GREMLIN Database
TIG - Trigger factor
UniProt: P0A850 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11003
Length: 432 (418)
Sequences: 3584 (2493)
Seq/√Len: 121.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_E236_N3.8991.00
205_H211_F3.8931.00
214_D230_A3.5261.00
142_D145_R3.2851.00
124_E416_K3.2681.00
158_V189_M3.2351.00
184_D238_K3.1991.00
153_E239_K2.8781.00
212_T232_K2.8481.00
275_E279_K2.6501.00
172_V229_K2.6391.00
152_K244_E2.6001.00
116_E299_D2.5851.00
205_H237_L2.5771.00
304_A308_D2.5671.00
138_D142_D2.5471.00
169_T181_K2.5391.00
353_E357_T2.5221.00
293_G296_K2.4761.00
40_R46_K2.4451.00
74_N105_Y2.4341.00
366_R406_Q2.4181.00
171_S234_A2.4151.00
268_A272_K2.3951.00
292_E343_R2.3741.00
224_E227_K2.3721.00
98_K101_E2.3601.00
77_D81_K2.3531.00
169_T176_E2.3311.00
157_A206_K2.3091.00
169_T234_A2.3021.00
206_K209_E2.2321.00
353_E356_R2.2301.00
126_E420_K2.2021.00
135_A139_G2.1881.00
134_D271_R2.1621.00
207_A240_V2.1611.00
214_D232_K2.1551.00
271_R275_E2.0831.00
165_T238_K2.0741.00
138_D267_R2.0711.00
167_D238_K2.0591.00
372_E376_S2.0561.00
212_T234_A2.0481.00
159_E242_E2.0341.00
160_A200_D2.0191.00
338_E342_K2.0141.00
216_T230_A1.9971.00
133_T136_D1.9791.00
121_E414_K1.9711.00
370_L373_E1.9701.00
18_T102_D1.9471.00
140_M143_T1.9361.00
172_V231_A1.9171.00
329_A332_L1.9161.00
135_A138_D1.9091.00
285_R289_Q1.8961.00
342_K346_V1.8961.00
264_E268_A1.8941.00
210_E234_A1.8721.00
269_E272_K1.8411.00
312_D334_R1.8391.00
136_D278_L1.8381.00
292_E296_K1.8371.00
272_K276_R1.8261.00
73_R77_D1.8131.00
146_K243_R1.7801.00
410_A414_K1.7781.00
142_D146_K1.7591.00
127_K419_E1.7591.00
332_L335_E1.7281.00
158_V164_V1.7231.00
160_A203_K1.7141.00
381_P384_V1.7131.00
272_K275_E1.7071.00
265_G268_A1.6931.00
335_E338_E1.6931.00
384_V387_F1.6911.00
96_E104_T1.6761.00
253_I263_V1.6531.00
14_R106_S1.6401.00
261_G265_G1.6331.00
18_T104_T1.6221.00
77_D80_I1.6221.00
165_T239_K1.6201.00
316_R319_A1.5651.00
25_E29_K1.5581.00
144_L266_L1.5551.00
250_A253_I1.5471.00
139_G142_D1.5471.00
145_R245_L1.5221.00
369_G372_E1.5151.00
126_E418_T1.5091.00
139_G143_T1.4941.00
260_D269_E1.4941.00
126_E289_Q1.4851.00
118_Q298_N1.4711.00
145_R248_L1.4511.00
161_E188_A1.4461.00
156_G162_D1.4431.00
339_E342_K1.4381.00
358_N410_A1.4381.00
12_G110_E1.4321.00
202_I205_H1.4311.00
154_K240_V1.4281.00
6_E14_R1.4191.00
262_S265_G1.4131.00
129_I419_E1.4131.00
382_K386_E1.4121.00
171_S176_E1.4111.00
166_I235_I1.4051.00
23_S26_T1.4021.00
119_G122_A1.4011.00
293_G297_A1.3991.00
263_V267_R1.3941.00
279_K283_R1.3921.00
156_G242_E1.3851.00
370_L405_E1.3801.00
120_L358_N1.3801.00
409_E413_A1.3491.00
