GREMLIN Database
DCTA - Aerobic C4-dicarboxylate transport protein
UniProt: P0A830 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20044
Length: 428 (393)
Sequences: 6279 (3711)
Seq/√Len: 187.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_G147_S4.5831.00
172_Q176_N3.6971.00
281_E287_K3.4271.00
97_N329_Q3.1441.00
95_I229_T3.0941.00
169_S172_Q3.0651.00
19_I201_F3.0401.00
76_V402_V3.0251.00
136_V155_L2.9561.00
54_F157_A2.8871.00
35_K39_D2.7821.00
58_V178_I2.7701.00
40_G137_I2.7161.00
23_L201_F2.6551.00
273_L294_I2.6351.00
12_Q194_R2.5961.00
286_R404_E2.5621.00
187_G190_N2.4911.00
173_L180_S2.4881.00
54_F58_V2.4831.00
100_Q103_A2.4631.00
400_K407_H2.4271.00
55_C181_F2.4241.00
325_D328_H2.4051.00
37_L202_G2.4011.00
8_S11_F2.3091.00
286_R399_A2.2711.00
227_Y382_A2.2571.00
160_F184_V2.2501.00
260_L389_V2.2421.00
131_A135_D2.1781.00
224_I228_I2.1701.00
84_V241_I2.1291.00
168_G171_G2.1281.00
80_Y394_A2.0961.00
76_V401_W2.0271.00
259_E279_K2.0261.00
14_L18_A1.9791.00
95_I232_L1.9761.00
243_K246_G1.9711.00
22_L26_F1.9661.00
90_I94_I1.9111.00
99_V225_C1.9061.00
174_I177_V1.9021.00
173_L176_N1.8951.00
94_I98_V1.8931.00
139_A143_G1.8791.00
16_A201_F1.8761.00
316_I368_G1.8531.00
75_A79_L1.8351.00
63_G179_E1.8341.00
149_N152_Q1.8321.00
230_C382_A1.8291.00
96_V314_V1.8261.00
285_C396_I1.8091.00
280_M392_G1.7811.00
55_C185_I1.7811.00
48_I192_I1.7801.00
101_P318_Q1.7661.00
376_D383_R1.7641.00
217_V221_Q1.7621.00
278_D282_K1.7421.00
174_I180_S1.7321.00
232_L236_L1.7061.00
7_K11_F1.6951.00
72_R402_V1.6851.00
166_R187_G1.6841.00
164_L184_V1.6731.00
174_I184_V1.6711.00
293_V395_T1.6661.00
99_V228_I1.6601.00
141_V156_F1.6451.00
245_T400_K1.6291.00
255_Y283_L1.6271.00
256_I392_G1.6221.00
285_C399_A1.6141.00
95_I225_C1.6091.00
142_I145_F1.6061.00
96_V311_M1.6031.00
16_A20_G1.6021.00
323_Q327_V1.5581.00
220_G224_I1.5511.00
320_T368_G1.5421.00
316_I364_L1.5321.00
276_M392_G1.5311.00
230_C386_T1.5281.00
380_S384_A1.5231.00
142_I146_A1.5141.00
40_G134_M1.5101.00
251_K254_R1.4941.00
229_T307_I1.4891.00
242_A393_V1.4721.00
62_A175_F1.4631.00
170_K183_Q1.4291.00
163_A188_I1.4231.00
260_L385_L1.4201.00
46_K139_A1.4161.00
177_V180_S1.4071.00
277_L290_V1.4041.00
399_A405_L1.4031.00
54_F145_F1.4021.00
255_Y282_K1.3811.00
250_F254_R1.3811.00
281_E290_V1.3791.00
39_D43_K1.3681.00
241_I397_V1.3621.00
11_F15_T1.3531.00
167_L171_G1.3521.00
135_D149_N1.3491.00
43_K139_A1.3481.00
179_E183_Q1.3481.00
270_E345_G1.3451.00
166_R191_M1.3391.00
