GREMLIN Database
RECO - DNA repair protein RecO
UniProt: P0A7H3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10832
Length: 242 (221)
Sequences: 3094 (2389)
Seq/√Len: 160.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_A24_V3.6411.00
154_S174_A3.6411.00
31_R97_S3.3901.00
154_S177_V3.3451.00
24_V58_L3.3251.00
92_I116_C3.3121.00
24_V34_L3.3021.00
6_R27_E3.1661.00
174_A177_V2.9761.00
27_E111_F2.9541.00
7_A58_L2.8401.00
91_Y135_E2.5511.00
96_L134_F2.5471.00
151_C154_S2.4421.00
8_F114_L2.4211.00
34_L69_L2.2531.00
34_L60_F2.1571.00
76_S118_Q2.1241.00
5_Q28_E2.1161.00
116_C130_A2.1101.00
7_A26_T2.1081.00
126_T202_L2.0541.00
92_I113_Y2.0341.00
151_C174_A1.9951.00
14_P40_R1.9741.00
96_L113_Y1.9731.00
23_D31_R1.9621.00
5_Q29_S1.9481.00
4_W57_L1.9121.00
55_P110_F1.8741.00
95_L135_E1.8501.00
21_M33_R1.8401.00
35_V66_V1.8321.00
20_L39_A1.7951.00
49_A72_A1.7321.00
62_G67_K1.6681.00
136_L209_T1.6081.00
152_A171_G1.5891.00
21_M66_V1.5721.00
89_G93_N1.5681.00
8_F113_Y1.5631.00
74_A77_L1.5581.00
22_L50_L1.5351.00
14_P20_L1.5181.00
147_N150_H1.5111.00
33_R66_V1.4991.00
15_W21_M1.4961.00
12_S20_L1.4851.00
106_F141_H1.4821.00
132_R135_E1.4791.00
10_L52_P1.4691.00
37_K68_T1.4681.00
156_E176_V1.4631.00
59_R71_S1.4301.00
55_P78_A1.4191.00
199_A203_R1.4161.00
99_V142_L1.4111.00
54_T74_A1.3951.00
6_R55_P1.3881.00
55_P114_L1.3861.00
15_W35_V1.3831.00
4_W59_R1.3791.00
25_F106_F1.3621.00
85_T123_V1.3161.00
53_F89_G1.3141.00
184_T187_Q1.2941.00
210_R225_R1.2831.00
151_C177_V1.2671.00
161_T164_Y1.2541.00
25_F96_L1.2481.00
6_R57_L1.2411.00
78_A117_I1.2381.00
214_K221_P1.2221.00
78_A114_L1.2041.00
60_F67_K1.1941.00
13_R21_M1.1921.00
49_A52_P1.1861.00
80_P121_A1.1861.00
36_A69_L1.1611.00
31_R100_L1.1581.00
140_G145_G1.1531.00
128_E206_K1.1481.00
55_P76_S1.1401.00
23_D33_R1.1401.00
57_L73_E1.1391.00
9_V22_L1.1241.00
135_E206_K1.1191.00
210_R229_R1.1161.00
221_P226_E1.1141.00
16_S35_V1.1011.00
92_I131_L1.1011.00
13_R23_D1.0941.00
91_Y132_R1.0850.99
135_E139_L1.0790.99
114_L118_Q1.0770.99
25_F109_L1.0600.99
10_L31_R1.0500.99
6_R75_V1.0420.99
26_T30_G1.0410.99
22_L34_L1.0350.99
16_S19_S1.0250.99
128_E202_L1.0210.99
76_S121_A1.0190.99
63_R67_K1.0180.99
12_S22_L1.0160.99
108_E141_H1.0110.99
27_E107_S1.0080.99
96_L100_L1.0070.99
46_L69_L1.0060.99
88_S131_L1.0040.99
18_T40_R1.0040.99
166_Y171_G1.0040.99
93_N113_Y0.9890.99
