GREMLIN Database
SELA - L-seryl-tRNA(Sec) selenium transferase
UniProt: P0A821 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10941
Length: 463 (443)
Sequences: 1005 (760)
Seq/√Len: 36.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
208_A247_L5.1601.00
390_C408_A4.7531.00
163_A318_H4.4381.00
212_R250_E4.2811.00
248_G255_V4.1691.00
162_A318_H4.1331.00
221_L256_V4.0631.00
91_L98_A3.9471.00
135_A146_D3.7341.00
140_R342_L3.6111.00
101_A337_T3.5931.00
99_L353_T3.5921.00
437_G444_L3.5211.00
160_M256_V3.2731.00
390_C406_S3.2241.00
9_Y52_R3.1101.00
288_L315_L3.0591.00
108_V329_M2.9831.00
359_R367_Q2.8701.00
103_A350_K2.8621.00
168_K220_A2.8541.00
120_Y436_I2.8411.00
15_I44_L2.8351.00
245_V255_V2.8281.00
79_A133_A2.7781.00
173_S206_T2.7311.00
15_I40_L2.6031.00
365_Q369_Q2.5771.00
46_E71_R2.5321.00
131_D321_K2.5251.00
160_M290_S2.4351.00
176_E224_K2.3971.00
309_K313_A2.3921.00
101_A340_L2.3901.00
169_E216_N2.3771.00
198_H216_N2.3621.00
18_L40_L2.3040.99
120_Y124_D2.2990.99
207_H237_K2.2980.99
392_S406_S2.2690.99
437_G446_L2.2010.99
410_T443_R2.1920.99
148_C321_K2.1870.99
192_Q318_H2.1770.99
107_A336_A2.1730.99
169_E219_T2.1550.99
170_V221_L2.1550.99
43_M68_V2.1430.99
388_M410_T2.0880.99
288_L311_M2.0510.99
256_V290_S1.9930.98
282_I306_V1.9860.98
171_V222_L1.9840.98
392_S447_D1.9810.98
391_L403_R1.9490.98
215_V222_L1.9130.98
257_T281_L1.8940.98
408_A445_W1.8900.98
98_A353_T1.8680.98
33_H37_V1.8590.97
389_P407_A1.8460.97
188_D319_P1.8440.97
287_S308_K1.8300.97
84_I451_L1.8280.97
170_V195_C1.7920.97
162_A192_Q1.7900.97
138_L306_V1.7870.97
448_L451_L1.7450.96
138_L147_A1.7390.96
215_V253_V1.7200.96
37_V41_R1.6800.95
99_L114_S1.6760.95
372_Q387_V1.6570.95
102_E113_R1.6380.95
222_L253_V1.6330.95
222_L248_G1.6160.94
209_N213_Q1.6110.94
134_L331_L1.5950.94
165_A170_V1.5850.94
428_W444_L1.5750.93
241_E286_V1.5730.93
158_L323_A1.5540.93
422_E425_A1.5480.93
453_D456_R1.5460.93
274_K280_E1.5380.93
257_T286_V1.5350.92
326_A330_T1.5350.92
451_L455_Q1.5340.92
406_S447_D1.5170.92
178_V186_I1.5030.92
410_T445_W1.4910.91
310_E313_A1.4900.91
412_T442_G1.4820.91
207_H239_I1.4800.91
227_T230_Y1.4730.91
188_D191_R1.4670.91
245_V249_K1.4630.91
232_I236_T1.4620.90
431_L434_P1.4390.90
91_L398_S1.4380.90
134_L147_A1.4340.90
117_T122_L1.4130.89
268_S274_K1.4120.89
77_Q81_R1.4040.89
308_K311_M1.3990.88
409_L448_L1.3960.88
9_Y51_I1.3940.88
365_Q407_A1.3930.88
425_A429_R1.3920.88
245_V248_G1.3870.88
242_A284_A1.3860.88
176_E238_A1.3780.88
104_A107_A1.3770.88
145_E308_K1.3740.87
248_G251_L1.3700.87
267_L354_L1.3630.87
359_R364_I1.3600.87
102_E106_E1.3560.87
241_E257_T1.3500.87
421_L444_L1.3490.87
233_Q401_V1.3460.86
45_D49_E1.3440.86
159_L315_L1.3430.86
105_V109_A1.3410.86
426_A430_E1.3310.86
241_E281_L1.3280.86
248_G253_V1.3160.85
