GREMLIN Database
SMG - Protein Smg
UniProt: P0A828 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11605
Length: 157 (150)
Sequences: 345 (229)
Seq/√Len: 18.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_L106_V3.9271.00
98_L111_L2.8380.99
1_M44_L2.7940.98
110_V118_F2.6650.98
74_T78_C2.6370.98
73_Y107_I2.5950.97
49_K112_A2.5330.97
9_F145_E2.4480.96
73_Y87_G2.2560.94
88_F120_L2.0430.90
5_L9_F1.9730.89
85_C123_L1.9430.88
1_M36_E1.9400.88
50_L128_L1.9200.87
1_M142_Q1.9050.87
9_F136_G1.8810.86
145_E148_L1.7560.82
9_F129_M1.7440.81
39_D109_R1.7150.80
1_M143_Q1.6980.80
5_L33_A1.6880.79
109_R112_A1.6680.78
80_R117_E1.6670.78
63_L121_D1.6500.78
66_D99_N1.6480.77
1_M132_F1.6390.77
87_G94_Q1.6130.76
43_A46_W1.5950.75
1_M40_I1.5920.75
121_D136_G1.5710.74
131_L134_I1.5510.73
99_N137_C1.5260.72
64_A84_S1.4550.68
110_V123_L1.4040.65
4_V90_L1.3970.65
1_M27_E1.3590.62
40_I149_F1.3580.62
111_L116_A1.3500.62
8_L128_L1.3390.61
2_F12_Y1.3320.61
81_L123_L1.3300.61
25_K112_A1.3140.60
140_A144_M1.3010.59
90_L94_Q1.2880.58
89_L107_I1.2860.58
6_M133_N1.2730.57
110_V115_N1.2610.57
125_W133_N1.2210.54
73_Y144_M1.2160.54
13_I26_L1.2150.54
90_L98_L1.2120.53
86_R124_K1.2070.53
124_K138_E1.2020.53
8_L131_L1.1850.52
55_E126_V1.1850.52
24_D36_E1.1800.51
113_L125_W1.1650.51
96_Q137_C1.1630.50
124_K147_L1.1600.50
106_V117_E1.1580.50
4_V47_L1.1530.50
6_M88_F1.1490.50
2_F27_E1.1360.49
128_L134_I1.1340.49
55_E98_L1.1260.48
141_Y149_F1.1220.48
106_V140_A1.0940.46
56_G119_E1.0880.46
82_D110_V1.0880.46
40_I81_L1.0830.45
105_M108_E1.0830.45
124_K128_L1.0780.45
109_R126_V1.0690.45
76_E108_E1.0640.44
78_C107_I1.0380.43
119_E126_V1.0200.42
38_E84_S1.0200.42
10_E128_L1.0110.41
82_D86_R1.0080.41
72_I79_E1.0080.41
132_F142_Q1.0070.41
47_L124_K1.0060.41
97_V136_G0.9980.40
85_C120_L0.9960.40
146_E152_N0.9900.40
80_R115_N0.9860.39
5_L46_W0.9830.39
87_G93_E0.9760.39
93_E103_R0.9620.38
32_D112_A0.9550.38
44_L81_L0.9320.36
10_E124_K0.9210.36
4_V43_A0.9210.36
18_E140_A0.9100.35
85_C122_D0.9090.35
17_A75_P0.9040.35
5_L145_E0.9030.35
12_Y110_V0.9000.34
46_W109_R0.8990.34
139_N143_Q0.8980.34
2_F10_E0.8920.34
9_F88_F0.8900.34
25_K150_E0.8880.34
97_V123_L0.8850.34
113_L123_L0.8770.33
126_V143_Q0.8750.33
55_E118_F0.8740.33
42_N124_K0.8720.33
16_E79_E0.8660.33
102_T144_M0.8640.32
13_I102_T0.8630.32
43_A109_R0.8510.32
29_D42_N0.8510.32
113_L131_L0.8490.32
116_A153_E0.8480.32
23_Q98_L0.8480.32
13_I88_F0.8300.31
34_G77_E0.8290.31
30_L77_E0.8290.31
30_L34_G0.8290.31
