GREMLIN Database
RL10 - 50S ribosomal protein L10
UniProt: P0A7J3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10871
Length: 165 (157)
Sequences: 2965 (1715)
Seq/√Len: 136.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_P122_Q3.5501.00
156_A160_D3.0291.00
75_A110_A2.9931.00
18_V51_Y2.9791.00
156_A159_R2.8681.00
21_G86_M2.5141.00
16_S20_K2.4971.00
149_G153_R2.3711.00
62_R65_E2.3491.00
132_Y136_I2.3161.00
40_E44_A2.3141.00
16_S66_G2.2371.00
5_L9_Q2.1771.00
17_E21_G2.1741.00
121_S124_D2.1381.00
98_E102_A2.1181.00
44_A47_E2.0181.00
124_D128_T1.9851.00
134_E138_R1.9801.00
44_A98_E1.9651.00
37_K103_N1.9381.00
116_E122_Q1.9181.00
157_A160_D1.7401.00
49_G87_E1.7361.00
15_V55_V1.7241.00
65_E70_E1.7221.00
97_K128_T1.7161.00
6_Q9_Q1.6621.00
44_A102_A1.6481.00
29_D107_E1.6131.00
113_F118_I1.6061.00
13_A17_E1.5891.00
34_T37_K1.5721.00
97_K124_D1.5481.00
138_R141_A1.5401.00
150_K153_R1.5091.00
99_F103_N1.4821.00
142_T145_E1.4321.00
28_A52_M1.3991.00
17_E20_K1.3961.00
28_A81_L1.3521.00
61_R73_K1.3381.00
29_D109_K1.3381.00
131_T135_A1.3241.00
120_A124_D1.3191.00
5_L8_K1.3091.00
10_A13_A1.2911.00
98_E101_K1.2881.00
139_L143_M1.2821.00
131_T134_E1.2601.00
16_S67_T1.2481.00
52_M81_L1.2451.00
55_V60_L1.2441.00
45_G50_V1.2401.00
71_C117_L1.2371.00
38_M52_M1.2201.00
60_L82_I1.2171.00
43_K47_E1.2091.00
150_K154_T1.2071.00
31_R79_P1.2041.00
52_M83_A1.2011.00
19_A60_L1.1951.00
90_G94_R1.1710.99
140_M143_M1.1690.99
122_Q125_R1.1570.99
137_A141_A1.1470.99
41_L99_F1.1290.99
9_Q12_V1.1270.99
19_A64_V1.1230.99
153_R156_A1.1220.99
9_Q13_A1.1210.99
18_V84_Y1.1190.99
133_E136_I1.0990.99
65_E73_K1.0930.99
80_T109_K1.0780.99
6_Q10_A1.0670.99
27_V72_L1.0650.99
88_H91_A1.0590.99
70_E73_K1.0380.99
136_I140_M1.0330.99
33_V106_F1.0160.98
48_A95_L1.0070.98
7_D10_A1.0060.98
40_E102_A1.0010.98
45_G81_L1.0010.98
36_D40_E0.9960.98
37_K105_K0.9860.98
140_M144_K0.9800.98
97_K127_A0.9790.98
139_L142_T0.9740.98
151_L155_L0.9710.98
10_A14_E0.9700.98
15_V60_L0.9530.98
29_D80_T0.9520.98
45_G96_F0.9470.98
137_A140_M0.9350.97
60_L80_T0.9340.97
158_V161_A0.9310.97
50_V83_A0.9270.97
5_L12_V0.9170.97
14_E53_R0.9030.97
154_T158_V0.8840.96
23_L87_E0.8690.96
58_T61_R0.8490.95
85_S92_A0.8350.95
153_R160_D0.8320.95
11_I59_L0.8310.95
76_F82_I0.8250.95
97_K108_V0.8230.95
14_E18_V0.8210.94
26_V83_A0.8090.94
13_A66_G0.8080.94
125_R128_T0.7980.94
66_G70_E0.7960.94
139_L151_L0.7940.93
45_G95_L0.7930.93
19_A84_Y0.7920.93
124_D127_A0.7850.93
35_V39_T0.7840.93
37_K40_E0.7840.93
150_K157_A0.7810.93
153_R157_A0.7710.92
48_A91_A0.7670.92
38_M81_L0.7640.92
