QUEA - ECOLI - GREMLIN Contacts

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QUEA - S-adenosylmethionine:tRNA ribosyltransferase-isomerase

UniProt:	P0A7F9	Sequences: MRVTDFSFELPESLIAHYPMPERSSCRLLSLDGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGKIEVLVERMLDDKRILAHIRASKAPKPGAELLLGDDESINATMTARHGALFEVEFNDERSVLDILNSIGHMPLPPYIDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLEKLRAKGVEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQDVVDAVLAAKARGNRVIAVGTTSVRSLESAAQAAKNDLIEPFFDDTQIFIYPGFQYKVVDALVTNFHLPESTLIMLVSAFAGYQHTMNAYKAAVEEKYRFFSYGDAMFITYNPQAINERVGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10812
Length:	356 (336)
Sequences:	3290 (1997)
Seq/√Len:	109.0

ECOLI - QUEA
BACSU - QUEA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
40_H	326_A	4.854	1.00
234_Q	238_D	3.982	1.00
7_S	304_E	3.651	1.00
317_Y	321_M	3.254	1.00
219_T	222_D	3.090	1.00
41_G	45_D	3.003	1.00
58_F	202_F	2.926	1.00
55_L	243_A	2.919	1.00
60_N	202_F	2.854	1.00
13_S	331_K	2.768	1.00
14_L	331_K	2.635	1.00
40_H	332_Y	2.564	1.00
191_E	195_A	2.522	1.00
199_E	239_A	2.508	1.00
194_R	200_M	2.453	1.00
325_K	329_E	2.426	1.00
243_A	248_N	2.206	1.00
41_G	49_K	2.157	1.00
22_E	25_S	2.154	1.00
201_A	239_A	2.130	1.00
242_A	246_R	2.050	1.00
201_A	236_V	2.035	1.00
230_A	276_F	2.012	1.00
172_K	231_E	1.985	1.00
238_D	242_A	1.977	1.00
231_E	277_F	1.935	1.00
36_G	319_H	1.928	1.00
60_N	204_T	1.916	1.00
25_S	44_T	1.879	1.00
73_A	106_E	1.861	1.00
191_E	194_R	1.861	1.00
31_L	319_H	1.853	1.00
251_I	295_A	1.848	1.00
48_D	196_K	1.847	1.00
51_N	248_N	1.817	1.00
115_I	119_M	1.808	1.00
284_I	288_F	1.804	1.00
249_R	295_A	1.797	1.00
30_S	49_K	1.789	1.00
26_C	164_L	1.782	1.00
169_Y	182_G	1.760	1.00
319_H	322_N	1.750	1.00
65_P	162_R	1.749	1.00
72_K	105_A	1.740	1.00
24_S	186_D	1.728	1.00
90_R	128_E	1.725	1.00
61_T	175_A	1.705	1.00
149_L	153_I	1.677	1.00
118_T	130_E	1.676	1.00
233_P	236_V	1.666	1.00
146_H	156_P	1.649	1.00
244_K	294_D	1.630	1.00
101_P	107_L	1.610	1.00
43_F	297_V	1.608	1.00
47_L	196_K	1.602	1.00
265_A	292_V	1.602	1.00
41_G	48_D	1.600	1.00
106_E	116_N	1.593	1.00
252_A	258_V	1.584	1.00
70_G	107_L	1.578	1.00
252_A	261_L	1.572	1.00
80_V	95_I	1.569	1.00
58_F	200_M	1.569	1.00
60_N	171_E	1.566	1.00
199_E	242_A	1.544	1.00
31_L	323_A	1.543	1.00
234_Q	275_P	1.531	1.00
240_V	273_I	1.529	1.00
315_A	323_A	1.525	1.00
290_Y	313_A	1.515	1.00
215_V	309_M	1.510	1.00
62_R	163_E	1.510	1.00
252_A	293_V	1.507	1.00
30_S	344_T	1.481	1.00
27_R	330_E	1.474	1.00
87_D	90_R	1.464	1.00
237_V	273_I	1.458	1.00
