GREMLIN Database
RF1 - Peptide chain release factor 1
UniProt: P0A7I0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10761
Length: 360 (338)
Sequences: 5951 (3119)
Seq/√Len: 169.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
282_E285_K4.3741.00
280_A284_A3.1721.00
284_A288_Q3.0681.00
15_R41_E2.9601.00
142_R338_D2.9451.00
113_L164_A2.9421.00
281_A285_K2.7261.00
312_F333_M2.7011.00
227_F256_E2.6921.00
13_H53_T2.6561.00
139_A166_I2.6361.00
60_E64_T2.5611.00
224_I246_I2.5051.00
31_D34_R2.4661.00
110_N208_E2.4661.00
136_S146_V2.4601.00
222_L246_I2.4301.00
228_R241_D2.4011.00
328_R331_E2.3661.00
222_L271_L2.3631.00
19_V38_L2.3371.00
132_F164_A2.3141.00
246_I271_L2.1941.00
285_K289_A2.1681.00
223_R249_L2.1471.00
264_H268_A2.1141.00
27_Q30_A2.1051.00
132_F162_I2.0941.00
142_R174_R2.0621.00
34_R37_A2.0501.00
332_V340_L2.0481.00
232_A236_H1.9891.00
229_S236_H1.9811.00
119_T200_A1.9701.00
18_E22_L1.9541.00
91_Q95_Q1.9521.00
61_D64_T1.9481.00
66_Q86_K1.9091.00
331_E336_K1.9081.00
46_S50_R1.8781.00
283_M287_Q1.8741.00
147_E167_S1.8531.00
54_D88_K1.8521.00
115_V128_A1.8331.00
232_A261_R1.8251.00
22_L34_R1.8201.00
131_L201_C1.8121.00
57_Q61_D1.7751.00
132_F136_S1.7571.00
191_E195_R1.7521.00
138_Y338_D1.7111.00
236_H240_T1.7061.00
279_H283_M1.6931.00
236_H261_R1.6891.00
62_I82_L1.6761.00
324_L339_M1.6651.00
225_D247_T1.6631.00
287_Q291_A1.6501.00
260_E265_K1.6261.00
22_L25_D1.6251.00
146_V164_A1.6181.00
236_H242_S1.6131.00
20_Q46_S1.6121.00
51_C95_Q1.5961.00
147_E165_K1.5901.00
283_M286_R1.5871.00
110_N167_S1.5831.00
88_K91_Q1.5811.00
42_Y46_S1.5581.00
191_E197_H1.5481.00
236_H239_T1.5261.00
23_L39_S1.5241.00
58_V89_S1.5221.00
260_E269_K1.5181.00
80_D84_E1.5081.00
151_A159_Y1.5081.00
224_I267_K1.4901.00
17_E20_Q1.4831.00
20_Q42_Y1.4781.00
247_T254_V1.4721.00
132_F148_I1.4681.00
317_V340_L1.4601.00
282_E286_R1.4391.00
229_S239_T1.4371.00
80_D83_R1.4251.00
312_F329_L1.4241.00
226_T244_I1.4011.00
145_R167_S1.3921.00
33_E37_A1.3821.00
259_D269_K1.3811.00
133_R334_E1.3701.00
273_V277_R1.3641.00
58_V85_A1.3641.00
58_V92_L1.3611.00
268_A272_S1.3471.00
148_I162_I1.3431.00
286_R290_E1.3431.00
226_T241_D1.3301.00
52_F56_Q1.3231.00
33_E36_R1.3201.00
51_C99_L1.3111.00
289_A292_S1.3011.00
139_A146_V1.2901.00
223_R247_T1.2881.00
141_A336_K1.2701.00
269_K272_S1.2501.00
329_L333_M1.2411.00
115_V162_I1.2411.00
264_H267_K1.2311.00
222_L249_L1.2281.00
210_P213_E1.2271.00
15_R18_E1.2211.00
144_W175_L1.2181.00
90_E94_Q1.2131.00
284_A287_Q1.2101.00
326_L332_V1.2041.00
10_E14_E1.2031.00
35_F39_S1.1971.00
87_E91_Q1.1891.00
315_G330_D1.1821.00
253_I281_A1.1731.00
23_L28_T1.1661.00
122_D154_G1.1621.00
165_K208_E1.1611.00
