GREMLIN Database
RL1 - 50S ribosomal protein L1
UniProt: P0A7L0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10864
Length: 234 (224)
Sequences: 3147 (1467)
Seq/√Len: 98.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_D184_K3.8071.00
175_I189_L3.5371.00
85_E89_A3.2761.00
67_H187_E3.2671.00
67_H184_K3.0941.00
14_K32_E3.0811.00
115_I156_A3.0441.00
39_V179_D3.0411.00
83_N86_A3.0341.00
50_I165_N2.9081.00
10_V13_E2.8571.00
148_N151_E2.8241.00
28_A32_E2.6761.00
85_E88_K2.6221.00
28_A182_A2.5341.00
46_V196_L2.3451.00
102_D106_K2.2971.00
4_L8_M2.2661.00
195_A199_A2.1931.00
103_Q108_E2.1861.00
30_L216_T2.1641.00
24_N186_K2.1261.00
213_S221_G2.0841.00
78_F114_V2.0371.00
173_T192_L1.9461.00
9_R13_E1.9441.00
42_V178_V1.9071.00
105_K126_Q1.8851.00
5_T8_M1.8651.00
76_A94_L1.8441.00
41_S174_T1.8441.00
36_A40_E1.8431.00
94_L108_E1.8421.00
7_R35_T1.8361.00
88_K95_V1.8161.00
98_E123_V1.8031.00
31_K181_D1.7891.00
52_A165_N1.7571.00
49_G204_A1.7481.00
101_A123_V1.7461.00
44_V189_L1.7291.00
176_G185_L1.6851.00
150_A154_K1.6811.00
4_L9_R1.6371.00
23_I189_L1.5991.00
183_D187_E1.5901.00
46_V193_L1.5851.00
97_M120_A1.5831.00
151_E155_N1.5551.00
38_F218_M1.5511.00
155_N160_Q1.5461.00
79_T84_A1.4921.00
76_A114_V1.4561.00
44_V192_L1.4541.00
14_K33_L1.4481.00
34_A40_E1.4221.00
45_A215_S1.3650.99
42_V216_T1.3630.99
27_I214_I1.3560.99
27_I185_L1.3400.99
82_A85_E1.3300.99
163_Y199_A1.3210.99
22_D25_E1.3120.99
8_M12_R1.3000.99
46_V212_V1.2950.99
19_K25_E1.2720.99
84_A95_V1.2650.99
15_V29_L1.2640.99
16_D19_K1.2500.99
30_L222_V1.2410.99
76_A100_L1.2320.99
30_L178_V1.2300.99
27_I182_A1.2210.99
216_T219_G1.2160.99
76_A108_E1.2150.99
7_R10_V1.2120.99
186_K190_E1.1990.98
197_K209_I1.1980.98
74_R110_N1.1890.98
86_A150_A1.1870.98
80_Q123_V1.1860.98
34_A178_V1.1740.98
80_Q119_D1.1730.98
22_D225_D1.1680.98
30_L34_A1.1570.98
45_A172_H1.1540.98
7_R11_I1.1380.98
15_V21_Y1.1310.98
83_N147_P1.1290.98
33_L219_G1.1270.98
27_I186_K1.1210.98
96_G99_D1.1210.98
93_E157_K1.1100.97
77_V115_I1.1100.97
102_D105_K1.1100.97
154_K158_A1.1080.97
212_V224_V1.1060.97
10_V14_K1.1030.97
170_I211_K1.0890.97
111_F114_V1.0720.97
98_E102_D1.0680.97
195_A198_K1.0670.97
80_Q97_M1.0650.97
78_F100_L1.0560.96
96_G100_L1.0420.96
31_K182_A1.0410.96
103_Q106_K1.0380.96
94_L103_Q1.0350.96
94_L100_L1.0350.96
5_T9_R1.0330.96
151_E154_K1.0260.96
190_E194_V1.0260.96
171_I196_L1.0220.96