326_I330_I1.3261.00
59_T178_I1.3221.00
61_I158_V1.3221.00
47_M156_F1.3181.00
23_L27_Y1.3021.00
225_C311_M1.2981.00
286_R289_V1.2951.00
106_N321_N1.2901.00
53_I150_I1.2871.00
77_A293_V1.2811.00
173_L177_V1.2791.00
93_L329_Q1.2681.00
28_P209_G1.2581.00
137_I155_L1.2551.00
190_N278_D1.2541.00
299_S302_L1.2471.00
256_I389_V1.2391.00
106_N109_P1.2351.00
7_K15_T1.2321.00
163_A191_M1.2311.00
289_V399_A1.2281.00
17_I204_M1.2251.00
248_S251_K1.2191.00
276_M294_I1.2171.00
235_V239_G1.2131.00
160_F181_F1.2121.00
164_L174_I1.2081.00
218_Q221_Q1.1971.00
206_F210_K1.1931.00
223_I375_I1.1841.00
313_A332_L1.1741.00
191_M195_L1.1741.00
185_I189_I1.1701.00
323_Q328_H1.1701.00
399_A403_K1.1631.00
27_Y30_I1.1611.00
79_L83_I1.1481.00
332_L361_V1.1461.00
128_G131_A1.1451.00
159_L188_I1.1451.00
48_I189_I1.1381.00
234_V386_T1.1341.00
263_V384_A1.1321.00
35_K206_F1.1311.00
94_I97_N1.1261.00
69_A288_S1.1261.00
167_L180_S1.1221.00
236_L239_G1.1191.00
158_V162_F1.1091.00
72_R76_V1.1091.00
221_Q224_I1.1071.00
168_G172_Q1.1051.00
272_A276_M1.1041.00
81_F293_V1.1001.00
252_F256_I1.0971.00
351_F373_L1.0851.00
308_Y376_D1.0841.00
247_F405_L1.0791.00
172_Q175_F1.0771.00
50_A153_V1.0771.00
246_G400_K1.0701.00
12_Q16_A1.0701.00
399_A404_E1.0661.00
40_G44_L1.0661.00
273_L298_Y1.0641.00
242_A247_F1.0631.00
258_E282_K1.0611.00
280_M294_I1.0611.00
176_N180_S1.0581.00
143_G146_A1.0541.00
243_K248_S1.0521.00
217_V220_G1.0511.00
84_V303_D1.0491.00
73_T289_V1.0471.00
330_I334_I1.0461.00
57_V154_L1.0411.00
303_D340_S1.0391.00
83_I87_I1.0391.00
37_L195_L1.0291.00
276_M388_L1.0281.00
22_L25_H1.0261.00
55_C59_T1.0241.00
18_A22_L1.0221.00
267_S377_R1.0211.00
90_I333_L1.0131.00
102_G318_Q1.0091.00
106_N110_A1.0080.99
305_T350_G1.0010.99
223_I378_F1.0000.99
90_I330_I0.9980.99
174_I178_I0.9940.99
308_Y383_R0.9890.99
214_G217_V0.9850.99
195_L198_I0.9840.99
23_L205_A0.9830.99
247_F251_K0.9750.99
240_S243_K0.9740.99
29_E32_E0.9660.99
167_L184_V0.9620.99
285_C290_V0.9600.99
176_N179_E0.9580.99
400_K403_K0.9570.99
238_L241_I0.9540.99
221_Q318_Q0.9510.99
280_M285_C0.9490.99
92_G310_T0.9480.99
95_I99_V0.9480.99
233_F237_V0.9430.99
82_E86_T0.9410.99
124_A127_Q0.9350.99
347_T380_S0.9340.99
19_I23_L0.9330.99
233_F307_I0.9280.99
254_R257_R0.9260.99
23_L34_M0.9240.99
38_G203_A0.9240.99
326_I329_Q0.9230.99
107_V110_A0.9220.99
155_L159_L0.9210.99
272_A275_R0.9200.99
66_S69_A0.9200.99
255_Y279_K0.9190.99
187_G191_M0.9180.99
309_L354_L0.9120.99
281_E291_G0.9100.99
88_A233_F0.9100.99
