GREMLIN Database
RL19 - 50S ribosomal protein L19
UniProt: P0A7K6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10880
Length: 115 (111)
Sequences: 2147 (874)
Seq/√Len: 82.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_K83_S3.6771.00
50_I57_S3.3631.00
29_K42_A2.8191.00
46_V100_L2.7701.00
27_E44_E2.7691.00
3_N6_K2.6301.00
29_K40_L2.5601.00
26_V47_V2.2861.00
103_R107_A2.2581.00
90_G110_I2.1531.00
52_N57_S2.0621.00
29_K85_S1.9331.00
9_E56_H1.9281.00
20_F47_V1.9121.00
31_W38_K1.8401.00
13_M77_H1.8071.00
27_E87_K1.7771.00
27_E85_S1.7061.00
53_R57_S1.6691.00
20_F59_F1.6681.00
14_K77_H1.6601.00
27_E42_A1.6571.00
31_W82_D1.6511.00
49_A96_K1.6381.00
71_E101_R1.6111.00
30_V72_R1.6091.00
6_K10_Q1.5421.00
88_R112_E1.5351.00
21_R113_R1.5351.00
33_V38_K1.5150.99
105_G108_A1.4930.99
33_V36_S1.4840.99
9_E55_L1.3560.99
25_T46_V1.2900.98
38_K80_V1.2800.98
30_V74_F1.2700.98
7_Q10_Q1.2700.98
44_E87_K1.2660.98
8_L11_E1.2450.98
33_V80_V1.2420.98
50_I76_T1.2280.98
91_A113_R1.2100.97
49_A73_V1.1710.97
91_A111_K1.1680.97
21_R89_R1.1680.97
6_K9_E1.1520.96
48_I98_Y1.1210.96
60_T73_V1.1140.96
16_D77_H1.1090.96
97_L100_L1.1090.96
49_A98_Y1.0380.94
28_V81_V1.0290.93
10_Q13_M1.0290.93
25_T90_G1.0270.93
99_Y110_I1.0110.93
44_E88_R1.0070.93
5_I8_L0.9890.92
57_S76_T0.9860.92
26_V61_V0.9550.91
15_Q77_H0.9480.90
22_P95_A0.9380.90
89_R113_R0.9200.89
51_R58_A0.9030.88
7_Q11_E0.8990.88
75_Q80_V0.8870.87
5_I9_E0.8840.87
46_V110_I0.8820.87
30_V80_V0.8690.86
57_S77_H0.8560.85
58_A68_E0.8560.85
100_L105_G0.8540.85
28_V59_F0.8530.85
63_K66_N0.8330.84
5_I11_E0.8330.84
47_V59_F0.8290.83
4_I7_Q0.8290.83
30_V81_V0.8210.83
22_P63_K0.8080.82
103_R108_A0.7920.80
54_G57_S0.7910.80
51_R56_H0.7800.79
8_L12_Q0.7780.79
59_F81_V0.7730.79
14_K17_V0.7720.79
9_E12_Q0.7700.78
22_P110_I0.7620.78
22_P109_R0.7550.77
10_Q15_Q0.7520.77
94_K97_L0.7520.77
17_V84_I0.7450.76
4_I8_L0.7290.75
3_N7_Q0.7260.74
92_V110_I0.7180.73
65_S108_A0.7090.73
51_R73_V0.7090.73
58_A76_T0.7090.73
20_F50_I0.7040.72
40_L82_D0.7020.72
24_D89_R0.6980.71
38_K82_D0.6940.71
86_V89_R0.6870.70
81_V84_I0.6850.70
104_T109_R0.6850.70
34_E37_K0.6810.69
5_I12_Q0.6800.69
68_E73_V0.6800.69
37_K66_N0.6760.69
51_R98_Y0.6740.69
60_T75_Q0.6690.68
42_A83_S0.6600.67
20_F24_D0.6470.66
40_L83_S0.6450.65
64_I109_R0.6430.65
44_E85_S0.6350.64
18_P86_V0.6310.64
16_D111_K0.6310.64
21_R97_L0.6100.61
58_A73_V0.6070.61
22_P97_L0.6020.60
20_F86_V0.5980.60
43_F61_V0.5970.59
43_F74_F0.5930.59
99_Y106_K0.5890.58
20_F112_E0.5860.58
48_I101_R0.5860.58
75_Q112_E0.5820.57
89_R110_I0.5810.57
59_F76_T0.5800.57
36_S64_I0.5780.57
25_T87_K0.5760.57
49_A60_T0.5700.56
59_F73_V0.5700.56
61_V74_F0.5680.56
19_S89_R0.5590.54
37_K44_E0.5580.54
56_H96_K0.5560.54
89_R112_E0.5530.54
62_R70_V0.5460.53
109_R113_R0.5420.52
46_V105_G0.5400.52
94_K99_Y0.5390.52
24_D90_G0.5380.52
22_P66_N0.5380.52
41_Q63_K0.5360.51
72_R109_R0.5280.50
32_V37_K0.5260.50
98_Y101_R0.5240.50
31_W43_F0.5220.50
46_V88_R0.5210.49
17_V77_H0.5200.49
20_F28_V0.5130.48
95_A98_Y0.5110.48
60_T101_R0.5100.48
52_N88_R0.5100.48
35_G60_T0.5080.48
17_V76_T0.5080.48
42_A68_E0.5070.48
12_Q73_V0.5060.47
22_P50_I0.5050.47
43_F65_S0.5040.47
51_R66_N0.5020.47
82_D86_V0.5020.47
8_L53_R0.5010.47
42_A87_K0.5010.47
53_R68_E0.5000.47
4_I11_E0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb6T 1 1 100 0.069 Contact Map
2zjrM 1 0.8783 100 0.071 Contact Map
4tp9P 1 0.9913 100 0.083 Contact Map
3j3wP 1 0.9739 100 0.086 Contact Map
3j7yQ 1 0.9217 100 0.165 Contact Map
3bboR 1 0.9565 100 0.185 Contact Map
1vw4M 1 0.9739 100 0.248 Contact Map
4hczA 1 0.4783 38.4 0.929 Contact Map
1pjrA 1 0.1391 27.3 0.934 Contact Map
2lq8A 1 0.6435 20.7 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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