GREMLIN Database
SURE - 5'/3'-nucleotidase SurE
UniProt: P0A840 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11817
Length: 253 (239)
Sequences: 3014 (2059)
Seq/√Len: 133.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_R28_D4.6311.00
172_R221_Y3.6881.00
113_G120_A3.4701.00
215_A219_E3.1161.00
87_V113_G3.0011.00
174_T223_S2.9811.00
23_L88_V2.9801.00
163_L220_G2.8991.00
170_G221_Y2.7851.00
123_V160_V2.7561.00
21_K135_A2.6601.00
52_R190_D2.6061.00
216_A223_S2.5861.00
187_P195_T2.2961.00
5_L20_A2.2851.00
158_I224_I2.2231.00
174_T216_A2.2121.00
123_V138_T2.2121.00
169_K221_Y2.1661.00
93_A131_Y2.1281.00
22_A25_E2.0901.00
26_F143_R2.0231.00
188_Q196_L2.0181.00
25_E139_C1.9901.00
41_A44_S1.9811.00
11_V61_I1.9461.00
78_A187_P1.9341.00
86_I142_L1.9291.00
121_L158_I1.9081.00
136_A165_L1.8871.00
134_A160_V1.8351.00
97_L217_V1.8161.00
49_S65_M1.7761.00
2_R30_Q1.7541.00
217_V223_S1.7431.00
14_P18_T1.7421.00
42_S108_A1.7341.00
6_S109_A1.7331.00
35_D38_R1.7191.00
38_R41_A1.7081.00
190_D194_N1.6421.00
137_V222_V1.6341.00
123_V158_I1.6061.00
20_A31_V1.5961.00
80_M84_P1.5921.00
20_A61_I1.5871.00
230_D234_H1.5801.00
137_V160_V1.5711.00
175_R211_G1.5681.00
88_V123_V1.5271.00
144_A148_E1.5171.00
55_T58_N1.5011.00
103_Y112_E1.4991.00
18_T135_A1.4881.00
22_A135_A1.4671.00
5_L29_V1.4491.00
3_I86_I1.4011.00
53_T79_L1.3971.00
164_P167_Q1.3971.00
154_R233_A1.3951.00
55_T60_D1.3741.00
175_R212_T1.3601.00
114_R155_I1.3581.00
233_A236_A1.3461.00
14_P93_A1.3441.00
176_C225_T1.3421.00
32_V75_G1.3381.00
28_D59_G1.3331.00
18_T22_A1.3321.00
13_A93_A1.3281.00
139_C143_R1.3221.00
107_V227_L1.3221.00
158_I222_V1.3211.00
22_A139_C1.3051.00
6_S89_S1.2911.00
20_A24_R1.2701.00
191_P198_W1.2641.00
234_H238_D1.2561.00
130_H133_T1.2501.00
2_R82_P1.2431.00
172_R211_G1.2411.00
137_V168_I1.2211.00
50_S198_W1.2171.00
76_V118_F1.2161.00
58_N61_I1.2151.00
74_L197_Y1.2051.00
140_S144_A1.1980.99
23_L26_F1.1910.99
236_A239_V1.1910.99
89_S109_A1.1910.99
56_F63_V1.1860.99
211_G215_A1.1830.99
169_K220_G1.1820.99
5_L88_V1.1820.99
73_Y185_V1.1810.99
76_V116_L1.1420.99
228_H233_A1.1380.99
57_E61_I1.1350.99
216_A221_Y1.1330.99
35_D65_M1.1250.99
136_A140_S1.1060.99
110_A120_A1.1050.99
97_L100_D1.1030.99
5_L23_L1.0970.99
17_Q21_K1.0940.99
145_L149_P1.0820.99
43_N108_A1.0780.99
137_V171_I1.0780.99
43_N112_E1.0730.99
172_R219_E1.0730.99
30_Q62_A1.0580.99
173_V237_Q1.0550.99
95_P126_D1.0530.99
228_H235_S1.0440.99
22_A136_A1.0400.99
37_N93_A1.0330.98
143_R147_K1.0300.98
16_I33_A1.0300.98
84_P118_F1.0160.98
189_Q195_T1.0140.98
