GREMLIN Database
GLYA - Serine hydroxymethyltransferase
UniProt: P0A825 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10408
Length: 417 (405)
Sequences: 4085 (1833)
Seq/√Len: 91.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_R191_D4.3911.00
159_E192_S4.3211.00
76_Q80_D3.3411.00
163_K192_S3.2861.00
109_L222_V3.1131.00
180_V214_P3.0101.00
293_K376_E2.9381.00
151_G308_K2.9021.00
157_D160_K2.8891.00
153_I158_L2.8201.00
82_A238_L2.8011.00
115_T141_N2.8011.00
225_T238_L2.7491.00
159_E163_K2.6561.00
21_Q73_I2.6501.00
159_E185_K2.6231.00
333_A390_L2.5841.00
381_E405_K2.5831.00
375_K378_E2.5361.00
388_D405_K2.5271.00
277_K281_E2.5171.00
30_I369_I2.4831.00
160_K164_E2.4211.00
184_A188_E2.3831.00
210_A288_Q2.3311.00
290_Q375_K2.3301.00
161_Q165_H2.3301.00
289_Q293_K2.3211.00
115_T165_H2.3011.00
300_E304_E2.2781.00
18_A73_I2.2271.00
212_V292_A2.2191.00
290_Q376_E2.1361.00
91_A240_L2.1221.00
305_R384_G2.0841.00
179_G315_D2.0651.00
301_V383_A2.0501.00
374_F382_L2.0471.00
76_Q79_I2.0311.00
305_R387_C2.0281.00
158_L186_M2.0191.00
301_V304_E2.0191.00
199_V220_A2.0121.00
385_W402_I2.0001.00
143_V165_H1.9901.00
307_Y387_C1.9771.00
82_A225_T1.9761.00
389_V402_I1.9651.00
344_V364_V1.9571.00
369_I379_A1.9521.00
178_S309_V1.8931.00
116_V142_I1.8921.00
301_V380_K1.8791.00
47_Q268_V1.8691.00
18_A74_V1.8691.00
301_V384_G1.8671.00
110_L169_M1.8201.00
90_Y241_A1.7941.00
80_D84_E1.7781.00
241_A249_Y1.7581.00
204_V213_Y1.7501.00
327_N354_K1.7211.00
157_D161_Q1.6881.00
115_T143_V1.6811.00
392_S395_D1.6741.00
38_Y415_V1.6681.00
21_Q70_Y1.6651.00
90_Y253_N1.6531.00
290_Q293_K1.6321.00
378_E413_Y1.5951.00
40_S278_E1.5921.00
99_S128_T1.5921.00
172_G186_M1.5921.00
297_A301_V1.5901.00
47_Q271_G1.5881.00
70_Y73_I1.5721.00
186_M197_L1.5711.00
32_L369_I1.5661.00
324_V354_K1.5621.00
294_N370_T1.5531.00
298_M379_A1.5501.00
84_E280_M1.5461.00
221_H242_K1.5221.00
155_Y185_K1.5131.00
212_V288_Q1.5091.00
23_K27_E1.5091.00
15_L74_V1.5081.00
249_Y253_N1.5021.00
339_R399_I1.5011.00
381_E385_W1.5011.00
295_A314_T1.4951.00
401_R405_K1.4871.00
298_M383_A1.4801.00
90_Y249_Y1.4751.00
106_Y171_I1.4701.00
103_F135_F1.4510.99
285_K289_Q1.4450.99
387_C391_D1.4340.99
377_A380_K1.4190.99
15_L274_V1.4190.99
212_V289_Q1.4170.99
299_V319_F1.4060.99
24_V28_E1.4030.99
89_D242_K1.4030.99
122_A348_S1.3840.99
51_L74_V1.3750.99
336_A393_I1.3710.99
85_L279_A1.3680.99
88_A217_V1.3640.99
301_V305_R1.3460.99
307_Y326_K1.3440.99
215_N218_P1.3390.99
169_M198_F1.3350.99
29_H338_G1.3340.99
340_A389_V1.3230.99
18_A70_Y1.3140.99
204_V316_N1.3110.99