67_R	79_E	1.453	1.00
54_D	249_R	1.451	1.00
57_V	201_A	1.450	1.00
155_R	337_Y	1.448	1.00
295_A	344_T	1.447	1.00
136_S	139_D	1.442	1.00
51_N	249_R	1.441	1.00
199_E	243_A	1.440	1.00
326_A	329_E	1.436	1.00
3_V	220_I	1.431	1.00
236_V	239_A	1.430	1.00
60_N	172_K	1.429	1.00
82_V	91_I	1.416	1.00
227_S	281_Q	1.415	1.00
17_H	153_I	1.414	1.00
308_I	320_T	1.414	1.00
69_F	146_H	1.407	1.00
50_L	198_V	1.405	1.00
84_R	279_D	1.401	1.00
225_M	306_T	1.394	1.00
258_V	293_V	1.392	1.00
125_A	129_V	1.390	1.00
51_N	196_K	1.367	1.00
123_H	127_F	1.363	1.00
232_V	264_A	1.360	1.00
14_L	328_V	1.355	1.00
28_L	340_A	1.351	1.00
55_L	239_A	1.350	1.00
266_Q	288_F	1.339	1.00
90_R	130_E	1.338	1.00
326_A	330_E	1.333	1.00
47_L	192_K	1.324	0.99
33_G	314_F	1.308	0.99
266_Q	270_N	1.307	0.99
217_V	222_D	1.296	0.99
47_L	193_L	1.295	0.99
3_V	304_E	1.285	0.99
258_V	296_L	1.281	0.99
263_S	280_T	1.278	0.99
26_C	43_F	1.278	0.99
50_L	251_I	1.272	0.99
18_Y	155_R	1.268	0.99
85_M	138_L	1.267	0.99
295_A	342_F	1.262	0.99
55_L	199_E	1.255	0.99
48_D	192_K	1.254	0.99
325_K	328_V	1.254	0.99
224_I	281_Q	1.254	0.99
31_L	343_I	1.246	0.99
32_D	39_T	1.245	0.99
80_V	109_L	1.244	0.99
192_K	196_K	1.238	0.99
8_F	282_I	1.232	0.99
46_L	189_L	1.231	0.99
4_T	304_E	1.229	0.99
31_L	315_A	1.229	0.99
326_A	332_Y	1.226	0.99
55_L	201_A	1.218	0.99
121_A	125_A	1.216	0.99
32_D	35_T	1.216	0.99
33_G	344_T	1.211	0.99
237_V	241_L	1.207	0.99
20_M	24_S	1.193	0.99
30_S	41_G	1.192	0.99
315_A	320_T	1.191	0.99
203_V	232_V	1.188	0.99
29_L	326_A	1.181	0.99
240_V	292_V	1.180	0.99
62_R	170_S	1.171	0.99
97_A	100_A	1.167	0.99
199_E	246_R	1.166	0.99
241_L	272_L	1.164	0.99
51_N	54_D	1.157	0.99
84_R	92_L	1.156	0.99
221_E	285_Y	1.141	0.98
230_A	260_S	1.138	0.98
312_S	317_Y	1.134	0.98
2_R	219_T	1.131	0.98
24_S	44_T	1.128	0.98
237_V	275_P	1.122	0.98
320_T	343_I	1.114	0.98
3_V	217_V	1.111	0.98
86_L	90_R	1.103	0.98
31_L	320_T	1.092	0.98
46_L	297_V	1.087	0.98
239_A	243_A	1.082	0.98
243_A	246_R	1.078	0.98
57_V	261_L	1.077	0.98
192_K	195_A	1.070	0.98
127_F	131_F	1.065	0.98
263_S	278_D	1.064	0.98
20_M	25_S	1.062	0.98
55_L	248_N	1.061	0.98
115_I	118_T	1.060	0.98
174_G	206_H	1.060	0.98
80_V	107_L	1.051	0.97
229_Y	279_D	1.044	0.97
161_D	337_Y	1.039	0.97
245_A	272_L	1.036	0.97
168_V	190_L	1.033	0.97
68_L	82_V	1.029	0.97
5_D	317_Y	1.027	0.97
311_V	320_T	1.027	0.97
187_E	191_E	1.027	0.97
244_K	292_V	1.026	0.97
203_V	260_S	1.024	0.97
58_F	190_L	1.018	0.97
266_Q	274_E	1.017	0.97
260_S	264_A	1.012	0.97
93_A	129_V	1.004	0.97
314_F	343_I	0.993	0.96
273_I	292_V	0.993	0.96
322_N	326_A	0.991	0.96
