GREMLIN Database
RL7 - 50S ribosomal protein L7/L12
UniProt: P0A7K2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10873
Length: 121 (117)
Sequences: 2664 (1070)
Seq/√Len: 98.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_A30_K3.0781.00
82_K86_D2.9681.00
108_K112_E2.9001.00
7_Q11_A2.7801.00
76_A107_L2.7391.00
111_L116_A2.7171.00
106_A110_A2.4961.00
60_K119_E2.4961.00
60_K117_E2.4741.00
65_N68_A2.4201.00
61_A117_E2.3111.00
58_I94_A2.2661.00
72_A75_G2.1911.00
109_K113_E2.1351.00
75_G110_A2.1281.00
5_K15_M1.7531.00
62_A89_E1.6881.00
56_D98_G1.5621.00
86_D90_S1.5321.00
51_E101_K1.5231.00
8_I11_A1.5051.00
100_S103_D1.4901.00
108_K118_V1.4871.00
21_V25_S1.4671.00
10_E14_A1.4561.00
9_I27_M1.4511.00
13_A31_F1.4451.00
73_V88_V1.3940.99
10_E13_A1.3930.99
17_V20_V1.3890.99
103_D106_A1.3620.99
68_A114_A1.3530.99
61_A64_A1.3500.99
105_E109_K1.3380.99
106_A109_K1.3110.99
96_K103_D1.2720.99
6_D10_E1.2660.99
52_K55_F1.2310.99
7_Q10_E1.1980.98
25_S28_E1.1790.98
5_K26_A1.1750.98
96_K107_L1.1740.98
11_A14_A1.1620.98
6_D26_A1.1600.98
72_A113_E1.1480.98
12_V31_F1.1370.98
38_A41_V1.1140.98
112_E117_E1.0610.97
109_K112_E1.0540.97
54_E98_G1.0350.96
5_K11_A1.0340.96
99_V120_V1.0310.96
58_I119_E1.0290.96
73_V95_L1.0250.96
52_K56_D1.0200.96
11_A15_M1.0200.96
55_F101_K1.0170.96
8_I23_L1.0110.96
90_S93_A1.0080.95
102_D106_A1.0060.95
9_I13_A0.9880.95
65_N114_A0.9740.95
66_K88_V0.9690.94
18_M21_V0.9650.94
103_D107_L0.9640.94
72_A110_A0.9590.94
9_I26_A0.9590.94
12_V27_M0.9530.94
101_K105_E0.9440.94
59_L91_A0.9430.94
67_V74_R0.9370.93
83_E86_D0.9350.93
108_K120_V0.9240.93
56_D94_A0.9150.93
86_D93_A0.9110.92
9_I31_F0.9060.92
20_V27_M0.9020.92
5_K9_I0.8920.92
99_V107_L0.8780.91
16_S19_D0.8770.91
102_D105_E0.8720.91
28_E35_A0.8580.90
57_V104_A0.8560.90
76_A110_A0.8340.89
87_L93_A0.8150.87
99_V103_D0.8060.87
88_V91_A0.8000.86
8_I26_A0.8000.86
52_K98_G0.7940.86
5_K8_I0.7880.86
110_A113_E0.7860.85
8_I12_V0.7860.85
56_D97_E0.7840.85
45_P49_A0.7820.85
43_A47_E0.7820.85
63_G69_V0.7810.85
38_A42_A0.7790.85
94_A97_E0.7760.85
57_V107_L0.7710.84
80_G83_E0.7680.84
63_G116_A0.7620.84
56_D121_K0.7590.83
21_V27_M0.7550.83
44_G47_E0.7410.82
60_K121_K0.7390.82
28_E34_S0.7360.82
60_K92_P0.7340.81
112_E120_V0.7290.81
51_E55_F0.7150.80
78_G96_K0.7090.79
112_E118_V0.7050.79
37_A42_A0.7020.78
74_R77_T0.6970.78
26_A30_K0.6970.78
70_I74_R0.6970.78
74_R79_L0.6960.78
74_R80_G0.6900.77
8_I27_M0.6900.77
15_M27_M0.6830.76
15_M31_F0.6760.76
76_A111_L0.6740.76
12_V34_S0.6730.75
87_L95_L0.6680.75
12_V23_L0.6590.74
9_I30_K0.6570.74
55_F120_V0.6480.73
67_V70_I0.6340.71
23_L27_M0.6320.71
53_T120_V0.6270.70
24_I31_F0.6260.70
44_G49_A0.6250.70
60_K91_A0.6220.70
45_P48_A0.6100.68
90_S94_A0.6070.68
12_V17_V0.6060.68
52_K101_K0.6040.67
79_L87_L0.6000.67
52_K100_S0.6000.67
39_V42_A0.5950.66
77_T80_G0.5940.66
88_V92_P0.5920.66
77_T96_K0.5890.65
105_E120_V0.5880.65
19_D22_E0.5850.65
59_L66_K0.5790.64
77_T95_L0.5780.64
21_V24_I0.5760.64
111_L118_V0.5750.64
46_V49_A0.5750.64
111_L114_A0.5740.63
13_A27_M0.5700.63
7_Q15_M0.5620.62
99_V104_A0.5580.61
25_S29_E0.5560.61
37_A41_V0.5490.60
27_M31_F0.5470.60
28_E33_V0.5420.59
54_E100_S0.5400.59
6_D30_K0.5400.59
59_L116_A0.5380.59
12_V15_M0.5330.58
20_V23_L0.5300.57
72_A111_L0.5270.57
59_L62_A0.5170.56
5_K20_V0.5130.55
67_V89_E0.5120.55
28_E31_F0.5120.55
72_A76_A0.5100.55
25_S32_G0.5100.55
5_K30_K0.5070.54
87_L94_A0.5070.54
20_V24_I0.5060.54
95_L111_L0.5050.54
34_S37_A0.5030.54
66_K89_E0.5000.53
68_A72_A0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kix6 1 0.2479 100 0.046 Contact Map
2zjq5 1 0.5868 100 0.08 Contact Map
1dd3A 6 0.9835 100 0.086 Contact Map
2ftcE 2 0.9835 100 0.115 Contact Map
1ctfA 2 0.562 99.9 0.338 Contact Map
4qs1e 1 0.595 99.9 0.378 Contact Map
4kcze 1 0.595 99.9 0.381 Contact Map
1dd4C 7 0.3306 98.4 0.749 Contact Map
1zavU 5 0.2479 97.1 0.811 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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