33_V36_A1.3421.00
312_D316_R1.3321.00
141_L263_V1.3251.00
124_E418_T1.3171.00
165_T186_V1.3161.00
288_S292_E1.3121.00
251_E254_K1.2941.00
264_E267_R1.2941.00
80_I83_K1.2901.00
167_D236_N1.2811.00
380_D384_V1.2771.00
298_N350_L1.2761.00
276_R280_S1.2671.00
304_A338_E1.2661.00
151_W163_R1.2651.00
369_G373_E1.2571.00
362_A402_A1.2561.00
250_A262_S1.2370.99
176_E181_K1.2370.99
10_G301_D1.2340.99
364_E399_R1.2300.99
149_A243_R1.2290.99
197_G200_D1.2220.99
363_D366_R1.2120.99
250_A254_K1.1970.99
308_D334_R1.1910.99
12_G108_E1.1830.99
51_M55_A1.1770.99
110_E305_A1.1740.99
201_G213_I1.1730.99
165_T241_E1.1730.99
310_E344_R1.1710.99
29_K33_V1.1690.99
211_F237_L1.1680.99
156_G159_E1.1610.99
20_A23_S1.1450.99
311_I338_E1.1440.99
16_T104_T1.1430.99
158_V237_L1.1330.99
17_I105_Y1.1320.99
205_H213_I1.1260.99
248_L263_V1.1230.99
362_A403_L1.1160.99
121_E358_N1.1140.99
76_I80_I1.1120.99
163_R188_A1.1110.99
124_E293_G1.1090.99
190_G199_E1.1060.99
202_I211_F1.1060.99
32_L62_V1.0950.99
316_R320_Q1.0940.99
302_V307_I1.0920.99
26_T30_S1.0870.99
166_I202_I1.0840.99
188_A243_R1.0810.98
320_Q324_G1.0800.98
366_R369_G1.0790.98
308_D312_D1.0770.98
331_E335_E1.0760.98
283_R412_L1.0750.98
49_V54_V1.0750.98
320_Q323_G1.0730.98
364_E368_K1.0720.98
22_D25_E1.0700.98
141_L145_R1.0670.98
15_V78_A1.0570.98
317_Q321_R1.0570.98
213_I235_I1.0540.98
268_A271_R1.0530.98
128_P285_R1.0470.98
171_S232_K1.0470.98
150_T244_E1.0420.98
365_E369_G1.0420.98
365_E368_K1.0410.98
371_I382_K1.0340.98
52_N56_Q1.0280.98
207_A239_K1.0240.98
164_V240_V1.0240.98
368_K372_E1.0230.98
269_E273_N1.0230.98
253_I266_L1.0210.98
355_I407_A1.0190.98
268_A275_E1.0180.98
167_D183_S1.0160.98
72_S76_I1.0110.98
339_E343_R1.0030.98
19_I70_L1.0000.97
3_V82_E0.9980.97
91_T108_E0.9980.97
41_I49_V0.9970.97
96_E101_E0.9970.97
396_D399_R0.9970.97
52_N55_A0.9930.97
277_E281_A0.9910.97
31_E65_D0.9900.97
115_V353_E0.9870.97
351_L407_A0.9850.97
140_M277_E0.9840.97
112_Y352_G0.9830.97
158_V202_I0.9820.97
311_I334_R0.9790.97
134_D138_D0.9780.97
294_L350_L0.9730.97
30_S69_D0.9720.97
148_Q255_R0.9690.97
22_D26_T0.9660.97
22_D102_D0.9650.97
143_T146_K0.9630.97
138_D141_L0.9610.97
154_K157_A0.9600.97
189_M203_K0.9600.97
128_P286_V0.9590.97
31_E69_D0.9570.97
136_D139_G0.9550.97
163_R241_E0.9540.97
16_T106_S0.9540.97
215_V233_F0.9530.97
32_L54_V0.9520.97
79_I86_P0.9520.97
27_A30_S0.9510.97
177_F180_G0.9500.97
205_H209_E0.9440.96
145_R263_V0.9410.96
154_K242_E0.9400.96
368_K386_E0.9300.96
134_D137_V0.9300.96
290_A411_V0.9300.96
300_I346_V0.9240.96
23_S73_R0.9240.96
310_E313_V0.9180.96
249_T252_F0.9170.96
14_R108_E0.9160.96
315_R334_R0.9130.96