62_R	173_P	0.988	0.96
32_D	37_A	0.984	0.96
240_V	250_V	0.984	0.96
251_I	342_F	0.980	0.96
190_L	200_M	0.976	0.96
189_L	297_V	0.974	0.96
2_R	5_D	0.973	0.96
106_E	118_T	0.965	0.96
187_E	194_R	0.960	0.96
244_K	247_G	0.957	0.95
253_V	297_V	0.957	0.95
2_R	218_D	0.956	0.95
199_E	248_N	0.953	0.95
33_G	36_G	0.952	0.95
261_L	293_V	0.950	0.95
8_F	308_I	0.947	0.95
125_A	131_F	0.946	0.95
64_I	173_P	0.946	0.95
94_H	126_L	0.932	0.95
220_I	285_Y	0.932	0.95
91_I	137_V	0.929	0.95
123_H	128_E	0.925	0.95
31_L	38_L	0.923	0.94
302_L	335_F	0.909	0.94
288_F	291_K	0.909	0.94
266_Q	291_K	0.905	0.94
24_S	189_L	0.902	0.94
123_H	129_V	0.901	0.94
94_H	209_A	0.899	0.94
83_E	94_H	0.894	0.93
72_K	76_G	0.890	0.93
296_L	311_V	0.890	0.93
110_G	144_I	0.888	0.93
4_T	7_S	0.887	0.93
43_F	185_F	0.887	0.93
188_P	192_K	0.884	0.93
3_V	221_E	0.881	0.93
81_L	147_M	0.879	0.93
322_N	325_K	0.878	0.93
126_L	129_V	0.874	0.93
121_A	127_F	0.873	0.93
18_Y	160_A	0.871	0.93
40_H	330_E	0.866	0.92
167_T	182_G	0.861	0.92
73_A	108_L	0.860	0.92
83_E	209_A	0.859	0.92
50_L	56_L	0.856	0.92
116_N	132_N	0.852	0.92
86_L	128_E	0.852	0.92
17_H	154_D	0.850	0.92
37_A	319_H	0.847	0.92
123_H	131_F	0.841	0.91
171_E	202_F	0.830	0.91
236_V	240_V	0.829	0.91
117_A	131_F	0.823	0.90
207_V	256_T	0.822	0.90
118_T	132_N	0.819	0.90
142_N	173_P	0.818	0.90
316_G	319_H	0.814	0.90
45_D	49_K	0.812	0.90
95_I	101_P	0.812	0.90
45_D	48_D	0.808	0.89
3_V	219_T	0.803	0.89
120_T	125_A	0.798	0.89
120_T	128_E	0.795	0.89
122_R	129_V	0.793	0.89
52_P	196_K	0.791	0.88
3_V	7_S	0.788	0.88
223_H	306_T	0.786	0.88
46_L	50_L	0.783	0.88
35_T	319_H	0.781	0.88
124_G	127_F	0.781	0.88
38_L	326_A	0.780	0.88
25_S	42_T	0.779	0.88
122_R	127_F	0.779	0.88
328_V	331_K	0.776	0.88
47_L	189_L	0.770	0.87
202_F	236_V	0.769	0.87
159_D	162_R	0.769	0.87
27_R	331_K	0.766	0.87
125_A	128_E	0.766	0.87
318_Q	322_N	0.760	0.86
188_P	191_E	0.760	0.86
39_T	49_K	0.756	0.86
81_L	176_V	0.756	0.86
82_V	137_V	0.753	0.86
6_F	309_M	0.749	0.86
126_L	131_F	0.749	0.86
229_Y	277_F	0.748	0.86
69_F	77_K	0.748	0.86
328_V	335_F	0.747	0.85
193_L	200_M	0.741	0.85
20_M	333_R	0.737	0.85
76_G	97_A	0.735	0.85
232_V	260_S	0.735	0.85
189_L	340_A	0.733	0.84
169_Y	257_S	0.733	0.84
242_A	245_A	0.731	0.84
318_Q	321_M	0.731	0.84
22_E	188_P	0.731	0.84
215_V	306_T	0.730	0.84
14_L	27_R	0.726	0.84
296_L	314_F	0.723	0.84
31_L	341_M	0.722	0.83
155_R	161_D	0.718	0.83
67_R	81_L	0.717	0.83
177_A	180_T	0.717	0.83
122_R	125_A	0.714	0.83
4_T	218_D	0.712	0.83
250_V	292_V	0.710	0.82
266_Q	272_L	0.708	0.82
122_R	126_L	0.707	0.82
213_Q	216_R	0.701	0.82
