GREMLIN Database
RS2 - 30S ribosomal protein S2
UniProt: P0A7V0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10901
Length: 241 (227)
Sequences: 2198 (888)
Seq/√Len: 58.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_K85_L4.2461.00
65_G159_D3.9371.00
92_V100_M3.2491.00
186_I202_G3.0851.00
83_A86_S3.0621.00
162_F217_V2.9981.00
49_M52_E2.9871.00
57_L217_V2.8631.00
56_E184_F2.7871.00
31_I189_T2.7601.00
113_R140_E2.7131.00
220_T224_G2.6611.00
119_T123_D2.5871.00
61_A67_I2.5131.00
83_A215_G2.5031.00
118_E152_K2.4581.00
145_E149_G2.4541.00
161_L176_A2.4511.00
60_I160_A2.3911.00
121_S138_T2.3621.00
57_L184_F2.2751.00
163_V183_V2.2171.00
86_S219_A2.1821.00
177_N195_G2.1781.00
60_I65_G2.0451.00
87_C221_V1.9881.00
118_E141_L1.9651.00
26_K194_D1.9601.00
160_A184_F1.9561.00
121_S126_F1.9381.00
14_V202_G1.9151.00
186_I213_Y1.8911.00
50_F216_A1.8521.00
141_L145_E1.7500.99
124_G127_D1.7480.99
41_I189_T1.7440.99
58_N223_E1.7390.99
76_A210_V1.7360.99
60_I184_F1.7180.99
56_E160_A1.7160.99
54_L220_T1.7160.99
126_F134_A1.7100.99
121_S141_L1.6990.99
177_N197_D1.6930.99
9_M14_V1.6480.99
187_V199_V1.6380.99
174_K178_N1.6260.99
42_N45_K1.6180.99
79_A83_A1.5650.98
14_V209_A1.5540.98
86_S222_R1.5110.98
126_F129_L1.4990.98
162_F214_L1.4700.98
117_L137_R1.4010.97
115_K153_D1.3920.97
13_G16_F1.3790.97
23_W39_H1.3720.96
94_H147_S1.3720.96
4_V50_F1.3600.96
170_H174_K1.3450.96
135_L139_R1.3430.96
215_G219_A1.3390.96
118_E145_E1.3150.95
185_A196_V1.3130.95
94_H146_N1.2900.95
10_L14_V1.2810.95
24_N192_D1.2710.95
177_N183_V1.2610.94
159_D182_P1.2520.94
120_Q124_G1.2410.94
164_I186_I1.2340.94
188_D205_D1.2260.93
18_H205_D1.2250.93
157_L181_I1.2220.93
138_T142_E1.2190.93
115_K152_K1.2000.93
30_F49_M1.1870.92
105_K109_Q1.1860.92
3_T54_L1.1850.92
167_D191_S1.1740.92
130_T135_L1.1730.92
83_A218_A1.1730.92
56_E198_F1.1710.92
66_K90_F1.1560.91
56_E60_I1.1560.91
104_W156_G1.1550.91
166_A196_V1.1510.91
129_L137_R1.1510.91
54_L217_V1.1390.91
61_A221_V1.1350.90
73_K76_A1.1320.90
112_K116_D1.1160.90
52_E55_A1.1160.90
66_K159_D1.1150.90
136_M139_R1.1130.90
221_V225_R1.1130.90
20_T34_A1.1130.90
58_N227_Q1.1080.89
59_K63_R1.1040.89
45_K49_M1.0890.89
77_S104_W1.0810.88
187_V196_V1.0800.88
117_L141_L1.0790.88
145_E152_K1.0720.88
54_L216_A1.0630.87
9_M50_F1.0590.87
176_A183_V1.0540.87
110_S113_R1.0500.87
70_V161_L1.0470.87
86_S218_A1.0420.86
49_M201_P1.0410.86
77_S94_H1.0400.86
8_D216_A1.0330.86
173_I196_V1.0230.85