196_T218_N1.3020.84
364_I448_L1.2980.84
237_K243_E1.2970.84
43_M71_R1.2950.84
212_R247_L1.2900.84
107_A111_A1.2890.84
158_L193_A1.2830.84
248_G254_P1.2610.83
131_D148_C1.2590.82
240_D243_E1.2590.82
28_R33_H1.2500.82
406_S448_L1.2500.82
221_L254_P1.2420.82
372_Q409_L1.2380.81
270_Y358_T1.2380.81
164_T315_L1.2350.81
21_D24_F1.2350.81
361_A389_P1.2250.81
82_P110_Q1.2110.80
86_L446_L1.1980.79
15_I37_V1.1960.79
135_A316_Q1.1760.78
39_L68_V1.1740.78
50_V55_Q1.1700.77
359_R363_V1.1670.77
149_I334_L1.1610.77
149_I326_A1.1580.77
28_R36_V1.1560.77
438_R447_D1.1510.76
115_P396_S1.1500.76
134_L146_D1.1460.76
383_F413_P1.1460.76
40_L72_L1.1440.76
104_A336_A1.1430.76
65_A68_V1.1360.75
190_M223_M1.1350.75
161_L190_M1.1340.75
220_A254_P1.1310.75
131_D189_V1.1280.75
105_V113_R1.1220.74
12_L44_L1.1140.74
221_L248_G1.1090.74
90_V392_S1.1070.73
160_M305_I1.1070.73
164_T288_L1.1060.73
368_A387_V1.1050.73
363_V366_I1.1020.73
280_E284_A1.1000.73
391_L405_P1.0980.73
208_A237_K1.0930.72
32_G36_V1.0910.72
215_V219_T1.0890.72
28_R32_G1.0840.72
309_K436_I1.0820.72
91_L393_Q1.0730.71
246_A250_E1.0720.71
161_L170_V1.0690.71
452_E455_Q1.0680.71
208_A239_I1.0640.70
189_V323_A1.0540.70
372_Q376_A1.0510.69
189_V192_Q1.0400.69
304_I334_L1.0380.68
337_T352_P1.0380.68
176_E279_Q1.0350.68
421_L442_G1.0290.68
455_Q458_L1.0280.68
361_A365_Q1.0240.67
413_P424_L1.0220.67
367_Q456_R1.0140.67
191_R213_Q1.0010.66
224_K239_I1.0000.66
33_H36_V0.9990.65
135_A139_C0.9970.65
18_L64_W0.9960.65
86_L451_L0.9950.65
277_M280_E0.9920.65
99_L452_E0.9920.65
162_A166_S0.9880.65
423_S427_R0.9860.64
172_V178_V0.9810.64
86_L396_S0.9750.64
388_M445_W0.9720.63
430_E434_P0.9710.63
393_Q403_R0.9690.63
24_F65_A0.9670.63
361_A407_A0.9660.63
153_N290_S0.9550.62
188_D202_T0.9550.62
265_V270_Y0.9540.62
178_V330_T0.9540.62
176_E233_Q0.9530.62
215_V251_L0.9460.61
104_A332_A0.9430.61
368_A409_L0.9400.61
386_Q410_T0.9370.60
387_V407_A0.9370.60
86_L193_A0.9350.60
178_V215_V0.9330.60
255_V287_S0.9320.60
227_T231_S0.9310.60
158_L189_V0.9280.60
355_R452_E0.9270.60
158_L162_A0.9230.59
138_L282_I0.9190.59
372_Q385_V0.9190.59
108_V333_A0.9160.59
413_P421_L0.9160.59
82_P433_V0.9130.58
293_G302_A0.9130.58
183_A290_S0.9120.58
158_L186_I0.9120.58
266_D271_G0.9110.58
44_L52_R0.9100.58
209_N212_R0.9090.58
382_E385_V0.9070.58
18_L21_D0.9070.58
42_Q75_E0.9040.58
163_A315_L0.8980.57
8_L51_I0.8970.57
433_V455_Q0.8970.57
129_H316_Q0.8960.57
196_T252_D0.8910.57
90_V450_C0.8870.56
388_M408_A0.8840.56
278_P291_F0.8820.56
365_Q389_P0.8820.56
16_D19_L0.8800.56
162_A320_L0.8670.54
291_F306_V0.8620.54
38_E140_R0.8620.54
339_R342_L0.8570.54
333_A337_T0.8560.53
91_L320_L0.8520.53
392_S408_A0.8510.53
310_E378_H0.8490.53
122_L311_M0.8450.53
19_L33_H0.8430.52
157_V259_L0.8430.52
266_D270_Y0.8390.52
155_A324_L0.8390.52
