GREMLIN Database
SUCC - Succinyl-CoA ligase [ADP-forming] subunit beta
UniProt: P0A836 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10981
Length: 388 (377)
Sequences: 2774 (1497)
Seq/√Len: 77.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
359_K363_D5.7111.00
333_I360_K5.1371.00
21_V100_A4.1591.00
313_A381_V4.0891.00
135_K139_E3.7571.00
186_T190_E3.3571.00
23_Y37_K3.2051.00
277_K282_E3.1051.00
157_P182_M3.0731.00
32_E70_R2.9181.00
23_Y34_A2.8951.00
241_R254_A2.8241.00
179_K183_G2.7801.00
15_Y190_E2.6691.00
356_L359_K2.5971.00
140_T143_L2.5871.00
300_E303_K2.5591.00
128_E143_L2.4891.00
176_Q208_D2.4561.00
105_A205_K2.3861.00
63_V72_F2.3771.00
64_N68_D2.3531.00
42_P101_A2.3431.00
26_T30_E2.3411.00
103_D205_K2.3271.00
147_V159_Q2.2781.00
125_A163_L2.2401.00
76_W79_K2.1751.00
26_T95_Q2.1621.00
18_P180_I2.1581.00
132_E135_K2.1481.00
233_R238_E2.1451.00
65_S68_D2.1091.00
315_L377_A2.1061.00
29_R70_R2.1031.00
9_K99_E2.0731.00
108_L203_I2.0671.00
147_V162_E2.0281.00
14_R191_R2.0081.00
42_P64_N1.9841.00
11_L187_I1.9621.00
295_K334_G1.9581.00
31_A35_A1.9571.00
299_T338_E1.9551.00
145_H166_K1.9431.00
17_L211_C1.9191.00
110_L181_F1.9171.00
72_F75_N1.9081.00
369_I384_A1.8991.00
3_L218_A1.8401.00
379_Q383_A1.8271.00
10_Q14_R1.8201.00
13_A21_V1.8021.00
187_I191_R1.8001.00
353_N356_L1.7771.00
281_G382_V1.7651.00
150_D154_G1.7641.00
32_E36_S1.7521.00
12_F214_G1.7421.00
123_F181_F1.7411.00
165_F174_V1.7111.00
295_K330_D1.7101.00
218_A229_L1.7061.00
8_A214_G1.7001.00
70_R74_E1.6931.00
248_W300_E1.6901.00
33_E36_S1.6861.00
36_S66_K1.6811.00
380_Q383_A1.6731.00
25_C35_A1.6731.00
279_H379_Q1.6441.00
12_F187_I1.6351.00
160_G164_A1.6201.00
330_D334_G1.6191.00
32_E69_I1.6171.00
244_Q247_Q1.6081.00
33_E37_K1.6071.00
155_P160_G1.5871.00
373_G376_D1.5750.99
44_V62_V1.5550.99
94_N236_S1.5540.99
103_D206_Q1.5510.99
25_C31_A1.5480.99
73_A96_I1.5410.99
279_H375_T1.5190.99
356_L360_K1.5100.99
30_E33_E1.5020.99
158_Y161_R1.4990.99
22_G97_L1.4750.99
71_A75_N1.4460.99
263_V269_A1.4460.99
376_D380_Q1.4310.99
323_V327_L1.4270.99
350_E354_A1.4220.99
243_A247_Q1.4190.99
25_C30_E1.4090.99
330_D360_K1.4060.99
193_L196_I1.3980.99
45_V96_I1.3920.99
313_A385_V1.3860.99
43_W69_I1.3820.99
68_D71_A1.3790.99
262_M305_I1.3740.99
31_A69_I1.3730.99
358_A372_K1.3700.99
66_K69_I1.3700.99
114_V188_F1.3550.98
28_P32_E1.3460.98
77_L96_I1.3420.98