116_E357_T0.9080.96
155_D159_E0.9050.95
29_K51_M0.9030.95
216_T219_E0.9030.95
386_E389_S0.8990.95
383_E386_E0.8970.95
85_N112_Y0.8960.95
163_R186_V0.8950.95
361_K399_R0.8940.95
152_K242_E0.8940.95
395_M399_R0.8920.95
290_A412_L0.8920.95
158_V203_K0.8890.95
295_V347_V0.8850.95
74_N77_D0.8830.95
158_V205_H0.8780.95
171_S181_K0.8720.94
360_L410_A0.8710.94
166_I237_L0.8700.94
354_V407_A0.8690.94
328_Q336_L0.8680.94
155_D206_K0.8670.94
8_T14_R0.8650.94
160_A188_A0.8620.94
200_D203_K0.8620.94
215_V231_A0.8610.94
35_V39_V0.8600.94
384_V388_Y0.8590.94
289_Q293_G0.8590.94
185_F193_R0.8580.94
330_L334_R0.8580.94
373_E376_S0.8560.94
356_R359_E0.8540.94
283_R409_E0.8540.94
132_V274_M0.8530.94
75_F109_F0.8450.94
151_W188_A0.8430.93
154_K207_A0.8400.93
187_L194_M0.8300.93
280_S284_N0.8290.93
67_L103_F0.8280.93
321_R325_N0.8230.93
299_D346_V0.8210.93
281_A285_R0.8140.92
331_E334_R0.8110.92
135_A142_D0.8110.92
4_S16_T0.8100.92
62_V66_V0.8090.92
143_T147_Q0.8080.92
39_V54_V0.8080.92
75_F86_P0.8060.92
213_I232_K0.8050.92
367_V399_R0.8040.92
158_V240_V0.8040.92
27_A66_V0.8010.92
127_K286_V0.7990.91
164_V202_I0.7970.91
23_S77_D0.7960.91
354_V358_N0.7900.91
295_V298_N0.7890.91
168_F182_A0.7890.91
165_T184_D0.7890.91
156_G206_K0.7850.91
213_I231_A0.7830.91
7_T13_R0.7820.91
410_A413_A0.7800.90
54_V58_Y0.7760.90
219_E228_G0.7760.90
64_Q68_G0.7740.90
34_N38_K0.7730.90
202_I237_L0.7720.90
264_E271_R0.7720.90
149_A245_L0.7710.90
170_G221_Y0.7700.90
172_V175_E0.7690.90
13_R111_V0.7690.90
276_R279_K0.7690.90
314_L341_A0.7660.90
328_Q332_L0.7660.90
391_N394_L0.7650.90
134_D267_R0.7630.90
141_L253_I0.7620.89
360_L407_A0.7610.89
370_L402_A0.7600.89
118_Q297_A0.7570.89
167_D184_D0.7540.89
257_G262_S0.7520.89
206_K240_V0.7520.89
141_L266_L0.7490.89
168_F185_F0.7450.88
304_A342_K0.7440.88
30_S34_N0.7430.88
192_G199_E0.7400.88
25_E100_G0.7390.88
367_V395_M0.7390.88
35_V62_V0.7380.88
122_A297_A0.7380.88
319_A323_G0.7370.88
153_E241_E0.7370.88
31_E34_N0.7350.88
348_G404_E0.7340.88
119_G297_A0.7320.88
355_I403_L0.7320.88
153_E207_A0.7300.87
46_K49_V0.7300.87
289_Q292_E0.7290.87
19_I105_Y0.7250.87
134_D275_E0.7230.87
260_D265_G0.7230.87
39_V62_V0.7230.87
356_R403_L0.7210.87
31_E66_V0.7210.87
223_A226_L0.7210.87
170_G177_F0.7200.87
254_K261_G0.7130.86
340_Q343_R0.7130.86
309_S312_D0.7120.86
173_D229_K0.7110.86
24_I70_L0.7100.86
115_V298_N0.7100.86
368_K371_I0.7080.86
371_I395_M0.7080.86
144_L147_Q0.7070.86
21_A100_G0.7060.86
87_A306_L0.7060.86
278_L281_A0.7050.85
5_V13_R0.7030.85
88_G110_E0.7020.85
383_E387_F0.7010.85
170_G217_F0.7000.85
30_S33_V0.7000.85
42_D57_R0.6990.85
