GREMLIN Database
RECA - Protein RecA
UniProt: P0A7G6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10823
Length: 353 (329)
Sequences: 2521 (964)
Seq/√Len: 53.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_D114_N6.4611.00
57_L80_V5.2491.00
198_M214_N4.1951.00
224_L245_V4.0201.00
308_A312_D3.7651.00
267_E311_K3.7211.00
80_V141_V3.5971.00
45_S274_E3.4571.00
131_D182_N3.3781.00
319_E323_K3.3101.00
54_A252_I3.2381.00
47_S274_E3.0421.00
264_L307_T3.0201.00
52_L222_V2.9891.00
43_T57_L2.9761.00
309_W316_T2.9751.00
57_L189_L2.9581.00
224_L247_V2.8961.00
42_S87_E2.8311.00
40_T54_A2.7751.00
245_V261_F2.7201.00
19_E24_K2.6121.00
321_E325_R2.5661.00
63_V189_L2.5011.00
94_I130_C2.4651.00
284_L320_I2.4471.00
279_G324_V2.4361.00
121_D125_Q2.3981.00
161_G174_Q2.3841.00
295_K323_K2.3341.00
229_I244_R2.3331.00
275_L317_A2.3221.00
309_W313_N2.2711.00
41_I84_A2.2431.00
294_Y319_E2.2221.00
84_A141_V2.1851.00
272_Y311_K2.1581.00
183_L190_L2.1441.00
91_C141_V2.1221.00
231_A238_V2.1191.00
43_T80_V2.0861.00
200_I209_T2.0581.00
122_T156_I1.9701.00
244_R258_Q1.9481.00
202_V206_N1.9311.00
164_H174_Q1.9251.00
107_K267_E1.9231.00
153_K157_E1.8630.99
81_I93_F1.8580.99
10_A14_A1.8560.99
50_I328_L1.8410.99
81_I143_V1.8410.99
286_E296_G1.8190.99
17_Q21_Q1.8140.99
277_D303_K1.7730.99
80_V191_I1.7320.99
280_V292_Y1.7090.99
41_I189_L1.6660.99
299_I316_T1.6620.99
295_K319_E1.6610.99
202_V207_P1.6580.99
196_I225_D1.6420.98
154_A167_L1.6380.98
242_E260_E1.6370.98
313_N316_T1.6220.98
18_I26_S1.6210.98
81_I91_C1.6040.98
304_A307_T1.5560.98
77_T193_I1.5520.98
11_L15_L1.5290.97
282_E328_L1.5220.97
76_L226_I1.5190.97
171_M176_M1.4800.97
230_G242_E1.4760.97
276_V285_I1.4730.97
318_K321_E1.4720.97
5_E8_Q1.4640.97
9_K12_A1.4510.97
242_E262_Q1.4220.96
273_G277_D1.4200.96
314_P317_A1.4170.96
6_N9_K1.3990.96
234_E304_A1.3790.95
228_R231_A1.3740.95
273_G303_K1.3740.95
78_L100_L1.3620.95
168_A211_T1.3610.95
276_V303_K1.3570.95
318_K322_K1.3550.95
165_M200_I1.3330.94
322_K326_E1.3320.94
282_E324_V1.3110.94
279_G317_A1.3100.94
90_T139_V1.3010.94
271_F321_E1.3010.94
57_L63_V1.2870.93
228_R241_S1.2820.93
314_P318_K1.2810.93
306_A309_W1.2780.93
308_A311_K1.2720.93
229_I242_E1.2680.93
323_K326_E1.2610.93
232_V239_V1.2430.92
92_A133_L1.2140.91
79_Q83_A1.2120.91
200_I214_N1.2110.91
274_E278_L1.2100.91
68_P227_R1.2080.91
18_I27_I1.1910.90
130_C190_L1.1900.90
46_L50_I1.1780.90
68_P225_D1.1690.89
164_H167_L1.1640.89
225_D229_I1.1530.89
272_Y317_A1.1510.89
39_E59_M1.1490.89
293_S298_K1.1460.88
29_R114_N1.1390.88
62_I180_A1.1310.88
262_Q303_K1.1260.88
14_A132_A1.1240.87
