GREMLIN Database
RIBB - 3,4-dihydroxy-2-butanone 4-phosphate synthase
UniProt: P0A7J0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10465
Length: 217 (202)
Sequences: 3409 (1733)
Seq/√Len: 121.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_R77_Q3.8201.00
22_A27_R3.5511.00
177_N187_E3.4211.00
151_G206_V2.9411.00
48_E167_K2.8121.00
59_I66_V2.7101.00
22_A198_A2.5521.00
157_T170_G2.4561.00
124_D167_K2.3611.00
47_A169_A2.3471.00
19_A200_V2.3081.00
18_N198_A2.2521.00
177_N181_T2.2191.00
45_F54_Q2.2181.00
68_L121_A2.0981.00
59_I176_T2.0821.00
75_R141_R2.0511.00
126_A131_L2.0331.00
76_K141_R2.0321.00
14_E18_N2.0151.00
72_E144_A2.0061.00
143_Q149_T2.0031.00
70_I75_R1.9621.00
65_I109_V1.9501.00
49_T166_F1.9381.00
191_F195_H1.9301.00
21_A25_E1.9101.00
116_T120_A1.8851.00
118_V137_V1.8641.00
99_I121_A1.8541.00
120_A131_L1.8191.00
31_V156_A1.7981.00
43_M191_F1.7791.00
72_E76_K1.7581.00
46_P166_F1.6861.00
55_M66_V1.6721.00
75_R80_L1.6421.00
145_G149_T1.6401.00
101_A120_A1.6311.00
29_V160_L1.6221.00
72_E141_R1.6111.00
142_A158_I1.6021.00
28_G45_F1.5741.00
189_I199_L1.5671.00
73_D144_A1.5511.00
98_T138_F1.5451.00
120_A123_A1.5381.00
189_I193_N1.5311.00
60_R63_S1.5301.00
159_D209_R1.5231.00
21_A24_R1.5101.00
30_M192_A1.4751.00
23_L46_P1.4561.00
55_M118_V1.4291.00
32_L201_T1.4181.00
15_R18_N1.4031.00
23_L29_V1.3881.00
43_M62_G1.3751.00
65_I138_F1.3441.00
32_L185_A1.3341.00
60_R178_D1.2821.00
41_G188_C1.2761.00
23_L161_M1.2290.99
57_L195_H1.2260.99
50_M115_I1.2180.99
160_L200_V1.2100.99
28_G54_Q1.2080.99
43_M197_M1.2030.99
127_K130_D1.2030.99
31_V200_V1.1930.99
185_A199_L1.1910.99
177_N183_A1.1890.99
32_L199_L1.1830.99
48_E166_F1.1800.99
82_M141_R1.1700.99
50_M55_M1.1620.99
157_T172_L1.1610.99
52_V115_I1.1550.99
148_L209_R1.1490.99
30_M197_M1.1470.99
118_V171_V1.1430.99
116_T119_R1.1300.99
102_A132_N1.1300.99
51_T54_Q1.1300.99
115_I119_R1.1290.99
70_I169_A1.1230.99
101_A105_V1.1180.99
71_T168_P1.1040.99
175_L188_C1.1030.99
28_G43_M1.1020.99
187_E190_E1.0970.99
68_L118_V1.0800.98
175_L183_A1.0790.98
209_R213_E1.0750.98
44_I172_L1.0740.98
192_A199_L1.0690.98
66_V173_C1.0630.98
103_E116_T1.0500.98
106_T113_D1.0390.98
122_I169_A1.0370.98
27_R198_A1.0290.98
30_M175_L1.0230.98
68_L99_I1.0170.98
56_A63_S1.0090.98
79_D133_R1.0060.98
16_V200_V0.9730.97
90_A132_N0.9700.97
16_V205_L0.9630.97
50_M54_Q0.9520.97
75_R82_M0.9470.97
20_L163_L0.9450.96
61_H194_K0.9430.96
144_A149_T0.9360.96
22_A25_E0.9290.96
74_R167_K0.9280.96
207_A211_A0.9280.96
55_M171_V0.9240.96
70_I121_A0.9210.96
31_V44_I0.9190.96
46_P161_M0.9180.96
161_M169_A0.9020.95
46_P49_T0.9020.95
61_H191_F0.9000.95
185_A189_I0.8990.95
69_C172_L0.8870.95
151_G203_E0.8850.95
61_H178_D0.8840.95
148_L159_D0.8800.95
204_D207_A0.8770.95
13_F201_T0.8770.95
44_I153_H0.8710.94
68_L137_V0.8650.94
71_T74_R0.8630.94
147_V159_D0.8620.94
38_E42_D0.8570.94
13_F185_A0.8520.94
63_S176_T0.8520.94
57_L197_M0.8480.94
58_T66_V0.8430.93
43_M57_L0.8380.93
14_E198_A0.8380.93
28_G197_M0.8320.93
120_A126_A0.8320.93
52_V112_A0.8240.93
148_L210_Q0.8210.93
89_S132_N0.8180.92
192_A197_M0.8170.92
69_C158_I0.8170.92
101_A131_L0.8150.92
190_E193_N0.7970.91
112_A181_T0.7970.91
88_T133_R0.7910.91
156_A202_I0.7830.91
37_R42_D0.7830.91
15_R204_D0.7810.91
40_E154_T0.7800.90
14_E193_N0.7780.90
190_E194_K0.7670.90