27_V80_T0.7630.92
145_E150_K0.7610.92
152_V156_A0.7590.92
51_Y86_M0.7590.92
5_L62_R0.7520.91
41_L103_N0.7450.91
7_D11_I0.7410.91
40_E103_N0.7360.91
13_A16_S0.7350.91
154_T157_A0.7350.91
23_L114_E0.7330.90
140_M152_V0.7320.90
19_A25_A0.7290.90
101_K128_T0.7110.89
60_L64_V0.7100.89
71_C74_D0.7050.89
96_F106_F0.7020.88
45_G92_A0.7010.88
50_V95_L0.6950.88
25_A82_I0.6840.87
55_V59_L0.6830.87
33_V103_N0.6830.87
83_A96_F0.6820.87
24_S85_S0.6820.87
75_A117_L0.6810.87
83_A93_A0.6770.87
27_V110_A0.6760.86
111_A123_I0.6750.86
12_V59_L0.6670.86
61_R77_V0.6600.85
36_D39_T0.6600.85
149_G158_V0.6600.85
96_F108_V0.6530.85
4_N7_D0.6510.84
107_E120_A0.6500.84
43_K46_R0.6490.84
25_A64_V0.6400.83
141_A145_E0.6390.83
138_R142_T0.6390.83
49_G86_M0.6360.83
33_V37_K0.6350.83
69_F112_A0.6350.83
8_K12_V0.6250.82
28_A106_F0.6250.82
61_R74_D0.6250.82
130_P138_R0.6250.82
97_K101_K0.6230.82
140_M147_S0.6160.81
45_G52_M0.6150.81
20_K67_T0.6100.80
50_V92_A0.6090.80
18_V86_M0.6070.80
57_N109_K0.6060.80
144_K148_A0.6050.80
74_D77_V0.6000.79
141_A149_G0.5980.79
118_I126_L0.5960.79
153_R159_R0.5940.79
26_V85_S0.5940.79
30_S38_M0.5920.78
21_G87_E0.5870.78
11_I14_E0.5850.78
64_V67_T0.5830.77
100_A103_N0.5830.77
48_A94_R0.5820.77
100_A106_F0.5800.77
72_L80_T0.5800.77
64_V73_K0.5790.77
76_F80_T0.5780.77
44_A48_A0.5780.77
44_A95_L0.5770.77
29_D82_I0.5750.76
4_N8_K0.5740.76
155_L158_V0.5720.76
72_L109_K0.5700.76
20_K68_P0.5670.75
15_V84_Y0.5660.75
155_L159_R0.5650.75
151_L158_V0.5640.75
137_A157_A0.5620.75
103_N107_E0.5610.75
50_V85_S0.5590.74
57_N80_T0.5530.73
50_V59_L0.5480.73
149_G160_D0.5450.72
118_I149_G0.5430.72
130_P135_A0.5420.72
35_V38_M0.5410.72
40_E47_E0.5380.71
15_V19_A0.5330.71
68_P71_C0.5310.70
85_S110_A0.5270.70
98_E134_E0.5260.70
126_L129_L0.5260.70
55_V82_I0.5240.69
29_D105_K0.5240.69
128_T134_E0.5210.69
153_R158_V0.5180.69
108_V120_A0.5180.69
72_L76_F0.5180.69
11_I58_T0.5170.68
148_A153_R0.5140.68
108_V123_I0.5140.68
72_L117_L0.5140.68
22_A84_Y0.5120.68
64_V76_F0.5100.67
30_S33_V0.5090.67
31_R78_G0.5030.66
72_L112_A0.5020.66
21_G51_Y0.5020.66
13_A44_A0.5010.66
23_L131_T0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kix5 1 0.897 100 0.1 Contact Map
1zavA 1 0.9758 100 0.163 Contact Map
3j7yI 1 0.7333 100 0.176 Contact Map
3a1yG 1 0.6182 99.9 0.518 Contact Map
1vq8G 1 0 99.9 0.518 Contact Map
4hubG 1 0.8727 99.9 0.524 Contact Map
3j65n 1 0.9818 99.9 0.526 Contact Map
3j21k 1 0.9212 99.9 0.532 Contact Map
4nwbA 2 0.9273 99.9 0.55 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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