GREMLIN Database
METK - S-adenosylmethionine synthase
UniProt: P0A817 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10589
Length: 384 (378)
Sequences: 3043 (1247)
Seq/√Len: 64.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_N293_D5.6161.00
45_Y54_G4.0301.00
319_E323_S3.6811.00
74_R87_A3.6161.00
146_V167_S3.3431.00
31_I38_A3.3221.00
172_Q180_G3.1721.00
257_R296_E3.0481.00
30_A33_E2.9511.00
300_S309_T2.8331.00
12_S165_A2.7881.00
160_W202_A2.7421.00
133_V140_T2.6321.00
268_P352_Y2.6161.00
233_I238_G2.5691.00
20_A46_V2.5081.00
182_D222_K2.4771.00
293_D320_K2.4441.00
75_E353_K2.4161.00
37_K348_L2.4121.00
5_L170_T2.3571.00
148_R151_E2.3141.00
74_R88_N2.3041.00
196_Q200_Q2.2891.00
307_E331_R2.2771.00
329_L333_F2.2711.00
67_E71_N2.2231.00
371_T374_A2.2221.00
180_G218_T2.2021.00
279_A299_V2.1971.00
115_Q269_S2.1871.00
205_E209_K2.1811.00
137_A141_Y2.1731.00
19_I76_I2.1671.00
53_V69_T2.1671.00
42_C57_I2.1541.00
337_R340_G2.1391.00
31_I59_T2.1091.00
355_T366_F2.0751.00
151_E155_N2.0591.00
102_D230_R2.0441.00
53_V65_I2.0321.00
282_V336_L1.9811.00
134_L371_T1.9801.00
39_R108_D1.9591.00
24_S44_T1.9501.00
104_N108_D1.9391.00
34_Q61_A1.9381.00
72_T353_K1.9231.00
346_D349_H1.9221.00
278_A336_L1.8951.00
79_V83_M1.8951.00
204_M209_K1.8901.00
286_I295_C1.8741.00
184_V212_L1.8611.00
186_L203_V1.8041.00
183_A224_F1.7821.00
26_A353_K1.7541.00
51_V73_V1.7330.99
22_Q26_A1.7160.99
281_Y372_D1.7000.99
187_S227_P1.6840.99
22_Q356_A1.6790.99
217_L223_F1.6690.99
195_D198_S1.6420.99
45_Y52_L1.6320.99
12_S146_V1.6150.99
321_V329_L1.6120.99
296_E316_F1.6100.99
147_Q151_E1.6040.99
354_E366_F1.6010.99
325_Q328_L1.5860.99
198_S202_A1.5730.99
328_L332_E1.5700.99
105_Q228_T1.5680.99
354_E365_H1.5510.99
145_L186_L1.5460.99
333_F380_A1.5430.99
13_E154_K1.5400.99
13_E150_A1.5390.99
146_V165_A1.5330.99
22_Q72_T1.5310.99
291_L377_L1.5180.99
321_V325_Q1.5160.99
355_T361_F1.5160.99
139_I143_H1.5140.99
281_Y344_M1.4920.98
47_K97_G1.4740.98
54_G240_C1.4740.98
13_E358_Y1.4690.98
27_V42_C1.4660.98
257_R316_F1.4570.98
282_V330_V1.4450.98
181_I212_L1.4420.98
50_M91_A1.4340.98
106_G228_T1.4220.98
64_D67_E1.4150.98
188_T203_V1.3980.98
201_E205_E1.3840.97
46_V51_V1.3710.97
339_Y343_Q1.3690.97
200_Q204_M1.3670.97
6_F124_F1.3500.97
278_A344_M1.3410.97
26_A72_T1.3360.97
344_M373_K1.3330.97
322_P325_Q1.3290.97
38_A60_S1.3280.97
73_V85_F1.3210.97
