GREMLIN Database
RIBA - GTP cyclohydrolase-2
UniProt: P0A7I7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11331
Length: 196 (191)
Sequences: 3764 (2114)
Seq/√Len: 153.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_F139_L4.4661.00
8_E19_L3.6571.00
112_Y120_Q3.5421.00
144_E164_N3.5331.00
53_E90_R3.3111.00
78_I86_L2.8721.00
37_Y79_A2.8521.00
5_R21_V2.6611.00
146_R167_E2.6521.00
10_K17_D2.5661.00
116_E189_K2.5381.00
25_E28_T2.4201.00
146_R169_V2.3661.00
75_L86_L2.3591.00
119_H125_A2.3231.00
5_R139_L2.3101.00
100_N123_F2.2361.00
21_V36_V2.1911.00
180_E184_D2.1681.00
184_D188_E2.1601.00
85_I142_V2.1581.00
22_G99_L2.1041.00
4_K26_L1.9921.00
8_E21_V1.9761.00
10_K19_L1.9371.00
153_K190_M1.9201.00
73_A76_T1.9081.00
142_V145_V1.8871.00
124_A127_E1.8671.00
45_P166_V1.8651.00
9_A20_M1.8511.00
87_L136_M1.8351.00
76_T80_E1.8311.00
145_V163_I1.8131.00
81_E146_R1.7481.00
14_P72_E1.7421.00
4_K24_E1.6851.00
55_L60_L1.6641.00
115_V190_M1.6551.00
45_P144_E1.6541.00
156_E160_E1.5081.00
159_T164_N1.4791.00
106_A110_Q1.4661.00
13_T18_F1.4451.00
36_V85_I1.4421.00
153_K157_I1.4321.00
63_L178_N1.4271.00
44_T83_R1.4141.00
34_A85_I1.4131.00
144_E166_V1.3961.00
32_H90_R1.3901.00
5_R8_E1.3521.00
47_L77_Q1.3381.00
96_I118_N1.3301.00
77_Q81_E1.3271.00
168_R193_L1.2891.00
47_L169_V1.2791.00
184_D187_A1.2791.00
6_V24_E1.2561.00
77_Q169_V1.2521.00
20_M33_V1.2511.00
131_T160_E1.2451.00
40_I46_V1.2211.00
14_P69_F1.2191.00
34_A140_L1.2141.00
149_T155_V1.2131.00
42_G83_R1.1941.00
77_Q148_L1.1921.00
123_F127_E1.1871.00
175_R180_E1.1721.00
146_R166_V1.1661.00
71_L86_L1.1441.00
85_I140_L1.1391.00
47_L81_E1.1291.00
116_E119_H1.1271.00
5_R23_F1.1241.00
9_A102_I1.1110.99
43_H83_R1.1040.99
64_R109_D1.1030.99
181_H184_D1.0870.99
73_A77_Q1.0530.99
15_W72_E1.0390.99
155_V193_L1.0370.99
55_L59_A1.0340.99
100_N103_R1.0300.99
127_E155_V1.0240.99
69_F174_G1.0220.99
13_T16_G1.0180.99
156_E159_T1.0100.99
15_W76_T1.0080.99
12_P17_D1.0010.99
131_T135_D1.0000.99
48_A145_V0.9960.99
138_K143_N0.9950.99
7_A106_A0.9940.99
134_A161_A0.9940.99
172_I175_R0.9830.99
45_P167_E0.9780.99
14_P63_L0.9680.99
10_K178_N0.9670.99
21_V140_L0.9650.99
47_L146_R0.9600.98
32_H136_M0.9590.98
7_A102_I0.9520.98
63_L176_N0.9300.98
50_V89_H0.9290.98
44_T144_E0.9230.98
24_E31_D0.9220.98
37_Y82_G0.9210.98
40_I83_R0.9100.98
18_F75_L0.9090.98
89_H133_C0.9000.98
113_D189_K0.8980.98
155_V168_R0.8960.98
177_P180_E0.8940.98
125_A190_M0.8910.98
43_H144_E0.8880.97
175_R183_L0.8860.97
157_I160_E0.8830.97
135_D161_A0.8820.97
39_D42_G0.8810.97
33_V55_L0.8750.97
176_N179_N0.8750.97
54_C67_C0.8650.97
133_C163_I0.8540.97
54_C65_C0.8500.97
77_Q80_E0.8440.97
74_A148_L0.8430.97
48_A137_F0.8400.96
35_L86_L0.8370.96
173_V176_N0.8330.96
69_F176_N0.8310.96
57_G67_C0.8230.96
137_F142_V0.8210.96
69_F72_E0.8140.96
106_A109_D0.8020.95
22_G102_I0.8010.95
27_A135_D0.7970.95
185_T189_K0.7960.95
22_G33_V0.7880.95
60_L88_Y0.7880.95
46_V83_R0.7700.94
96_I107_L0.7700.94
153_K156_E0.7690.94
54_C57_G0.7630.94
14_P61_F0.7610.94
62_S105_Y0.7600.94
72_E79_A0.7570.94
181_H185_T0.7550.94
42_G46_V0.7440.93
60_L71_L0.7370.93