62_Q66_D0.8230.30
122_D134_I0.8150.30
106_V127_I0.8080.29
73_Y93_E0.8070.29
12_Y119_E0.7930.29
3_D89_L0.7910.29
9_F139_N0.7840.28
67_P75_P0.7790.28
2_F43_A0.7790.28
21_V122_D0.7770.28
125_W145_E0.7710.28
78_C86_R0.7690.27
125_W141_Y0.7680.27
8_L124_K0.7640.27
43_A108_E0.7610.27
37_R67_P0.7580.27
67_P70_M0.7470.26
42_N51_A0.7460.26
69_S111_L0.7420.26
97_V141_Y0.7410.26
1_M122_D0.7380.26
105_M134_I0.7350.26
29_D140_A0.7340.26
92_L98_L0.7340.26
25_K44_L0.7300.26
111_L134_I0.7160.25
129_M132_F0.7110.25
69_S80_R0.7090.25
11_T84_S0.7050.24
32_D36_E0.7010.24
21_V133_N0.6980.24
140_A143_Q0.6980.24
36_E118_F0.6940.24
16_E39_D0.6900.24
136_G139_N0.6800.23
4_V148_L0.6720.23
83_A99_N0.6710.23
93_E130_V0.6650.23
120_L150_E0.6640.23
108_E127_I0.6620.22
1_M147_L0.6550.22
122_D136_G0.6550.22
51_A86_R0.6530.22
88_F129_M0.6510.22
4_V44_L0.6490.22
84_S119_E0.6490.22
79_E107_I0.6400.21
52_D147_L0.6400.21
3_D7_Y0.6370.21
45_L118_F0.6350.21
125_W149_F0.6340.21
100_L106_V0.6280.21
13_I141_Y0.6270.21
132_F140_A0.6230.21
66_D74_T0.6210.21
14_H44_L0.6160.20
37_R68_L0.6130.20
7_Y42_N0.6110.20
69_S95_I0.6100.20
2_F149_F0.6060.20
34_G71_R0.6010.20
30_L71_R0.6010.20
71_R77_E0.6010.20
33_A149_F0.6010.20
2_F15_T0.6000.20
3_D95_I0.5900.19
96_Q99_N0.5850.19
6_M102_T0.5830.19
14_H148_L0.5800.19
128_L147_L0.5780.19
61_M79_E0.5740.19
64_A67_P0.5740.19
4_V32_D0.5720.19
27_E44_L0.5700.19
21_V126_V0.5690.19
26_L69_S0.5690.19
92_L107_I0.5690.19
55_E72_I0.5660.19
2_F101_E0.5660.19
18_E21_V0.5650.18
49_K73_Y0.5620.18
75_P84_S0.5600.18
48_E95_I0.5580.18
124_K130_V0.5560.18
75_P79_E0.5530.18
85_C144_M0.5450.18
1_M21_V0.5450.18
80_R111_L0.5420.18
5_L112_A0.5420.18
93_E100_L0.5410.18
40_I132_F0.5410.18
10_E138_E0.5410.18
36_E112_A0.5360.17
36_E102_T0.5340.17
84_S97_V0.5270.17
15_T18_E0.5240.17
27_E88_F0.5230.17
36_E146_E0.5210.17
82_D144_M0.5190.17
7_Y93_E0.5180.17
52_D63_L0.5140.17
72_I127_I0.5130.17
105_M122_D0.5070.16
100_L153_E0.5060.16
145_E149_F0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z96A 1 0.2357 34.7 0.939 Contact Map
2dahA 1 0.2611 22 0.945 Contact Map
2g3qA 1 0.2675 22 0.945 Contact Map
2dakA 1 0.3312 15.7 0.949 Contact Map
2jy5A 1 0.242 15.3 0.949 Contact Map
3broA 2 0.6624 14.8 0.949 Contact Map
4un2B 1 0.1975 14 0.949 Contact Map
2k9lA 1 0.2994 13.7 0.95 Contact Map
4ae4A 2 0.6624 13.6 0.95 Contact Map
2jujA 1 0.3567 13.6 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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