340_G344_M1.3200.97
157_T206_E1.3110.96
255_M294_R1.3060.96
373_K376_L1.3020.96
26_A68_I1.2950.96
329_L380_A1.2930.96
112_P343_Q1.2860.96
162_R191_S1.2840.96
60_S101_P1.2760.96
45_Y240_C1.2710.96
71_N75_E1.2660.96
319_E326_L1.2650.96
149_Q165_A1.2580.95
333_F374_A1.2580.95
218_T221_T1.2570.95
31_I57_I1.2560.95
269_S348_L1.2540.95
278_A281_Y1.2430.95
27_V65_I1.2290.95
334_F373_K1.2280.95
144_R147_Q1.1980.94
202_A206_E1.1970.94
217_L221_T1.1910.94
332_E380_A1.1890.94
286_I292_A1.1870.94
73_V90_C1.1860.94
286_I291_L1.1860.94
79_V87_A1.1840.94
148_R210_P1.1840.94
80_H83_M1.1770.94
376_L379_D1.1660.93
50_M93_L1.1570.93
102_D232_V1.1550.93
194_I199_L1.1530.93
158_L202_A1.1510.93
49_G91_A1.1480.93
183_A222_K1.1460.93
375_Q378_R1.1430.93
278_A282_V1.1240.92
19_I46_V1.1200.92
374_A378_R1.1100.91
3_K174_D1.1090.91
147_Q366_F1.1040.91
65_I94_S1.1030.91
154_K358_Y1.1000.91
315_T326_L1.0940.91
10_S143_H1.0870.91
313_V330_V1.0840.90
138_P255_M1.0790.90
354_E367_P1.0740.90
329_L377_L1.0730.90
71_N74_R1.0720.90
208_I223_F1.0700.90
112_P339_Y1.0700.90
174_D179_V1.0660.90
152_V207_I1.0650.90
335_D340_G1.0610.89
329_L374_A1.0530.89
68_I72_T1.0480.89
213_P216_W1.0480.89
31_I63_V1.0480.89
196_Q199_L1.0480.89
333_F376_L1.0470.89
160_W194_I1.0450.89
314_E323_S1.0410.89
171_F181_I1.0340.88
80_H88_N1.0270.88
148_R152_V1.0260.88
66_E94_S1.0240.88
75_E154_K1.0210.88
133_V144_R1.0180.87
50_M95_A1.0170.87
122_L276_A1.0120.87
172_Q218_T1.0110.87
307_E335_D1.0060.87
134_L288_A1.0040.87
285_N374_A0.9960.86
299_V311_I0.9880.86
69_T72_T0.9860.86
30_A34_Q0.9820.85
62_W65_I0.9810.85
206_E210_P0.9780.85
3_K172_Q0.9750.85
58_T101_P0.9750.85
152_V165_A0.9740.85
12_S149_Q0.9740.85
314_E319_E0.9730.85
62_W98_K0.9720.85
67_E98_K0.9710.85
30_A63_V0.9670.85
105_Q230_R0.9660.84
63_V68_I0.9660.84
361_F366_F0.9630.84
286_I377_L0.9620.84
286_I330_V0.9610.84
51_V69_T0.9590.84
39_R58_T0.9570.84
129_N320_K0.9540.84
356_A363_R0.9530.84
148_R206_E0.9480.83
72_T75_E0.9470.83
149_Q188_T0.9440.83
313_V323_S0.9420.83
133_V364_E0.9390.83
315_T323_S0.9390.83
199_L202_A0.9370.83
357_A363_R0.9360.83
150_A358_Y0.9330.82
197_K201_E0.9230.82
212_L217_L0.9210.82
113_L339_Y0.9210.82
58_T104_N0.9150.81
306_A337_R0.9120.81
299_V336_L0.9110.81
52_L95_A0.9100.81
248_I258_H0.9090.81
203_V225_I0.9050.80
376_L380_A0.9040.80
137_A171_F0.9010.80
135_M362_G0.8980.80
22_Q353_K0.8960.80