244_Q300_E1.3300.98
112_A121_V1.3250.98
173_L207_G1.3150.98
56_K132_E1.3020.98
191_R228_D1.3010.98
42_P62_V1.2950.98
13_A19_A1.2880.98
172_K175_Q1.2860.98
161_R165_F1.2820.98
125_A167_L1.2770.98
61_K75_N1.2760.98
381_V385_V1.2730.98
123_F149_L1.2680.98
75_N79_K1.2650.97
32_E67_E1.2460.97
346_V381_V1.2450.97
4_H50_H1.2420.97
123_F163_L1.2400.97
316_V332_I1.2230.97
359_K362_A1.2220.97
124_M144_I1.2160.97
128_E140_T1.2130.97
14_R228_D1.2030.97
303_K338_E1.2010.97
375_T379_Q1.1980.97
25_C34_A1.1810.96
58_G61_K1.1800.96
157_P161_R1.1790.96
106_K203_I1.1780.96
27_T30_E1.1760.96
327_L330_D1.1750.96
104_I202_V1.1740.96
15_Y191_R1.1730.96
369_I380_Q1.1710.96
35_A43_W1.1570.96
177_F181_F1.1520.96
258_N312_K1.1510.96
156_M159_Q1.1330.95
120_R151_P1.1290.95
72_F76_W1.1290.95
110_L125_A1.1270.95
196_I216_L1.1240.95
28_P31_A1.1180.95
57_A76_W1.1170.95
296_E300_E1.1080.95
102_T212_L1.1080.95
2_N217_G1.1010.94
118_S148_A1.0950.94
71_A74_E1.0930.94
111_G124_M1.0820.94
102_T202_V1.0780.94
45_V72_F1.0690.93
29_R32_E1.0640.93
191_R226_Q1.0550.93
192_D225_R1.0550.93
183_G186_T1.0520.93
354_A358_A1.0510.93
160_G178_T1.0470.93
28_P66_K1.0450.93
193_L216_L1.0410.93
330_D356_L1.0380.92
61_K72_F1.0310.92
29_R33_E1.0270.92
66_K70_R1.0220.92
32_E66_K1.0220.92
12_F17_L1.0150.92
187_I196_I1.0130.92
45_V98_V1.0120.91
10_Q13_A1.0100.91
10_Q232_M1.0050.91
234_D237_Q1.0020.91
35_A66_K0.9970.91
371_A376_D0.9940.91
195_L217_G0.9940.91
324_R352_N0.9940.91
156_M161_R0.9930.91
63_V69_I0.9890.91
28_P69_I0.9860.90
323_V354_A0.9860.90
20_P99_E0.9840.90
56_K131_V0.9830.90
235_Q243_A0.9790.90
334_G337_A0.9780.90
67_E71_A0.9770.90
52_G55_G0.9770.90
191_R229_L0.9740.90
275_I279_H0.9720.90
51_A89_N0.9720.90
332_I347_V0.9640.89
122_V146_K0.9620.89
281_G381_V0.9620.89
61_K76_W0.9600.89
334_G338_E0.9560.89
299_T303_K0.9540.89
27_T31_A0.9510.89
20_P100_A0.9400.88
20_P102_T0.9400.88
259_I382_V0.9400.88
256_D282_E0.9230.87
149_L185_A0.9200.87
51_A86_T0.9200.87
25_C32_E0.9170.87
11_L216_L0.9170.87
102_T210_I0.9150.87
157_P178_T0.9150.87
57_A79_K0.9140.87
17_L183_G0.9130.87
239_D254_A0.9100.86
92_P237_Q0.9090.86
21_V37_K0.9070.86
86_T92_P0.9060.86
31_A98_V0.9040.86
289_V328_I0.8990.86
136_V140_T0.8970.86
227_P231_E0.8940.85
28_P74_E0.8930.85
41_G65_S0.8870.85
130_G199_N0.8850.85
355_E359_K0.8840.85
100_A208_D0.8820.85
162_E166_K0.8760.84
4_H234_D0.8750.84
