GREMLIN Database
TGT - Queuine tRNA-ribosyltransferase
UniProt: P0A847 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10996
Length: 375 (361)
Sequences: 3227 (1645)
Seq/√Len: 86.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_R350_E3.9771.00
47_E83_K3.3301.00
8_T237_A3.2991.00
152_W193_D3.2071.00
72_L293_S3.1691.00
167_K171_E2.9361.00
67_Q133_D2.8991.00
106_E164_R2.8641.00
303_D336_R2.8031.00
277_L330_N2.7901.00
302_C307_C2.6861.00
156_K160_E2.6051.00
16_R25_E2.5781.00
347_K351_E2.5711.00
256_V345_L2.5561.00
257_R358_V2.5501.00
45_E328_R2.5291.00
201_G204_D2.5271.00
73_H295_T2.4271.00
71_K133_D2.4211.00
16_R23_V2.3901.00
25_E52_Q2.3611.00
196_D200_K2.2301.00
163_L198_S2.2231.00
163_L201_G2.1611.00
303_D340_R2.1171.00
152_W156_K2.1111.00
125_E168_R2.1011.00
197_I201_G2.0911.00
47_E84_G2.0761.00
296_G300_P2.0751.00
223_D226_R2.0541.00
304_C307_C2.0371.00
4_E16_R2.0331.00
40_G324_I2.0221.00
257_R354_L2.0101.00
166_A207_F1.9881.00
6_D16_R1.9781.00
296_G312_R1.9531.00
281_D364_R1.9231.00
229_E258_R1.9111.00
18_V23_V1.9021.00
126_K129_E1.8941.00
345_L354_L1.8831.00
256_V342_M1.8731.00
289_A292_K1.8701.00
123_D126_K1.8451.00
62_W120_I1.8411.00
4_E18_V1.8411.00
291_Y294_D1.8131.00
186_I235_I1.8111.00
151_D154_Y1.8091.00
155_A189_S1.7951.00
196_D234_Q1.7901.00
192_E226_R1.7841.00
212_V260_I1.7711.00
199_V231_V1.7681.00
70_M134_L1.7681.00
156_K197_I1.7471.00
112_R119_P1.7291.00
129_E172_R1.7261.00
144_E154_Y1.7151.00
160_E197_I1.6921.00
167_K205_I1.6921.00
280_T344_G1.6921.00
49_T335_L1.6901.00
172_R175_S1.6851.00
22_G85_P1.6701.00
136_S139_V1.6431.00
68_E133_D1.6351.00
344_G357_F1.6291.00
336_R340_R1.6071.00
36_G80_M1.6021.00
7_T352_G1.5991.00
306_T332_I1.5891.00
220_P223_D1.5801.00
340_R343_A1.5761.00
76_L86_I1.5631.00
166_A202_L1.5511.00
44_E310_Y1.5471.00
44_E48_A1.5361.00
305_Y309_N1.5271.00
253_V345_L1.5151.00
14_R25_E1.5081.00
113_N116_N1.5011.00
360_D364_R1.4750.99
277_L286_I1.4540.99
184_G207_F1.4410.99
146_T155_A1.4410.99
6_D14_R1.4390.99
141_I169_S1.4390.99
253_V358_V1.4370.99
269_T331_T1.4370.99
254_E258_R1.4330.99
110_H119_P1.4310.99
42_T45_E1.4190.99
341_L357_F1.4160.99
17_L24_V1.4050.99
296_G311_S1.3890.99
28_C339_Q1.3810.99
192_E230_H1.3690.99
43_P310_Y1.3620.99
9_D352_G1.3580.99
225_H254_E1.3430.99
42_T328_R1.3420.99
81_Q310_Y1.3380.99
277_L298_L1.3270.99
196_D230_H1.3260.99
324_I327_A1.3120.99
69_I293_S1.3100.99
319_D330_N1.3100.99
77_H86_I1.2930.99
127_S131_Q1.2750.98
357_F361_F1.2720.98
25_E350_E1.2690.98
53_I138_I1.2690.98
301_E364_R1.2600.98
316_H320_R1.2560.98
340_R344_G1.2390.98
252_L342_M1.2310.98
199_V234_Q1.2290.98
221_K251_D1.2200.98
132_Y174_D1.2200.98
243_L260_I1.2160.98
305_Y332_I1.2160.98
110_H121_F1.1990.98
105_T121_F1.1960.98
319_D326_G1.1950.98
271_N274_N1.1950.98
155_A191_Y1.1950.98
141_I166_A1.1920.97
280_T301_E1.1910.97
276_H283_V1.1840.97
