337_Q422_I0.5910.16
212_A455_T0.5910.16
79_S152_N0.5900.16
263_M280_L0.5900.16
132_S401_L0.5900.16
194_T331_L0.5890.16
192_V225_V0.5890.16
22_T44_E0.5870.15
116_K247_D0.5870.15
255_R259_K0.5850.15
314_A317_R0.5850.15
229_A460_V0.5840.15
236_Y328_L0.5830.15
367_L442_V0.5830.15
130_A298_C0.5830.15
181_E445_N0.5820.15
264_L279_L0.5820.15
271_D358_H0.5800.15
215_S244_E0.5800.15
99_T296_T0.5800.15
333_Y367_L0.5800.15
189_P300_V0.5800.15
73_A299_V0.5790.15
153_V179_G0.5790.15
269_K312_G0.5790.15
350_V391_I0.5760.15
406_K455_T0.5750.15
297_L420_L0.5740.15
14_R360_A0.5740.15
117_R167_F0.5740.15
240_Q293_E0.5730.15
70_G312_G0.5710.15
32_I81_Y0.5690.15
33_K42_D0.5690.15
229_A283_K0.5680.15
20_K47_F0.5680.15
73_A258_Y0.5680.15
188_V459_K0.5670.15
266_M431_H0.5670.15
178_R244_E0.5670.15
112_V293_E0.5650.15
248_W256_E0.5650.15
401_L413_C0.5650.15
78_R310_L0.5640.15
130_A388_V0.5640.15
263_M282_M0.5620.15
191_I216_I0.5620.15
150_V463_H0.5620.15
383_C387_K0.5610.15
247_D375_Q0.5610.15
108_I154_Y0.5610.15
245_Y257_T0.5600.15
47_F61_Q0.5600.15
208_A240_Q0.5600.15
197_S463_H0.5600.15
67_M84_A0.5580.15
118_E279_L0.5570.15
174_E178_R0.5570.15
229_A400_L0.5570.15
263_M298_C0.5570.15
14_R342_V0.5570.15
174_E186_N0.5560.15
343_D450_K0.5550.15
247_D339_Q0.5550.15
137_D229_A0.5540.15
343_D355_A0.5540.15
50_L358_H0.5540.15
104_G176_L0.5540.15
132_S197_S0.5530.15
36_M468_L0.5530.15
334_R358_H0.5530.15
361_F403_R0.5530.15
65_A215_S0.5520.15
115_K447_A0.5520.15
91_F294_C0.5510.14
337_Q432_M0.5500.14
347_E444_E0.5490.14
292_T459_K0.5480.14
52_T386_Y0.5480.14
60_T63_M0.5470.14
137_D331_L0.5460.14
376_F409_K0.5460.14
137_D231_F0.5450.14
352_C417_L0.5440.14
44_E188_V0.5430.14
176_L213_M0.5430.14
191_I339_Q0.5430.14
333_Y465_T0.5420.14
345_L357_G0.5420.14
56_T233_E0.5410.14
19_V33_K0.5400.14
76_G416_E0.5400.14
85_E406_K0.5390.14
156_K218_K0.5390.14
174_E221_D0.5380.14
70_G78_R0.5360.14
395_E417_L0.5350.14
163_V236_Y0.5350.14
216_I254_T0.5350.14
269_K334_R0.5340.14
22_T46_V0.5330.14
63_M324_D0.5330.14
194_T383_C0.5300.14
67_M317_R0.5300.14
280_L294_C0.5300.14
77_S458_P0.5290.14
186_N293_E0.5280.14
293_E296_T0.5280.14
80_Y89_N0.5270.14
211_K246_K0.5270.14
86_S259_K0.5260.14
64_Q363_D0.5260.14
190_Y280_L0.5260.14
77_S457_E0.5250.14
238_I259_K0.5250.14
149_T170_N0.5250.14
293_E343_D0.5250.14
373_A378_A0.5240.14
194_T232_A0.5230.14
346_E350_V0.5230.14
12_R17_E0.5220.14
400_L403_R0.5220.14
9_E12_R0.5210.14
321_G424_R0.5210.14
96_T454_F0.5210.14
180_I187_N0.5200.14
370_H377_P0.5200.14
229_A418_L0.5200.14
194_T396_I0.5200.14
85_E170_N0.5190.14
219_K249_T0.5190.14
275_P360_A0.5190.14
38_P394_V0.5180.14
231_F235_A0.5180.14
65_A409_K0.5170.14
376_F398_S0.5160.14
152_N197_S0.5140.14
293_E346_E0.5140.14
365_G373_A0.5130.14
70_G313_G0.5130.14
197_S394_V0.5120.14
160_D459_K0.5120.14
106_E423_P0.5100.13
165_Y170_N0.5100.13
153_V299_V0.5100.13
17_E72_E0.5080.13
85_E88_K0.5080.13
62_S66_A0.5070.13
261_A460_V0.5060.13
157_E163_V0.5050.13
60_T75_S0.5050.13
19_V166_D0.5040.13
82_A320_V0.5040.13
293_E376_F0.5020.13
28_E164_R0.5020.13
164_R343_D0.5010.13
129_V187_N0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ez2A 4 0.966 100 0.689 Contact Map
2oqxA 4 0.9873 100 0.698 Contact Map
1ax4A 4 0.983 100 0.758 Contact Map
4iw7A 2 0.6794 100 0.872 Contact Map
1jg8A 4 0.707 99.9 0.879 Contact Map
4lnjA 4 0.6858 99.9 0.895 Contact Map
3wgcA 4 0.6815 99.9 0.899 Contact Map
3b46A 2 0.8301 99.9 0.9 Contact Map
1v72A 4 0.6964 99.8 0.902 Contact Map
1svvA 4 0.6943 99.8 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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