GREMLIN Database
RECF - DNA replication and repair protein RecF
UniProt: P0A7H0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10828
Length: 357 (328)
Sequences: 5707 (4567)
Seq/√Len: 252.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_L72_G5.0771.00
259_R262_G3.8911.00
4_T75_Q3.7531.00
241_D248_A3.4091.00
10_D62_R3.2361.00
5_R18_D2.9231.00
260_A263_A2.7341.00
308_L316_L2.6551.00
5_R20_A2.4631.00
7_L18_D2.2831.00
119_P122_F2.2021.00
21_L328_F2.1971.00
232_E236_R2.1721.00
104_K107_E2.1591.00
5_R73_R2.1531.00
231_A235_E2.1331.00
3_L72_G2.1281.00
179_K183_P2.1271.00
8_I14_I2.1221.00
84_G96_R2.1181.00
62_R65_Q2.1001.00
10_D65_Q2.0881.00
3_L43_I2.0861.00
7_L16_T2.0761.00
120_E126_N2.0581.00
15_E62_R2.0441.00
162_N247_T2.0121.00
73_R80_E2.0111.00
67_A86_T1.9821.00
9_R16_T1.9561.00
112_M115_Q1.9541.00
7_L71_H1.9341.00
227_E231_A1.9271.00
66_E89_K1.9091.00
81_T98_D1.9081.00
259_R263_A1.8961.00
238_F242_R1.8321.00
178_D238_F1.8271.00
228_T232_E1.8001.00
199_I203_M1.7971.00
112_M116_L1.7891.00
14_I17_A1.7811.00
290_T296_R1.7511.00
147_F154_L1.7501.00
252_H256_L1.7171.00
148_F151_W1.7081.00
40_L300_L1.6801.00
144_E191_W1.6751.00
173_Q177_W1.6701.00
119_P124_L1.6691.00
314_G318_S1.6631.00
69_V84_G1.6581.00
241_D249_H1.6531.00
154_L158_L1.6471.00
118_T126_N1.6371.00
113_P116_L1.6321.00
175_R238_F1.5851.00
163_A167_Q1.5721.00
113_P117_I1.5551.00
240_R244_L1.5361.00
15_E65_Q1.5341.00
189_S193_A1.5291.00
118_T124_L1.5161.00
327_V332_I1.5161.00
4_T80_E1.4961.00
240_R243_Q1.4961.00
251_P256_L1.4951.00
68_F87_K1.4921.00
229_E232_E1.4791.00
182_I231_A1.4761.00
149_T153_N1.4751.00
112_M298_L1.4751.00
235_E238_F1.4741.00
162_N166_R1.4651.00
69_V86_T1.4651.00
252_H255_D1.4641.00
154_L157_L1.4561.00
161_R165_L1.4541.00
313_R333_S1.4481.00
196_S200_A1.4381.00
241_D252_H1.4371.00
245_T252_H1.4331.00
150_A187_Q1.4281.00
183_P227_E1.4251.00
114_M117_I1.4241.00
109_A116_L1.4221.00
245_T256_L1.3771.00
233_V236_R1.3751.00
231_A238_F1.3531.00
63_H261_D1.3431.00
179_K182_I1.3231.00
207_C211_L1.3081.00
180_E184_L1.2991.00
239_E243_Q1.2991.00
265_V269_L1.2841.00
157_L184_L1.2771.00
241_D245_T1.2761.00
336_H339_D1.2671.00
71_H84_G1.2581.00
245_T249_H1.2441.00
61_I89_K1.2431.00
147_F151_W1.2411.00
118_T122_F1.2351.00
148_F152_S1.2341.00
131_Y134_A1.2321.00
315_L318_S1.2271.00
248_A252_H1.2141.00
148_F154_L1.2051.00
132_R139_G1.2051.00
25_F329_V1.2011.00
73_R82_A1.2001.00
112_M117_I1.1911.00
202_D205_D1.1851.00
109_A113_P1.1831.00
181_L185_A1.1771.00
151_W154_L1.1761.00
237_N241_D1.1751.00
109_A117_I1.1721.00
276_L312_R1.1651.00
156_R160_Q1.1631.00
259_R265_V1.1621.00
31_A311_E1.1581.00