22_L36_A0.9880.99
9_V24_V0.9840.99
160_D163_T0.9810.99
187_Q190_A0.9630.99
19_S38_G0.9560.99
156_E160_D0.9550.99
133_R137_A0.9530.99
6_R114_L0.9390.99
26_T29_S0.9390.99
135_E210_R0.9360.98
209_T213_L0.9340.98
109_L138_L0.9330.98
223_K226_E0.9270.98
119_S130_A0.9250.98
205_A208_F0.9200.98
29_S62_G0.9180.98
88_S228_F0.9160.98
76_S114_L0.9110.98
214_K219_G0.9070.98
56_L72_A0.9060.98
183_F187_Q0.8920.98
132_R213_L0.8910.98
25_F100_L0.8870.98
91_Y131_L0.8850.98
54_T78_A0.8780.98
85_T127_P0.8760.98
153_G177_V0.8750.98
100_L109_L0.8730.98
203_R207_R0.8710.98
112_D137_A0.8650.97
151_C155_G0.8640.97
109_L134_F0.8630.97
28_E107_S0.8600.97
38_G41_S0.8500.97
129_P202_L0.8450.97
5_Q27_E0.8390.97
15_W33_R0.8340.97
170_K173_I0.8310.97
10_L97_S0.8270.97
21_M35_V0.8260.97
26_T32_V0.8230.97
204_A211_M0.8220.97
98_R222_L0.8210.97
104_T144_Y0.8170.96
89_G120_L0.8140.96
173_I178_I0.8120.96
98_R220_K0.8090.96
159_D162_M0.8060.96
49_A74_A0.7980.96
187_Q204_A0.7940.96
18_T41_S0.7930.96
91_Y95_L0.7930.96
131_L135_E0.7840.95
29_S60_F0.7820.95
32_V36_A0.7770.95
61_G68_T0.7730.95
19_S40_R0.7730.95
9_V56_L0.7730.95
172_F185_G0.7720.95
91_Y210_R0.7710.95
132_R206_K0.7710.95
36_A72_A0.7700.95
19_S41_S0.7620.95
25_F113_Y0.7590.95
80_P83_G0.7580.95
61_G70_R0.7560.94
19_S37_K0.7560.94
112_D141_H0.7530.94
11_H23_D0.7490.94
212_A216_Y0.7470.94
94_E224_S0.7460.94
51_Q82_S0.7430.94
181_K184_T0.7430.94
190_A194_R0.7420.94
186_R189_K0.7390.94
185_G190_A0.7370.94
46_L72_A0.7350.94
18_T38_G0.7310.93
78_A118_Q0.7300.93
115_H119_S0.7290.93
36_A46_L0.7230.93
191_L196_F0.7210.93
170_K174_A0.7200.93
135_E225_R0.7180.93
50_L56_L0.7140.93
36_A50_L0.7130.93
22_L52_P0.7100.92
201_T204_A0.7080.92
42_K46_L0.7050.92
36_A48_G0.7000.92
84_I127_P0.6980.92
156_E159_D0.6950.92
168_E211_M0.6930.91
38_G42_K0.6890.91
15_W66_V0.6870.91
23_D97_S0.6850.91
175_S179_D0.6830.91
183_F192_N0.6820.91
129_P196_F0.6820.91
176_V179_D0.6790.91
91_Y228_F0.6770.91
63_R66_V0.6770.91
78_A121_A0.6750.90
106_F109_L0.6730.90
53_F90_L0.6690.90
81_L89_G0.6650.90
207_R210_R0.6640.90
19_S35_V0.6570.89
39_A44_S0.6510.89
8_F110_F0.6430.88
93_N117_I0.6410.88
113_Y134_F0.6410.88
32_V67_K0.6390.88
103_E106_F0.6390.88
12_S52_P0.6390.88
182_T187_Q0.6370.88
20_L50_L0.6360.88
136_L146_V0.6290.87
24_V56_L0.6280.87
24_V60_F0.6270.87
64_G67_K0.6250.87
207_R211_M0.6240.87
196_F205_A0.6230.87
180_N184_T0.6200.86
