GREMLIN Database
RL27 - 50S ribosomal protein L27
UniProt: P0A7L8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG50002
Length: 85 (81)
Sequences: 1954 (638)
Seq/√Len: 70.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_L41_R3.7651.00
53_C57_H3.3611.00
25_R31_V3.2571.00
52_G62_K2.9171.00
32_L35_S2.8731.00
25_R35_S2.8681.00
23_V38_V2.2991.00
51_V59_L2.2931.00
70_E81_S2.0981.00
46_H77_R1.9991.00
25_R29_E1.8511.00
52_G60_F1.8471.00
54_G58_T1.7931.00
45_F80_I1.7331.00
17_E20_R1.7051.00
30_S66_K1.6430.99
38_V45_F1.6230.99
45_F78_K1.5950.99
71_V78_K1.5230.99
33_A64_D1.4030.98
72_K79_F1.3860.98
23_V69_F1.3280.98
27_G68_K1.3250.98
70_E79_F1.3230.98
23_V26_F1.3100.97
32_L64_D1.2890.97
53_C59_L1.2790.97
41_R57_H1.2610.97
43_T53_C1.2200.96
39_R56_D1.2040.96
25_R67_V1.1960.95
73_G76_N1.1640.95
39_R58_T1.1430.94
7_G10_T1.0780.92
25_R32_L1.0630.92
30_S64_D1.0540.91
47_A59_L1.0510.91
37_I59_L1.0460.91
50_N63_A1.0390.91
43_T57_H1.0340.91
25_R37_I1.0340.91
31_V35_S0.9760.88
33_A62_K0.9410.86
31_V37_I0.9190.85
4_K12_N0.8670.81
72_K81_S0.8630.81
46_H53_C0.8560.80
10_T13_G0.8450.79
49_A62_K0.8430.79
71_V76_N0.8360.78
19_K57_H0.8300.78
51_V82_I0.8280.78
68_K81_S0.8260.78
71_V77_R0.8180.77
43_T46_H0.8070.76
19_K41_R0.7940.75
5_K8_G0.7920.75
47_A53_C0.7720.73
75_K79_F0.7570.71
61_A82_I0.7470.70
26_F29_E0.7420.70
25_R30_S0.7420.70
35_S64_D0.7330.69
44_K78_K0.7290.68
6_A11_R0.7150.67
27_G78_K0.7060.66
59_L80_I0.7050.66
71_V79_F0.6900.64
1_M27_G0.6770.63
72_K76_N0.6750.62
70_E82_I0.6730.62
76_N79_F0.6700.62
21_L57_H0.6670.62
7_G11_R0.6670.62
38_V80_I0.6490.59
72_K75_K0.6410.58
47_A54_G0.6220.56
23_V45_F0.6190.56
69_F72_K0.6190.56
45_F69_F0.6160.55
73_G77_R0.6130.55
52_G58_T0.6110.55
67_V80_I0.6080.55
1_M26_F0.6050.54
43_T47_A0.6030.54
6_A79_F0.6010.54
3_H7_G0.6000.54
5_K9_S0.5870.52
44_K57_H0.5850.52
49_A79_F0.5780.51
49_A81_S0.5770.51
4_K38_V0.5750.51
26_F68_K0.5720.50
49_A63_A0.5720.50
66_K73_G0.5660.49
46_H71_V0.5650.49
23_V27_G0.5640.49
54_G60_F0.5600.49
39_R54_G0.5600.49
9_S13_G0.5560.48
12_N16_S0.5550.48
35_S82_I0.5540.48
10_T14_R0.5530.48
11_R15_D0.5530.48
75_K78_K0.5480.47
37_I80_I0.5430.47
4_K46_H0.5420.46
47_A57_H0.5400.46
73_G78_K0.5370.46
38_V69_F0.5310.45
49_A70_E0.5250.44
6_A12_N0.5230.44
29_E35_S0.5220.44
26_F38_V0.5200.44
9_S12_N0.5110.43
2_A5_K0.5100.43
15_D45_F0.5080.42
66_K70_E0.5080.42
7_G75_K0.5070.42
59_L62_K0.5030.42
63_A66_K0.5000.41
50_N62_K0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bboX 1 0.9765 100 0.04 Contact Map
4kixW 1 0.9294 100 0.042 Contact Map
4rb60 1 0.9765 100 0.055 Contact Map
1vw4R 1 0.9059 100 0.072 Contact Map
1pnuU 1 0.9765 100 0.082 Contact Map
3j7yW 1 0.8588 100 0.103 Contact Map
4tp9W 1 0.8941 100 0.166 Contact Map
4ifdG 1 0.6941 86.6 0.875 Contact Map
2ba0A 1 0.5647 81 0.883 Contact Map
2nn6G 1 0.6 79 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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