GREMLIN Database
RL33 - 50S ribosomal protein L33
UniProt: P0A7N9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10891
Length: 55 (53)
Sequences: 456 (121)
Seq/√Len: 16.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_H49_Y6.1791.00
12_V52_A3.8081.00
35_E48_I3.0580.99
39_F46_H2.0120.86
20_F33_K2.0050.86
6_R27_K1.9990.86
7_E27_K1.8240.80
6_R24_T1.6350.72
15_A43_V1.5990.71
33_K53_K1.5430.68
10_K52_A1.4170.61
7_E53_K1.2580.52
9_I41_P1.1690.46
23_T29_T1.1650.46
10_K20_F1.1590.46
11_L38_K1.1370.45
30_K36_L1.1170.43
20_F53_K1.0880.42
5_I28_R1.0680.41
12_V20_F1.0430.39
35_E50_K1.0270.38
1_M5_I1.0100.37
19_H41_P1.0050.37
28_R36_L0.9870.36
21_Y38_K0.9800.36
4_G44_R0.9410.34
7_E33_K0.9330.33
14_S47_V0.9180.32
9_I25_K0.9170.32
9_I21_Y0.8870.31
10_K41_P0.8720.30
24_T45_Q0.8610.30
30_K34_L0.8560.29
14_S50_K0.8550.29
11_L21_Y0.8460.29
17_T49_Y0.8380.28
8_K20_F0.8320.28
5_I24_T0.8040.27
2_A5_I0.7960.26
37_K52_A0.7910.26
21_Y41_P0.7820.26
36_L39_F0.7780.26
32_E50_K0.7780.26
23_T30_K0.7660.25
18_G28_R0.7590.25
37_K48_I0.7420.24
8_K23_T0.7370.24
6_R36_L0.7270.23
32_E35_E0.7140.23
1_M44_R0.7130.23
35_E52_A0.6800.21
19_H42_V0.6730.21
11_L36_L0.6530.20
8_K29_T0.6500.20
11_L22_T0.6440.20
12_V33_K0.6400.20
37_K46_H0.6310.20
22_T46_H0.6220.19
22_T49_Y0.6120.19
17_T40_D0.6110.19
21_Y25_K0.5980.18
10_K42_V0.5970.18
7_E20_F0.5950.18
27_K30_K0.5920.18
7_E22_T0.5800.18
16_G22_T0.5620.17
28_R32_E0.5480.17
10_K33_K0.5470.17
5_I29_T0.5390.16
32_E39_F0.5340.16
8_K50_K0.5310.16
12_V28_R0.5230.16
9_I48_I0.5210.16
6_R39_F0.5210.16
20_F36_L0.5180.16
6_R23_T0.5150.16
10_K19_H0.5120.15
17_T42_V0.5090.15
4_G32_E0.5040.15
6_R14_S0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb66 1 0.9636 99.8 0.272 Contact Map
1nkw1 1 0.9455 99.8 0.273 Contact Map
2zjr1 1 0.9455 99.8 0.279 Contact Map
4tp91 1 0.9091 99.7 0.338 Contact Map
3bbo3 1 0.9636 99.7 0.345 Contact Map
1vw4X 1 0.9091 99.7 0.348 Contact Map
3j7y1 1 0.8909 99.7 0.355 Contact Map
1xdnA 1 0.3455 4.5 0.917 Contact Map
3pnrB 1 0.8 4.3 0.918 Contact Map
5aj3P 1 0.9636 3 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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