39_A50_L0.6190.86
108_E111_F0.6180.86
73_E79_L0.6170.86
58_L69_L0.6160.86
162_M176_V0.6150.86
108_E200_D0.6120.86
180_N196_F0.6100.85
168_E215_P0.6100.85
214_K225_R0.6040.85
16_S37_K0.6030.85
136_L183_F0.6010.85
113_Y224_S0.6010.85
5_Q26_T0.6000.84
31_R102_Y0.5970.84
100_L106_F0.5950.84
156_E161_T0.5930.84
182_T186_R0.5920.84
52_P93_N0.5920.84
163_T166_Y0.5910.84
112_D115_H0.5900.83
189_K192_N0.5840.83
44_S48_G0.5840.83
101_E105_R0.5840.83
14_P21_M0.5820.83
152_A170_K0.5820.83
151_C170_K0.5800.82
180_N188_L0.5790.82
183_F188_L0.5780.82
45_T70_R0.5750.82
186_R191_L0.5730.82
180_N190_A0.5730.82
42_K45_T0.5680.81
33_R102_Y0.5670.81
51_Q54_T0.5660.81
69_L72_A0.5660.81
79_L83_G0.5610.80
25_F30_G0.5600.80
186_R190_A0.5590.80
108_E112_D0.5570.80
187_Q197_P0.5560.80
166_Y212_A0.5560.80
211_M215_P0.5560.80
205_A209_T0.5550.80
152_A173_I0.5530.79
12_S51_Q0.5530.79
91_Y94_E0.5530.79
82_S86_L0.5520.79
6_R110_F0.5520.79
53_F86_L0.5520.79
119_S125_G0.5490.79
96_L138_L0.5480.79
31_R101_E0.5480.79
183_F194_R0.5470.79
187_Q192_N0.5460.79
184_T188_L0.5450.78
173_I179_D0.5410.78
161_T175_S0.5400.78
37_K40_R0.5400.78
95_L222_L0.5380.77
200_D204_A0.5380.77
180_N189_K0.5370.77
133_R194_R0.5370.77
150_H155_G0.5330.77
192_N195_E0.5320.77
146_V212_A0.5300.76
17_E103_E0.5260.76
36_A41_S0.5260.76
166_Y208_F0.5260.76
86_L90_L0.5250.76
26_T82_S0.5250.76
154_S173_I0.5240.76
81_L90_L0.5240.76
206_K210_R0.5230.76
204_A207_R0.5230.76
49_A56_L0.5220.75
81_L120_L0.5210.75
148_F151_C0.5210.75
175_S178_I0.5200.75
99_V138_L0.5180.75
10_L25_F0.5170.75
165_R177_V0.5140.74
182_T191_L0.5120.74
27_E30_G0.5110.74
181_K187_Q0.5090.74
146_V209_T0.5090.74
136_L148_F0.5080.73
13_R33_R0.5070.73
162_M172_F0.5040.73
9_V58_L0.5040.73
92_I120_L0.5020.73
27_E104_T0.5010.72
172_F179_D0.5010.72
65_E102_Y0.5010.72
85_T121_A0.5010.72
144_Y217_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q8dA 1 0.9545 100 0.15 Contact Map
1u5kA 2 0.9339 100 0.233 Contact Map
2owaA 1 0.4587 89.2 0.911 Contact Map
2iqjA 1 0.4174 85.6 0.916 Contact Map
3subA 1 0.4339 82.1 0.919 Contact Map
2crrA 1 0.4711 78.4 0.922 Contact Map
1dcqA 1 0.4339 77.5 0.923 Contact Map
3lvqE 1 0.438 76.8 0.924 Contact Map
3o47A 2 0.4504 73.6 0.926 Contact Map
2b0oE 3 0.4463 64.9 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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