282_E327_L1.1220.87
93_F100_L1.1190.87
59_M84_A1.1010.86
183_L189_L1.0960.86
203_M209_T1.0940.86
137_G266_G1.0890.86
30_L112_I1.0870.86
141_V191_I1.0700.85
291_W301_Q1.0570.84
244_R260_E1.0540.84
184_K187_N1.0540.84
9_K13_A1.0520.84
165_M203_M1.0520.84
201_G207_P1.0450.83
300_G306_A1.0440.83
57_L141_V1.0430.83
303_K307_T1.0420.83
47_S278_L1.0350.83
283_K327_L1.0260.82
211_T214_N1.0170.82
13_A17_Q1.0150.81
130_C144_V1.0120.81
134_A183_L1.0080.81
182_N186_S1.0030.81
163_S174_Q1.0030.81
96_A150_L0.9940.80
299_I309_W0.9890.80
242_E303_K0.9860.80
48_L224_L0.9850.79
14_A17_Q0.9830.79
315_E318_K0.9770.79
130_C134_A0.9760.79
14_A18_I0.9750.79
323_K327_L0.9720.79
151_T181_G0.9690.78
92_A116_L0.9590.78
8_Q90_T0.9570.77
139_V142_I0.9550.77
326_E330_S0.9540.77
33_D36_M0.9520.77
42_S49_D0.9450.77
8_Q12_A0.9420.76
242_E277_D0.9380.76
78_L93_F0.9360.76
83_A271_F0.9260.75
206_N225_D0.9220.75
59_M89_K0.9190.75
103_I107_K0.9180.74
286_E295_K0.9170.74
276_V279_G0.9150.74
96_A152_P0.9100.74
83_A87_E0.9030.73
40_T252_I0.8980.73
130_C142_I0.8930.72
276_V306_A0.8920.72
270_N307_T0.8910.72
81_I141_V0.8820.71
12_A16_G0.8760.71
311_K317_A0.8730.71
208_E227_R0.8680.70
139_V188_T0.8640.70
93_F117_C0.8630.70
274_E279_G0.8620.70
122_T153_K0.8580.69
74_T93_F0.8520.69
317_A321_E0.8490.69
47_S259_A0.8480.68
89_K140_D0.8470.68
204_F207_P0.8450.68
163_S167_L0.8440.68
50_I281_K0.8420.68
288_A298_K0.8410.68
284_L324_V0.8410.68
283_K286_E0.8400.68
45_S269_I0.8370.67
154_A164_H0.8350.67
122_T157_E0.8320.67
84_A114_N0.8320.67
7_K10_A0.8310.67
38_V252_I0.8310.67
179_L183_L0.8230.66
36_M102_P0.8230.66
290_A301_Q0.8230.66
13_A16_G0.8200.66
11_L138_A0.8180.66
239_V264_L0.8110.65
298_K305_N0.8100.65
134_A171_M0.8100.65
317_A324_V0.8060.65
15_L27_I0.8060.65
262_Q270_N0.8060.65
93_F98_H0.8060.65
328_L331_N0.8050.64
160_I178_K0.7990.64
324_V328_L0.7990.64
47_S50_I0.7970.64
14_A137_G0.7930.63
96_A211_T0.7900.63
315_E319_E0.7890.63
200_I230_G0.7870.63
310_L320_I0.7870.63
262_Q273_G0.7850.62
64_E223_R0.7840.62
271_F275_L0.7840.62
196_I286_E0.7800.62
5_E12_A0.7750.61
270_N304_A0.7710.61
46_L325_R0.7690.61
241_S263_I0.7670.61
10_A24_K0.7630.60
147_V172_M0.7630.60
30_L93_F0.7580.60
77_T81_I0.7530.59
135_R186_S0.7470.59
76_L190_L0.7430.58
9_K16_G0.7420.58
238_V265_Y0.7420.58
322_K329_L0.7420.58
77_T93_F0.7410.58
226_I245_V0.7380.58
11_L32_E0.7370.58
200_I211_T0.7330.57
107_K286_E0.7320.57
322_K331_N0.7300.57
30_L106_R0.7270.57
102_P214_N0.7260.56
151_T214_N0.7260.56
21_Q230_G0.7230.56
155_E177_R0.7230.56
36_M39_E0.7230.56
237_N257_K0.7200.56
104_Y266_G0.7190.56