308_D311_V0.8730.84
374_L377_A0.8720.84
159_Q162_E0.8720.84
137_A141_P0.8700.84
153_T159_Q0.8680.84
204_T210_I0.8680.84
249_E297_R0.8600.83
112_A188_F0.8590.83
49_V88_A0.8520.83
127_T143_L0.8510.83
161_R174_V0.8500.82
122_V148_A0.8480.82
17_L20_P0.8460.82
160_G182_M0.8440.82
336_V366_L0.8430.82
121_V188_F0.8420.82
28_P96_I0.8400.82
101_A212_L0.8390.82
24_A96_I0.8390.82
323_V328_I0.8380.82
228_D231_E0.8380.82
324_R327_L0.8340.81
24_A95_Q0.8340.81
204_T208_D0.8310.81
147_V166_K0.8280.81
155_P181_F0.8270.81
22_G99_E0.8260.81
203_I209_L0.8260.81
130_G134_E0.8250.81
12_F196_I0.8230.80
345_V368_I0.8220.80
68_D72_F0.8220.80
25_C98_V0.8220.80
259_I281_G0.8200.80
361_L368_I0.8200.80
149_L154_G0.8160.80
174_V178_T0.8140.80
99_E212_L0.8130.80
34_A37_K0.8100.79
173_L176_Q0.8060.79
131_V140_T0.8050.79
293_A323_V0.8050.79
125_A177_F0.7990.78
158_Y162_E0.7980.78
16_G183_G0.7960.78
242_E245_A0.7960.78
32_E35_A0.7950.78
107_E130_G0.7920.78
332_I361_L0.7920.78
244_Q307_S0.7910.78
39_G43_W0.7880.77
1_M223_L0.7830.77
313_A346_V0.7810.77
179_K182_M0.7790.77
261_C269_A0.7760.76
169_L203_I0.7720.76
127_T168_G0.7690.76
76_W97_L0.7670.76
112_A123_F0.7660.75
64_N101_A0.7660.75
105_A207_G0.7620.75
155_P383_A0.7600.75
164_A174_V0.7560.74
127_T140_T0.7550.74
256_D310_K0.7550.74
240_P244_Q0.7550.74
302_F316_V0.7530.74
155_P159_Q0.7520.74
7_Q50_H0.7500.74
118_S122_V0.7500.74
297_R327_L0.7490.74
196_I214_G0.7480.74
3_L216_L0.7450.73
1_M230_R0.7440.73
124_M146_K0.7400.73
173_L203_I0.7380.73
238_E243_A0.7360.72
176_Q209_L0.7360.72
130_G213_D0.7350.72
297_R323_V0.7330.72
227_P230_R0.7280.72
160_G181_F0.7260.71
128_E131_V0.7260.71
376_D379_Q0.7260.71
129_G213_D0.7250.71
295_K327_L0.7240.71
123_F155_P0.7230.71
202_V212_L0.7230.71
295_K299_T0.7210.71
331_G335_A0.7210.71
266_A286_F0.7200.71
252_Y304_I0.7180.71
175_Q178_T0.7180.71
134_E199_N0.7170.70
9_K97_L0.7160.70
43_W63_V0.7150.70
45_V69_I0.7120.70
298_V331_G0.7120.70
3_L87_D0.7120.70
295_K338_E0.7100.70
315_L374_L0.7090.70
337_A365_G0.7080.70
108_L169_L0.7070.69
163_L166_K0.7060.69
120_R150_D0.7060.69
316_V328_I0.7040.69
47_C76_W0.7000.69
321_G348_R0.7000.69
35_A69_I0.7000.69
371_A380_Q0.6990.69
254_A310_K0.6990.69
150_D160_G0.6960.68
69_I73_A0.6960.68
132_E136_V0.6960.68
223_L230_R0.6950.68
111_G196_I0.6940.68
264_N317_N0.6910.68
188_F259_I0.6900.68
47_C93_V0.6880.67
244_Q248_W0.6880.67