17_Q21_Q1.3100.99
148_D154_D1.3040.99
109_L248_L1.3000.99
82_A276_L1.2950.99
308_K322_D1.2900.99
201_M240_L1.2890.99
286_T289_Q1.2830.99
374_F379_A1.2740.99
341_N407_L1.2740.99
326_K391_D1.2730.99
91_A238_L1.2720.99
213_Y316_N1.2680.99
248_L251_K1.2680.99
398_V402_I1.2650.99
385_W405_K1.2620.99
298_M302_F1.2610.99
308_K325_D1.2460.98
142_I171_I1.2410.98
56_A266_M1.2400.98
225_T276_L1.2280.98
211_G285_K1.2200.98
299_V309_V1.2170.98
61_G76_Q1.2150.98
110_L114_D1.2150.98
340_A402_I1.2140.98
147_I351_N1.2120.98
29_H341_N1.2010.98
105_V222_V1.1870.98
328_L390_L1.1870.98
198_F224_T1.1860.98
143_V161_Q1.1850.98
300_E380_K1.1810.98
111_E114_D1.1810.98
104_A256_V1.1730.98
51_L71_V1.1690.98
305_R388_D1.1630.98
369_I382_L1.1620.98
114_D168_K1.1560.97
28_E407_L1.1520.97
183_W213_Y1.1500.97
11_Y277_K1.1420.97
39_T44_M1.1410.97
172_G199_V1.1400.97
389_V399_I1.1380.97
78_A273_A1.1370.97
148_D157_D1.1360.97
31_E343_T1.1340.97
16_W20_E1.1280.97
9_A16_W1.1250.97
348_S352_D1.1200.97
156_A185_K1.1180.97
159_E188_E1.1170.97
381_E412_R1.1100.97
344_V362_I1.1090.97
185_K188_E1.1080.97
297_A380_K1.1050.97
381_E384_G1.1020.97
384_G388_D1.0990.96
324_V353_P1.0960.96
191_D221_H1.0950.96
109_L196_Y1.0950.96
66_G334_D1.0900.96
174_F181_V1.0720.96
296_K300_E1.0720.96
305_R380_K1.0670.96
221_H248_L1.0650.96
15_L18_A1.0610.96
303_L312_G1.0600.96
302_F387_C1.0500.95
23_K50_Q1.0470.95
90_Y242_K1.0460.95
172_G197_L1.0460.95
341_N403_K1.0450.95
111_E168_K1.0440.95
196_Y248_L1.0420.95
71_V266_M1.0400.95
187_R221_H1.0390.95
201_M208_V1.0380.95
242_K248_L1.0330.95
119_M146_G1.0290.95
88_A240_L1.0250.95
30_I374_F1.0250.95
388_D401_R1.0210.95
155_Y158_L1.0210.95
336_A389_V1.0200.95
293_K375_K1.0190.95
180_V213_Y1.0180.95
118_G128_T1.0160.95
148_D351_N1.0150.95
354_K358_V1.0140.95
89_D241_A1.0100.94
56_A68_C1.0010.94
329_T354_K0.9950.94
385_W409_I0.9940.94
90_Y252_L0.9940.94
388_D398_V0.9910.94
378_E409_I0.9870.94
308_K312_G0.9850.94
305_R391_D0.9800.93
340_A399_I0.9790.93
103_F260_G0.9770.93
407_L411_A0.9770.93
120_N144_P0.9760.93
141_N165_H0.9740.93
184_A219_H0.9680.93
339_R396_E0.9650.93
118_G144_P0.9630.93
234_P271_G0.9610.93
326_K387_C0.9600.93
404_G408_D0.9590.93
176_A320_L0.9590.93
337_L344_V0.9590.93
108_A255_A0.9570.93
155_Y186_M0.9560.93
120_N123_H0.9540.93
15_L51_L0.9530.92
110_L116_V0.9520.92
117_L143_V0.9520.92
174_F204_V0.9480.92
111_E138_K0.9460.92
12_D81_R0.9410.92
295_A367_P0.9390.92
232_A371_R0.9340.92
309_V319_F0.9320.92
256_V260_G0.9320.92
375_K413_Y0.9280.91
319_F364_V0.9240.91
87_G211_G0.9240.91
300_E303_L0.9240.91