141_V146_A0.9090.99
301_N391_N0.9030.99
280_M290_V0.9020.99
223_I379_M0.9010.99
279_K282_K0.8990.99
314_V329_Q0.8980.99
259_E276_M0.8960.99
226_F379_M0.8940.99
255_Y259_E0.8930.99
205_A209_G0.8910.99
171_G180_S0.8890.99
86_T90_I0.8880.99
226_F311_M0.8870.99
91_I232_L0.8870.99
127_Q131_A0.8840.99
30_I33_Q0.8840.99
48_I188_I0.8820.99
259_E272_A0.8810.99
264_L381_E0.8810.99
127_Q135_D0.8810.99
133_I137_I0.8770.99
308_Y379_M0.8720.99
278_D281_E0.8700.99
160_F188_I0.8680.98
227_Y231_I0.8660.98
162_F166_R0.8640.98
43_K46_K0.8640.98
239_G253_I0.8620.98
33_Q36_P0.8610.98
131_A134_M0.8580.98
339_S357_T0.8580.98
269_S387_N0.8560.98
132_F138_P0.8560.98
34_M205_A0.8550.98
355_A369_L0.8520.98
320_T367_A0.8500.98
237_V241_I0.8500.98
257_R261_L0.8480.98
8_S12_Q0.8460.98
59_T179_E0.8460.98
134_M138_P0.8450.98
262_I272_A0.8430.98
55_C178_I0.8420.98
58_V164_L0.8410.98
157_A161_G0.8370.98
93_L97_N0.8370.98
302_L391_N0.8370.98
7_K12_Q0.8370.98
289_V293_V0.8350.98
130_V134_M0.8290.98
159_L191_M0.8290.98
144_A156_F0.8270.98
252_F392_G0.8250.98
228_I231_I0.8250.98
164_L178_I0.8210.98
238_L242_A0.8190.98
34_M202_G0.8180.98
262_I275_R0.8160.98
141_V144_A0.8120.98
236_L240_S0.8100.98
38_G199_G0.8100.98
239_G243_K0.8070.98
137_I140_S0.8070.98
190_N194_R0.8060.98
351_F369_L0.8050.98
27_Y34_M0.8040.98
141_V148_G0.8030.98
129_I133_I0.8030.98
73_T398_V0.8030.98
324_M328_H0.8010.97
168_G175_F0.8000.97
108_D111_T0.8000.97
145_F156_F0.7970.97
262_I266_T0.7960.97
201_F205_A0.7940.97
140_S156_F0.7920.97
182_S186_F0.7910.97
95_I228_I0.7900.97
400_K405_L0.7890.97
312_A372_I0.7880.97
177_V181_F0.7880.97
125_K128_G0.7870.97
92_G311_M0.7840.97
58_V160_F0.7800.97
399_A406_D0.7790.97
228_I232_L0.7770.97
222_L311_M0.7740.97
252_F396_I0.7730.97
39_D134_M0.7720.97
171_G175_F0.7710.97
309_L351_F0.7700.97
27_Y205_A0.7620.97
223_I227_Y0.7610.97
41_F196_A0.7600.97
67_M162_F0.7590.96
231_I235_V0.7580.96
56_T182_S0.7560.96
222_L379_M0.7530.96
355_A359_S0.7520.96
132_F135_D0.7510.96
259_E275_R0.7480.96
298_Y391_N0.7480.96
300_F341_K0.7470.96
100_Q318_Q0.7460.96
263_V388_L0.7440.96
58_V157_A0.7420.96
222_L308_Y0.7420.96
222_L372_I0.7400.96
156_F160_F0.7330.96
267_S380_S0.7320.96
29_E209_G0.7310.96
64_M73_T0.7270.96
196_A199_G0.7220.95
226_F230_C0.7210.95
13_V196_A0.7150.95
101_P104_G0.7150.95
134_M137_I0.7140.95
30_I34_M0.7140.95
33_Q37_L0.7120.95
44_L137_I0.7110.95
185_I192_I0.7100.95
225_C228_I0.7100.95
95_I98_V0.7080.95
68_K71_G0.7080.95
244_A397_V0.7060.95