121_S124_G1.0150.85
82_D211_T1.0130.85
202_G209_A1.0020.84
81_K93_N1.0000.84
138_T141_L0.9670.82
55_A58_N0.9650.82
26_K150_G0.9640.82
173_I183_V0.9560.81
90_F166_A0.9540.81
61_A225_R0.9340.80
26_K192_D0.9330.79
127_D134_A0.9260.79
57_L221_V0.9240.79
154_M157_L0.9100.78
120_Q126_F0.9060.77
62_S227_Q0.9000.77
30_F199_V0.8970.77
120_Q129_L0.8970.77
124_G128_K0.8950.77
87_C222_R0.8830.76
97_L100_M0.8790.75
113_R117_L0.8760.75
68_L161_L0.8630.74
53_A199_V0.8630.74
5_S8_D0.8600.74
115_K155_G0.8580.73
95_R98_G0.8560.73
202_G213_Y0.8470.72
67_I160_A0.8460.72
22_Y75_A0.8460.72
71_G76_A0.8440.72
132_K136_M0.8430.72
6_M14_V0.8420.72
107_V151_I0.8360.71
200_I213_Y0.8340.71
5_S178_N0.8290.71
123_D126_F0.8140.69
188_D204_D0.8140.69
184_F198_F0.8110.69
97_L148_L0.8040.69
170_H195_G0.8010.68
18_H204_D0.7930.67
126_F137_R0.7880.67
60_I159_D0.7870.67
120_Q125_T0.7870.67
83_A211_T0.7870.67
216_A219_A0.7860.67
85_L91_F0.7860.67
143_K147_S0.7830.66
79_A210_V0.7810.66
211_T215_G0.7740.66
128_K134_A0.7730.65
18_H188_D0.7710.65
187_V191_S0.7690.65
124_G134_A0.7670.65
70_V181_I0.7650.65
101_L179_L0.7580.64
73_K165_D0.7470.63
10_L35_R0.7470.63
60_I67_I0.7470.63
116_D120_Q0.7470.63
79_A209_A0.7450.63
78_E117_L0.7420.62
42_N75_A0.7400.62
83_A219_A0.7350.62
129_L134_A0.7290.61
219_A222_R0.7270.61
56_E59_K0.7260.61
166_A185_A0.7220.60
87_C218_A0.7160.60
213_Y217_V0.7140.59
58_N224_G0.7140.59
73_K169_E0.7130.59
165_D168_H0.7120.59
107_V110_S0.7120.59
33_G50_F0.7090.59
28_K39_H0.7090.59
134_A138_T0.7090.59
50_F213_Y0.7080.59
4_V216_A0.7060.58
66_K89_Q0.7050.58
74_R138_T0.7050.58
57_L160_A0.7030.58
183_V195_G0.7030.58
67_I221_V0.7020.58
97_L189_T0.7020.58
57_L67_I0.6980.58
222_R226_S0.6960.57
114_L152_K0.6940.57
106_T179_L0.6930.57
196_V199_V0.6900.57
3_T50_F0.6860.56
126_F152_K0.6850.56
226_S229_L0.6820.56
113_R208_R0.6810.56
185_A210_V0.6770.55
130_T133_E0.6750.55
89_Q225_R0.6740.55
97_L106_T0.6710.55
3_T51_N0.6690.54
166_A195_G0.6690.54
193_P205_D0.6670.54
16_F75_A0.6650.54
140_E167_D0.6640.54
161_L172_A0.6620.54
61_A89_Q0.6580.53
59_K62_S0.6570.53
80_V226_S0.6540.53
7_R162_F0.6530.53
47_V186_I0.6530.53
214_L217_V0.6500.52
58_N226_S0.6500.52
224_G228_D0.6440.52
192_D195_G0.6430.52
58_N62_S0.6420.51
79_A208_R0.6400.51
163_V173_I0.6390.51
66_K156_G0.6360.51
164_I169_E0.6340.51
135_L211_T0.6300.50
59_K224_G0.6280.50
168_H185_A0.6230.49
125_T128_K0.6220.49
61_A159_D0.6210.49
69_F218_A0.6200.49
38_V206_A0.6190.49