81_S237_M0.8940.80
79_V88_N0.8920.79
20_A51_V0.8910.79
115_Q348_L0.8870.79
124_F248_I0.8860.79
291_L326_L0.8860.79
324_E327_T0.8860.79
319_E325_Q0.8850.79
327_T331_R0.8790.78
126_Y255_M0.8750.78
111_D114_E0.8730.78
91_A95_A0.8720.78
149_Q207_I0.8710.78
49_G95_A0.8700.78
39_R104_N0.8660.77
150_A154_K0.8650.77
349_H365_H0.8650.77
149_Q152_V0.8630.77
62_W96_I0.8620.77
130_E294_R0.8610.77
174_D177_K0.8610.77
30_A68_I0.8610.77
345_L367_P0.8510.76
140_T144_R0.8480.76
49_G66_E0.8480.76
160_W198_S0.8470.76
172_Q182_D0.8460.76
28_L40_V0.8460.76
19_I73_V0.8450.76
227_P302_A0.8430.75
319_E322_P0.8370.75
365_H370_K0.8370.75
203_V207_I0.8320.74
123_M271_V0.8260.74
148_R157_T0.8230.74
13_E153_R0.8220.74
204_M225_I0.8210.73
19_I237_M0.8210.73
48_T97_G0.8200.73
351_I367_P0.8150.73
185_V225_I0.8110.73
31_I61_A0.8110.73
38_A61_A0.8080.72
129_N290_G0.8040.72
32_L38_A0.8020.72
371_T378_R0.7990.71
177_K293_D0.7990.71
349_H367_P0.7990.71
344_M372_D0.7990.71
185_V224_F0.7980.71
285_N371_T0.7970.71
52_L93_L0.7960.71
192_E232_V0.7950.71
66_E95_A0.7930.71
161_L188_T0.7920.71
323_S327_T0.7910.71
66_E91_A0.7900.71
19_I23_I0.7900.71
74_R79_V0.7900.71
20_A45_Y0.7880.70
38_A59_T0.7860.70
81_S86_D0.7810.70
199_L203_V0.7800.70
336_L340_G0.7770.69
59_T62_W0.7770.69
268_P342_I0.7750.69
325_Q332_E0.7730.69
115_Q339_Y0.7730.69
372_D376_L0.7720.69
197_K200_Q0.7720.69
286_I329_L0.7720.69
97_G240_C0.7680.68
315_T319_E0.7670.68
288_A371_T0.7670.68
37_K60_S0.7630.68
321_V326_L0.7610.68
129_N177_K0.7610.68
102_D106_G0.7590.67
195_D199_L0.7590.67
268_P348_L0.7560.67
81_S89_S0.7560.67
285_N372_D0.7500.67
134_L138_P0.7500.67
162_R192_E0.7500.67
204_M223_F0.7500.67
364_E370_K0.7470.66
52_L91_A0.7430.66
5_L182_D0.7420.66
113_L307_E0.7420.66
158_L161_L0.7420.66
128_T134_L0.7380.65
49_G81_S0.7360.65
62_W66_E0.7350.65
333_F373_K0.7330.65
31_I65_I0.7330.65
4_H174_D0.7320.65
275_A299_V0.7320.65
187_S302_A0.7300.64
363_R366_F0.7270.64
342_I348_L0.7260.64
152_V158_L0.7260.64
299_V337_R0.7230.64
113_L337_R0.7210.64
167_S186_L0.7210.64
346_D370_K0.7190.63
148_R211_I0.7150.63
255_M296_E0.7110.62
353_K356_A0.7110.62
101_P105_Q0.7100.62
135_M139_I0.7090.62
28_L53_V0.7090.62
325_Q329_L0.7070.62
12_S167_S0.7070.62
27_V69_T0.7060.62
83_M87_A0.6990.61
89_S237_M0.6980.61
295_C377_L0.6970.61
311_I331_R0.6960.61
82_D88_N0.6960.61
345_L355_T0.6950.61
148_R155_N0.6940.61