68_L122_I0.7600.89
60_R194_K0.7570.89
19_A31_V0.7510.89
163_L205_L0.7500.89
20_L164_A0.7450.88
65_I173_C0.7450.88
45_F58_T0.7430.88
66_V176_T0.7320.87
203_E206_V0.7310.87
19_A29_V0.7290.87
45_F50_M0.7240.87
57_L61_H0.7200.87
105_V120_A0.7180.86
70_I74_R0.7150.86
100_E131_L0.7130.86
101_A116_T0.7110.86
104_G116_T0.7110.86
105_V131_L0.7090.86
44_I157_T0.7090.86
146_G159_D0.7020.85
69_C157_T0.7010.85
105_V113_D0.6990.85
122_I167_K0.6980.85
95_F138_F0.6950.85
62_G173_C0.6940.85
80_L121_A0.6920.84
30_M191_F0.6910.84
161_M166_F0.6900.84
89_S100_E0.6900.84
203_E207_A0.6900.84
89_S92_G0.6880.84
73_D77_Q0.6850.84
163_L208_Y0.6850.84
59_I63_S0.6840.84
57_L191_F0.6830.84
101_A104_G0.6830.84
34_D151_G0.6810.83
81_P85_E0.6790.83
83_M98_T0.6770.83
43_M175_L0.6760.83
104_G113_D0.6720.83
65_I95_F0.6720.83
55_M59_I0.6710.83
151_G210_Q0.6690.82
156_A205_L0.6650.82
40_E153_H0.6630.82
100_E133_R0.6580.81
94_G143_Q0.6580.81
27_R196_N0.6560.81
188_C199_L0.6560.81
32_L188_C0.6550.81
88_T132_N0.6550.81
72_E75_R0.6540.81
38_E174_E0.6540.81
56_A62_G0.6530.81
65_I98_T0.6520.81
42_D174_E0.6500.81
42_D154_T0.6480.80
183_A187_E0.6470.80
20_L23_L0.6460.80
59_I62_G0.6420.80
126_A130_D0.6410.80
105_V132_N0.6400.80
79_D129_S0.6370.79
186_P189_I0.6370.79
42_D153_H0.6360.79
59_I65_I0.6350.79
37_R40_E0.6340.79
16_V20_L0.6320.79
157_T161_M0.6310.79
63_S109_V0.6280.78
37_R174_E0.6220.78
185_A201_T0.6210.77
62_G176_T0.6170.77
206_V209_R0.6160.77
61_H195_H0.6130.77
102_A105_V0.6110.76
123_A126_A0.6110.76
41_G186_P0.6090.76
30_M188_C0.6080.76
46_P164_A0.6050.76
193_N196_N0.6040.76
153_H202_I0.5990.75
15_R200_V0.5990.75
137_V171_V0.5950.74
43_M195_H0.5930.74
47_A171_V0.5910.74
62_G191_F0.5880.74
42_D67_C0.5870.73
55_M58_T0.5850.73
97_V133_R0.5850.73
82_M94_G0.5850.73
106_T184_R0.5830.73
33_D40_E0.5810.73
18_N21_A0.5810.73
112_A116_T0.5810.73
154_T174_E0.5790.72
30_M199_L0.5760.72
62_G65_I0.5720.72
23_L164_A0.5700.71
23_L160_L0.5700.71
34_D203_E0.5700.71
177_N194_K0.5690.71
100_E105_V0.5680.71
91_Y132_N0.5680.71
63_S175_L0.5660.71
210_Q214_R0.5660.71
189_I192_A0.5650.71
71_T75_R0.5620.70
37_R154_T0.5610.70
211_A214_R0.5580.70
206_V210_Q0.5510.69
56_A111_A0.5500.69
140_L172_L0.5480.68
35_E185_A0.5470.68
71_T144_A0.5430.68
40_E174_E0.5420.67
69_C140_L0.5410.67
35_E41_G0.5400.67
128_P133_R0.5380.67
77_Q167_K0.5370.67
79_D128_P0.5350.66
38_E153_H0.5340.66
38_E154_T0.5280.65
153_H156_A0.5280.65
71_T162_T0.5260.65
105_V116_T0.5230.65
89_S94_G0.5210.64
99_I131_L0.5200.64
23_L44_I0.5190.64
208_Y212_H0.5160.64
14_E192_A0.5140.63
162_T168_P0.5130.63
87_N93_T0.5110.63
20_L205_L0.5110.63
15_R19_A0.5080.63
28_G46_P0.5080.63
14_E189_I0.5070.62
91_Y153_H0.5070.62
17_E208_Y0.5070.62
147_V209_R0.5050.62
113_D116_T0.5040.62
177_N180_G0.5020.62
140_L154_T0.5010.61
68_L169_A0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g57A 2 0.9677 100 0.058 Contact Map
4p6dA 2 0.9355 100 0.066 Contact Map
1k4iA 2 0.9401 100 0.071 Contact Map
3mioA 2 0.8894 100 0.081 Contact Map
4ffjA 2 0.8986 100 0.082 Contact Map
4i14A 2 0.9171 100 0.085 Contact Map
1tksA 2 0.8986 100 0.087 Contact Map
1snnA 2 0.9032 100 0.1 Contact Map
4gimA 3 0.8479 65.5 0.949 Contact Map
1vkmA 5 0.8018 40.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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