GREMLIN Database
SSRP - SsrA-binding protein
UniProt: P0A832 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11782
Length: 160 (147)
Sequences: 3088 (1644)
Seq/√Len: 135.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_L68_A2.5761.00
54_S68_A2.5021.00
29_E126_K2.3461.00
144_E148_Q2.2971.00
27_E109_Y2.2701.00
148_Q152_A2.2561.00
62_E89_K2.1941.00
49_A116_L2.1861.00
63_A92_L2.1641.00
26_I114_L2.1421.00
115_S126_K2.1161.00
140_S144_E2.1051.00
26_I130_A1.9561.00
35_A89_K1.9531.00
26_I128_G1.9471.00
66_F87_T1.8521.00
94_Q98_D1.8291.00
41_V123_C1.7951.00
57_L66_F1.7791.00
65_L125_V1.7551.00
56_V63_A1.7421.00
58_L63_A1.7331.00
147_W151_K1.7281.00
27_E131_K1.6941.00
39_W76_A1.6601.00
56_V127_I1.6391.00
19_R23_E1.6351.00
63_A97_L1.6201.00
21_R29_E1.6181.00
44_L49_A1.5931.00
39_W82_C1.5871.00
14_I118_W1.5771.00
142_I145_R1.5491.00
58_L97_L1.5351.00
101_Y105_N1.5191.00
142_I146_E1.4931.00
31_E117_Y1.4921.00
41_V118_W1.4911.00
16_L21_R1.4531.00
133_K141_D1.4521.00
30_F100_L1.4491.00
69_N85_T1.4261.00
16_L115_S1.3881.00
32_A92_L1.3711.00
59_R87_T1.3651.00
25_F131_K1.3401.00
39_W81_V1.3371.00
34_L125_V1.3271.00
151_K154_I1.3121.00
147_W154_I1.3071.00
51_I68_A1.2961.00
14_I123_C1.2781.00
111_V127_I1.2751.00
98_D102_G1.2731.00
146_E150_D1.2691.00
56_V111_V1.2551.00
109_Y131_K1.2501.00
143_K147_W1.2311.00
93_N122_W1.2291.00
103_R106_R1.2221.00
92_L97_L1.2191.00
141_D144_E1.2061.00
116_L125_V1.2031.00
103_R129_V1.2021.00
30_F92_L1.1780.99
76_A81_V1.1600.99
11_S115_S1.1490.99
140_S143_K1.1250.99
44_L70_I1.1100.99
41_V44_L1.0990.99
150_D153_R1.0890.99
46_A74_A1.0860.99
148_Q151_K1.0680.99
58_L111_V1.0580.99
146_E149_V1.0570.99
31_E93_N1.0520.99
55_Y66_F1.0480.99
13_T16_L1.0390.99
50_N53_D1.0280.99
114_L128_G0.9970.98
64_F87_T0.9960.98
26_I29_E0.9940.98
21_R26_I0.9930.98
59_R66_F0.9700.98
104_V111_V0.9630.98
44_L118_W0.9620.98
44_L123_C0.9620.98
149_V152_A0.9620.98
98_D101_Y0.9500.98
72_P83_D0.9420.97
68_A116_L0.9360.97
25_F141_D0.9350.97
45_R118_W0.9330.97
100_L111_V0.9200.97
96_E99_S0.9000.97
11_S119_K0.8960.97
61_G101_Y0.8950.96
77_S80_V0.8910.96
14_I45_R0.8890.96
117_Y126_K0.8880.96
46_A75_V0.8790.96
92_L129_V0.8730.96
57_L87_T0.8650.96
69_N84_P0.8650.96
19_R52_S0.8630.96
30_F129_V0.8510.95
29_E115_S0.8500.95
77_S81_V0.8470.95
116_L123_C0.8370.95
152_A156_K0.8350.95
14_I116_L0.8350.95
145_R148_Q0.8340.95
37_Q82_C0.8330.95
76_A80_V0.8300.95
15_A49_A0.8270.95
63_A111_V0.8230.94
34_L123_C0.8220.94