375_Q379_D0.6930.60
333_F377_L0.6930.60
47_K95_A0.6920.60
281_Y373_K0.6920.60
183_A309_T0.6890.60
274_S341_L0.6890.60
149_Q186_L0.6890.60
194_I202_A0.6860.60
113_L343_Q0.6850.60
99_Q103_I0.6850.60
146_V149_Q0.6840.59
346_D367_P0.6840.59
91_A94_S0.6830.59
145_L167_S0.6830.59
256_A296_E0.6820.59
109_R112_P0.6750.58
101_P233_I0.6750.58
152_V157_T0.6720.58
212_L216_W0.6700.58
294_R316_F0.6640.57
147_Q354_E0.6630.57
224_F309_T0.6630.57
285_N288_A0.6600.57
358_Y363_R0.6590.57
160_W199_L0.6580.57
112_P337_R0.6580.57
152_V161_L0.6560.56
289_A377_L0.6550.56
176_G294_R0.6550.56
306_A338_P0.6540.56
86_D90_C0.6530.56
281_Y285_N0.6520.56
377_L380_A0.6490.55
313_V327_T0.6480.55
251_T258_H0.6460.55
102_D233_I0.6460.55
48_T237_M0.6450.55
83_M191_S0.6440.55
210_P213_P0.6440.55
71_N353_K0.6430.55
109_R339_Y0.6410.55
122_L255_M0.6390.54
19_I85_F0.6380.54
281_Y333_F0.6380.54
49_G62_W0.6350.54
295_C330_V0.6340.54
181_I217_L0.6340.54
138_P178_I0.6340.54
66_E97_G0.6340.54
159_P191_S0.6320.54
128_T135_M0.6290.53
85_F90_C0.6290.53
171_F216_W0.6290.53
109_R115_Q0.6290.53
34_Q59_T0.6270.53
102_D228_T0.6270.53
348_L352_Y0.6270.53
209_K217_L0.6260.53
94_S97_G0.6260.53
350_P354_E0.6230.52
364_E367_P0.6220.52
319_E327_T0.6220.52
12_S152_V0.6200.52
58_T108_D0.6200.52
126_Y294_R0.6190.52
286_I326_L0.6190.52
85_F89_S0.6180.52
286_I315_T0.6170.52
312_M330_V0.6160.52
103_I107_V0.6150.52
115_Q342_I0.6110.51
149_Q161_L0.6100.51
34_Q60_S0.6090.51
329_L376_L0.6060.50
35_D38_A0.6050.50
291_L295_C0.6040.50
291_L330_V0.6030.50
327_T330_V0.6020.50
281_Y371_T0.6020.50
155_N158_L0.6000.50
23_I46_V0.5990.50
108_D228_T0.5990.50
102_D105_Q0.5990.50
49_G93_L0.5980.50
291_L319_E0.5980.50
278_A341_L0.5970.49
113_L340_G0.5950.49
123_M299_V0.5950.49
66_E69_T0.5950.49
193_E230_R0.5870.48
109_R113_L0.5870.48
34_Q63_V0.5860.48
294_R314_E0.5860.48
208_I221_T0.5840.48
148_R207_I0.5840.48
192_E230_R0.5830.48
137_A178_I0.5810.48
251_T254_G0.5800.47
69_T90_C0.5800.47
47_K66_E0.5790.47
51_V90_C0.5790.47
31_I60_S0.5790.47
328_L331_R0.5790.47
158_L194_I0.5740.47
104_N109_R0.5740.47
6_F255_M0.5730.47
158_L199_L0.5730.47
65_I96_I0.5720.47
335_D343_Q0.5710.46
103_I116_G0.5700.46
48_T85_F0.5700.46
256_A336_L0.5690.46
135_M363_R0.5680.46
124_F254_G0.5680.46
180_G221_T0.5680.46
99_Q116_G0.5670.46
132_D292_A0.5660.46
160_W191_S0.5650.46
322_P326_L0.5650.46
352_Y367_P0.5650.46