305_T309_L0.7060.95
145_F152_Q0.7050.95
23_L31_G0.7050.95
313_A357_T0.7040.95
276_M391_N0.7030.95
229_T311_M0.6990.94
251_K255_Y0.6950.94
183_Q187_G0.6950.94
167_L183_Q0.6930.94
351_F379_M0.6930.94
305_T343_A0.6930.94
155_L195_L0.6920.94
20_G205_A0.6920.94
62_A165_H0.6910.94
247_F406_D0.6900.94
41_F195_L0.6790.94
135_D138_P0.6790.94
296_T300_F0.6780.94
235_V240_S0.6780.94
404_E407_H0.6760.93
170_K176_N0.6760.93
242_A245_T0.6730.93
327_V331_T0.6720.93
28_P32_E0.6710.93
79_L82_E0.6700.93
81_F394_A0.6700.93
86_T337_L0.6680.93
200_A347_T0.6660.93
91_I229_T0.6620.93
189_I264_L0.6620.93
82_E341_K0.6570.92
12_Q198_I0.6560.92
58_V181_F0.6550.92
343_A353_V0.6500.92
298_Y302_L0.6490.92
196_A266_T0.6490.92
356_A362_G0.6450.92
40_G155_L0.6450.92
77_A398_V0.6440.92
15_T19_I0.6440.92
97_N326_I0.6440.92
84_V88_A0.6430.92
341_K391_N0.6430.92
317_A322_S0.6420.92
327_V330_I0.6420.92
287_K291_G0.6420.92
247_F255_Y0.6400.91
160_F174_I0.6400.91
43_K135_D0.6390.91
365_P368_G0.6380.91
309_L343_A0.6380.91
313_A317_A0.6330.91
65_E68_K0.6320.91
179_E182_S0.6320.91
32_E209_G0.6320.91
336_L353_V0.6310.91
331_T361_V0.6310.91
294_I395_T0.6300.91
140_S144_A0.6270.91
243_K249_I0.6270.91
92_G307_I0.6250.90
233_F303_D0.6240.90
23_L30_I0.6240.90
198_I202_G0.6210.90
345_G348_G0.6210.90
172_Q177_V0.6210.90
222_L312_A0.6200.90
30_I209_G0.6180.90
180_S183_Q0.6170.90
121_A124_A0.6150.90
368_G371_L0.6140.90
44_L159_L0.6140.90
123_Q126_D0.6130.90
104_G221_Q0.6120.90
171_G184_V0.6080.89
91_I237_V0.6070.89
37_L198_I0.6040.89
69_A404_E0.6030.89
81_F391_N0.6030.89
329_Q333_L0.6020.89
256_I276_M0.6010.89
309_L313_A0.6010.89
180_S184_V0.6000.89
44_L195_L0.5990.89
128_G132_F0.5990.89
277_L294_I0.5970.88
69_A72_R0.5970.88
59_T63_G0.5960.88
66_S74_G0.5960.88
302_L343_A0.5960.88
267_S271_S0.5950.88
164_L175_F0.5950.88
395_T399_A0.5940.88
95_I224_I0.5930.88
270_E298_Y0.5900.88
69_A74_G0.5900.88
283_L396_I0.5900.88
323_Q326_I0.5890.88
120_Y123_Q0.5870.88
81_F233_F0.5870.88
333_L336_L0.5870.88
335_V360_A0.5860.87
397_V401_W0.5860.87
144_A148_G0.5850.87
275_R278_D0.5830.87
87_I90_I0.5820.87
222_L230_C0.5810.87
252_F283_L0.5810.87
345_G349_S0.5790.87
50_A145_F0.5790.87
92_G308_Y0.5770.87
331_T335_V0.5750.86
199_G203_A0.5750.86
20_G24_G0.5710.86
72_R75_A0.5710.86
146_A149_N0.5700.86
288_S404_E0.5700.86
47_M188_I0.5690.86
84_V300_F0.5690.86
31_G209_G0.5680.86
224_I227_Y0.5670.86
328_H331_T0.5670.86
121_A125_K0.5660.86
303_D390_G0.5640.85
272_A298_Y0.5630.85
310_T336_L0.5620.85
