GREMLIN Database
RNPA - Ribonuclease P protein component
UniProt: P0A7Y8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10862
Length: 119 (105)
Sequences: 2147 (1636)
Seq/√Len: 159.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_R84_D3.6171.00
30_T104_A3.1171.00
97_D100_A3.0071.00
63_N66_K2.8721.00
49_L69_T2.8711.00
71_E74_R2.7491.00
47_I73_F2.6921.00
64_R68_L2.5921.00
76_R106_E2.3411.00
71_E75_L2.1681.00
18_F48_G2.0811.00
59_A63_N2.0471.00
12_L21_V2.0011.00
87_V105_L1.9311.00
15_P19_T1.8961.00
32_Q104_A1.8661.00
30_T107_K1.8491.00
51_V65_I1.8051.00
10_L77_Q1.7281.00
32_Q96_L1.6971.00
66_K70_R1.6791.00
69_T87_V1.5261.00
40_N84_D1.5151.00
75_L102_S1.4761.00
68_L101_L1.4671.00
39_L83_M1.4641.00
102_S106_E1.4491.00
10_L44_H1.4481.00
72_S101_L1.4411.00
76_R79_E1.3341.00
28_A37_G1.3121.00
76_R102_S1.2841.00
29_G90_K1.2821.00
19_T23_Q1.2531.00
96_L104_A1.2491.00
20_F38_R1.2381.00
7_P10_L1.1661.00
22_F50_T1.1601.00
37_G83_M1.1421.00
59_A66_K1.1331.00
27_R34_T1.1191.00
8_R13_L1.0820.99
68_L72_S1.0740.99
68_L71_E1.0490.99
58_R61_E1.0460.99
98_N102_S1.0040.99
72_S98_N0.9960.99
27_R90_K0.9780.99
99_R102_S0.9700.99
93_V101_L0.9690.99
25_P38_R0.9660.99
29_G34_T0.9470.99
50_T88_V0.9400.98
21_V38_R0.9390.98
35_I108_L0.9310.98
30_T108_L0.9170.98
32_Q92_G0.9140.98
36_L88_V0.9110.98
21_V86_V0.9060.98
47_I87_V0.8990.98
72_S109_W0.8880.98
40_N44_H0.8850.98
68_L98_N0.8820.98
33_I69_T0.8790.98
79_E106_E0.8710.98
103_E107_K0.8680.97
72_S105_L0.8680.97
28_A111_R0.8630.97
22_F88_V0.8510.97
92_G96_L0.8510.97
65_I93_V0.8390.97
33_I105_L0.8320.97
14_T17_Q0.8260.97
34_T90_K0.8100.96
10_L45_P0.7890.96
65_I89_A0.7860.95
49_L73_F0.7830.95
51_V89_A0.7830.95
65_I94_A0.7820.95
56_V65_I0.7810.95
72_S102_S0.7740.95
17_Q20_F0.7600.95
89_A93_V0.7600.95
80_L109_W0.7570.94
45_P77_Q0.7540.94
28_A108_L0.7470.94
91_K94_A0.7440.94
35_I87_V0.7410.94
72_S76_R0.7300.93
64_R98_N0.7280.93
73_F77_Q0.7220.93
56_V61_E0.7190.93
20_F24_Q0.7120.92
61_E94_A0.7110.92
37_G112_H0.7040.92
105_L109_W0.7030.92
24_Q38_R0.7010.92
47_I85_F0.7000.92
36_L90_K0.6760.90
25_P36_L0.6730.90
35_I85_F0.6700.90
96_L101_L0.6610.89
49_L70_R0.6600.89
51_V66_K0.6540.89
44_H82_A0.6510.89
61_E65_I0.6460.88
45_P85_F0.6440.88
78_H81_P0.6420.88
56_V91_K0.6350.87
56_V94_A0.6290.87
9_E44_H0.6250.87
79_E110_R0.6250.87
57_R89_A0.6220.86
29_G104_A0.6220.86
73_F87_V0.6210.86
22_F54_K0.6200.86
63_N70_R0.6190.86
22_F36_L0.6180.86
17_Q84_D0.6160.86
104_A107_K0.6100.85
26_Q37_G0.6080.85
30_T33_I0.6050.85
56_V89_A0.5990.84
18_F70_R0.5950.84
20_F42_L0.5920.83
93_V96_L0.5900.83
16_S28_A0.5650.81
61_E95_D0.5610.80
39_L79_E0.5590.80
50_T90_K0.5570.80
100_A110_R0.5540.79
34_T50_T0.5530.79
39_L81_P0.5530.79
30_T34_T0.5490.79
19_T50_T0.5470.78
64_R71_E0.5470.78
7_P77_Q0.5430.78
99_R103_E0.5400.78
12_L18_F0.5380.77
57_R61_E0.5360.77
51_V56_V0.5320.76
53_K56_V0.5310.76
45_P80_L0.5310.76
70_R105_L0.5300.76
40_N82_A0.5260.76
68_L97_D0.5260.76
12_L74_R0.5220.75
69_T105_L0.5170.74
41_S82_A0.5170.74
39_L42_L0.5140.74
45_P81_P0.5140.74
18_F47_I0.5110.74
14_T25_P0.5090.73
37_G85_F0.5070.73
53_K58_R0.5020.72
107_K110_R0.5010.72
11_R47_I0.5000.72
96_L100_A0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ljpA 1 1 100 0.112 Contact Map
1nz0A 4 0.8908 100 0.176 Contact Map
1d6tA 1 0.9664 100 0.212 Contact Map
4jg4A 1 0.9496 100 0.213 Contact Map
4oxpA 1 0.8739 98.8 0.679 Contact Map
2bx2L 3 0.7647 42.8 0.9 Contact Map
2j5aA 1 0.3697 12.2 0.924 Contact Map
4bqmA 3 0.2521 12 0.924 Contact Map
1cqmA 1 0.3361 8.3 0.929 Contact Map
3r3tA 3 0.3445 5.6 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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