385_I389_S0.6980.85
249_T253_I0.6970.85
372_E382_K0.6970.85
295_V346_V0.6970.85
221_Y233_F0.6960.85
128_P289_Q0.6950.85
217_F221_Y0.6940.85
308_D338_E0.6910.84
164_V189_M0.6900.84
275_E278_L0.6890.84
308_D311_I0.6870.84
144_L252_F0.6870.84
20_A102_D0.6860.84
195_I221_Y0.6860.84
118_Q299_D0.6840.84
218_P221_Y0.6830.84
137_V271_R0.6820.84
198_F233_F0.6810.83
249_T255_R0.6800.83
131_E134_D0.6780.83
394_L397_N0.6780.83
151_W241_E0.6760.83
141_L270_V0.6760.83
305_A309_S0.6760.83
296_K343_R0.6760.83
159_E162_D0.6740.83
246_P252_F0.6730.83
380_D383_E0.6730.83
27_A70_L0.6720.83
32_L51_M0.6720.83
28_V62_V0.6720.83
95_G106_S0.6710.83
159_E206_K0.6690.82
171_S174_G0.6680.82
322_F326_E0.6660.82
150_T255_R0.6650.82
38_K46_K0.6640.82
175_E225_N0.6630.82
257_G269_E0.6610.82
131_E275_E0.6610.82
323_G326_E0.6610.82
125_V290_A0.6600.82
197_G230_A0.6590.81
160_A192_G0.6580.81
158_V209_E0.6580.81
314_L337_F0.6570.81
367_V398_M0.6570.81
403_L407_A0.6570.81
354_V411_V0.6560.81
29_K55_A0.6550.81
79_I84_I0.6530.81
164_V237_L0.6530.81
187_L191_Q0.6510.81
407_A411_V0.6480.80
145_R249_T0.6450.80
169_T236_N0.6450.80
50_P53_I0.6440.80
270_V273_N0.6420.80
360_L403_L0.6420.80
92_Y107_V0.6420.80
345_V349_L0.6380.79
376_S379_E0.6380.79
291_I347_V0.6370.79
129_I420_K0.6320.79
274_M278_L0.6320.79
130_V282_I0.6320.79
329_A333_P0.6320.79
184_D236_N0.6300.78
170_G198_F0.6300.78
127_K282_I0.6290.78
398_M402_A0.6270.78
26_T29_K0.6230.78
362_A406_Q0.6230.78
120_L411_V0.6230.78
202_I235_I0.6220.78
312_D315_R0.6220.78
195_I200_D0.6210.77
392_K395_M0.6200.77
286_V417_V0.6200.77
171_S175_E0.6190.77
9_Q12_G0.6180.77
51_M54_V0.6170.77
311_I315_R0.6160.77
286_V412_L0.6160.77
119_G123_I0.6150.77
166_I193_R0.6150.77
415_A418_T0.6130.77
257_G260_D0.6120.76
358_N414_K0.6120.76
187_L199_E0.6120.76
41_I53_I0.6110.76
75_F79_I0.6110.76
11_L110_E0.6100.76
123_I294_L0.6100.76
141_L248_L0.6100.76
168_F198_F0.6050.76
335_E339_E0.6030.75
93_V106_S0.6020.75
380_D389_S0.6020.75
273_N276_R0.6020.75
160_A189_M0.6010.75
140_M273_N0.6000.75
217_F220_E0.6000.75
283_R405_E0.5970.75
60_A99_L0.5960.75
53_I56_Q0.5950.74
313_V316_R0.5940.74
211_F235_I0.5920.74
43_G47_G0.5910.74
95_G104_T0.5910.74
244_E247_E0.5900.74
226_L229_K0.5880.74
205_H210_E0.5880.74
28_V63_R0.5870.73
39_V58_Y0.5860.73
170_G233_F0.5850.73
174_G232_K0.5850.73
86_P109_F0.5810.73
286_V289_Q0.5810.73
151_W243_R0.5800.73
145_R247_E0.5790.72
201_G215_V0.5780.72
302_V345_V0.5760.72
250_A260_D0.5750.72
84_I109_F0.5730.72
120_L354_V0.5710.71
131_E271_R0.5710.71
194_M198_F0.5700.71
125_V286_V0.5690.71
60_A63_R0.5650.71
115_V300_I0.5650.71
283_R287_K0.5630.70
