GREMLIN Database
RUVC - Crossover junction endodeoxyribonuclease RuvC
UniProt: P0A814 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10925
Length: 173 (155)
Sequences: 2550 (1527)
Seq/√Len: 122.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_I20_R3.7781.00
64_F92_A3.7591.00
107_V146_I3.6561.00
57_T95_Q3.2491.00
105_R116_S3.2071.00
28_Y31_S3.1441.00
102_Y150_H3.0221.00
4_I151_C2.7961.00
26_L148_I2.6991.00
46_K50_A2.5451.00
17_G144_L2.4781.00
63_Y154_S2.1911.00
49_Y94_N2.0651.00
126_V148_I2.0571.00
49_Y91_A2.0421.00
53_T94_N2.0251.00
20_R27_S1.9501.00
13_V35_R1.9161.00
132_L136_P1.8641.00
40_D43_S1.8531.00
16_Y32_G1.8481.00
103_A106_Q1.7521.00
123_Q141_A1.7391.00
124_H127_R1.6991.00
53_T95_Q1.6541.00
3_I29_L1.5991.00
65_A146_I1.5801.00
20_R29_L1.5581.00
33_C140_A1.5531.00
51_G54_E1.5371.00
50_A94_N1.5351.00
46_K93_V1.5331.00
5_L56_I1.5221.00
127_R135_N1.4761.00
46_K94_N1.4321.00
21_Q26_L1.4251.00
54_E58_Q1.4141.00
30_G58_Q1.4051.00
124_H128_T1.4031.00
87_V90_V1.3941.00
11_S80_K1.3881.00
30_G59_F1.3651.00
28_Y144_L1.3621.00
21_Q151_C1.3431.00
79_L82_G1.3281.00
136_P141_A1.2951.00
49_Y90_V1.2801.00
107_V145_A1.2430.99
45_L87_V1.2200.99
41_L83_Q1.2150.99
63_Y150_H1.2140.99
19_I151_C1.1980.99
90_V94_N1.1970.99
49_Y53_T1.1940.99
46_K96_E1.1840.99
85_R101_E1.1840.99
102_Y149_T1.1750.99
13_V139_D1.1620.99
16_Y30_G1.1480.99
74_N77_S1.1290.99
148_I152_H1.1240.99
47_L51_G1.1130.99
68_Q76_D1.0910.99
5_L64_F1.0850.99
29_L59_F1.0810.99
71_M78_A1.0790.99
31_S140_A1.0720.98
5_L18_V1.0630.98
121_Q125_M1.0610.98
106_Q153_V1.0550.98
7_I88_A1.0470.98
73_K76_D1.0380.98
11_S41_L1.0330.98
65_A150_H1.0320.98
72_A78_A1.0140.98
100_F150_H1.0090.98
138_A141_A1.0050.98
14_T88_A1.0040.98
34_I51_G0.9880.97
56_I91_A0.9820.97
76_D80_K0.9680.97
42_P93_V0.9590.97
64_F97_L0.9480.97
7_I52_V0.9370.96
19_I144_L0.9260.96
68_Q72_A0.9260.96
123_Q127_R0.9150.96
37_K47_L0.9150.96
75_A78_A0.9120.96
105_R114_I0.8820.95
125_M129_L0.8750.95
123_Q135_N0.8720.95
66_I86_G0.8680.94
26_L151_C0.8680.94
66_I89_I0.8650.94
53_T57_T0.8490.94
106_Q110_T0.8490.94
18_V59_F0.8450.94
18_V29_L0.8310.93
71_M81_L0.8300.93
14_T34_I0.8290.93
52_V91_A0.8240.93
63_Y98_P0.8240.93
56_I95_Q0.8150.92
13_V33_C0.8080.92
12_R38_V0.8050.92
22_V25_Q0.7960.91
48_I88_A0.7940.91
127_R134_A0.7930.91
43_S93_V0.7890.91
18_V55_I0.7810.91
75_A81_L0.7800.91
4_I19_I0.7740.90
11_S36_T0.7730.90
6_G147_A0.7730.90
17_G143_A0.7700.90
111_V129_L0.7690.90
92_A99_V0.7660.90
12_R36_T0.7640.90
120_S124_H0.7580.89
112_V122_V0.7570.89
77_S139_D0.7570.89
69_V83_Q0.7550.89
