GREMLIN Database
RS12 - 30S ribosomal protein S12
UniProt: P0A7S3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10911
Length: 124 (122)
Sequences: 1037 (304)
Seq/√Len: 27.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_R64_T5.9771.00
38_Y52_V4.0421.00
29_Q98_V3.8291.00
41_T49_L3.5191.00
97_T104_C3.3601.00
87_V96_H3.1781.00
39_T49_L2.9901.00
43_K86_R2.6841.00
27_C30_K2.5700.99
66_Y96_H2.3380.99
38_Y64_T2.2010.98
53_C97_T2.1780.98
4_V7_L2.1590.98
30_K59_N2.0620.97
30_K82_I1.8330.94
43_K91_P1.8190.94
3_T6_Q1.7740.93
31_R102_L1.7240.92
96_H116_K1.6950.91
2_A7_L1.5950.88
23_A63_V1.4890.84
30_K58_T1.4450.82
83_R96_H1.4440.82
9_R101_A1.4390.82
25_E59_N1.4190.81
25_E61_F1.3820.79
29_Q81_L1.3520.78
40_T94_R1.3270.76
48_A90_L1.2660.73
53_C67_I1.2550.72
70_E107_V1.2330.71
111_K122_P1.2290.71
51_K76_E1.2270.70
48_A76_E1.1950.68
95_Y110_R1.1890.68
65_S97_T1.1860.68
51_K66_Y1.1840.68
9_R12_R1.1770.67
63_V95_Y1.1760.67
73_N105_S1.1590.66
60_G94_R1.1460.65
36_R61_F1.1320.64
86_R96_H1.1250.64
34_C38_Y1.1200.63
40_T64_T1.1050.62
43_K87_V1.0940.61
36_R68_G1.0930.61
68_G104_C1.0850.61
63_V82_I1.0810.60
7_L10_K1.0740.60
14_R111_K1.0620.59
104_C109_D1.0590.59
27_C102_L1.0450.58
43_K93_V1.0300.57
12_R39_T1.0290.57
31_R104_C1.0050.55
106_G121_R0.9930.54
60_G122_P0.9900.54
62_E112_Q0.9860.53
78_S103_D0.9810.53
24_L52_V0.9780.53
24_L81_L0.9700.52
83_R116_K0.9670.52
31_R62_E0.9640.52
112_Q119_V0.9450.50
52_V64_T0.9410.50
8_V11_P0.9400.50
56_R62_E0.9300.49
2_A56_R0.9030.47
32_G57_L0.9010.47
33_V37_V0.8980.47
112_Q116_K0.8970.47
65_S68_G0.8680.44
25_E30_K0.8640.44
79_V88_K0.8600.44
7_L41_T0.8590.44
33_V70_E0.8520.43
41_T88_K0.8460.43
35_T68_G0.8450.43
20_N94_R0.8450.43
10_K15_K0.8430.43
98_V106_G0.8000.39
36_R40_T0.7920.39
88_K113_A0.7880.38
7_L12_R0.7830.38
83_R86_R0.7800.38
52_V90_L0.7790.38
8_V56_R0.7770.38
49_L102_L0.7760.38
10_K59_N0.7700.37
115_S118_G0.7690.37
62_E104_C0.7640.37
77_H107_V0.7620.37
15_K19_S0.7540.36
10_K14_R0.7520.36
24_L95_Y0.7460.36
66_Y76_E0.7400.35
71_G99_R0.7360.35
7_L11_P0.7330.35
31_R105_S0.7260.34
13_A36_R0.7200.34
65_S111_K0.7150.33
112_Q122_P0.7140.33
19_S22_P0.7130.33
100_G106_G0.7060.33
30_K98_V0.6990.32
16_V104_C0.6970.32
19_S112_Q0.6920.32
17_A20_N0.6900.32
34_C39_T0.6870.32
17_A26_A0.6800.31
51_K91_P0.6770.31
66_Y83_R0.6700.30
72_H78_S0.6700.30
53_C100_G0.6700.30
60_G75_Q0.6680.30
84_G95_Y0.6610.30
64_T104_C0.6610.30
37_V111_K0.6580.30
119_V122_P0.6560.30
40_T59_N0.6520.29
81_L102_L0.6500.29
100_G107_V0.6480.29
35_T119_V0.6370.28
75_Q99_R0.6360.28
61_F105_S0.6300.28
22_P95_Y0.6270.28
49_L104_C0.6230.27
26_A31_R0.6220.27
10_K113_A0.6220.27
86_R99_R0.6160.27
55_V109_D0.6160.27
75_Q86_R0.6140.27
87_V90_L0.6120.27
66_Y110_R0.5950.26
8_V113_A0.5950.26
55_V77_H0.5880.25
8_V107_V0.5860.25
75_Q79_V0.5830.25
81_L101_A0.5830.25
21_V108_K0.5730.25
27_C58_T0.5720.24
18_K25_E0.5680.24
89_D92_G0.5670.24
77_H99_R0.5660.24
39_T77_H0.5640.24
12_R28_P0.5630.24
31_R61_F0.5570.24
74_L104_C0.5560.24
87_V97_T0.5510.23
12_R18_K0.5500.23
36_R109_D0.5480.23
96_H113_A0.5440.23
108_K122_P0.5430.23
21_V26_A0.5410.23
52_V78_S0.5410.23
30_K95_Y0.5400.23
49_L87_V0.5380.23
10_K13_A0.5370.23
93_V103_D0.5360.23
65_S86_R0.5350.22
15_K18_K0.5340.22
20_N90_L0.5330.22
34_C75_Q0.5310.22
51_K116_K0.5300.22
77_H97_T0.5300.22
63_V84_G0.5260.22
34_C78_S0.5260.22
105_S119_V0.5260.22
33_V48_A0.5200.22
28_P36_R0.5200.22
40_T52_V0.5200.22
114_R117_Y0.5180.22
88_K94_R0.5160.21
67_I90_L0.5140.21
105_S108_K0.5140.21
98_V114_R0.5130.21
19_S88_K0.5070.21
10_K18_K0.5040.21
29_Q102_L0.5020.21
42_P74_L0.5010.21
14_R102_L0.5010.21
10_K112_Q0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ji1L 1 0.9839 100 0.085 Contact Map
4rb5L 1 0.9839 100 0.088 Contact Map
5aj3L 1 0.879 100 0.189 Contact Map
3j20N 1 0.9355 100 0.401 Contact Map
4bpeL 1 0.9032 100 0.411 Contact Map
4ujpY 1 0.9274 100 0.418 Contact Map
3zeyS 1 0.9274 100 0.427 Contact Map
2jpjA 1 0.129 4.8 0.962 Contact Map
4bpe0 1 0.7016 3.8 0.964 Contact Map
4likA 1 0.3306 3.2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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