50_F217_V0.6180.49
225_R228_D0.6170.49
57_L162_F0.6150.48
89_Q104_W0.6150.48
8_D11_K0.6130.48
92_V151_I0.6130.48
125_T129_L0.6120.48
45_K104_W0.6110.48
110_S117_L0.6100.48
76_A169_E0.6090.48
66_K184_F0.6090.48
67_I162_F0.6030.47
69_F84_A0.6010.47
16_F205_D0.5990.47
130_T136_M0.5970.46
135_L138_T0.5940.46
63_R127_D0.5940.46
20_T23_W0.5920.46
22_Y167_D0.5910.46
117_L120_Q0.5910.46
195_G199_V0.5870.45
99_G158_P0.5830.45
130_T134_A0.5830.45
151_I154_M0.5820.45
87_C90_F0.5810.45
66_K225_R0.5810.45
183_V196_V0.5790.44
185_A199_V0.5770.44
114_L141_L0.5760.44
80_V164_I0.5740.44
169_E191_S0.5730.44
119_T122_Q0.5720.44
23_W27_M0.5710.44
50_F186_I0.5710.44
200_I217_V0.5700.43
104_W160_A0.5700.43
33_G227_Q0.5690.43
106_T118_E0.5680.43
108_R111_I0.5660.43
35_R212_L0.5650.43
90_F211_T0.5650.43
8_D209_A0.5640.43
24_N194_D0.5630.43
27_M39_H0.5610.42
148_L179_L0.5580.42
117_L207_I0.5570.42
121_S128_K0.5560.42
155_G186_I0.5550.42
222_R225_R0.5540.42
126_F141_L0.5500.41
114_L117_L0.5500.41
107_V221_V0.5470.41
104_W174_K0.5470.41
81_K118_E0.5470.41
162_F213_Y0.5460.41
164_I210_V0.5450.41
123_D159_D0.5430.40
49_M161_L0.5390.40
5_S173_I0.5360.40
104_W155_G0.5360.40
99_G175_E0.5330.39
141_L152_K0.5330.39
177_N196_V0.5320.39
90_F154_M0.5310.39
121_S129_L0.5290.39
90_F160_A0.5290.39
165_D185_A0.5280.39
110_S165_D0.5280.39
108_R143_K0.5270.39
180_G183_V0.5260.39
80_V109_Q0.5260.39
109_Q148_L0.5240.38
170_H173_I0.5240.38
10_L16_F0.5220.38
8_D12_A0.5220.38
122_Q129_L0.5220.38
108_R112_K0.5200.38
43_L206_A0.5190.38
61_A224_G0.5190.38
180_G202_G0.5170.38
58_N78_E0.5130.37
39_H92_V0.5100.37
64_K228_D0.5100.37
45_K77_S0.5100.37
120_Q137_R0.5100.37
77_S93_N0.5090.37
173_I187_V0.5090.37
142_E146_N0.5080.37
105_K135_L0.5080.37
112_K115_K0.5080.37
31_I34_A0.5080.37
51_N80_V0.5080.37
7_R44_E0.5050.36
3_T12_A0.5040.36
65_G130_T0.5040.36
108_R196_V0.5040.36
135_L167_D0.5040.36
34_A65_G0.5030.36
94_H156_G0.5010.36
134_A141_L0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb5B 1 0.9585 100 0.093 Contact Map
3bbnB 1 0.9585 100 0.109 Contact Map
5aj3B 1 0.8091 100 0.269 Contact Map
4toiA 2 0.9917 100 0.281 Contact Map
3j7aC 1 0.751 100 0.295 Contact Map
3zeyC 1 0.7552 100 0.296 Contact Map
4ujpB 1 0.7593 100 0.298 Contact Map
4bpeB 1 0.751 100 0.299 Contact Map
3j38A 1 0.7967 100 0.304 Contact Map
3j60A 1 0.7552 100 0.304 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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