3_I59_F0.7520.89
69_V85_R0.7470.89
112_V117_A0.7370.88
21_Q24_R0.7350.88
16_Y51_G0.7330.88
89_I93_V0.7310.88
34_I48_I0.7280.87
89_I101_E0.7270.87
72_A116_S0.7260.87
71_M76_D0.7230.87
129_L152_H0.7140.86
56_I97_L0.7100.86
72_A75_A0.7100.86
57_T60_Q0.7070.86
122_V145_A0.7060.86
66_I88_A0.6960.85
76_D105_R0.6890.84
43_S50_A0.6890.84
45_L83_Q0.6860.84
45_L84_A0.6860.84
6_G10_G0.6850.84
68_Q104_A0.6850.84
69_V81_L0.6840.84
10_G13_V0.6810.84
78_A82_G0.6760.83
25_Q131_K0.6730.83
86_G90_V0.6730.83
16_Y55_I0.6710.83
11_S81_L0.6690.83
12_R37_K0.6660.82
68_Q106_Q0.6640.82
75_A82_G0.6630.82
110_T149_T0.6590.82
105_R109_Q0.6540.81
52_V88_A0.6510.81
17_G130_L0.6510.81
63_Y102_Y0.6500.81
41_L80_K0.6480.81
22_V27_S0.6470.80
130_L148_I0.6380.80
88_A93_V0.6330.79
120_S123_Q0.6330.79
69_V105_R0.6320.79
63_Y100_F0.6270.78
70_F103_A0.6270.78
9_P84_A0.6230.78
12_R81_L0.6220.78
49_Y87_V0.6210.78
32_G55_I0.6210.78
127_R136_P0.6170.77
50_A54_E0.6140.77
132_L138_A0.6090.76
133_P136_P0.6080.76
56_I92_A0.6080.76
65_A102_Y0.6080.76
36_T48_I0.6070.76
126_V145_A0.6050.76
30_G55_I0.6020.76
46_K90_V0.6010.75
47_L50_A0.6000.75
14_T48_I0.5980.75
71_M105_R0.5980.75
106_Q109_Q0.5980.75
109_Q114_I0.5950.75
72_A79_L0.5930.74
68_Q101_E0.5910.74
78_A81_L0.5890.74
49_Y86_G0.5890.74
23_G26_L0.5870.74
17_G28_Y0.5860.74
55_I143_A0.5860.74
54_E57_T0.5840.73
103_A114_I0.5800.73
3_I18_V0.5750.72
40_D98_P0.5710.72
45_L90_V0.5660.71
69_V72_A0.5630.71
3_I62_D0.5630.71
56_I61_P0.5580.70
4_I21_Q0.5580.70
91_A95_Q0.5540.69
74_N125_M0.5530.69
77_S80_K0.5500.69
52_V56_I0.5500.69
33_C137_Q0.5500.69
11_S72_A0.5500.69
45_L88_A0.5480.69
76_D81_L0.5470.68
84_A91_A0.5450.68
26_L152_H0.5440.68
27_S156_N0.5430.68
112_V124_H0.5410.68
71_M104_A0.5380.67
68_Q77_S0.5340.67
6_G9_P0.5320.66
112_V121_Q0.5290.66
11_S79_L0.5260.65
134_A137_Q0.5250.65
81_L88_A0.5220.65
70_F139_D0.5190.64
124_H135_N0.5190.64
43_S157_A0.5180.64
46_K49_Y0.5160.64
31_S136_P0.5090.63
26_L129_L0.5090.63
153_V156_N0.5080.63
41_L69_V0.5050.62
51_G58_Q0.5030.62
31_S144_L0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.9133 100 0.177 Contact Map
4ep4A 2 0.9306 100 0.214 Contact Map
4ktwA 2 0.8382 100 0.284 Contact Map
1vhxA 2 0.7861 99.9 0.617 Contact Map
1nu0A 1 0.7283 99.9 0.624 Contact Map
1iv0A 1 0.5665 99.6 0.714 Contact Map
1kcfA 2 0.9306 97.2 0.873 Contact Map
4ogeA 1 0.5549 96.5 0.884 Contact Map
3psiA 1 0.8902 96.2 0.888 Contact Map
3bzcA 1 0.8208 95.8 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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