GREMLIN Database
SFSA - Sugar fermentation stimulation protein A
UniProt: P0A823 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10949
Length: 234 (224)
Sequences: 1506 (1137)
Seq/√Len: 76.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_K109_S4.0301.00
154_T157_G3.9511.00
173_R211_E3.3311.00
90_K94_L3.1421.00
192_R199_A3.1031.00
192_R203_S2.9491.00
36_P66_T2.7791.00
89_T177_F2.6561.00
9_R50_T2.6091.00
93_I122_F2.6081.00
50_T71_Q2.4331.00
158_Q201_L2.4291.00
52_W77_F2.3241.00
24_I30_E2.3181.00
23_V53_Y2.2521.00
125_Q131_D2.2101.00
169_A208_R2.1581.00
55_T64_P1.9991.00
167_V172_Q1.9811.00
162_R204_E1.9301.00
133_Y167_V1.8921.00
199_A203_S1.8781.00
111_V133_Y1.8461.00
79_C181_L1.8421.00
14_Q22_D1.8331.00
202_L212_I1.8321.00
11_T24_I1.8181.00
23_V51_V1.7921.00
25_T31_L1.7291.00
21_A35_C1.7171.00
143_E193_H1.6951.00
158_Q195_D1.6931.00
147_G188_F1.6381.00
33_L53_Y1.6191.00
113_Y167_V1.6131.00
161_L176_I1.6051.00
114_G163_E1.6001.00
108_K111_V1.5770.99
8_Q53_Y1.5070.99
197_K200_Q1.5030.99
52_W71_Q1.5000.99
89_T179_A1.4880.99
165_M168_A1.4790.99
105_S126_A1.4690.99
146_Q187_R1.4660.99
191_A194_I1.4630.99
44_C70_T1.4270.99
10_A23_V1.4000.99
51_V67_W1.3930.99
117_R163_E1.3930.99
148_Y193_H1.3810.99
132_C175_V1.3730.98
206_Q212_I1.3670.98
165_M201_L1.3630.98
2_E223_G1.3630.98
205_A210_V1.3610.98
133_Y172_Q1.3570.98
118_S163_E1.3560.98
146_Q189_S1.3530.98
131_D172_Q1.3530.98
61_R66_T1.3330.98
100_E215_Y1.3320.98
104_Y132_C1.3240.98
84_W87_R1.3210.98
85_A138_S1.3150.98
106_S125_Q1.3100.98
89_T93_I1.3090.98
218_E227_K1.3080.98
166_S169_A1.2830.98
117_R159_K1.2810.98
109_S122_F1.2700.97
100_E229_S1.2670.97
104_Y124_L1.2640.97
49_D70_T1.2550.97
113_Y120_I1.2500.97
165_M205_A1.2450.97
215_Y226_L1.2390.97
46_T49_D1.2270.97
8_Q55_T1.2240.97
88_L224_M1.2110.97
123_M131_D1.2070.97
114_G118_S1.2000.96
2_E222_E1.1910.96
54_S68_E1.1900.96
147_G185_I1.1860.96
31_L53_Y1.1860.96
68_E81_N1.1860.96
134_I177_F1.1820.96
175_V213_L1.1810.96
124_L134_I1.1690.96
22_D32_T1.1670.96
10_A51_V1.1570.96
175_V211_E1.1510.95
188_F214_A1.1440.95
216_K228_K1.1400.95
35_C67_W1.1180.95
71_Q77_F1.1180.95
161_L202_L1.1110.94
142_A185_I1.1060.94
165_M208_R1.1010.94
180_V230_L1.0930.94
40_A43_G1.0800.94
79_C138_S1.0800.94
22_D30_E1.0780.94
90_K122_F1.0770.93
148_Y188_F1.0520.93
180_V214_A1.0520.93
201_L205_A1.0510.93
10_A53_Y1.0500.93
190_P203_S1.0500.93
155_E158_Q1.0490.93
220_S223_G1.0490.93