123_T127_G1.1561.00
96_R101_D1.1481.00
238_F245_T1.1481.00
122_F125_L1.1481.00
86_T94_K1.1471.00
47_G114_M1.1471.00
161_R247_T1.1461.00
109_A112_M1.1431.00
178_D182_I1.1371.00
244_L248_A1.1351.00
28_L328_F1.1331.00
143_N147_F1.1311.00
206_T209_Q1.1291.00
249_H252_H1.1231.00
44_Y49_G1.1231.00
147_F158_L1.1221.00
157_L164_A1.1181.00
9_R69_V1.1171.00
180_E183_P1.1171.00
245_T248_A1.1141.00
43_I328_F1.1021.00
227_E235_E1.0971.00
122_F126_N1.0941.00
150_A184_L1.0911.00
228_T231_A1.0881.00
229_E233_V1.0821.00
119_P126_N1.0811.00
182_I186_E1.0811.00
180_E185_A1.0791.00
238_F241_D1.0741.00
154_L161_R1.0711.00
238_F253_K1.0701.00
189_S195_Y1.0641.00
97_I102_G1.0581.00
177_W181_L1.0561.00
249_H256_L1.0561.00
187_Q191_W1.0531.00
160_Q164_A1.0511.00
164_A168_V1.0491.00
190_T193_A1.0461.00
159_K163_A1.0401.00
190_T194_E1.0371.00
269_L277_L1.0341.00
202_D206_T1.0331.00
158_L162_N1.0281.00
119_P125_L1.0271.00
95_V108_L1.0201.00
118_T125_L1.0131.00
83_I95_V1.0101.00
120_E123_T1.0101.00
265_V277_L1.0011.00
191_W194_E0.9991.00
50_R53_R0.9911.00
146_G150_A0.9901.00
327_V333_S0.9891.00
146_G149_T0.9871.00
13_N38_S0.9871.00
260_A265_V0.9861.00
155_K165_L0.9851.00
151_W155_K0.9841.00
154_L164_A0.9831.00
194_E198_G0.9831.00
141_F145_P0.9831.00
253_K258_I0.9821.00
124_L127_G0.9811.00
234_L241_D0.9781.00
106_A109_A0.9751.00
183_P187_Q0.9731.00
200_A204_A0.9701.00
27_F331_A0.9701.00
141_F144_E0.9671.00
201_A205_D0.9621.00
245_T251_P0.9621.00
8_I39_V0.9581.00
119_P127_G0.9551.00
192_R199_I0.9551.00
234_L238_F0.9521.00
11_F68_F0.9501.00
11_F60_V0.9461.00
237_N249_H0.9451.00
12_R38_S0.9411.00
234_L249_H0.9401.00
237_N240_R0.9361.00
95_V102_G0.9331.00
299_Y325_S0.9321.00
4_T73_R0.9271.00
249_H253_K0.9251.00
181_L184_L0.9251.00
94_K101_D0.9231.00
192_R195_Y0.9221.00
177_W185_A0.9191.00
203_M207_C0.9131.00
176_P179_K0.9091.00
200_A203_M0.9061.00
43_I300_L0.9021.00
11_F42_A0.9021.00
200_A217_T0.9021.00
230_Y234_L0.8991.00
196_S199_I0.8981.00
242_R249_H0.8981.00
233_V249_H0.8951.00
231_A242_R0.8951.00
154_L252_H0.8931.00
242_R246_Y0.8921.00
245_T253_K0.8891.00
178_D235_E0.8891.00
167_Q170_R0.8851.00
178_D181_L0.8841.00
205_D209_Q0.8831.00
176_P180_E0.8801.00
199_I207_C0.8791.00
83_I108_L0.8761.00
241_D255_D0.8761.00
278_M282_R0.8751.00
61_I68_F0.8751.00
231_A246_Y0.8711.00
191_W196_S0.8691.00
157_L161_R0.8681.00
235_E245_T0.8681.00
4_T20_A0.8640.99
289_L296_R0.8630.99
167_Q171_Y0.8620.99
6_L72_G0.8550.99
233_V237_N0.8520.99
246_Y250_G0.8510.99
241_D253_K0.8470.99
46_L70_L0.8440.99
311_E314_G0.8430.99
216_L220_F0.8430.99
219_S223_G0.8420.99
235_E241_D0.8420.99
58_G61_I0.8410.99