115_H155_I1.0130.98
111_M229_V1.0090.98
163_L167_Q1.0080.98
101_V107_V1.0060.98
192_R198_W0.9980.98
26_F139_C0.9850.98
100_D179_R0.9850.98
46_T70_D0.9830.98
53_T62_A0.9790.98
235_S238_D0.9730.98
30_Q80_M0.9730.98
125_L131_Y0.9550.97
87_V120_A0.9530.97
52_R196_L0.9420.97
107_V155_I0.9410.97
26_F142_L0.9060.97
22_A138_T0.9060.97
151_R154_R0.8990.96
210_P215_A0.8980.96
6_S72_V0.8910.96
30_Q59_G0.8810.96
3_I27_A0.8770.96
150_L156_L0.8740.96
163_L168_I0.8740.96
171_I224_I0.8690.96
173_V240_V0.8580.95
32_V79_L0.8560.95
98_G223_S0.8560.95
226_P232_T0.8410.95
111_M155_I0.8400.95
125_L134_A0.8400.95
53_T64_Q0.8370.95
142_L146_C0.8340.95
141_I171_I0.8330.94
83_R118_F0.8330.94
190_D198_W0.8300.94
23_L142_L0.8290.94
23_L27_A0.8260.94
35_D54_F0.8210.94
21_K132_D0.8180.94
140_S165_L0.8120.94
54_F63_V0.8110.94
18_T21_K0.8100.94
69_T111_M0.8080.94
187_P197_Y0.8050.93
15_G91_I0.8050.93
97_L214_F0.8040.93
96_N106_T0.8040.93
190_D193_G0.8040.93
51_L65_M0.8010.93
208_A211_G0.8010.93
11_V63_V0.7960.93
135_A139_C0.7940.93
114_R120_A0.7930.93
163_L169_K0.7920.93
107_V122_A0.7900.93
123_V142_L0.7900.93
133_T165_L0.7880.93
234_H237_Q0.7850.93
8_D96_N0.7830.92
144_A147_K0.7800.92
75_G78_A0.7750.92
138_T142_L0.7710.92
30_Q84_P0.7690.92
101_V227_L0.7690.92
100_D103_Y0.7660.92
130_H164_P0.7640.92
40_G47_L0.7630.91
16_I31_V0.7630.91
72_V87_V0.7600.91
26_F135_A0.7570.91
210_P219_E0.7570.91
13_A16_I0.7550.91
38_R67_T0.7540.91
111_M231_L0.7520.91
216_A219_E0.7510.91
50_S191_P0.7500.91
40_G108_A0.7490.91
210_P235_S0.7480.91
122_A225_T0.7460.91
98_G214_F0.7440.90
54_F194_N0.7440.90
8_D106_T0.7430.90
119_P149_P0.7430.90
38_R64_Q0.7420.90
158_I171_I0.7380.90
24_R27_A0.7360.90
141_I158_I0.7340.90
56_F59_G0.7340.90
173_V224_I0.7330.90
133_T163_L0.7300.90
5_L16_I0.7300.90
209_G212_T0.7280.89
188_Q198_W0.7250.89
17_Q57_E0.7200.89
192_R196_L0.7140.89
25_E29_V0.7120.88
127_G162_D0.7070.88
56_F61_I0.7010.88
2_R84_P0.6990.87
43_N111_M0.6970.87
36_R65_M0.6970.87
55_T62_A0.6960.87
86_I120_A0.6940.87
185_V199_I0.6940.87
167_Q220_G0.6930.87
37_N40_G0.6890.87
14_P17_Q0.6880.87
43_N103_Y0.6880.87
150_L153_G0.6870.87
98_G177_G0.6850.86
137_V165_L0.6840.86
91_I138_T0.6780.86
133_T168_I0.6770.86
71_C112_E0.6770.86
5_L31_V0.6770.86
152_T235_S0.6750.86
5_L91_I0.6730.85
150_L154_R0.6730.85
101_V176_C0.6700.85
4_L75_G0.6700.85
100_D112_E0.6690.85
171_I222_V0.6690.85
140_S143_R0.6680.85
17_Q20_A0.6680.85
20_A29_V0.6660.85
108_A228_H0.6640.85
24_R59_G0.6640.85
136_A147_K0.6620.85
71_C103_Y0.6590.84
95_P125_L0.6580.84
72_V76_V0.6530.84