89_T122_F1.0340.92
16_Y20_L1.0240.92
56_S66_T1.0240.92
16_Y22_D1.0210.92
140_T152_A1.0200.91
101_L175_V1.0190.91
152_A194_I1.0090.91
118_S159_K1.0080.91
216_K227_K1.0050.91
158_Q162_R1.0020.91
13_I30_E0.9990.91
183_S218_E0.9950.90
33_L63_Y0.9940.90
158_Q197_K0.9900.90
55_T65_H0.9870.90
33_L67_W0.9850.90
145_E186_T0.9780.90
165_M204_E0.9780.90
122_F134_I0.9730.89
126_A129_R0.9670.89
21_A67_W0.9640.89
181_L217_A0.9630.89
52_W69_L0.9620.89
217_A226_L0.9580.89
81_N85_A0.9580.89
8_Q27_D0.9540.89
142_A182_H0.9480.88
13_I24_I0.9450.88
179_A226_L0.9400.88
190_P199_A0.9390.88
168_A174_A0.9380.88
56_S61_R0.9330.87
196_E200_Q0.9300.87
190_P202_L0.9190.87
165_M169_A0.9170.86
204_E208_R0.9170.86
88_L179_A0.9150.86
53_Y65_H0.9050.86
12_L21_A0.8970.85
162_R201_L0.8950.85
93_I177_F0.8930.85
25_T29_R0.8910.85
54_S81_N0.8890.85
9_R52_W0.8870.85
87_R109_S0.8830.84
84_W224_M0.8800.84
89_T136_V0.8730.84
182_H185_I0.8700.83
166_S170_E0.8680.83
31_L64_P0.8650.83
197_K201_L0.8640.83
12_L45_A0.8640.83
54_S66_T0.8600.83
96_E103_G0.8490.82
129_R173_R0.8490.82
31_L65_H0.8420.81
176_I188_F0.8420.81
37_N41_M0.8410.81
218_E225_A0.8380.81
68_E84_W0.8370.81
112_K159_K0.8370.81
111_V118_S0.8290.80
122_F136_V0.8270.80
157_G161_L0.8240.80
40_A152_A0.8230.80
134_I175_V0.8180.79
21_A51_V0.8180.79
120_I133_Y0.8120.79
158_Q165_M0.8110.79
148_Y189_S0.7950.78
176_I198_Y0.7940.77
128_S131_D0.7930.77
113_Y163_E0.7840.77
44_C78_I0.7820.76
122_F177_F0.7820.76
104_Y211_E0.7800.76
33_L65_H0.7770.76
45_A49_D0.7760.76
213_L229_S0.7740.76
66_T81_N0.7650.75
17_K20_L0.7490.73
124_L132_C0.7470.73
103_G129_R0.7460.73
40_A153_V0.7430.73
215_Y229_S0.7380.72
73_Q76_A0.7340.72
141_L194_I0.7320.72
154_T190_P0.7280.71
104_Y126_A0.7260.71
139_V178_F0.7260.71
39_G151_D0.7240.71
180_V188_F0.7200.70
8_Q65_H0.7190.70
168_A173_R0.7170.70
16_Y32_T0.7060.69
107_L122_F0.7040.69
78_I185_I0.7040.69
176_I212_I0.7030.68
12_L67_W0.7020.68
183_S219_I0.7010.68
3_F7_L0.6990.68
57_D64_P0.6980.68
69_L77_F0.6970.68
41_M138_S0.6970.68
112_K117_R0.6960.68
76_A184_A0.6920.67
177_F215_Y0.6890.67
168_A210_V0.6840.66
147_G182_H0.6820.66
5_P54_S0.6800.66
92_A98_I0.6790.66
38_T152_A0.6770.66
159_K162_R0.6760.65
36_P85_A0.6750.65
141_L191_A0.6700.65
43_G194_I0.6650.64
10_A31_L0.6640.64
93_I134_I0.6620.64
98_I101_L0.6600.64
12_L20_L0.6570.63
11_T50_T0.6540.63
214_A230_L0.6540.63
67_W70_T0.6510.62
142_A145_E0.6480.62
7_L69_L0.6470.62