61_I87_K0.8370.99
144_E148_F0.8320.99
156_R159_K0.8310.99
204_A208_K0.8310.99
262_G265_V0.8280.99
235_E253_K0.8230.99
132_R136_L0.8200.99
194_E197_A0.8190.99
188_I195_Y0.8160.99
253_K257_R0.8130.99
45_T60_V0.8110.99
252_H258_I0.8110.99
218_F223_G0.8040.99
141_F148_F0.8010.99
250_G254_A0.7950.99
109_A115_Q0.7940.99
241_D258_I0.7900.99
106_A114_M0.7900.99
227_E241_D0.7880.99
105_V117_I0.7870.99
217_T221_Q0.7840.99
148_F158_L0.7800.99
253_K256_L0.7790.99
119_P123_T0.7790.99
173_Q176_P0.7780.99
286_G299_Y0.7770.99
242_R253_K0.7770.99
107_E110_H0.7770.99
182_I185_A0.7740.99
21_L28_L0.7730.99
136_L139_G0.7710.99
235_E239_E0.7690.99
86_T96_R0.7680.99
204_A207_C0.7670.99
177_W184_L0.7670.99
42_A70_L0.7660.99
305_A313_R0.7620.99
85_L95_V0.7560.99
179_K184_L0.7560.99
28_L39_V0.7560.99
178_D234_L0.7540.99
109_A114_M0.7510.99
154_L181_L0.7500.99
206_T210_F0.7500.99
186_E190_T0.7490.99
160_Q177_W0.7460.99
172_E175_R0.7430.98
175_R179_K0.7380.98
144_E147_F0.7380.98
326_Q331_A0.7360.98
192_R196_S0.7340.98
271_R307_E0.7320.98
327_V331_A0.7290.98
31_A34_S0.7250.98
13_N40_L0.7190.98
105_V109_A0.7190.98
155_K159_K0.7190.98
179_K231_A0.7170.98
12_R37_T0.7170.98
227_E238_F0.7160.98
166_R169_T0.7150.98
219_S257_R0.7130.98
333_S336_H0.7110.98
6_L21_L0.7110.98
162_N165_L0.7090.98
199_I202_D0.7070.98
41_E328_F0.7060.98
235_E242_R0.7060.98
197_A200_A0.7030.98
251_P258_I0.7030.98
231_A237_N0.7000.98
147_F157_L0.7000.98
242_R258_I0.7000.98
242_R245_T0.6980.98
132_R137_D0.6970.98
303_D330_S0.6940.98
158_L161_R0.6930.98
235_E249_H0.6920.98
187_Q190_T0.6910.98
199_I209_Q0.6890.97
151_W161_R0.6880.97
151_W158_L0.6880.97
231_A253_K0.6870.97
251_P255_D0.6870.97
241_D244_L0.6860.97
187_Q194_E0.6850.97
196_S256_L0.6850.97
204_A215_S0.6820.97
121_G124_L0.6820.97
177_W180_E0.6700.97
147_F150_A0.6670.97
238_F258_I0.6660.97
165_L169_T0.6660.97
111_L115_Q0.6650.97
132_R135_F0.6650.97
275_K307_E0.6620.97
158_L164_A0.6610.97
275_K304_F0.6590.97
185_A192_R0.6590.97
43_I72_G0.6570.97
150_A154_L0.6530.97
174_L179_K0.6520.97
195_Y199_I0.6510.96
327_V330_S0.6500.96
133_R137_D0.6480.96
205_D208_K0.6470.96
250_G253_K0.6450.96
239_E242_R0.6430.96
334_A338_I0.6430.96
185_A251_P0.6400.96
247_T255_D0.6400.96
12_R41_E0.6400.96
158_L165_L0.6390.96
12_R309_D0.6390.96
241_D256_L0.6390.96
71_H82_A0.6380.96
238_F256_L0.6360.96
231_A245_T0.6340.96
12_R32_N0.6330.96
155_K158_L0.6300.96
231_A258_I0.6280.96
251_P254_A0.6280.96
148_F165_L0.6270.96
154_L165_L0.6260.96
178_D185_A0.6260.96
271_R303_D0.6250.96
299_Y327_V0.6240.96
148_F164_A0.6210.95
119_P132_R0.6190.95
182_I230_Y0.6180.95
132_R140_C0.6170.95
136_L256_L0.6150.95