347_K350_E1.1750.97
200_K204_D1.1720.97
252_L345_L1.1710.97
280_T340_R1.1710.97
243_L255_G1.1700.97
144_E158_S1.1660.97
35_Y321_C1.1550.97
81_Q309_N1.1550.97
183_F262_M1.1530.97
348_A353_K1.1520.97
243_L246_V1.1360.97
202_L210_Y1.1330.97
19_F22_G1.1240.96
11_R233_P1.1220.96
294_D312_R1.1190.96
227_I230_H1.1180.96
336_R343_A1.1180.96
343_A347_K1.1110.96
280_T364_R1.1090.96
141_I162_S1.1090.96
128_M139_V1.1070.96
41_M335_L1.0970.96
62_W67_Q1.0960.96
153_D156_K1.0960.96
170_R205_I1.0920.96
127_S142_F1.0900.96
302_C333_H1.0850.96
170_R174_D1.0790.95
257_R355_E1.0760.95
135_G180_N1.0720.95
76_L134_L1.0700.95
199_V235_I1.0680.95
353_K356_S1.0650.95
267_M278_F1.0570.95
154_Y158_S1.0550.95
128_M169_S1.0530.95
129_E133_D1.0500.95
167_K204_D1.0490.95
206_G239_K1.0470.95
197_I200_K1.0470.95
9_D349_I1.0460.95
166_A205_I1.0460.95
153_D157_R1.0450.95
132_Y173_F1.0410.95
126_K130_I1.0400.94
307_C333_H1.0380.94
306_T315_L1.0240.94
286_I319_D1.0210.94
132_Y177_G1.0180.94
7_T14_R1.0160.94
104_I142_F1.0110.94
28_C262_M1.0040.93
192_E196_D1.0010.93
170_R208_D0.9950.93
46_V49_T0.9940.93
36_G56_G0.9910.93
280_T299_D0.9880.93
148_Y220_P0.9880.93
150_A189_S0.9870.93
159_M163_L0.9800.93
62_W122_L0.9730.92
292_K316_H0.9730.92
122_L127_S0.9730.92
19_F24_V0.9720.92
228_L255_G0.9700.92
146_T159_M0.9700.92
152_W191_Y0.9680.92
86_I136_S0.9640.92
152_W155_A0.9630.92
73_H313_A0.9550.92
51_A339_Q0.9530.91
287_R319_D0.9510.91
163_L202_L0.9480.91
128_M142_F0.9470.91
254_E362_Y0.9450.91
105_T110_H0.9420.91
272_A332_I0.9310.90
174_D177_G0.9270.90
284_V291_Y0.9270.90
279_V282_G0.9240.90
131_Q136_S0.9230.90
59_F114_P0.9200.90
149_P189_S0.9190.90
267_M338_Y0.9150.90
69_I72_L0.9100.89
192_E227_I0.9090.89
140_M185_I0.9090.89
38_V46_V0.9060.89
345_L348_A0.9040.89
102_R144_E0.9030.89
203_V210_Y0.9030.89
170_R207_F0.9020.89
198_S202_L0.9010.89
7_T350_E0.8970.89
303_D343_A0.8950.89
253_V361_F0.8910.88
148_Y190_V0.8870.88
248_K267_M0.8850.88
42_T325_L0.8850.88
280_T337_Y0.8800.88
200_K234_Q0.8760.88
80_M86_I0.8740.88
52_Q85_P0.8680.87
306_T309_N0.8680.87
359_T363_Q0.8670.87
56_G76_L0.8670.87
231_V234_Q0.8640.87
41_M332_I0.8630.87
294_D313_A0.8620.87
201_G205_I0.8610.87
278_F338_Y0.8580.87
198_S201_G0.8580.87
356_S360_D0.8540.86
295_T311_S0.8540.86
154_Y157_R0.8530.86
107_Q121_F0.8490.86
277_L315_L0.8490.86
348_A354_L0.8420.85
49_T339_Q0.8410.85
181_A208_D0.8400.85
9_D355_E0.8390.85
63_L115_I0.8330.85
284_V312_R0.8300.85
353_K360_D0.8290.85
222_A226_R0.8270.84
186_I199_V0.8260.84
5_L14_R0.8250.84
317_H323_E0.8180.84
253_V357_F0.8180.84
167_K201_G0.8160.84
257_R362_Y0.8150.84
78_D81_Q0.8120.83
354_L358_V0.8090.83
23_V52_Q0.8090.83
254_E358_V0.8090.83
163_L205_I0.8070.83
318_L325_L0.8040.83
275_G319_D0.8040.83
221_K224_M0.8030.83
231_V235_I0.8030.83
6_D350_E0.7980.82
250_E362_Y0.7980.82
140_M244_M0.7970.82
54_I80_M0.7930.82