10_K109_D0.7370.93
134_A138_K0.7290.92
189_K193_L0.7270.92
127_E153_K0.7260.92
155_V159_T0.7240.92
131_T157_I0.7160.92
58_D68_G0.7150.92
46_V85_I0.7130.92
65_C93_G0.7070.91
134_A157_I0.7060.91
46_V144_E0.7030.91
73_A171_L0.7020.91
62_S65_C0.7010.91
9_A12_P0.7000.91
181_H187_A0.6990.91
52_S57_G0.6990.91
16_G37_Y0.6960.91
79_A82_G0.6910.90
131_T161_A0.6900.90
17_D178_N0.6900.90
115_V185_T0.6840.90
12_P105_Y0.6720.89
57_G68_G0.6710.89
46_V143_N0.6660.89
174_G177_P0.6570.88
130_F155_V0.6570.88
21_V34_A0.6570.88
180_E188_E0.6540.88
33_V60_L0.6530.88
172_I193_L0.6490.87
41_S44_T0.6420.87
54_C101_K0.6390.87
97_G101_K0.6390.87
69_F173_V0.6360.86
184_D193_L0.6360.86
174_G180_E0.6320.86
36_V40_I0.6300.86
57_G65_C0.6290.86
57_G88_Y0.6280.86
107_L118_N0.6270.86
54_C93_G0.6250.85
52_S70_Q0.6240.85
148_L171_L0.6210.85
56_T62_S0.6170.85
64_R105_Y0.6160.84
126_D154_K0.6150.84
45_P83_R0.6120.84
101_K126_D0.6120.84
20_M35_L0.6090.84
171_L174_G0.6090.84
42_G143_N0.6070.84
175_R184_D0.6070.84
20_M102_I0.6070.84
175_R187_A0.6050.83
12_P64_R0.6030.83
138_K160_E0.5980.83
11_L20_M0.5970.83
66_D105_Y0.5910.82
115_V125_A0.5870.82
115_V189_K0.5840.81
94_R97_G0.5830.81
72_E76_T0.5820.81
61_F72_E0.5790.81
65_C97_G0.5790.81
15_W18_F0.5740.80
68_G72_E0.5690.80
6_V22_G0.5680.79
133_C160_E0.5680.79
178_N184_D0.5670.79
18_F190_M0.5670.79
133_C157_I0.5660.79
176_N180_E0.5640.79
12_P62_S0.5630.79
22_G31_D0.5630.79
101_K151_N0.5600.78
174_G187_A0.5590.78
178_N193_L0.5580.78
70_Q151_N0.5570.78
131_T156_E0.5570.78
174_G179_N0.5560.78
130_F134_A0.5520.77
35_L75_L0.5510.77
56_T70_Q0.5500.77
160_E187_A0.5480.77
52_S88_Y0.5480.77
126_D130_F0.5470.77
73_A173_V0.5460.77
129_D132_L0.5410.76
172_I187_A0.5410.76
70_Q94_R0.5400.76
42_G45_P0.5400.76
172_I180_E0.5390.76
24_E99_L0.5390.76
171_L190_M0.5360.75
62_S92_E0.5330.75
52_S154_K0.5320.75
122_G151_N0.5310.75
105_Y118_N0.5300.75
15_W61_F0.5290.74
6_V99_L0.5280.74
187_A193_L0.5280.74
56_T67_C0.5270.74
31_D99_L0.5240.74
54_C66_D0.5230.74
101_K105_Y0.5220.74
178_N188_E0.5210.73
50_V158_L0.5200.73
115_V119_H0.5200.73
54_C126_D0.5200.73
87_L133_C0.5200.73
48_A187_A0.5180.73
66_D94_R0.5180.73
18_F37_Y0.5170.73
179_N190_M0.5170.73
174_G178_N0.5160.73
175_R193_L0.5140.72
133_C161_A0.5130.72
95_N126_D0.5120.72
57_G151_N0.5120.72
56_T101_K0.5110.72
52_S126_D0.5100.72
93_G97_G0.5090.72
133_C136_M0.5080.72
70_Q154_K0.5080.72
177_P181_H0.5070.71
54_C158_L0.5070.71
104_A121_L0.5060.71
101_K104_A0.5060.71
62_S67_C0.5050.71
81_E169_V0.5050.71
67_C70_Q0.5040.71
23_F34_A0.5030.71
155_V165_I0.5020.71
133_C145_V0.5020.71
74_A171_L0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bz1A 2 0.8827 100 0.015 Contact Map
4i14A 2 0.6531 100 0.029 Contact Map
3mgdA 2 0.7194 27.5 0.955 Contact Map
3ur8A 1 0.4235 24.7 0.956 Contact Map
3te4A 1 0.7857 24.2 0.956 Contact Map
1vr9A 1 0.5204 19.8 0.958 Contact Map
1z4rA 1 0.7755 18.5 0.959 Contact Map
4e0aA 2 0.7041 17.7 0.959 Contact Map
4hpgA 1 0.4184 14.2 0.961 Contact Map
4fd4A 1 0.852 14 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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