18_P208_D0.6880.67
259_I354_A0.6860.67
261_C276_V0.6840.67
245_A249_E0.6820.67
273_M283_P0.6810.67
323_V349_L0.6800.66
28_P35_A0.6800.66
328_I349_L0.6770.66
258_N281_G0.6770.66
49_V93_V0.6770.66
62_V101_A0.6760.66
164_A171_G0.6750.66
327_L354_A0.6750.66
51_A57_A0.6730.66
111_G122_V0.6720.66
326_D353_N0.6710.65
51_A263_V0.6690.65
264_N288_D0.6680.65
62_V67_E0.6660.65
111_G132_E0.6660.65
3_L8_A0.6660.65
161_R178_T0.6620.64
42_P103_D0.6620.64
364_S368_I0.6600.64
8_A216_L0.6550.64
382_V385_V0.6530.63
42_P100_A0.6530.63
129_G199_N0.6510.63
15_Y186_T0.6500.63
9_K13_A0.6500.63
99_E102_T0.6480.63
107_E199_N0.6480.63
324_R356_L0.6470.63
294_T297_R0.6460.62
235_Q247_Q0.6460.62
133_I144_I0.6460.62
336_V340_G0.6440.62
259_I328_I0.6420.62
1_M8_A0.6410.62
35_A98_V0.6410.62
177_F209_L0.6400.62
41_G66_K0.6400.62
12_F216_L0.6370.61
3_L7_Q0.6360.61
233_R246_A0.6350.61
182_M186_T0.6330.61
73_A77_L0.6330.61
13_A99_E0.6310.61
264_N268_L0.6300.61
27_T70_R0.6300.61
107_E129_G0.6300.61
173_L209_L0.6260.60
127_T136_V0.6250.60
164_A181_F0.6240.60
194_A217_G0.6230.60
127_T145_H0.6220.60
254_A308_D0.6210.59
52_G215_K0.6190.59
171_G174_V0.6180.59
105_A202_V0.6170.59
346_V384_A0.6160.59
297_R301_A0.6150.59
158_Y175_Q0.6130.58
25_C70_R0.6120.58
266_A270_M0.6120.58
29_R74_E0.6090.58
23_Y35_A0.6080.58
115_D122_V0.6080.58
262_M316_V0.6070.58
322_I325_C0.6050.57
193_L218_A0.6050.57
20_P210_I0.6050.57
164_A167_L0.6040.57
288_D321_G0.6030.57
92_P209_L0.6030.57
332_I336_V0.6020.57
371_A384_A0.6010.57
158_Y165_F0.5990.57
61_K79_K0.5980.57
341_V345_V0.5960.56
12_F180_I0.5940.56
104_I212_L0.5900.56
191_R218_A0.5890.55
362_A372_K0.5890.55
49_V59_G0.5880.55
237_Q243_A0.5880.55
110_L201_L0.5870.55
125_A166_K0.5870.55
140_T146_K0.5840.55
107_E200_P0.5830.55
168_G171_G0.5830.55
36_S39_G0.5800.54
218_A226_Q0.5790.54
114_V194_A0.5770.54
178_T182_M0.5760.54
336_V367_N0.5730.53
148_A166_K0.5710.53
35_A38_I0.5710.53
33_E71_A0.5700.53
36_S67_E0.5700.53
285_N305_I0.5690.53
380_Q384_A0.5680.53
279_H301_A0.5670.53
105_A204_T0.5670.53
288_D317_N0.5650.52
161_R164_A0.5650.52
170_E173_L0.5630.52
31_A66_K0.5630.52
168_G208_D0.5630.52
51_A215_K0.5610.52
156_M165_F0.5600.52
109_Y265_G0.5600.52
112_A181_F0.5590.52
46_K199_N0.5580.52
25_C28_P0.5580.52
235_Q246_A0.5570.51
289_V293_A0.5560.51
4_H7_Q0.5550.51
269_A276_V0.5550.51
97_L102_T0.5550.51
217_G220_G0.5540.51