187_V194_G1.1611.00
84_E88_K1.1601.00
200_A300_S1.1581.00
16_H42_Y1.1571.00
50_R54_D1.1471.00
76_E80_D1.1461.00
309_T320_H1.1451.00
88_K92_L1.1381.00
137_R334_E1.1361.00
317_V332_V1.1321.00
108_E170_G1.1171.00
287_Q290_E1.1171.00
115_V203_V1.1041.00
243_A258_Q1.1021.00
326_L339_M1.1011.00
32_Q35_F1.0941.00
112_F149_M1.0871.00
51_C54_D1.0861.00
332_V337_L1.0851.00
112_F165_K1.0811.00
136_S164_A1.0811.00
61_D85_A1.0801.00
265_K272_S1.0781.00
166_I175_L1.0681.00
25_D28_T1.0671.00
64_T67_M1.0651.00
219_P222_L1.0611.00
288_Q292_S1.0560.99
227_F245_R1.0520.99
191_E194_G1.0510.99
69_L82_L1.0490.99
74_M78_A1.0490.99
81_E85_A1.0480.99
62_I89_S1.0470.99
236_H241_D1.0460.99
174_R342_E1.0400.99
298_L305_D1.0400.99
17_E21_A1.0390.99
248_H252_G1.0270.99
214_L275_G1.0270.99
128_A201_C1.0260.99
53_T56_Q1.0260.99
141_A334_E1.0240.99
111_A173_G1.0220.99
106_D109_R1.0170.99
291_A295_R1.0170.99
75_R79_Q1.0160.99
15_R22_L1.0110.99
324_L343_P1.0100.99
328_R339_M1.0090.99
113_L166_I1.0090.99
54_D58_V1.0060.99
226_T236_H1.0050.99
59_Q89_S1.0040.99
159_Y162_I0.9980.99
286_R289_A0.9980.99
62_I85_A0.9960.99
58_V88_K0.9940.99
217_I271_L0.9920.99
56_Q60_E0.9860.99
256_E259_D0.9830.99
63_E67_M0.9770.99
130_D312_F0.9770.99
32_Q36_R0.9750.99
126_L156_H0.9730.99
55_W59_Q0.9690.99
326_L329_L0.9650.99
179_S204_A0.9640.99
10_E56_Q0.9570.99
174_R338_D0.9540.99
177_F344_I0.9520.99
138_Y174_R0.9490.99
14_E18_E0.9480.99
339_M343_P0.9470.99
49_S53_T0.9460.99
108_E169_D0.9430.99
204_A294_R0.9400.99
222_L250_P0.9390.99
50_R53_T0.9380.99
13_H17_E0.9370.99
225_D245_R0.9360.99
71_D74_M0.9350.99
280_A283_M0.9340.99
285_K288_Q0.9290.99
294_R297_L0.9290.99
29_I35_F0.9270.99
253_I278_I0.9260.99
83_R87_E0.9240.99
29_I32_Q0.9160.99
315_G329_L0.9160.99
98_V101_L0.9150.99
125_A156_H0.9080.98
16_H49_S0.9030.98
64_T68_M0.9000.98
144_W171_V0.8970.98
54_D92_L0.8930.98
106_D283_M0.8900.98
148_I151_A0.8880.98
47_D50_R0.8880.98
132_F159_Y0.8870.98
44_Q169_D0.8870.98
90_E93_E0.8860.98
259_D265_K0.8830.98
259_D273_V0.8830.98
337_L341_I0.8820.98
211_D275_G0.8810.98
248_H251_T0.8780.98
275_G279_H0.8750.98
338_D342_E0.8730.98
267_K271_L0.8730.98
110_N165_K0.8710.98
236_H264_H0.8680.98
13_H56_Q0.8670.98
213_E216_D0.8610.98
11_A14_E0.8610.98
256_E273_V0.8610.98
94_Q97_Q0.8590.98
174_R345_I0.8570.98
16_H20_Q0.8560.98
16_H46_S0.8540.98
92_L95_Q0.8520.98
138_Y144_W0.8510.98
239_T244_I0.8470.98
70_D78_A0.8460.98
62_I86_K0.8450.98
137_R140_E0.8440.97
23_L42_Y0.8420.97
117_A124_A0.8400.97
249_L252_G0.8390.97
149_M165_K0.8380.97
281_A284_A0.8330.97
336_K339_M0.8250.97
309_T316_R0.8250.97
219_P271_L0.8230.97
21_A24_G0.8200.97
113_L175_L0.8190.97
151_A162_I0.8160.97