171_V219_T0.8380.52
101_A352_P0.8380.52
84_I455_Q0.8380.52
305_I312_I0.8330.51
245_V286_V0.8280.51
131_D326_A0.8280.51
18_L411_F0.8270.51
197_L283_A0.8270.51
40_L166_S0.8260.51
16_D205_R0.8230.51
112_M321_K0.8230.51
224_K238_A0.8230.51
368_A371_L0.8210.50
279_Q283_A0.8200.50
424_L444_L0.8190.50
98_A296_L0.8170.50
24_F68_V0.8160.50
179_E205_R0.8160.50
42_Q71_R0.8160.50
100_Q112_M0.8120.50
160_M221_L0.8120.50
329_M425_A0.8120.50
104_A333_A0.8100.49
209_N237_K0.8100.49
66_Q69_D0.8100.49
385_V411_F0.8100.49
108_V316_Q0.8090.49
157_V290_S0.8090.49
169_E196_T0.8070.49
189_V202_T0.8050.49
364_I407_A0.8040.49
71_R74_K0.8040.49
83_V122_L0.8020.49
171_V214_A0.8010.49
116_V133_A0.7990.49
81_R432_P0.7940.48
392_S449_R0.7940.48
120_Y153_N0.7940.48
392_S450_C0.7920.48
357_L398_S0.7890.48
266_D269_Q0.7890.48
49_E53_G0.7780.47
165_A221_L0.7780.47
111_A116_V0.7770.47
90_V364_I0.7760.47
120_Y126_G0.7760.47
371_L409_L0.7730.46
137_L335_E0.7730.46
120_Y425_A0.7720.46
91_L351_L0.7700.46
452_E456_R0.7670.46
319_P324_L0.7650.46
394_I398_S0.7640.45
216_N219_T0.7640.45
176_E321_K0.7600.45
143_G283_A0.7600.45
370_R453_D0.7590.45
89_T394_I0.7570.45
56_T64_W0.7520.44
16_D111_A0.7510.44
43_M46_E0.7510.44
183_A190_M0.7500.44
190_M207_H0.7500.44
16_D189_V0.7480.44
27_L31_Y0.7460.44
357_L394_I0.7460.44
163_A166_S0.7460.44
89_T393_Q0.7430.44
186_I190_M0.7430.44
313_A362_E0.7430.44
7_S10_S0.7420.44
19_L36_V0.7420.44
46_E55_Q0.7400.43
341_Y351_L0.7400.43
142_T264_L0.7390.43
282_I289_V0.7390.43
18_L198_H0.7360.43
120_Y320_L0.7350.43
51_I225_V0.7330.43
248_G443_R0.7330.43
177_L259_L0.7320.43
406_S450_C0.7310.43
21_D253_V0.7300.43
153_N230_Y0.7290.42
212_R251_L0.7290.42
8_L223_M0.7280.42
15_I280_E0.7270.42
278_P282_I0.7260.42
190_M197_L0.7240.42
108_V332_A0.7230.42
440_Y444_L0.7210.42
100_Q333_A0.7210.42
24_F40_L0.7210.42
316_Q326_A0.7200.42
158_L288_L0.7170.41
171_V198_H0.7170.41
148_C396_S0.7170.41
62_E243_E0.7130.41
162_A205_R0.7130.41
131_D205_R0.7120.41
23_S27_L0.7100.41
86_L89_T0.7080.41
161_L182_G0.7080.41
106_E109_A0.7050.40
158_L173_S0.7020.40
282_I285_G0.7010.40
369_Q373_A0.7000.40
180_I202_T0.7000.40
38_E342_L0.7000.40
163_A406_S0.7000.40
141_I269_Q0.7000.40
10_S137_L0.6990.40
166_S188_D0.6980.40
216_N242_A0.6980.40
223_M256_V0.6970.40
164_T254_P0.6970.40
288_L310_E0.6960.40
172_V177_L0.6940.40
108_V330_T0.6930.39
68_V71_R0.6920.39
172_V225_V0.6920.39
187_P197_L0.6890.39
175_G227_T0.6890.39
139_C147_A0.6890.39
147_A450_C0.6880.39
49_E52_R0.6880.39
315_L356_L0.6880.39
12_L18_L0.6880.39
95_L161_L0.6870.39
90_V393_Q0.6870.39
224_K257_T0.6820.39
70_A168_K0.6810.38
160_M273_P0.6780.38
406_S437_G0.6770.38
67_E435_V0.6740.38
69_D73_T0.6730.38
91_L236_T0.6700.38
355_R364_I0.6690.37
340_L344_P0.6670.37
368_A450_C0.6660.37
344_P354_L0.6630.37