78_I	97_A	0.699	0.81
235_D	238_D	0.697	0.81
159_D	337_Y	0.695	0.81
55_L	240_V	0.695	0.81
30_S	39_T	0.692	0.81
182_G	257_S	0.691	0.81
2_R	6_F	0.690	0.81
243_A	250_V	0.690	0.81
317_Y	320_T	0.689	0.81
203_V	236_V	0.689	0.81
106_E	132_N	0.689	0.81
321_M	325_K	0.689	0.81
38_L	323_A	0.688	0.80
138_L	142_N	0.687	0.80
38_L	322_N	0.684	0.80
193_L	198_V	0.684	0.80
215_V	223_H	0.683	0.80
27_R	328_V	0.683	0.80
56_L	251_I	0.683	0.80
306_T	309_M	0.683	0.80
176_V	209_A	0.681	0.80
308_I	312_S	0.678	0.79
170_S	173_P	0.678	0.79
29_L	38_L	0.673	0.79
95_I	129_V	0.673	0.79
80_V	129_V	0.670	0.79
29_L	323_A	0.670	0.79
53_G	243_A	0.670	0.79
76_G	100_A	0.670	0.79
3_V	306_T	0.669	0.79
21_P	160_A	0.669	0.79
49_K	342_F	0.667	0.78
91_I	97_A	0.665	0.78
111_D	114_S	0.664	0.78
174_G	204_T	0.663	0.78
177_A	336_S	0.658	0.77
135_R	139_D	0.657	0.77
138_L	173_P	0.657	0.77
180_T	336_S	0.657	0.77
140_I	144_I	0.656	0.77
103_P	120_T	0.653	0.77
121_A	124_G	0.649	0.76
265_A	291_K	0.645	0.76
131_F	137_V	0.644	0.76
297_V	342_F	0.644	0.76
83_E	176_V	0.643	0.76
235_D	239_A	0.642	0.76
225_M	283_F	0.642	0.76
21_P	164_L	0.640	0.75
266_Q	281_Q	0.639	0.75
227_S	279_D	0.638	0.75
194_R	202_F	0.637	0.75
163_E	170_S	0.636	0.75
12_E	154_D	0.632	0.75
249_R	294_D	0.631	0.74
32_D	344_T	0.631	0.74
71_R	77_K	0.629	0.74
95_I	127_F	0.629	0.74
238_D	241_L	0.628	0.74
62_R	166_Q	0.628	0.74
190_L	193_L	0.627	0.74
12_E	17_H	0.624	0.74
26_C	333_R	0.623	0.74
73_A	116_N	0.623	0.74
209_A	306_T	0.622	0.73
46_L	342_F	0.621	0.73
70_G	109_L	0.621	0.73
97_A	101_P	0.621	0.73
255_T	296_L	0.620	0.73
315_A	343_I	0.614	0.72
139_D	143_S	0.614	0.72
296_L	310_L	0.613	0.72
85_M	91_I	0.613	0.72
123_H	126_L	0.613	0.72
269_K	289_Q	0.612	0.72
315_A	319_H	0.612	0.72
76_G	98_S	0.610	0.72
30_S	342_F	0.609	0.72
54_D	198_V	0.607	0.72
8_F	328_V	0.607	0.72
264_A	273_I	0.606	0.71
266_Q	269_K	0.605	0.71
42_T	45_D	0.602	0.71
293_V	314_F	0.602	0.71
31_L	36_G	0.601	0.71
289_Q	325_K	0.601	0.71
108_L	116_N	0.600	0.71
101_P	105_A	0.600	0.71
232_V	236_V	0.599	0.71
120_T	127_F	0.599	0.71
120_T	124_G	0.596	0.70
155_R	159_D	0.596	0.70
230_A	278_D	0.594	0.70
149_L	175_A	0.593	0.70
89_K	130_E	0.592	0.70
36_G	322_N	0.591	0.70
177_A	211_T	0.591	0.70
194_R	199_E	0.590	0.69
252_A	257_S	0.590	0.69
147_M	162_R	0.590	0.69
314_F	317_Y	0.589	0.69
240_V	265_A	0.587	0.69
282_I	308_I	0.587	0.69
283_F	309_M	0.584	0.69
226_H	335_F	0.583	0.69
128_E	131_F	0.582	0.68
176_V	337_Y	0.582	0.68
37_A	322_N	0.581	0.68
189_L	193_L	0.581	0.68
78_I	101_P	0.577	0.68
265_A	270_N	0.576	0.68