226_T232_A0.8160.97
246_I267_K0.8090.97
311_N316_R0.8070.97
22_L38_L0.8060.97
16_H45_L0.8020.97
129_G154_G0.7980.96
342_E346_Q0.7980.96
318_T325_T0.7970.96
109_R210_P0.7960.96
185_Q309_T0.7950.96
255_V278_I0.7950.96
129_G159_Y0.7930.96
337_L340_L0.7850.96
261_R272_S0.7790.96
265_K268_A0.7770.96
185_Q311_N0.7750.96
224_I244_I0.7720.96
136_S140_E0.7670.96
55_W89_S0.7670.96
322_I343_P0.7650.96
227_F258_Q0.7640.96
25_D30_A0.7620.95
278_I281_A0.7590.95
165_K272_S0.7540.95
187_V193_Q0.7510.95
324_L332_V0.7490.95
69_L78_A0.7470.95
232_A239_T0.7460.95
117_A125_A0.7460.95
55_W58_V0.7460.95
224_I271_L0.7440.95
202_T301_G0.7420.95
54_D57_Q0.7400.95
117_A152_S0.7380.95
141_A338_D0.7370.95
107_D176_K0.7360.95
59_Q63_E0.7350.94
98_V349_Q0.7280.94
240_T262_S0.7270.94
125_A129_G0.7230.94
341_I345_I0.7220.94
85_A89_S0.7210.94
28_T38_L0.7200.94
213_E279_H0.7180.94
106_D279_H0.7150.94
136_S162_I0.7140.94
149_M273_V0.7130.94
314_Q325_T0.7090.93
313_P316_R0.7080.93
209_L213_E0.7080.93
87_E90_E0.7060.93
322_I344_I0.7060.93
65_A85_A0.7050.93
58_V62_I0.7040.93
239_T264_H0.7030.93
14_E17_E0.7030.93
28_T34_R0.7020.93
41_E44_Q0.7020.93
320_H323_N0.7010.93
257_C269_K0.7000.93
225_D249_L0.6990.93
211_D272_S0.6990.93
130_D333_M0.6980.93
228_R236_H0.6970.93
271_L275_G0.6970.93
37_A41_E0.6970.93
314_Q318_T0.6960.93
239_T256_E0.6950.93
119_T302_D0.6950.93
74_M77_M0.6920.93
330_D334_E0.6920.93
155_E306_R0.6920.93
223_R256_E0.6900.92
53_T57_Q0.6900.92
289_A293_T0.6890.92
317_V329_L0.6880.92
83_R86_K0.6840.92
251_T278_I0.6830.92
200_A302_D0.6820.92
62_I66_Q0.6810.92
247_T256_E0.6780.92
28_T35_F0.6770.92
132_F151_A0.6770.92
230_S240_T0.6770.92
20_Q24_G0.6760.92
39_S42_Y0.6750.92
79_Q83_R0.6730.91
221_D250_P0.6660.91
95_Q99_L0.6640.91
65_A82_L0.6620.91
61_D65_A0.6580.91
132_F146_V0.6570.90
134_M337_L0.6540.90
43_A46_S0.6530.90
48_V99_L0.6530.90
211_D214_L0.6520.90
257_C273_V0.6500.90
60_E63_E0.6490.90
237_V241_D0.6490.90
217_I246_I0.6470.90
109_R209_L0.6470.90
99_L170_G0.6470.90
44_Q103_K0.6460.90
21_A25_D0.6460.90
138_Y142_R0.6430.89
255_V273_V0.6400.89
152_S161_E0.6390.89
322_I340_L0.6390.89
18_E21_A0.6380.89
123_E197_H0.6380.89
45_L49_S0.6340.89
327_Y331_E0.6340.89
125_A160_K0.6310.89
111_A172_Y0.6290.88
150_S163_I0.6280.88
181_G297_L0.6270.88
138_Y341_I0.6260.88
340_L343_P0.6250.88
81_E84_E0.6230.88
173_G345_I0.6230.88
229_S243_A0.6220.88
193_Q197_H0.6220.88
179_S297_L0.6220.88
212_A286_R0.6210.88
227_F243_A0.6210.88
68_M78_A0.6200.88
209_L276_A0.6190.88
316_R320_H0.6180.88
249_L253_I0.6180.88
232_A241_D0.6150.87
115_V132_F0.6150.87
126_L312_F0.6140.87
117_A151_A0.6140.87
133_R137_R0.6130.87
85_A88_K0.6130.87
292_S295_R0.6110.87