102_I111_M0.6520.84
44_S67_T0.6500.83
99_D181_P0.6450.83
102_I229_V0.6410.83
219_E223_S0.6400.82
4_L113_G0.6400.82
53_T74_L0.6340.82
46_T50_S0.6330.82
217_V220_G0.6320.82
208_A218_D0.6320.82
160_V168_I0.6290.81
45_L69_T0.6240.81
190_D196_L0.6230.81
32_V71_C0.6150.80
73_Y99_D0.6140.80
114_R153_G0.6130.80
25_E135_A0.6110.80
191_P201_P0.6080.79
15_G19_L0.6070.79
137_V141_I0.6060.79
75_G80_M0.6040.79
27_A146_C0.6010.78
88_V121_L0.6010.78
78_A197_Y0.6010.78
155_I227_L0.5970.78
69_T229_V0.5970.78
22_A88_V0.5970.78
168_I221_Y0.5950.78
12_H56_F0.5910.77
28_D82_P0.5910.77
138_T158_I0.5900.77
78_A81_R0.5890.77
212_T215_A0.5860.77
35_D63_V0.5850.77
9_D96_N0.5830.76
23_L123_V0.5820.76
87_V118_F0.5820.76
15_G131_Y0.5810.76
189_Q193_G0.5810.76
42_S103_Y0.5760.75
139_C142_L0.5760.75
44_S69_T0.5750.75
154_R236_A0.5710.75
141_I224_I0.5710.75
130_H162_D0.5710.75
3_I23_L0.5700.75
134_A138_T0.5680.74
171_I221_Y0.5680.74
169_K172_R0.5670.74
11_V33_A0.5670.74
38_R44_S0.5660.74
47_L100_D0.5650.74
43_N69_T0.5650.74
92_N96_N0.5650.74
126_D129_K0.5620.74
133_T137_V0.5620.74
99_D179_R0.5600.73
37_N73_Y0.5600.73
42_S46_T0.5590.73
155_I229_V0.5550.73
20_A59_G0.5540.73
74_L78_A0.5530.72
169_K219_E0.5530.72
102_I231_L0.5510.72
120_A155_I0.5500.72
2_R85_D0.5500.72
32_V64_Q0.5500.72
15_G70_D0.5500.72
97_L179_R0.5490.72
37_N48_E0.5470.72
13_A17_Q0.5450.71
191_P194_N0.5440.71
106_T159_N0.5400.71
43_N155_I0.5380.70
73_Y112_E0.5340.70
30_Q81_R0.5320.70
66_G70_D0.5320.70
38_R65_M0.5310.69
227_L231_L0.5310.69
12_H35_D0.5310.69
153_G178_T0.5300.69
64_Q71_C0.5300.69
19_L88_V0.5290.69
92_N106_T0.5290.69
143_R238_D0.5260.69
119_P156_L0.5260.69
64_Q74_L0.5210.68
206_C218_D0.5180.68
40_G48_E0.5160.67
148_E240_V0.5120.67
31_V61_I0.5120.67
180_H183_D0.5120.67
112_E232_T0.5120.67
52_R188_Q0.5090.66
70_D103_Y0.5080.66
41_A75_G0.5080.66
121_L138_T0.5080.66
204_G207_D0.5060.66
133_T136_A0.5050.66
143_R158_I0.5040.65
23_L135_A0.5040.65
125_L160_V0.5030.65
191_P197_Y0.5030.65
138_T141_I0.5010.65
8_D92_N0.5000.65
40_G101_V0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v4nA 2 0.996 100 0.06 Contact Map
3ty2A 2 0.9802 100 0.072 Contact Map
2wqkA 3 0.9684 100 0.074 Contact Map
4zg5D 3 0.9644 100 0.078 Contact Map
1j9jA 3 0.9565 100 0.089 Contact Map
1l5xA 4 0.9842 100 0.101 Contact Map
2e6cA 4 0.9209 100 0.111 Contact Map
3h4tA 1 0.8458 90 0.935 Contact Map
4rifA 2 0.9012 81 0.943 Contact Map
4amgA 2 0.8854 75.9 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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