32_A125_V0.8200.94
73_M76_A0.8070.94
141_D145_R0.8060.94
25_F133_K0.7980.93
13_T115_S0.7980.93
64_F89_K0.7950.93
34_L90_L0.7890.93
49_A68_A0.7820.93
102_G106_R0.7740.92
101_Y104_V0.7650.92
151_K155_M0.7640.92
54_S113_A0.7600.92
107_E131_K0.7590.92
23_E135_Q0.7480.91
31_E119_K0.7480.91
48_K71_T0.7380.90
95_R98_D0.7340.90
113_A125_V0.7320.90
30_F96_E0.7280.90
119_K122_W0.7130.89
110_T130_A0.7050.88
55_Y67_G0.6990.88
19_R22_H0.6980.88
112_V130_A0.6960.88
118_W122_W0.6880.87
100_L104_V0.6850.87
20_A114_L0.6850.87
118_W123_C0.6810.87
39_W78_T0.6790.86
106_R109_Y0.6780.86
103_R109_Y0.6720.86
34_L116_L0.6700.86
52_S85_T0.6700.86
85_T88_R0.6690.86
65_L88_R0.6670.85
102_G105_N0.6670.85
72_P84_P0.6660.85
103_R107_E0.6590.85
110_T132_G0.6520.84
50_N69_N0.6440.83
96_E120_N0.6440.83
35_A122_W0.6420.83
100_L129_V0.6410.83
95_R103_R0.6360.83
22_H25_F0.6360.83
21_R114_L0.6360.83
93_N96_E0.6350.83
43_S71_T0.6340.82
29_E128_G0.6320.82
39_W77_S0.6260.82
144_E147_W0.6240.81
20_A112_V0.6180.81
23_E52_S0.6170.81
43_S73_M0.6130.80
28_E99_S0.6100.80
152_A155_M0.6090.80
39_W80_V0.6070.80
78_T81_V0.6060.80
21_R145_R0.6040.79
32_A111_V0.6010.79
15_A31_E0.6010.79
50_N71_T0.6000.79
149_V153_R0.5970.79
72_P82_C0.5890.78
61_G94_Q0.5870.77
14_I44_L0.5860.77
37_Q86_R0.5850.77
102_G129_V0.5850.77
118_W121_A0.5780.76
31_E126_K0.5680.75
63_A93_N0.5650.75
51_I151_K0.5640.75
53_D68_A0.5630.74
30_F99_S0.5610.74
44_L71_T0.5590.74
15_A54_S0.5500.73
14_I49_A0.5500.73
58_L101_Y0.5490.73
37_Q77_S0.5490.73
52_S71_T0.5480.72
37_Q88_R0.5430.72
18_K22_H0.5340.71
22_H138_K0.5310.70
61_G102_G0.5310.70
20_A130_A0.5290.70
22_H141_D0.5280.70
73_M78_T0.5260.69
22_H133_K0.5250.69
132_G138_K0.5230.69
14_I18_K0.5220.69
146_E153_R0.5120.67
39_W73_M0.5110.67
42_K96_E0.5100.67
109_Y134_K0.5090.67
25_F130_A0.5070.67
76_A82_C0.5060.66
84_P153_R0.5040.66
67_G85_T0.5030.66
12_A47_G0.5020.66
78_T82_C0.5020.66
18_K52_S0.5010.66
20_A133_K0.5010.66
44_L116_L0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1p6vA 1 0.775 100 0.059 Contact Map
1j1hA 1 0.7625 100 0.074 Contact Map
1wjxA 1 0.6937 100 0.205 Contact Map
4w23I 1 0.4437 4.4 0.965 Contact Map
4q28A 1 0.3688 3.6 0.967 Contact Map
1ri9A 1 0.3625 3.3 0.968 Contact Map
4cycA 1 0.3187 3.2 0.968 Contact Map
3d3aA 1 0.5375 3.2 0.968 Contact Map
2cksA 1 0.5625 3.2 0.968 Contact Map
4pasA 1 0.2188 2.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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