267_L270_Y0.6630.37
367_Q453_D0.6630.37
191_R198_H0.6620.37
227_T232_I0.6610.37
190_M354_L0.6590.37
91_L205_R0.6590.37
247_L250_E0.6580.37
156_A178_V0.6580.37
46_E67_E0.6580.37
146_D257_T0.6560.36
40_L68_V0.6540.36
105_V112_M0.6540.36
145_E304_I0.6520.36
269_Q344_P0.6520.36
252_D310_E0.6500.36
98_A148_C0.6490.36
172_V219_T0.6480.36
32_G35_R0.6450.36
122_L434_P0.6450.36
273_P357_L0.6450.36
50_V56_T0.6430.35
24_F36_V0.6430.35
399_L402_D0.6410.35
43_M67_E0.6390.35
134_L138_L0.6380.35
23_S69_D0.6370.35
116_V450_C0.6370.35
160_M188_D0.6350.35
165_A248_G0.6340.35
64_W68_V0.6340.35
58_P62_E0.6330.35
21_D65_A0.6320.35
100_Q104_A0.6320.35
89_T364_I0.6310.34
340_L350_K0.6300.34
390_C440_Y0.6260.34
90_V390_C0.6260.34
220_A253_V0.6250.34
281_L284_A0.6240.34
17_R171_V0.6240.34
153_N173_S0.6230.34
15_I41_R0.6220.34
104_A331_L0.6220.34
115_P406_S0.6220.34
106_E110_Q0.6210.34
98_A402_D0.6210.34
345_E350_K0.6200.34
10_S231_S0.6200.34
408_A448_L0.6200.34
396_S450_C0.6180.33
238_A241_E0.6180.33
189_V435_V0.6180.33
288_L314_R0.6170.33
146_D450_C0.6170.33
178_V225_V0.6160.33
263_S399_L0.6160.33
16_D256_V0.6140.33
105_V290_S0.6140.33
329_M333_A0.6130.33
266_D411_F0.6100.33
74_K110_Q0.6100.33
142_T306_V0.6100.33
167_G196_T0.6090.33
158_L206_T0.6090.33
39_L43_M0.6090.33
55_Q62_E0.6090.33
352_P356_L0.6080.33
223_M253_V0.6080.33
125_A429_R0.6080.33
392_S399_L0.6080.33
232_I430_E0.6070.33
238_A249_K0.6070.33
351_L356_L0.6060.32
98_A137_L0.6060.32
177_L187_P0.6060.32
115_P148_C0.6040.32
104_A146_D0.6040.32
131_D396_S0.6010.32
78_S107_A0.5990.32
16_D187_P0.5990.32
230_Y263_S0.5980.32
16_D33_H0.5980.32
27_L69_D0.5980.32
82_P455_Q0.5970.32
186_I225_V0.5960.32
183_A267_L0.5930.31
158_L290_S0.5930.31
26_S215_V0.5930.31
197_L230_Y0.5910.31
21_D243_E0.5900.31
321_K396_S0.5890.31
112_M408_A0.5890.31
269_Q358_T0.5890.31
54_S357_L0.5890.31
158_L278_P0.5880.31
81_R308_K0.5870.31
128_G132_R0.5870.31
427_R435_V0.5850.31
244_L247_L0.5850.31
25_L443_R0.5830.31
94_N396_S0.5820.31
102_E105_V0.5820.31
123_D430_E0.5810.31
137_L211_Y0.5800.31
26_S29_D0.5800.31
65_A69_D0.5790.30
394_I399_L0.5780.30
166_S191_R0.5770.30
120_Y398_S0.5770.30
255_V282_I0.5760.30
14_A425_A0.5760.30
384_A412_T0.5750.30
43_M64_W0.5750.30
98_A192_Q0.5740.30
253_V385_V0.5730.30
29_D363_V0.5720.30
364_I392_S0.5720.30
281_L398_S0.5710.30
259_L278_P0.5710.30
141_I279_Q0.5710.30
360_S363_V0.5700.30
101_A336_A0.5700.30
18_L403_R0.5680.30
332_A336_A0.5680.30
244_L255_V0.5670.30
23_S62_E0.5660.30
426_A446_L0.5660.30
117_T326_A0.5650.29
162_A315_L0.5650.29
138_L145_E0.5650.29
32_G343_H0.5650.29
353_T406_S0.5640.29
178_V191_R0.5640.29
263_S277_M0.5640.29
331_L404_L0.5640.29
122_L202_T0.5640.29
305_I315_L0.5630.29
19_L22_S0.5620.29
355_R363_V0.5620.29
316_Q425_A0.5620.29
356_L452_E0.5620.29