184_K187_E1.0140.96
41_S177_K1.0120.95
43_D174_T1.0100.95
200_K204_A1.0020.95
146_T152_A1.0000.95
24_N28_A0.9960.95
104_I111_F0.9900.95
52_A169_G0.9850.95
89_A150_A0.9670.94
84_A97_M0.9600.94
26_A224_V0.9560.94
72_S93_E0.9500.94
182_A186_K0.9480.94
78_F124_V0.9390.93
47_N210_K0.9370.93
82_A147_P0.9350.93
30_L33_L0.9290.93
163_Y195_A0.9280.93
15_V18_T0.9160.92
43_D215_S0.9130.92
149_V153_V0.9120.92
94_L109_M0.9050.92
58_N165_N0.8920.91
78_F116_A0.8790.91
21_Y29_L0.8710.90
165_N169_G0.8710.90
64_V155_N0.8710.90
211_K223_A0.8660.90
123_V126_Q0.8640.90
5_T11_I0.8510.89
117_S147_P0.8460.89
20_Q226_Q0.8450.89
25_E28_A0.8420.89
113_V156_A0.8390.89
84_A88_K0.8310.88
83_N119_D0.8260.88
193_L209_I0.8240.88
31_K34_A0.8200.88
183_D186_K0.8170.87
124_V128_G0.8170.87
40_E178_V0.8140.87
63_T195_A0.8120.87
109_M114_V0.8100.87
175_I214_I0.8070.87
59_V204_A0.8050.87
163_Y192_L0.8040.86
44_V173_T0.7970.86
78_F101_A0.7920.86
200_K208_Y0.7810.85
113_V166_D0.7810.85
16_D21_Y0.7800.85
61_G163_Y0.7760.84
114_V124_V0.7710.84
33_L222_V0.7710.84
212_V226_Q0.7680.84
50_I55_S0.7670.84
127_L130_V0.7670.84
50_I59_V0.7670.84
81_G84_A0.7650.84
196_L209_I0.7590.83
150_A153_V0.7570.83
101_A124_V0.7560.83
87_A90_A0.7550.83
20_Q225_D0.7540.83
42_V185_L0.7540.83
52_A58_N0.7500.82
124_V127_L0.7490.82
43_D177_K0.7450.82
161_V173_T0.7440.82
78_F104_I0.7400.82
97_M123_V0.7370.81
79_T117_S0.7370.81
189_L214_I0.7330.81
104_I108_E0.7320.81
82_A86_A0.7290.81
35_T178_V0.7170.80
193_L212_V0.7110.79
8_M11_I0.7090.79
114_V127_L0.7070.79
94_L110_N0.7060.78
45_A173_T0.7040.78
87_A91_G0.7020.78
11_I35_T0.6980.78
7_R12_R0.6980.78
186_K189_L0.6970.78
165_N171_I0.6970.78
72_S158_A0.6950.77
29_L33_L0.6910.77
46_V209_I0.6900.77
101_A127_L0.6880.77
33_L40_E0.6870.77
24_N183_D0.6780.76
194_V198_K0.6770.76
29_L222_V0.6720.75
76_A109_M0.6710.75
44_V193_L0.6680.75
15_V19_K0.6670.74
23_I186_K0.6640.74
156_A160_Q0.6630.74
166_D170_I0.6620.74
62_A142_V0.6580.73
86_A89_A0.6570.73
23_I190_E0.6570.73
79_T116_A0.6520.73
7_R37_K0.6510.73
36_A218_M0.6500.73
215_S221_G0.6490.72
27_I189_L0.6430.72
22_D27_I0.6420.72
50_I58_N0.6390.71
55_S122_R0.6380.71
25_E29_L0.6370.71
86_A147_P0.6320.70
14_K216_T0.6310.70
46_V192_L0.6250.70
14_K28_A0.6250.70
45_A142_V0.6210.69
121_M140_P0.6170.69
20_Q23_I0.6160.68
36_A178_V0.6150.68
33_L216_T0.6130.68
142_V162_R0.6130.68
63_T191_A0.6120.68
67_H183_D0.6070.67
