GREMLIN Database
RPIA - Ribose-5-phosphate isomerase A
UniProt: P0A7Z0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11443
Length: 219 (211)
Sequences: 2430 (1433)
Seq/√Len: 98.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_A160_V4.7961.00
13_A16_Q3.8381.00
87_N91_Q3.8011.00
75_S111_E3.2721.00
79_Y110_A3.2541.00
38_A41_T3.0351.00
183_E195_V2.9991.00
144_A169_L2.8601.00
178_D181_A2.8241.00
117_A208_I2.7591.00
23_I76_L2.5801.00
12_W38_A2.5131.00
35_F80_V2.3371.00
37_D59_K2.2601.00
90_M206_A2.2531.00
187_N195_V2.2371.00
85_E127_G2.2001.00
86_I92_M2.2001.00
86_I117_A2.1761.00
51_S57_T2.1681.00
36_I56_S2.1321.00
147_L186_I2.1151.00
86_I206_A2.1101.00
49_A65_I2.0901.00
28_T99_A1.9801.00
57_T61_K1.9671.00
24_V78_I1.9001.00
6_L119_A1.8721.00
4_D34_H1.8621.00
10_V207_L1.8141.00
112_K205_V1.8081.00
8_K12_W1.8051.00
52_S106_I1.7941.00
26_V60_L1.7821.00
96_G129_F1.7791.00
54_D57_T1.7721.00
152_G171_V1.7121.00
184_N188_A1.6991.00
88_G124_D1.6591.00
136_I193_V1.6461.00
210_T215_K1.6381.00
92_M115_C1.6281.00
146_Q149_K1.6111.00
181_A185_A1.6061.00
35_F116_I1.4691.00
122_Q208_I1.4431.00
101_T136_I1.4411.00
80_V116_I1.4401.00
68_F73_V1.4371.00
12_W41_T1.4361.00
48_G68_F1.4281.00
77_G111_E1.3890.99
102_R164_N1.3790.99
135_V169_L1.3680.99
91_Q180_I1.3570.99
6_L211_P1.3540.99
17_Y114_I1.3380.99
79_Y113_F1.3200.99
133_V171_V1.2860.99
119_A210_T1.2700.99
32_A35_F1.2620.99
150_L185_A1.2340.99
19_Q22_T1.2300.99
152_G173_G1.2210.99
183_E187_N1.2170.99
142_A190_P1.2050.98
58_E62_S1.2010.98
8_K34_H1.1960.98
108_S190_P1.1930.98
70_L109_V1.1930.98
20_P45_Q1.1790.98
119_A211_P1.1630.98
15_L42_M1.1590.98
98_A168_I1.1560.98
15_L35_F1.1540.98
86_I208_I1.1540.98
210_T214_V1.1450.98
15_L38_A1.1440.98
32_A51_S1.1440.98
5_E8_K1.1420.98
142_A146_Q1.1300.98
144_A148_V1.1260.98
33_A55_A1.1260.98
187_N190_P1.1220.98
40_G63_L1.1210.98
119_A122_Q1.1150.98
86_I122_Q1.1030.97
180_I200_N1.1000.97
83_A117_A1.0940.97
22_T78_I1.0930.97
35_F39_L1.0860.97
207_L214_V1.0820.97
100_L168_I1.0730.97
28_T52_S1.0720.97
54_D58_E1.0660.97
20_P44_G1.0610.97
117_A206_A1.0510.96
11_G15_L1.0460.96
50_V76_L1.0430.96
140_R144_A1.0420.96
79_Y107_A1.0410.96
176_I179_P1.0390.96
186_I192_V1.0350.96
110_A113_F1.0170.96
148_V153_R1.0100.96
154_P169_L1.0030.95
100_L133_V0.9970.95
33_A37_D0.9850.95
85_E123_V0.9750.95
17_Y78_I0.9730.95
34_H37_D0.9670.94
60_L67_V0.9620.94
17_Y205_V0.9620.94
112_K204_D0.9580.94
33_A59_K0.9530.94
143_V189_I0.9530.94
144_A154_P0.9500.94
209_G214_V0.9370.93
42_M45_Q0.9360.93
113_F201_R0.9300.93
20_P46_I0.9200.93
6_L209_G0.9170.93
69_D72_E0.9160.93
125_I175_E0.9150.92
125_I177_L0.9140.92
11_G34_H0.9100.92
52_S79_Y0.9060.92
161_V165_G0.9030.92
176_I182_M0.8970.92
21_G46_I0.8970.92
50_V73_V0.8870.91
17_Y112_K0.8860.91
161_V167_V0.8810.91
6_L210_T0.8790.91
160_V168_I0.8730.91
181_A184_N0.8680.90
140_R156_Y0.8680.90
17_Y207_L0.8630.90
108_S146_Q0.8560.90
131_L197_L0.8550.90
92_M203_A0.8550.90
37_D63_L0.8420.89
50_V70_L0.8400.89
8_K37_D0.8340.89
36_I59_K0.8300.88
212_D215_K0.8240.88
156_Y167_V0.8220.88
34_H38_A0.8210.88
59_K63_L0.8180.88
47_E66_H0.8090.87
140_R169_L0.8090.87
22_T77_G0.8080.87
74_D145_R0.7970.86
6_L214_V0.7960.86
145_R148_V0.7900.86
13_A207_L0.7790.85
153_R172_H0.7770.85
133_V147_L0.7750.85
102_R138_M0.7710.84
133_V186_I0.7700.84
32_A36_I0.7690.84
58_E61_K0.7660.84
85_E128_K0.7620.84
24_V47_E0.7600.83