173_Q184_L0.6140.95
23_P26_N0.6140.95
187_Q193_A0.6130.95
118_T123_T0.6110.95
208_K215_S0.6110.95
269_L276_L0.6090.95
168_V171_Y0.6090.95
211_L214_F0.6070.95
310_D335_E0.6070.95
151_W165_L0.6060.95
166_R170_R0.6050.95
220_F223_G0.6040.95
231_A234_L0.6030.95
153_N156_R0.6030.95
250_G258_I0.6020.95
221_Q257_R0.6020.95
250_G257_R0.6020.95
8_I42_A0.6020.95
157_L160_Q0.6010.95
161_R167_Q0.6000.94
134_A138_W0.6000.94
275_K305_A0.5980.94
133_R140_C0.5980.94
200_A206_T0.5900.94
261_D265_V0.5890.94
108_L117_I0.5870.94
10_D15_E0.5870.94
203_M211_L0.5860.94
219_S222_R0.5830.94
232_E235_E0.5790.93
259_R264_P0.5760.93
278_M306_S0.5750.93
175_R235_E0.5750.93
237_N248_A0.5740.93
228_T234_L0.5720.93
147_F162_N0.5720.93
143_N148_F0.5700.93
122_F127_G0.5700.93
283_L316_L0.5680.93
17_A39_V0.5660.93
105_V108_L0.5660.93
202_D209_Q0.5650.93
13_N312_R0.5640.92
197_A206_T0.5620.92
117_I122_F0.5600.92
176_P185_A0.5600.92
63_H263_A0.5560.92
121_G125_L0.5560.92
193_A197_A0.5550.92
173_Q180_E0.5550.92
227_E233_V0.5550.92
141_F158_L0.5550.92
11_F45_T0.5540.92
264_P267_D0.5530.92
335_E338_I0.5530.92
217_T259_R0.5520.92
219_S259_R0.5510.92
179_K185_A0.5500.92
282_R285_Q0.5500.92
161_R164_A0.5440.91
38_S41_E0.5440.91
158_L181_L0.5430.91
32_N38_S0.5430.91
107_E115_Q0.5420.91
117_I275_K0.5420.91
105_V116_L0.5410.91
184_L187_Q0.5400.91
228_T238_F0.5390.91
13_N17_A0.5380.91
327_V334_A0.5370.91
120_E124_L0.5370.91
192_R207_C0.5330.90
150_A153_N0.5320.90
184_L189_S0.5320.90
223_G226_K0.5290.90
54_S57_I0.5280.90
198_G201_A0.5280.90
154_L185_A0.5260.90
244_L249_H0.5230.89
180_E193_A0.5220.89
190_T200_A0.5210.89
216_L221_Q0.5200.89
14_I39_V0.5200.89
254_A258_I0.5190.89
139_G285_Q0.5170.89
157_L165_L0.5160.89
149_T152_S0.5150.89
303_D307_E0.5150.89
250_G255_D0.5130.89
51_A60_V0.5110.88
191_W195_Y0.5100.88
104_K117_I0.5090.88
32_N312_R0.5090.88
133_R136_L0.5090.88
104_K112_M0.5070.88
197_A201_A0.5070.88
317_A329_V0.5060.88
287_E290_T0.5050.88
12_R312_R0.5040.88
25_F327_V0.5040.88
203_M206_T0.5040.88
268_T274_L0.5040.88
97_I111_L0.5030.88
282_R312_R0.5020.87
3_L298_L0.5010.87
118_T127_G0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3auyA 2 0.9356 100 0.384 Contact Map
4abyA 1 0.8683 100 0.384 Contact Map
4ad8A 1 0.9272 100 0.389 Contact Map
2o5vA 1 0.972 100 0.404 Contact Map
3zgxA 2 0.8543 100 0.408 Contact Map
1w1wA 2 0.7843 100 0.424 Contact Map
3qf7A 2 0.902 100 0.44 Contact Map
4ux3A 1 0.8964 100 0.452 Contact Map
3qktA 2 0.8683 100 0.46 Contact Map
4i99A 2 0.7899 100 0.476 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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