220_I	309_M	0.575	0.67
69_F	78_I	0.575	0.67
80_V	93_A	0.572	0.67
22_E	164_L	0.570	0.67
225_M	280_T	0.570	0.67
40_H	285_Y	0.568	0.67
56_L	297_V	0.567	0.66
114_S	119_M	0.564	0.66
112_D	143_S	0.563	0.66
319_H	323_A	0.563	0.66
71_R	108_L	0.562	0.66
146_H	162_R	0.558	0.65
56_L	253_V	0.557	0.65
60_N	233_P	0.557	0.65
91_I	186_D	0.556	0.65
233_P	237_V	0.556	0.65
270_N	274_E	0.554	0.65
264_A	278_D	0.554	0.65
3_V	222_D	0.552	0.64
320_T	323_A	0.551	0.64
162_R	337_Y	0.550	0.64
108_L	112_D	0.550	0.64
53_G	248_N	0.549	0.64
41_G	47_L	0.547	0.64
232_V	240_V	0.544	0.63
201_A	233_P	0.544	0.63
16_A	333_R	0.543	0.63
135_R	143_S	0.539	0.63
147_M	282_I	0.538	0.62
269_K	272_L	0.537	0.62
24_S	188_P	0.537	0.62
3_V	218_D	0.537	0.62
53_G	193_L	0.536	0.62
10_L	15_I	0.536	0.62
260_S	276_F	0.532	0.62
20_M	26_C	0.531	0.61
187_E	190_L	0.529	0.61
55_L	236_V	0.529	0.61
319_H	344_T	0.527	0.61
211_T	336_S	0.527	0.61
109_L	117_A	0.526	0.61
232_V	263_S	0.526	0.61
308_I	328_V	0.525	0.61
169_Y	190_L	0.524	0.60
17_H	149_L	0.524	0.60
108_L	143_S	0.524	0.60
49_K	344_T	0.524	0.60
95_I	98_S	0.524	0.60
69_F	79_E	0.524	0.60
116_N	119_M	0.523	0.60
142_N	162_R	0.523	0.60
76_G	101_P	0.522	0.60
127_F	130_E	0.522	0.60
68_L	141_L	0.522	0.60
218_D	221_E	0.521	0.60
295_A	314_F	0.521	0.60
60_N	175_A	0.521	0.60
264_A	276_F	0.520	0.60
207_V	211_T	0.520	0.60
258_V	308_I	0.518	0.60
76_G	99_K	0.517	0.59
49_K	52_P	0.517	0.59
177_A	212_F	0.516	0.59
65_P	147_M	0.514	0.59
312_S	315_A	0.512	0.59
6_F	221_E	0.512	0.59
203_V	257_S	0.511	0.58
44_T	47_L	0.511	0.58
41_G	332_Y	0.509	0.58
193_L	196_K	0.509	0.58
32_D	319_H	0.509	0.58
153_I	335_F	0.509	0.58
263_S	266_Q	0.509	0.58
56_L	198_V	0.509	0.58
308_I	321_M	0.507	0.58
244_K	248_N	0.506	0.58
26_C	290_Y	0.506	0.58
242_A	248_N	0.505	0.58
269_K	291_K	0.505	0.58
283_F	306_T	0.505	0.58
55_L	246_R	0.504	0.57
114_S	118_T	0.504	0.57
180_T	212_F	0.503	0.57
42_T	297_V	0.503	0.57
190_L	202_F	0.502	0.57
123_H	130_E	0.501	0.57
183_L	207_V	0.501	0.57
53_G	198_V	0.501	0.57
233_P	239_A	0.501	0.57
72_K	75_G	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1yy3A	1	0.8764	100	0.032	Contact Map
1wdiA	1	0.8006	100	0.039	Contact Map
1vkyA	2	0.7949	100	0.041	Contact Map
1ds1A	1	0.3006	30.3	0.978	Contact Map
4uu5A	1	0.191	25	0.979	Contact Map
2wbqA	1	0.2528	21.4	0.98	Contact Map
4xrpA	2	0.6994	19.2	0.98	Contact Map
2k32A	1	0.323	17.8	0.98	Contact Map
1oihA	3	0.2556	16.6	0.981	Contact Map
1earA	2	0.3989	16	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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