307_E337_R0.5640.46
315_T318_T0.5610.45
49_G92_V0.5610.45
123_M301_Y0.5610.45
256_A297_I0.5590.45
282_V297_I0.5590.45
135_M178_I0.5580.45
367_P370_K0.5570.45
20_A54_G0.5560.45
12_S150_A0.5550.45
66_E81_S0.5550.45
218_T224_F0.5530.44
124_F298_Q0.5530.44
121_G261_G0.5520.44
36_P348_L0.5520.44
105_Q110_A0.5520.44
176_G179_V0.5510.44
142_A165_A0.5510.44
331_R335_D0.5510.44
138_P173_Y0.5510.44
64_D98_K0.5500.44
54_G94_S0.5490.44
189_Q234_G0.5480.44
58_T98_K0.5480.44
182_D224_F0.5470.44
374_A380_A0.5470.44
176_G293_D0.5470.44
140_T147_Q0.5460.44
112_P340_G0.5420.43
295_C371_T0.5420.43
20_A240_C0.5420.43
318_T321_V0.5410.43
7_T170_T0.5400.43
139_I142_A0.5390.43
180_G220_A0.5370.43
330_V333_F0.5370.43
160_W206_E0.5350.42
47_K50_M0.5350.42
128_T255_M0.5340.42
83_M237_M0.5340.42
174_D178_I0.5330.42
290_G378_R0.5330.42
180_G216_W0.5300.42
4_H312_M0.5300.42
47_K53_V0.5300.42
83_M86_D0.5280.42
346_D352_Y0.5280.42
305_V338_P0.5270.41
47_K54_G0.5270.41
209_K214_A0.5260.41
82_D192_E0.5250.41
282_V334_F0.5250.41
23_I51_V0.5240.41
326_L377_L0.5240.41
5_L172_Q0.5240.41
24_S247_I0.5240.41
137_A216_W0.5240.41
112_P344_M0.5240.41
330_V334_F0.5230.41
228_T305_V0.5220.41
46_V97_G0.5210.41
97_G237_M0.5210.41
132_D364_E0.5210.41
170_T183_A0.5200.41
122_L297_I0.5200.41
189_Q231_F0.5200.41
302_A305_V0.5190.41
34_Q62_W0.5190.41
90_C295_C0.5180.40
158_L203_V0.5180.40
20_A128_T0.5170.40
165_A207_I0.5170.40
355_T367_P0.5160.40
152_V206_E0.5160.40
110_A113_L0.5150.40
140_T184_V0.5140.40
6_F298_Q0.5130.40
81_S85_F0.5130.40
86_D89_S0.5130.40
122_L138_P0.5120.40
269_S342_I0.5120.40
50_M94_S0.5120.40
62_W91_A0.5120.40
204_M208_I0.5110.40
195_D201_E0.5090.39
85_F149_Q0.5080.39
335_D344_M0.5080.39
299_V340_G0.5070.39
295_C315_T0.5050.39
222_K307_E0.5050.39
70_R90_C0.5050.39
129_N132_D0.5040.39
65_I69_T0.5020.39
35_D58_T0.5010.39
279_A311_I0.5000.38
320_K332_E0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s82A 4 0.9479 100 0.064 Contact Map
3imlA 2 0.9479 100 0.065 Contact Map
1p7lA 4 0.9974 100 0.066 Contact Map
3so4A 4 0.974 100 0.072 Contact Map
2p02A 2 0.9766 100 0.08 Contact Map
4le5A 2 0.9661 100 0.085 Contact Map
4odjA 2 0.974 100 0.088 Contact Map
4l7iA 3 0.8672 100 0.371 Contact Map
4l4qA 3 0.888 98.8 0.935 Contact Map
1csnA 2 0.1797 42 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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