140_R167_V0.7590.83
9_A209_G0.7590.83
130_P172_H0.7580.83
186_I195_V0.7560.83
95_G196_G0.7550.83
135_V143_V0.7510.83
154_P171_V0.7500.83
79_Y106_I0.7480.82
7_K30_S0.7430.82
59_K62_S0.7410.82
109_V142_A0.7390.82
101_T162_T0.7370.82
95_G132_P0.7360.81
68_F72_E0.7340.81
155_E172_H0.7320.81
162_T168_I0.7290.81
132_P196_G0.7280.81
28_T32_A0.7260.81
117_A122_Q0.7220.80
19_Q184_N0.7190.80
26_V56_S0.7160.80
4_D8_K0.7160.80
136_I164_N0.7150.80
37_D62_S0.7140.79
28_T34_H0.7140.79
74_D109_V0.7140.79
182_M197_L0.7110.79
55_A58_E0.7040.79
7_K31_T0.6990.78
91_Q179_P0.6890.77
71_N140_R0.6880.77
144_A156_Y0.6870.77
10_V116_I0.6860.77
133_V192_V0.6830.76
124_D175_E0.6820.76
138_M143_V0.6800.76
40_G65_I0.6780.76
122_Q215_K0.6760.76
11_G38_A0.6680.75
139_A143_V0.6670.75
91_Q200_N0.6610.74
6_L213_G0.6560.73
85_E126_L0.6530.73
139_A142_A0.6510.73
101_T193_V0.6480.73
26_V33_A0.6420.72
70_L142_A0.6420.72
180_I184_N0.6400.72
147_L152_G0.6390.72
123_V127_G0.6390.72
6_L9_A0.6360.71
94_K97_G0.6340.71
187_N194_T0.6320.71
125_I176_I0.6320.71
49_A60_L0.6290.70
90_M208_I0.6250.70
23_I73_V0.6240.70
147_L192_V0.6220.70
179_P182_M0.6190.69
51_S54_D0.6180.69
145_R149_K0.6160.69
135_V144_A0.6150.69
18_V42_M0.6140.69
176_I197_L0.6130.68
10_V209_G0.6110.68
18_V78_I0.6110.68
195_V199_A0.6090.68
141_S144_A0.6060.68
51_S67_V0.6040.67
85_E129_F0.6040.67
51_S69_D0.6000.67
70_L106_I0.6000.67
10_V34_H0.5970.66
21_G24_V0.5910.66
147_L169_L0.5900.65
210_T213_G0.5890.65
19_Q112_K0.5880.65
38_A42_M0.5870.65
47_E60_L0.5860.65
131_L174_M0.5800.64
54_D102_R0.5780.64
26_V32_A0.5760.64
93_I99_A0.5710.63
15_L41_T0.5670.62
9_A12_W0.5660.62
131_L176_I0.5650.62
28_T168_I0.5650.62
137_P167_V0.5620.62
47_E77_G0.5590.61
107_A201_R0.5580.61
57_T67_V0.5550.61
32_A57_T0.5540.61
99_A196_G0.5530.61
102_R163_D0.5520.60
151_G154_P0.5520.60
32_A55_A0.5510.60
88_G122_Q0.5510.60
48_G66_H0.5480.60
155_E158_Q0.5470.60
36_I63_L0.5470.60
28_T196_G0.5420.59
140_R154_P0.5420.59
166_N193_V0.5410.59
101_T194_T0.5400.59
6_L10_V0.5390.59
156_Y169_L0.5370.58
133_V169_L0.5360.58
19_Q77_G0.5350.58
83_A115_C0.5330.58
32_A40_G0.5330.58
81_D103_E0.5330.58
83_A95_G0.5320.58
54_D160_V0.5320.58
49_A52_S0.5280.57
68_F74_D0.5270.57
146_Q189_I0.5270.57
93_I131_L0.5270.57
174_M182_M0.5260.57
82_G94_K0.5250.57
35_F56_S0.5230.56
150_L186_I0.5230.56
54_D167_V0.5230.56
24_V38_A0.5210.56
8_K38_A0.5200.56
60_L138_M0.5200.56
95_G99_A0.5190.56
12_W34_H0.5190.56
83_A196_G0.5190.56
108_S142_A0.5170.55
14_A107_A0.5160.55
18_V21_G0.5130.55
11_G35_F0.5130.55
90_M203_A0.5130.55
51_S56_S0.5120.55
66_H72_E0.5120.55
101_T138_M0.5120.55
123_V128_K0.5100.54
137_P161_V0.5100.54
25_G104_K0.5080.54
92_M117_A0.5050.54
93_I98_A0.5050.54
83_A179_P0.5050.54
105_I139_A0.5040.54
60_L65_I0.5030.53
150_L173_G0.5030.53
134_E166_N0.5030.53
140_R143_V0.5020.53
143_V169_L0.5020.53
79_Y115_C0.5020.53
93_I126_L0.5010.53
149_K175_E0.5010.53
12_W16_Q0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x84A 2 0.9909 100 0.185 Contact Map
2f8mA 2 0.9954 100 0.209 Contact Map
1xtzA 3 0.9817 100 0.216 Contact Map
3hheA 2 0.9909 100 0.219 Contact Map
1lk5A 4 0.9954 100 0.223 Contact Map
1o8bA 2 0.9589 100 0.225 Contact Map
4nmlA 2 0.9954 100 0.225 Contact Map
1uj6A 2 0.9909 100 0.231 Contact Map
1m0sA 2 0.9909 100 0.232 Contact Map
3uw1A 2 0.9954 100 0.233 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.