222_V248_L0.9230.91
398_V401_R0.9230.91
247_E251_K0.9180.91
340_A385_W0.9150.91
196_Y222_V0.9100.91
174_F316_N0.9080.91
19_M46_A0.9080.91
14_E277_K0.9050.90
163_K193_I0.9040.90
400_E404_G0.9040.90
46_A274_V0.9030.90
392_S398_V0.9020.90
335_A339_R0.9020.90
378_E412_R0.9000.90
78_A93_V0.8980.90
107_T140_Y0.8920.90
135_F139_L0.8910.90
106_Y116_V0.8890.90
179_G313_G0.8880.90
162_A170_I0.8880.90
238_L276_L0.8850.89
388_D402_I0.8850.89
308_K349_V0.8840.89
307_Y321_V0.8830.89
43_V275_A0.8820.89
163_K166_K0.8790.89
277_K280_M0.8780.89
374_F409_I0.8710.89
392_S399_I0.8690.89
20_E23_K0.8670.88
100_Q103_F0.8620.88
13_A16_W0.8600.88
381_E408_D0.8550.88
320_L347_N0.8510.87
288_Q291_V0.8500.87
55_Y228_H0.8500.87
181_V186_M0.8480.87
14_E17_Q0.8440.87
28_E411_A0.8440.87
332_E336_A0.8400.87
13_A17_Q0.8400.87
41_P45_Q0.8390.87
295_A319_F0.8380.87
329_T332_E0.8380.87
184_A187_R0.8370.87
393_I399_I0.8300.86
303_L309_V0.8290.86
172_G201_M0.8290.86
153_I181_V0.8280.86
161_Q164_E0.8270.86
15_L277_K0.8230.86
404_G407_L0.8220.86
304_E380_K0.8190.85
224_T239_I0.8170.85
89_D246_E0.8150.85
403_K407_L0.8140.85
106_Y142_I0.8130.85
18_A21_Q0.8130.85
297_A376_E0.8130.85
170_I186_M0.8120.85
96_H100_Q0.8110.85
15_L77_L0.8080.85
374_F413_Y0.8080.85
80_D83_K0.8070.85
122_A352_D0.8040.84
132_P142_I0.8030.84
82_A240_L0.8020.84
73_I76_Q0.8010.84
178_S319_F0.8010.84
160_K163_K0.7970.84
374_F378_E0.7960.84
286_T290_Q0.7950.84
172_G220_A0.7950.84
402_I405_K0.7940.84
332_E394_N0.7900.83
105_V110_L0.7830.83
241_A253_N0.7820.83
65_Y228_H0.7810.83
8_I45_Q0.7800.83
19_M51_L0.7800.83
105_V198_F0.7790.82
241_A252_L0.7780.82
389_V398_V0.7740.82
120_N146_G0.7710.82
158_L189_I0.7530.80
11_Y42_R0.7530.80
288_Q367_P0.7510.80
89_D248_L0.7480.80
187_R197_L0.7480.80
383_A387_C0.7480.80
241_A248_L0.7470.80
204_V208_V0.7460.80
279_A284_F0.7430.79
105_V224_T0.7420.79
232_A287_Y0.7420.79
55_Y65_Y0.7410.79
28_E341_N0.7390.79
82_A91_A0.7380.79
218_P223_V0.7330.78
110_L198_F0.7320.78
292_A296_K0.7310.78
302_F383_A0.7300.78
408_D412_R0.7290.78
334_D338_G0.7270.78
405_K408_D0.7270.78
352_D355_S0.7250.78
301_V387_C0.7250.78
99_S256_V0.7240.78
13_A42_R0.7240.78
336_A399_I0.7230.77
83_K91_A0.7190.77
117_L142_I0.7140.77
88_A223_V0.7130.77
8_I19_M0.7130.77
217_V223_V0.7110.76
197_L220_A0.7110.76
119_M181_V0.7100.76
332_E354_K0.7090.76
305_R383_A0.7080.76
117_L165_H0.7080.76
79_I83_K0.7070.76
88_A215_N0.7060.76
117_L144_P0.7050.76
389_V393_I0.7040.76
284_F291_V0.7020.75
183_W204_V0.7000.75
298_M364_V0.7000.75
251_K254_S0.7000.75
201_M209_A0.6970.75