134_R217_T0.6060.67
191_A195_A0.6040.67
35_T40_E0.6040.67
129_Q163_Y0.6040.67
189_L193_L0.6020.67
67_H181_D0.6000.66
116_A119_D0.5980.66
30_L214_I0.5960.66
104_I109_M0.5950.66
4_L12_R0.5940.66
55_S165_N0.5910.65
12_R15_V0.5900.65
37_K190_E0.5840.64
49_G200_K0.5820.64
10_V33_L0.5810.64
23_I175_I0.5810.64
80_Q120_A0.5770.63
122_R125_G0.5760.63
103_Q109_M0.5760.63
94_L104_I0.5750.63
182_A214_I0.5750.63
29_L32_E0.5730.63
46_V59_V0.5720.63
40_E216_T0.5720.63
116_A120_A0.5710.63
27_I42_V0.5700.63
9_R12_R0.5680.62
51_D70_G0.5680.62
154_K184_K0.5670.62
54_K58_N0.5670.62
79_T83_N0.5670.62
55_S58_N0.5660.62
54_K203_Q0.5640.62
69_T180_F0.5570.61
105_K127_L0.5550.61
62_A195_A0.5520.60
212_V215_S0.5520.60
30_L219_G0.5520.60
27_I31_K0.5510.60
37_K167_K0.5510.60
23_I214_I0.5500.60
141_K149_V0.5500.60
97_M117_S0.5490.60
7_R13_E0.5490.60
5_T13_E0.5470.59
59_V195_A0.5470.59
213_S223_A0.5460.59
51_D57_Q0.5450.59
45_A168_N0.5440.59
100_L124_V0.5440.59
216_T221_G0.5440.59
107_G111_F0.5430.59
47_N170_I0.5390.58
171_I192_L0.5380.58
40_E218_M0.5380.58
51_D68_G0.5370.58
132_G135_G0.5350.58
7_R40_E0.5340.58
94_L111_F0.5330.57
10_V22_D0.5330.57
128_G169_G0.5330.57
74_R134_R0.5320.57
52_A171_I0.5310.57
79_T95_V0.5310.57
81_G95_V0.5310.57
184_K209_I0.5310.57
7_R36_A0.5300.57
113_V140_P0.5300.57
87_A149_V0.5290.57
7_R34_A0.5290.57
64_V158_A0.5250.56
77_V84_A0.5250.56
44_V175_I0.5250.56
20_Q224_V0.5240.56
102_D126_Q0.5240.56
28_A181_D0.5190.55
45_A169_G0.5190.55
201_P208_Y0.5170.55
27_I30_L0.5170.55
91_G95_V0.5160.55
39_V177_K0.5150.55
81_G87_A0.5150.55
105_K130_V0.5140.55
127_L189_L0.5130.55
16_D223_A0.5130.55
122_R147_P0.5110.54
63_T173_T0.5090.54
124_V147_P0.5090.54
122_R126_Q0.5080.54
26_A220_A0.5080.54
49_G206_G0.5070.54
107_G130_V0.5060.54
45_A170_I0.5060.54
49_G52_A0.5050.53
15_V33_L0.5040.53
126_Q196_L0.5010.53
5_T10_V0.5010.53
142_V160_Q0.5000.53
12_R16_D0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qoyA 1 1 100 0.127 Contact Map
4reoA 1 0.9402 100 0.133 Contact Map
3bboD 1 0.9701 100 0.135 Contact Map
3j8g5 1 1 100 0.136 Contact Map
3j3w5 1 0.5128 100 0.152 Contact Map
4lq4A 1 0.859 100 0.268 Contact Map
3j21A 1 0.8803 100 0.269 Contact Map
4cxdu 1 0.8547 100 0.272 Contact Map
1mzpA 1 0.8761 100 0.276 Contact Map
4w27z 1 0.8803 100 0.296 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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