167_G218_N0.5610.29
165_A256_V0.5610.29
102_E361_A0.5610.29
300_P333_A0.5600.29
128_G173_S0.5600.29
104_A113_R0.5600.29
259_L290_S0.5590.29
16_D20_R0.5580.29
42_Q136_Q0.5570.29
385_V408_A0.5560.29
133_A331_L0.5540.29
86_L359_R0.5540.29
40_L114_S0.5540.29
421_L439_I0.5530.29
117_T330_T0.5510.28
187_P356_L0.5510.28
270_Y357_L0.5500.28
349_E363_V0.5500.28
183_A257_T0.5500.28
18_L65_A0.5490.28
90_V353_T0.5480.28
165_A195_C0.5470.28
24_F163_A0.5460.28
35_R76_A0.5460.28
370_R454_E0.5450.28
141_I182_G0.5430.28
116_V327_D0.5420.28
241_E255_V0.5410.28
293_G327_D0.5410.28
256_V268_S0.5400.28
206_T449_R0.5400.28
67_E70_A0.5390.28
163_A314_R0.5380.28
145_E316_Q0.5380.28
230_Y345_E0.5380.28
14_A259_L0.5370.27
198_H242_A0.5370.27
129_H133_A0.5360.27
232_I391_L0.5360.27
223_M290_S0.5360.27
400_P438_R0.5360.27
318_H321_K0.5350.27
160_M315_L0.5350.27
273_P358_T0.5350.27
413_P444_L0.5340.27
255_V286_V0.5340.27
371_L448_L0.5340.27
263_S267_L0.5340.27
66_Q369_Q0.5330.27
224_K241_E0.5320.27
202_T296_L0.5310.27
128_G161_L0.5310.27
112_M329_M0.5310.27
100_Q129_H0.5300.27
250_E283_A0.5300.27
332_A337_T0.5290.27
187_P272_L0.5280.27
196_T314_R0.5270.27
141_I357_L0.5260.27
14_A17_R0.5250.27
176_E425_A0.5250.27
451_L454_E0.5250.27
312_I317_S0.5240.27
249_K255_V0.5230.26
189_V326_A0.5230.26
54_S62_E0.5230.26
257_T263_S0.5210.26
9_Y14_A0.5210.26
183_A329_M0.5200.26
188_D399_L0.5200.26
53_G124_D0.5180.26
360_S406_S0.5170.26
16_D48_R0.5170.26
230_Y359_R0.5170.26
221_L255_V0.5170.26
166_S409_L0.5160.26
182_G316_Q0.5160.26
159_L321_K0.5140.26
169_E198_H0.5140.26
245_V282_I0.5130.26
53_G369_Q0.5130.26
52_R186_I0.5130.26
304_I447_D0.5130.26
270_Y398_S0.5130.26
336_A340_L0.5120.26
129_H230_Y0.5120.26
32_G456_R0.5120.26
310_E386_Q0.5110.26
123_D426_A0.5110.26
170_V220_A0.5100.26
172_V206_T0.5100.26
172_V195_C0.5090.26
356_L359_R0.5090.26
163_A230_Y0.5090.26
190_M193_A0.5090.26
91_L189_V0.5090.26
363_V453_D0.5080.25
33_H290_S0.5080.25
172_V190_M0.5070.25
336_A425_A0.5070.25
192_Q315_L0.5070.25
153_N177_L0.5070.25
208_A407_A0.5060.25
302_A326_A0.5050.25
35_R72_L0.5050.25
165_A358_T0.5040.25
121_D124_D0.5030.25
290_S305_I0.5030.25
165_A255_V0.5030.25
36_V68_V0.5020.25
362_E374_P0.5010.25
146_D313_A0.5010.25
91_L222_L0.5000.25
93_T181_G0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wcnA 2 0.9546 100 0.653 Contact Map
3wcoA 2 0.8164 100 0.752 Contact Map
3madA 2 0.8013 99.9 0.88 Contact Map
4w8iA 2 0.7106 99.9 0.885 Contact Map
3mc6A 2 0.7797 99.8 0.893 Contact Map
4lhdA 2 0.8423 99.8 0.896 Contact Map
3tqxA 2 0.784 99.7 0.905 Contact Map
4q6rA 2 0.7775 99.7 0.906 Contact Map
2vi8A 2 0.7451 99.7 0.907 Contact Map
2yrrA 2 0.6803 99.7 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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