168_F217_F0.5630.70
136_D274_M0.5630.70
61_S64_Q0.5620.70
84_I111_V0.5620.70
310_E348_G0.5620.70
382_K389_S0.5610.70
366_R402_A0.5610.70
198_F218_P0.5600.70
132_V137_V0.5590.70
207_A237_L0.5580.70
122_A416_K0.5580.70
187_L195_I0.5580.70
145_R252_F0.5570.70
180_G217_F0.5570.70
302_V342_K0.5560.69
209_E240_V0.5560.69
144_L256_F0.5550.69
192_G200_D0.5550.69
137_V267_R0.5550.69
218_P233_F0.5550.69
28_V66_V0.5540.69
72_S105_Y0.5520.69
49_V53_I0.5520.69
43_G50_P0.5490.68
17_I74_N0.5490.68
189_M202_I0.5490.68
284_N288_S0.5480.68
132_V275_E0.5480.68
314_L317_Q0.5480.68
120_L357_T0.5470.68
191_Q199_E0.5470.68
27_A73_R0.5470.68
132_V271_R0.5460.68
85_N356_R0.5460.68
40_R49_V0.5460.68
370_L374_M0.5460.68
340_Q344_R0.5450.68
300_I350_L0.5440.68
24_I28_V0.5440.68
2_Q18_T0.5430.68
137_V270_V0.5430.68
172_V220_E0.5420.67
5_V82_E0.5410.67
259_E262_S0.5410.67
168_F194_M0.5400.67
180_G221_Y0.5400.67
192_G196_P0.5400.67
168_F221_Y0.5390.67
170_G180_G0.5360.67
250_A263_V0.5350.66
317_Q320_Q0.5340.66
140_M144_L0.5340.66
166_I187_L0.5340.66
384_V389_S0.5340.66
371_I375_A0.5330.66
222_H227_K0.5330.66
382_K385_I0.5320.66
12_G304_A0.5300.66
60_A98_K0.5290.66
58_Y65_D0.5290.66
399_R403_L0.5290.66
65_D69_D0.5280.65
36_A49_V0.5280.65
138_D264_E0.5280.65
182_A185_F0.5270.65
186_V241_E0.5270.65
158_V207_A0.5270.65
280_S283_R0.5270.65
208_G238_K0.5270.65
123_I293_G0.5260.65
368_K389_S0.5240.65
98_K102_D0.5240.65
196_P200_D0.5240.65
67_L71_M0.5220.65
130_V278_L0.5200.64
36_A54_V0.5190.64
21_A25_E0.5180.64
117_L353_E0.5170.64
400_N404_E0.5170.64
381_P387_F0.5170.64
164_V235_I0.5170.64
223_A227_K0.5160.64
17_I78_A0.5160.64
28_V32_L0.5150.64
137_V141_L0.5140.63
188_A193_R0.5140.63
315_R333_P0.5140.63
132_V278_L0.5130.63
198_F221_Y0.5130.63
39_V57_R0.5130.63
188_A191_Q0.5120.63
148_Q252_F0.5100.63
312_D330_L0.5090.63
3_V15_V0.5090.63
34_N69_D0.5090.63
53_I57_R0.5090.63
219_E227_K0.5090.63
250_A264_E0.5080.63
294_L297_A0.5070.62
116_E353_E0.5060.62
177_F217_F0.5050.62
317_Q344_R0.5050.62
11_L111_V0.5050.62
287_K412_L0.5040.62
266_L270_V0.5040.62
96_E102_D0.5030.62
117_L298_N0.5030.62
141_L267_R0.5010.61
27_A69_D0.5010.61
47_G50_P0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w26A 1 1 100 0.067 Contact Map
1t11A 3 0.8681 100 0.129 Contact Map
3gtyX 1 0.9352 100 0.139 Contact Map
1zxjA 4 0.4514 100 0.688 Contact Map
1p9yA 1 0.2708 100 0.695 Contact Map
2d3o1 1 0.2292 100 0.716 Contact Map
2nscA 2 0.2523 100 0.73 Contact Map
2nsaA 2 0.3727 99.9 0.742 Contact Map
1hxvA 1 0.1968 99.7 0.816 Contact Map
3prbA 2 0.3472 99.7 0.823 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0115 seconds.