24_I28_G0.6450.62
114_G117_R0.6440.62
27_D30_E0.6430.62
98_I177_F0.6410.61
77_F221_A0.6340.60
45_A70_T0.6270.60
25_T53_Y0.6220.59
108_K123_M0.6210.59
89_T134_I0.6190.59
10_A25_T0.6190.59
97_S226_L0.6180.59
43_G46_T0.6140.58
9_R221_A0.6100.58
132_C173_R0.6070.57
37_N151_D0.6070.57
17_K40_A0.6060.57
162_R197_K0.6050.57
201_L204_E0.6040.57
161_L165_M0.6030.57
166_S208_R0.6010.56
139_V230_L0.6000.56
16_Y41_M0.6000.56
155_E197_K0.5970.56
179_A217_A0.5930.55
143_E148_Y0.5920.55
20_L32_T0.5910.55
93_I96_E0.5910.55
76_A182_H0.5900.55
76_A185_I0.5890.55
23_V33_L0.5890.55
97_S215_Y0.5880.55
100_E213_L0.5870.55
36_P83_L0.5860.55
185_I188_F0.5860.55
113_Y118_S0.5830.54
57_D60_K0.5820.54
105_S127_D0.5800.54
86_N110_E0.5770.53
35_C41_M0.5750.53
79_C85_A0.5730.53
191_A198_Y0.5710.53
85_A181_L0.5700.53
40_A140_T0.5690.52
117_R120_I0.5650.52
141_L159_K0.5650.52
91_E95_N0.5620.52
162_R165_M0.5610.51
19_F82_T0.5610.51
10_A63_Y0.5600.51
102_S105_S0.5590.51
36_P86_N0.5580.51
69_L79_C0.5560.51
187_R231_P0.5550.51
17_K32_T0.5540.50
25_T30_E0.5530.50
120_I123_M0.5520.50
142_A184_A0.5490.50
173_R213_L0.5470.50
13_I74_S0.5460.49
25_T28_G0.5450.49
133_Y174_A0.5430.49
107_L124_L0.5430.49
13_I189_S0.5420.49
44_C202_L0.5390.49
13_I25_T0.5390.49
79_C217_A0.5380.48
33_L51_V0.5380.48
20_L63_Y0.5380.48
153_V191_A0.5360.48
120_I167_V0.5320.48
83_L88_L0.5310.48
112_K120_I0.5310.48
79_C88_L0.5310.48
3_F223_G0.5310.48
113_Y170_E0.5310.48
148_Y190_P0.5300.47
90_K107_L0.5300.47
170_E207_Q0.5290.47
59_T64_P0.5290.47
93_I107_L0.5220.46
110_E119_R0.5220.46
109_S112_K0.5190.46
17_K81_N0.5170.46
52_W221_A0.5150.46
216_K230_L0.5130.45
85_A140_T0.5130.45
168_A171_G0.5100.45
203_S206_Q0.5080.45
11_T48_G0.5060.44
104_Y175_V0.5050.44
218_E223_G0.5040.44
90_K99_S0.5040.44
93_I136_V0.5040.44
12_L35_C0.5030.44
225_A231_P0.5030.44
178_F202_L0.5020.44
162_R166_S0.5010.44
35_C68_E0.5000.44
69_L219_I0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dapA 1 0.9915 100 0.005 Contact Map
4da2A 1 0.9658 100 0.032 Contact Map
2eo0A 2 0.5342 55.2 0.953 Contact Map
3n28A 1 0.359 43.7 0.956 Contact Map
2ostA 4 0.547 36.1 0.958 Contact Map
1m0dA 2 0.5171 34.1 0.959 Contact Map
3fovA 2 0.4316 32.4 0.959 Contact Map
1gefA 2 0.5 28.5 0.961 Contact Map
2oqkA 1 0.3718 27.4 0.961 Contact Map
1jt8A 1 0.3675 23.6 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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