GREMLIN Database
RS18 - 30S ribosomal protein S18
UniProt: P0A7T7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10917
Length: 75 (68)
Sequences: 1381 (572)
Seq/√Len: 69.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_R51_Y3.9641.00
14_T48_R3.8031.00
14_T51_Y3.0751.00
33_I68_L2.8701.00
64_Y70_Y2.7651.00
47_T55_L2.7501.00
11_C14_T2.4941.00
11_C48_R2.0831.00
12_R31_N1.9831.00
49_A53_R1.9731.00
25_D28_T1.9721.00
12_R16_E1.9001.00
11_C51_Y1.8911.00
21_I58_A1.6871.00
39_I59_I1.6730.99
12_R47_T1.6670.99
29_L68_L1.6000.99
21_I55_L1.4040.98
26_I67_L1.3550.98
21_I65_L1.2400.96
17_G21_I1.1870.95
13_F55_L1.0840.92
9_K46_G1.0710.92
27_A30_K1.0680.91
13_F51_Y1.0610.91
18_V54_Q1.0470.91
35_E43_R1.0190.89
18_V28_T0.9910.88
42_S64_Y0.9720.87
18_V21_I0.9520.86
37_G44_I0.9290.85
22_D61_R0.9160.84
30_K68_L0.8600.80
19_Q28_T0.8600.80
22_D58_A0.8330.77
5_F12_R0.8300.77
23_Y71_T0.8260.77
36_S42_S0.8120.76
58_A61_R0.8110.76
22_D67_L0.8070.75
56_A64_Y0.8020.75
40_V45_T0.7980.74
10_F13_F0.7950.74
30_K42_S0.7900.74
7_R10_F0.7680.72
64_Y71_T0.7680.72
41_P46_G0.7650.71
6_R40_V0.7470.69
33_I37_G0.7400.69
36_S65_L0.7400.69
42_S71_T0.7390.69
17_G48_R0.7370.68
10_F15_A0.7130.66
38_K43_R0.7130.66
40_V44_I0.7110.66
20_E54_Q0.6980.64
47_T56_A0.6970.64
29_L32_Y0.6880.63
57_R61_R0.6860.63
35_E71_T0.6860.63
13_F21_I0.6730.61
13_F72_D0.6720.61
9_K20_E0.6710.61
29_L59_I0.6670.61
51_Y54_Q0.6570.59
50_K61_R0.6500.59
26_I30_K0.6380.57
30_K35_E0.6350.57
32_Y50_K0.6350.57
25_D38_K0.6320.57
25_D58_A0.6290.56
45_T66_S0.6140.54
30_K64_Y0.6080.54
9_K51_Y0.6020.53
10_F42_S0.5940.52
28_T55_L0.5860.51
40_V64_Y0.5810.50
39_I47_T0.5750.50
64_Y72_D0.5680.49
13_F47_T0.5670.49
12_R32_Y0.5620.48
38_K59_I0.5590.48
32_Y40_V0.5560.47
35_E66_S0.5530.47
10_F20_E0.5440.46
7_R53_R0.5420.46
35_E38_K0.5410.46
28_T58_A0.5410.46
21_I25_D0.5360.45
57_R66_S0.5340.45
33_I47_T0.5310.44
32_Y55_L0.5280.44
26_I32_Y0.5270.44
55_L59_I0.5230.43
26_I34_T0.5210.43
34_T55_L0.5200.43
12_R27_A0.5190.43
46_G51_Y0.5170.43
53_R68_L0.5170.43
35_E44_I0.5080.42
42_S49_A0.5030.41
31_N56_A0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kiyR 1 0.7333 100 0.153 Contact Map
5aj3p 1 1 100 0.194 Contact Map
4rb5R 1 0.8933 100 0.209 Contact Map
3j7yr 1 0.9867 100 0.211 Contact Map
5aj3R 1 0.96 99.9 0.238 Contact Map
3bbnR 1 0.76 99.9 0.242 Contact Map
4tp8R 1 0.7333 99.9 0.31 Contact Map
4wz0A 1 0.76 9.4 0.924 Contact Map
3m62A 1 0.5867 7.8 0.927 Contact Map
4geqE 1 0.2533 6.7 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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