65_I191_I0.7170.56
267_E270_N0.7170.56
132_A325_R0.7160.55
241_S265_Y0.7150.55
48_L52_L0.7080.55
73_K145_D0.7070.54
56_G73_K0.7070.54
79_Q89_K0.7060.54
294_Y320_I0.7040.54
198_M211_T0.7020.54
127_L175_A0.7010.54
19_E27_I0.6910.53
226_I243_T0.6900.53
39_E130_C0.6900.53
289_G302_G0.6890.53
8_Q231_A0.6880.52
39_E187_N0.6870.52
230_G236_E0.6850.52
328_L332_P0.6840.52
236_E258_Q0.6800.52
5_E318_K0.6780.51
278_L282_E0.6760.51
8_Q16_G0.6750.51
56_G67_G0.6730.51
141_V189_L0.6690.50
131_D242_E0.6650.50
307_T311_K0.6650.50
5_E9_K0.6640.50
6_N13_A0.6630.50
306_A310_L0.6620.50
98_H126_A0.6610.50
76_L191_I0.6590.49
36_M40_T0.6580.49
130_C179_L0.6560.49
193_I198_M0.6560.49
16_G20_K0.6550.49
9_K22_F0.6550.49
279_G286_E0.6540.49
326_E329_L0.6500.48
305_N308_A0.6440.48
116_L139_V0.6430.48
231_A258_Q0.6420.48
16_G34_R0.6390.47
280_V287_K0.6390.47
14_A135_R0.6370.47
165_M204_F0.6350.47
48_L76_L0.6340.47
192_F216_L0.6330.47
16_G117_C0.6330.47
32_E35_S0.6330.47
125_Q287_K0.6320.47
296_G299_I0.6320.47
84_A189_L0.6310.46
67_G73_K0.6290.46
138_A326_E0.6290.46
116_L133_L0.6280.46
22_F196_I0.6280.46
29_R32_E0.6270.46
322_K330_S0.6250.46
293_S306_A0.6240.46
325_R328_L0.6230.46
56_G145_D0.6210.45
146_S212_G0.6200.45
149_A216_L0.6190.45
201_G204_F0.6190.45
50_I282_E0.6180.45
295_K298_K0.6180.45
10_A13_A0.6170.45
243_T265_Y0.6150.45
193_I214_N0.6150.45
277_D280_V0.6120.44
19_E26_S0.6120.44
231_A243_T0.6120.44
193_I298_K0.6110.44
90_T180_A0.6110.44
39_E87_E0.6100.44
264_L273_G0.6090.44
285_I306_A0.6080.44
79_Q269_I0.6080.44
79_Q84_A0.6070.44
80_V91_C0.6070.44
182_N235_G0.6070.44
259_A275_L0.6070.44
7_K12_A0.6060.44
160_I171_M0.6050.44
11_L102_P0.6040.44
10_A17_Q0.6040.44
151_T156_I0.6040.44
228_R244_R0.6030.44
199_K207_P0.6030.44
162_D167_L0.6020.43
131_D135_R0.6020.43
33_D274_E0.6020.43
316_T319_E0.6000.43
83_A86_R0.6000.43
16_G330_S0.5990.43
107_K266_G0.5980.43
327_L332_P0.5980.43
48_L191_I0.5970.43
192_F250_N0.5970.43
6_N19_E0.5960.43
27_I116_L0.5960.43
100_L110_V0.5960.43
306_A328_L0.5950.43
250_N253_A0.5950.43
63_V222_V0.5920.42
52_L247_V0.5920.42
261_F269_I0.5920.42
80_V189_L0.5910.42
234_E239_V0.5880.42
204_F238_V0.5880.42
283_K288_A0.5880.42
59_M140_D0.5870.42
203_M206_N0.5870.42
159_E178_K0.5860.42
14_A21_Q0.5830.41
327_L330_S0.5820.41
327_L331_N0.5810.41
84_A91_C0.5810.41
90_T114_N0.5800.41
196_I230_G0.5800.41
323_K329_L0.5800.41
104_Y265_Y0.5800.41
9_K17_Q0.5760.41
316_T324_V0.5750.41
98_H184_K0.5750.41
203_M207_P0.5740.41
8_Q13_A0.5720.40
97_E146_S0.5720.40
170_R173_S0.5710.40
312_D332_P0.5700.40
234_E237_N0.5690.40
20_K236_E0.5680.40