65_A69_L0.6110.87
227_F247_T0.6110.87
13_H49_S0.6080.87
218_N221_D0.6060.87
122_D156_H0.6060.87
315_G325_T0.6050.86
214_L217_I0.6050.86
12_L48_V0.6050.86
47_D51_C0.6010.86
84_E87_E0.6000.86
35_F42_Y0.6000.86
223_R271_L0.5990.86
37_A40_R0.5980.86
118_G200_A0.5970.86
255_V277_R0.5970.86
66_Q82_L0.5960.86
239_T265_K0.5950.86
171_V175_L0.5930.85
126_L129_G0.5930.85
115_V201_C0.5920.85
192_S197_H0.5920.85
167_S171_V0.5900.85
137_R141_A0.5900.85
38_L42_Y0.5880.85
48_V96_L0.5870.85
92_L96_L0.5860.85
265_K269_K0.5860.85
322_I325_T0.5850.85
129_G151_A0.5850.85
269_K273_V0.5840.85
23_L35_F0.5810.84
246_I255_V0.5800.84
14_E25_D0.5800.84
181_G200_A0.5780.84
51_C92_L0.5770.84
200_A305_D0.5760.84
229_S256_E0.5750.84
116_R202_T0.5730.83
326_L340_L0.5690.83
209_L279_H0.5670.83
124_A181_G0.5660.83
65_A68_M0.5650.83
236_H262_S0.5630.82
86_K90_E0.5630.82
118_G181_G0.5620.82
82_L89_S0.5610.82
10_E13_H0.5600.82
181_G202_T0.5580.82
94_Q98_V0.5580.82
63_E66_Q0.5580.82
150_S161_E0.5580.82
278_I282_E0.5570.82
133_R136_S0.5560.82
255_V260_E0.5560.82
239_T260_E0.5550.81
290_E294_R0.5530.81
326_L331_E0.5520.81
331_E334_E0.5500.81
64_T71_D0.5500.81
30_A35_F0.5480.81
117_A160_K0.5480.81
227_F254_V0.5470.80
130_D189_A0.5450.80
181_G305_D0.5440.80
116_R204_A0.5430.80
224_I247_T0.5410.80
82_L86_K0.5400.80
36_R39_S0.5400.80
315_G320_H0.5400.80
129_G156_H0.5400.80
232_A267_K0.5370.79
68_M74_M0.5370.79
176_K348_H0.5370.79
34_R38_L0.5350.79
209_L283_M0.5340.79
130_D184_V0.5320.79
144_W174_R0.5300.78
118_G160_K0.5290.78
221_D249_L0.5290.78
122_D155_E0.5270.78
311_N314_Q0.5270.78
102_P176_K0.5260.78
128_A159_Y0.5250.78
44_Q108_E0.5240.78
10_E52_F0.5240.78
212_A275_G0.5230.77
226_T239_T0.5220.77
19_V42_Y0.5210.77
230_S256_E0.5210.77
206_M276_A0.5200.77
241_D264_H0.5190.77
73_E77_M0.5170.77
242_S264_H0.5150.76
177_F348_H0.5140.76
225_D256_E0.5140.76
47_D95_Q0.5130.76
217_I275_G0.5100.76
116_R161_E0.5100.76
12_L45_L0.5100.76
65_A78_A0.5090.76
226_T264_H0.5070.75
58_V61_D0.5060.75
298_L301_G0.5050.75
204_A277_R0.5050.75
181_G298_L0.5050.75
69_L77_M0.5040.75
223_R240_T0.5020.75
89_S93_E0.5020.75
77_M80_D0.5010.74
317_V326_L0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b3tB 1 0.8333 100 0.088 Contact Map
3d5aX 1 0.9833 100 0.098 Contact Map
1zbtA 1 0.8833 100 0.102 Contact Map
2ihr1 1 0.9528 100 0.157 Contact Map
1rq0A 3 0.8861 100 0.158 Contact Map
1gqeA 1 0.95 100 0.173 Contact Map
2rsmA 1 0.3194 100 0.702 Contact Map
3j7yp 1 0.1611 100 0.746 Contact Map
1j26A 1 0.2417 100 0.794 Contact Map
4dh9Y 1 0.2639 99.9 0.807 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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