366_T379_A0.6960.75
107_T255_A0.6910.74
96_H265_L0.6900.74
184_A218_P0.6850.74
234_P275_A0.6840.73
82_A86_F0.6840.73
331_K357_F0.6820.73
107_T260_G0.6810.73
74_V266_M0.6810.73
323_L326_K0.6810.73
11_Y281_E0.6790.73
205_A230_T0.6770.73
399_I402_I0.6760.73
401_R408_D0.6760.73
117_L162_A0.6760.73
210_A289_Q0.6740.72
190_A197_L0.6740.72
116_V169_M0.6740.72
106_Y169_M0.6740.72
132_P357_F0.6730.72
171_I198_F0.6720.72
328_L332_E0.6720.72
208_V213_Y0.6720.72
38_Y368_A0.6720.72
135_F140_Y0.6680.72
284_F288_Q0.6670.72
158_L161_Q0.6670.72
112_P139_L0.6660.72
158_L172_G0.6650.71
292_A366_T0.6650.71
180_V215_N0.6640.71
336_A392_S0.6640.71
154_D157_D0.6640.71
242_K249_Y0.6630.71
336_A339_R0.6610.71
329_T358_V0.6600.71
44_M53_N0.6570.70
336_A340_A0.6560.70
319_F366_T0.6560.70
399_I403_K0.6550.70
380_K384_G0.6540.70
408_D411_A0.6530.70
16_W45_Q0.6520.70
302_F309_V0.6520.70
24_V27_E0.6490.70
133_V254_S0.6420.69
332_E393_I0.6420.69
401_R404_G0.6420.69
8_I42_R0.6410.69
83_K88_A0.6400.68
207_L292_A0.6370.68
384_G405_K0.6370.68
338_G341_N0.6360.68
323_L327_N0.6350.68
95_P256_V0.6350.68
246_E249_Y0.6340.68
290_Q370_T0.6320.68
323_L349_V0.6320.68
111_E141_N0.6310.67
335_A338_G0.6310.67
27_E415_V0.6290.67
29_H410_C0.6270.67
190_A195_A0.6270.67
385_W388_D0.6260.67
119_M155_Y0.6260.67
88_A242_K0.6260.67
288_Q292_A0.6250.67
156_A160_K0.6240.67
69_E338_G0.6220.66
36_E55_Y0.6210.66
118_G142_I0.6210.66
157_D165_H0.6200.66
84_E87_G0.6200.66
248_L252_L0.6190.66
63_R72_D0.6190.66
297_A300_E0.6170.66
172_G181_V0.6160.66
307_Y391_D0.6150.65
55_Y263_G0.6150.65
275_A279_A0.6140.65
242_K247_E0.6140.65
355_S358_V0.6140.65
283_E286_T0.6110.65
309_V321_V0.6080.65
178_S318_L0.6080.65
310_V323_L0.6080.65
364_V386_M0.6070.64
297_A379_A0.6040.64
321_V344_V0.6030.64
338_G343_T0.6020.64
178_S311_S0.6020.64
233_G275_A0.6020.64
396_E400_E0.6000.64
303_L308_K0.5990.63
385_W389_V0.5990.63
377_A413_Y0.5970.63
278_E287_Y0.5970.63
217_V240_L0.5970.63
109_L169_M0.5960.63
21_Q24_V0.5960.63
301_V379_A0.5960.63
159_E189_I0.5960.63
184_A191_D0.5960.63
79_I253_N0.5960.63
115_T161_Q0.5950.63
232_A278_E0.5940.63
218_P242_K0.5940.63
139_L255_A0.5920.62
39_T43_V0.5920.62
255_A260_G0.5920.62
210_A285_K0.5900.62
123_H146_G0.5870.62
276_L280_M0.5860.62
156_A192_S0.5830.61
234_P268_V0.5800.61
107_T135_F0.5800.61
328_L333_A0.5770.61
102_N224_T0.5760.60
99_S106_Y0.5730.60
77_L277_K0.5710.60
348_S355_S0.5690.59
156_A159_E0.5680.59
18_A51_L0.5680.59
272_K276_L0.5660.59
348_S357_F0.5660.59
372_R414_P0.5640.59
151_G349_V0.5630.59
183_W208_V0.5620.59
103_F107_T0.5620.59