16_G286_E0.5660.40
34_R37_D0.5650.40
225_D244_R0.5640.40
326_E331_N0.5630.39
242_E304_A0.5620.39
134_A179_L0.5620.39
188_T272_Y0.5610.39
66_Y225_D0.5600.39
196_I214_N0.5600.39
91_C131_D0.5590.39
272_Y307_T0.5570.39
15_L116_L0.5560.39
316_T320_I0.5560.39
27_I92_A0.5550.39
233_K236_E0.5540.39
282_E330_S0.5540.39
176_M182_N0.5540.39
238_V243_T0.5530.38
15_L132_A0.5520.38
18_I23_G0.5520.38
12_A46_L0.5520.38
14_A189_L0.5520.38
184_K242_E0.5520.38
229_I258_Q0.5510.38
318_K326_E0.5510.38
89_K185_Q0.5490.38
92_A219_Y0.5490.38
322_K332_P0.5480.38
276_V297_E0.5480.38
144_V176_M0.5480.38
112_I234_E0.5470.38
206_N227_R0.5470.38
121_D160_I0.5470.38
50_I330_S0.5470.38
16_G196_I0.5450.38
7_K327_L0.5450.38
32_E329_L0.5440.38
180_A211_T0.5430.37
318_K331_N0.5430.37
320_I324_V0.5420.37
35_S102_P0.5410.37
204_F239_V0.5410.37
112_I193_I0.5380.37
236_E242_E0.5380.37
46_L324_V0.5380.37
108_L132_A0.5370.37
176_M192_F0.5360.37
13_A116_L0.5350.37
322_K327_L0.5340.37
29_R154_A0.5340.37
184_K243_T0.5330.36
207_P227_R0.5320.36
262_Q307_T0.5310.36
54_A132_A0.5300.36
302_G305_N0.5300.36
159_E164_H0.5290.36
321_E324_V0.5290.36
21_Q24_K0.5270.36
134_A142_I0.5260.36
47_S57_L0.5250.36
67_G145_D0.5250.36
16_G283_K0.5250.36
116_L132_A0.5250.36
189_L325_R0.5250.36
286_E293_S0.5250.36
222_V252_I0.5240.36
21_Q76_L0.5240.36
270_N273_G0.5230.35
97_E212_G0.5230.35
13_A331_N0.5220.35
16_G333_N0.5220.35
242_E273_G0.5220.35
306_A313_N0.5200.35
6_N329_L0.5200.35
43_T49_D0.5200.35
37_D226_I0.5190.35
8_Q33_D0.5180.35
38_V221_S0.5170.35
117_C261_F0.5170.35
267_E272_Y0.5160.35
8_Q132_A0.5160.35
282_E329_L0.5160.35
264_L270_N0.5160.35
62_I187_N0.5160.35
45_S230_G0.5160.35
275_L321_E0.5150.35
234_E308_A0.5150.35
47_S261_F0.5150.35
310_L316_T0.5150.35
12_A330_S0.5140.35
243_T261_F0.5130.34
322_K333_N0.5100.34
108_L291_W0.5100.34
29_R313_N0.5100.34
57_L81_I0.5100.34
32_E36_M0.5100.34
243_T257_K0.5090.34
59_M87_E0.5070.34
16_G329_L0.5060.34
43_T222_V0.5060.34
137_G186_S0.5040.34
18_I22_F0.5030.34
6_N309_W0.5030.34
6_N17_Q0.5020.33
231_A265_Y0.5020.33
234_E283_K0.5020.33
10_A19_E0.5000.33
159_E204_F0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hr8A 1 0.9518 100 0.363 Contact Map
4ppfA 1 0.8782 100 0.365 Contact Map
3cmwA 1 0.8924 100 0.37 Contact Map
3cmuA 1 0.8867 100 0.375 Contact Map
1u94A 3 0.8669 100 0.387 Contact Map
1xp8A 3 0.8414 100 0.434 Contact Map
3io5A 2 0.7082 100 0.438 Contact Map
2z43A 1 0.6572 100 0.637 Contact Map
3ldaA 1 0.6544 100 0.641 Contact Map
1v5wA 5 0.6232 100 0.643 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0111 seconds.