95_V142_F0.7850.81
10_G355_E0.7720.80
52_Q84_G0.7720.80
186_I202_L0.7700.80
24_V28_C0.7670.80
130_I134_L0.7660.80
304_C329_L0.7650.80
41_M46_V0.7650.80
345_L357_F0.7640.79
229_E232_C0.7640.79
190_V227_I0.7620.79
295_T313_A0.7600.79
266_V270_R0.7600.79
196_D233_P0.7590.79
159_M198_S0.7580.79
355_E359_T0.7550.79
109_V142_F0.7540.79
128_M141_I0.7530.78
159_M197_I0.7530.78
175_S179_K0.7500.78
28_C53_I0.7500.78
271_N276_H0.7500.78
170_R206_G0.7490.78
190_V223_D0.7490.78
314_Y317_H0.7480.78
41_M331_T0.7480.78
337_Y341_L0.7460.78
199_V232_C0.7420.77
286_I330_N0.7410.77
95_V109_V0.7370.77
252_L255_G0.7370.77
40_G328_R0.7360.77
4_E23_V0.7360.77
305_Y310_Y0.7350.77
43_P305_Y0.7350.77
78_D83_K0.7340.77
110_H123_D0.7310.76
9_D356_S0.7310.76
43_P80_M0.7310.76
128_M132_Y0.7300.76
190_V216_A0.7290.76
227_I231_V0.7280.76
157_R161_M0.7270.76
199_V203_V0.7230.76
298_L330_N0.7220.76
302_C329_L0.7200.75
150_A155_A0.7200.75
170_R210_Y0.7200.75
144_E161_M0.7170.75
275_G286_I0.7170.75
69_I73_H0.7160.75
50_G343_A0.7160.75
44_E81_Q0.7160.75
277_L319_D0.7160.75
322_N327_A0.7110.74
157_R160_E0.7060.74
74_G78_D0.7030.74
307_C329_L0.7020.73
271_N278_F0.7020.73
50_G84_G0.7000.73
304_C333_H0.7000.73
326_G330_N0.6990.73
67_Q129_E0.6970.73
155_A194_L0.6940.73
64_R115_I0.6940.73
163_L204_D0.6940.73
4_E25_E0.6930.72
100_D112_R0.6920.72
328_R332_I0.6890.72
62_W126_K0.6890.72
57_N61_L0.6880.72
121_F126_K0.6840.72
35_Y64_R0.6800.71
315_L330_N0.6780.71
171_E175_S0.6760.71
146_T190_V0.6750.71
16_R52_Q0.6740.70
302_C309_N0.6720.70
232_C258_R0.6710.70
348_A357_F0.6700.70
306_T310_Y0.6700.70
149_P190_V0.6700.70
41_M328_R0.6690.70
15_G26_T0.6690.70
228_L232_C0.6680.70
248_K338_Y0.6680.70
62_W130_I0.6670.70
230_H234_Q0.6660.70
49_T336_R0.6650.69
315_L319_D0.6640.69
267_M271_N0.6560.68
223_D227_I0.6550.68
248_K251_D0.6550.68
20_D181_A0.6530.68
14_R354_L0.6520.68
319_D327_A0.6510.68
146_T158_S0.6480.67
332_I336_R0.6460.67
5_L8_T0.6460.67
14_R345_L0.6450.67
344_G347_K0.6430.67
186_I231_V0.6430.67
132_Y139_V0.6420.67
127_S169_S0.6410.67
33_G38_V0.6390.66
253_V354_L0.6390.66
170_R204_D0.6390.66
212_V215_L0.6380.66
36_G76_L0.6380.66
67_Q70_M0.6380.66
285_K288_N0.6380.66
210_Y239_K0.6360.66
139_V173_F0.6360.66
128_M182_L0.6360.66
24_V52_Q0.6360.66
11_R229_E0.6350.66
19_F180_N0.6330.66
29_F268_P0.6260.65
140_M242_Y0.6250.65
173_F208_D0.6250.65
40_G327_A0.6240.64
302_C336_R0.6230.64
57_N60_H0.6220.64
289_A316_H0.6220.64
19_F85_P0.6200.64
149_P220_P0.6190.64
232_C241_R0.6190.64
271_N277_L0.6180.64
158_S161_M0.6180.64
302_C306_T0.6170.64
314_Y318_L0.6170.64
275_G287_R0.6160.64
358_V362_Y0.6140.63
253_V341_L0.6130.63
284_V296_G0.6130.63
73_H311_S0.6130.63
46_V50_G0.6120.63
255_G263_F0.6120.63
271_N330_N0.6100.63
202_L205_I0.6100.63
129_E175_S0.6080.62
54_I86_I0.6070.62
240_P262_M0.6070.62
106_E161_M0.6060.62
196_D199_V0.6040.62
232_C235_I0.6040.62