153_T158_Y0.5540.51
325_C347_V0.5530.51
180_I201_L0.5530.51
53_G56_K0.5520.51
150_D153_T0.5510.51
243_A246_A0.5500.51
219_D267_G0.5500.51
62_V68_D0.5490.50
253_V350_E0.5490.50
1_M50_H0.5480.50
192_D222_A0.5470.50
20_P97_L0.5460.50
286_F290_G0.5450.50
121_V276_V0.5450.50
110_L163_L0.5440.50
55_G131_V0.5430.50
41_G69_I0.5420.50
45_V77_L0.5420.50
323_V357_G0.5420.50
35_A73_A0.5420.50
116_R321_G0.5410.49
110_L123_F0.5410.49
12_F18_P0.5400.49
288_D322_I0.5400.49
111_G262_M0.5400.49
136_V141_P0.5390.49
372_K376_D0.5380.49
136_V144_I0.5360.49
184_L196_I0.5360.49
120_R148_A0.5340.48
117_S256_D0.5330.48
15_Y187_I0.5330.48
366_L369_I0.5310.48
164_A177_F0.5310.48
111_G185_A0.5300.48
17_L187_I0.5290.48
336_V341_V0.5270.48
198_I345_V0.5260.47
264_N272_T0.5260.47
47_C59_G0.5250.47
21_V38_I0.5250.47
317_N325_C0.5240.47
50_H234_D0.5240.47
286_F293_A0.5230.47
62_V205_K0.5220.47
270_M286_F0.5220.47
268_L293_A0.5220.47
264_N286_F0.5210.47
216_L226_Q0.5210.47
346_V380_Q0.5190.47
21_V186_T0.5190.47
159_Q165_F0.5190.47
176_Q180_I0.5190.47
20_P212_L0.5180.46
107_E213_D0.5170.46
71_A186_T0.5170.46
120_R152_L0.5170.46
205_K208_D0.5150.46
5_E9_K0.5140.46
200_P213_D0.5140.46
4_H237_Q0.5120.46
356_L363_D0.5120.46
264_N293_A0.5120.46
134_E200_P0.5120.46
350_E376_D0.5120.46
269_A273_M0.5110.46
9_K22_G0.5110.46
240_P243_A0.5110.46
38_I42_P0.5110.46
65_S92_P0.5090.45
270_M285_N0.5080.45
129_G133_I0.5080.45
167_L177_F0.5080.45
272_T317_N0.5070.45
318_I321_G0.5060.45
116_R348_R0.5060.45
283_P286_F0.5050.45
33_E38_I0.5040.45
295_K305_I0.5040.45
260_G285_N0.5030.45
264_N287_L0.5030.45
155_P182_M0.5030.45
130_G133_I0.5030.45
286_F321_G0.5020.44
36_S69_I0.5020.44
288_D348_R0.5020.44
300_E309_D0.5010.44
33_E139_E0.5010.44
43_W98_V0.5010.44
133_I199_N0.5010.44
332_I335_A0.5010.44
56_K135_K0.5010.44
97_L193_L0.5000.44
198_I211_C0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pffA 2 0.9665 100 0.175 Contact Map
2nu8B 2 0.9974 100 0.269 Contact Map
2fp4B 1 0.9923 100 0.273 Contact Map
3mwdA 2 0.9639 100 0.287 Contact Map
3ufxB 2 0.9716 100 0.326 Contact Map
1wr2A 1 0.5258 100 0.69 Contact Map
2csuA 2 0.9098 100 0.761 Contact Map
3dmyA 2 0.4948 99.7 0.837 Contact Map
3mwdB 1 0.6134 99.6 0.848 Contact Map
2fp4A 1 0.6495 99.5 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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