47_Q267_H0.5620.59
400_E403_K0.5610.58
250_K254_S0.5610.58
85_L276_L0.5610.58
19_M50_Q0.5600.58
291_V366_T0.5600.58
103_F134_N0.5600.58
15_L70_Y0.5580.58
39_T52_T0.5570.58
292_A295_A0.5570.58
281_E286_T0.5570.58
99_S103_F0.5560.58
99_S134_N0.5550.58
397_A400_E0.5550.58
307_Y386_M0.5540.57
155_Y181_V0.5530.57
64_Y133_V0.5530.57
395_D398_V0.5510.57
369_I374_F0.5510.57
105_V169_M0.5510.57
148_D152_H0.5500.57
293_K296_K0.5500.57
76_Q266_M0.5490.57
144_P161_Q0.5480.57
103_F139_L0.5480.57
39_T271_G0.5470.57
78_A276_L0.5470.57
107_T139_L0.5460.56
123_H351_N0.5450.56
14_E73_I0.5450.56
337_L362_I0.5450.56
199_V204_V0.5450.56
96_H99_S0.5440.56
282_P286_T0.5440.56
208_V316_N0.5430.56
14_E84_E0.5430.56
296_K315_D0.5430.56
188_E192_S0.5430.56
62_K357_F0.5420.56
307_Y325_D0.5420.56
103_F140_Y0.5410.56
89_D249_Y0.5380.55
221_H249_Y0.5380.55
265_L268_V0.5380.55
44_M50_Q0.5370.55
241_A251_K0.5370.55
279_A288_Q0.5360.55
70_Y74_V0.5360.55
77_L81_R0.5360.55
242_K251_K0.5350.55
151_G307_Y0.5350.55
329_T359_T0.5330.55
377_A397_A0.5310.54
110_L168_K0.5300.54
378_E381_E0.5290.54
175_S202_A0.5290.54
293_K297_A0.5270.54
180_V292_A0.5250.53
379_A382_L0.5250.53
352_D357_F0.5240.53
210_A215_N0.5240.53
116_V168_K0.5240.53
29_H69_E0.5230.53
57_E63_R0.5210.53
68_C265_L0.5210.53
377_A384_G0.5210.53
68_C272_K0.5200.53
212_V285_K0.5200.53
85_L280_M0.5200.53
227_T236_G0.5200.53
227_T238_L0.5190.53
81_R274_V0.5190.53
266_M269_I0.5190.53
337_L386_M0.5170.52
205_A225_T0.5160.52
152_H179_G0.5150.52
396_E399_I0.5150.52
291_V295_A0.5150.52
48_G52_T0.5130.52
170_I189_I0.5130.52
40_S287_Y0.5130.52
182_D185_K0.5130.52
89_D247_E0.5130.52
47_Q99_S0.5130.52
96_H272_K0.5130.52
110_L196_Y0.5120.52
31_E368_A0.5120.52
333_A362_I0.5120.52
36_E228_H0.5110.52
107_T138_K0.5100.51
19_M23_K0.5090.51
47_Q50_Q0.5070.51
202_A224_T0.5070.51
117_L158_L0.5060.51
321_V326_K0.5050.51
31_E66_G0.5040.51
302_F364_V0.5020.50
222_V252_L0.5020.50
120_N142_I0.5010.50
404_G412_R0.5010.50
100_Q265_L0.5010.50
87_G217_V0.5000.50
210_A292_A0.5000.50
37_N287_Y0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rv3A 3 0.9928 100 0.462 Contact Map
3ou5A 2 0.9089 100 0.49 Contact Map
3h7fA 2 0.988 100 0.583 Contact Map
4wxgA 2 0.9784 100 0.591 Contact Map
3n0lA 2 0.952 100 0.609 Contact Map
3gbxA 2 0.9305 100 0.623 Contact Map
3ecdA 2 0.9113 100 0.627 Contact Map
2dkjA 2 0.9616 100 0.636 Contact Map
4msoA 2 0.9281 100 0.64 Contact Map
2vi8A 2 0.9688 100 0.648 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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