306_T336_R0.6020.62
281_D300_P0.5950.61
286_I315_L0.5940.61
225_H251_D0.5920.60
62_W118_D0.5920.60
274_N324_I0.5920.60
21_R75_D0.5910.60
136_S141_I0.5910.60
256_V263_F0.5890.60
314_Y323_E0.5870.60
212_V231_V0.5830.59
331_T338_Y0.5830.59
44_E309_N0.5830.59
69_I292_K0.5820.59
40_G272_A0.5810.59
28_C52_Q0.5810.59
67_Q130_I0.5800.59
148_Y189_S0.5800.59
43_P81_Q0.5780.59
30_M53_I0.5780.59
139_V142_F0.5780.59
253_V362_Y0.5770.59
122_L130_I0.5770.59
205_I208_D0.5760.58
298_L306_T0.5760.58
160_E164_R0.5750.58
185_I244_M0.5740.58
276_H285_K0.5730.58
277_L284_V0.5720.58
106_E158_S0.5710.58
122_L126_K0.5700.58
253_V256_V0.5690.57
96_F216_A0.5690.57
139_V180_N0.5680.57
215_L219_E0.5670.57
104_I154_Y0.5670.57
101_I114_P0.5660.57
24_V85_P0.5650.57
184_G210_Y0.5640.57
307_C336_R0.5630.57
280_T298_L0.5630.57
253_V337_Y0.5620.57
344_G348_A0.5620.57
155_A159_M0.5620.57
229_E233_P0.5610.56
250_E361_F0.5610.56
70_M293_S0.5600.56
163_L203_V0.5590.56
173_F180_N0.5590.56
132_Y172_R0.5590.56
270_R273_R0.5580.56
348_A352_G0.5570.56
161_M164_R0.5560.56
152_W194_L0.5550.56
87_L140_M0.5540.55
281_D301_E0.5530.55
30_M140_M0.5530.55
219_E242_Y0.5520.55
141_I207_F0.5510.55
216_A219_E0.5490.55
37_T325_L0.5480.55
339_Q343_A0.5480.55
342_M345_L0.5460.54
221_K250_E0.5450.54
68_E293_S0.5440.54
99_G102_R0.5420.54
192_E234_Q0.5420.54
115_I321_C0.5420.54
48_A308_R0.5420.54
30_M87_L0.5390.53
8_T11_R0.5390.53
202_L207_F0.5390.53
75_D78_D0.5370.53
72_L313_A0.5370.53
20_D173_F0.5360.53
197_I204_D0.5330.53
168_R172_R0.5320.53
106_E168_R0.5300.52
329_L333_H0.5300.52
170_R173_F0.5290.52
72_L295_T0.5290.52
3_F6_D0.5270.52
188_G195_R0.5270.52
44_E328_R0.5250.52
337_Y362_Y0.5240.51
148_Y155_A0.5240.51
252_L338_Y0.5220.51
207_F210_Y0.5210.51
57_N143_D0.5210.51
274_N319_D0.5200.51
11_R237_A0.5200.51
304_C336_R0.5190.51
184_G202_L0.5190.51
271_N338_Y0.5190.51
13_R241_R0.5170.50
221_K225_H0.5170.50
355_E358_V0.5160.50
18_V25_E0.5160.50
211_A218_G0.5160.50
217_V246_V0.5160.50
145_C247_G0.5160.50
41_M324_I0.5140.50
308_R322_N0.5130.50
101_I109_V0.5120.50
141_I211_A0.5120.50
348_A351_E0.5110.50
225_H258_R0.5100.50
278_F330_N0.5090.49
272_A306_T0.5090.49
89_D143_D0.5090.49
299_D340_R0.5090.49
206_G210_Y0.5080.49
21_R180_N0.5080.49
232_C260_I0.5070.49
55_L87_L0.5060.49
44_E47_E0.5040.49
26_T261_D0.5020.48
151_D155_A0.5010.48
55_L60_H0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q8wA 2 0.968 100 0.046 Contact Map
2ashA 3 0.96 100 0.059 Contact Map
1iq8A 2 0.904 100 0.184 Contact Map
1vcfA 3 0.7227 90.7 0.954 Contact Map
4jn6A 2 0.7573 88.6 0.956 Contact Map
1ydoA 3 0.6987 88.4 0.956 Contact Map
3ewbX 2 0.6427 87.8 0.956 Contact Map
4xp7A 1 0.8107 84.5 0.958 Contact Map
4oqvA 1 0.752 79.7 0.961 Contact Map
1vhnA 1 0.7547 77.8 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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