254_R258_E0.5620.85
305_T383_R0.5610.85
104_G218_Q0.5600.85
313_A316_I0.5600.85
9_L12_Q0.5590.85
59_T175_F0.5570.85
312_A376_D0.5570.85
25_H213_V0.5570.85
219_L222_L0.5550.85
221_Q225_C0.5540.84
174_I181_F0.5530.84
154_L320_T0.5520.84
403_K407_H0.5520.84
18_A407_H0.5520.84
285_C395_T0.5510.84
263_V385_L0.5490.84
97_N314_V0.5490.84
73_T402_V0.5490.84
387_N391_N0.5470.84
23_L26_F0.5470.84
88_A307_I0.5470.84
284_G406_D0.5470.84
333_L337_L0.5460.84
164_L180_S0.5460.84
286_R290_V0.5460.84
52_V154_L0.5460.84
175_F179_E0.5460.84
44_L192_I0.5440.83
350_G357_T0.5440.83
308_Y312_A0.5430.83
263_V380_S0.5420.83
355_A366_V0.5400.83
187_G194_R0.5400.83
172_Q180_S0.5370.83
167_L187_G0.5370.83
394_A397_V0.5360.82
28_P31_G0.5340.82
238_L243_K0.5330.82
289_V404_E0.5320.82
361_V364_L0.5310.82
16_A220_G0.5310.82
48_I52_V0.5310.82
239_G250_F0.5310.82
272_A388_L0.5310.82
100_Q314_V0.5290.82
348_G352_I0.5290.82
27_Y209_G0.5280.82
306_S337_L0.5270.81
250_F253_I0.5270.81
177_V184_V0.5260.81
305_T380_S0.5260.81
366_V369_L0.5260.81
93_L333_L0.5260.81
99_V221_Q0.5250.81
316_I353_V0.5250.81
133_I136_V0.5230.81
17_I381_E0.5220.81
332_L336_L0.5210.81
52_V185_I0.5200.81
286_R403_K0.5200.81
243_K250_F0.5180.80
144_A147_S0.5170.80
49_I371_L0.5170.80
389_V393_V0.5150.80
201_F212_G0.5150.80
256_I260_L0.5150.80
17_I200_A0.5150.80
280_M391_N0.5150.80
122_D125_K0.5140.80
49_I349_S0.5130.80
271_S302_L0.5130.80
343_A350_G0.5130.80
81_F297_G0.5130.80
89_L337_L0.5120.80
134_M140_S0.5110.79
375_I379_M0.5110.79
149_N153_V0.5110.79
43_K134_M0.5110.79
87_I237_V0.5100.79
234_V253_I0.5090.79
194_R198_I0.5090.79
132_F136_V0.5090.79
239_G242_A0.5080.79
324_M332_L0.5080.79
152_Q348_G0.5080.79
263_V272_A0.5080.79
252_F389_V0.5070.79
239_G249_I0.5050.79
245_T393_V0.5050.79
34_M37_L0.5050.79
238_L390_G0.5030.78
35_K210_K0.5030.78
219_L223_I0.5030.78
222_L227_Y0.5020.78
304_G386_T0.5020.78
319_A371_L0.5010.78
396_I405_L0.5010.78
193_M196_A0.5010.78
229_T233_F0.5000.78
271_S276_M0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.8972 100 0.1 Contact Map
3nd0A 2 0.8575 65.8 0.958 Contact Map
3zuxA 1 0.7079 49.2 0.962 Contact Map
4eneA 2 0.8879 31 0.966 Contact Map
3klyA 3 0.5164 21.7 0.968 Contact Map
4bwzA 2 0.7944 16.7 0.97 Contact Map
4cz8A 2 0.6402 14.3 0.971 Contact Map
4n7wA 2 0.3645 13.8 0.971 Contact Map
4czbA 2 0.6332 12.5 0.972 Contact Map
3kcuA 3 0.5 10.2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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