GREMLIN Database
QUEA - S-adenosylmethionine:tRNA ribosyltransferase-isomerase
UniProt: P0A7F9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10812
Length: 356 (336)
Sequences: 3290 (1997)
Seq/√Len: 109.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_H326_A4.8541.00
234_Q238_D3.9821.00
7_S304_E3.6511.00
317_Y321_M3.2541.00
219_T222_D3.0901.00
41_G45_D3.0031.00
58_F202_F2.9261.00
55_L243_A2.9191.00
60_N202_F2.8541.00
13_S331_K2.7681.00
14_L331_K2.6351.00
40_H332_Y2.5641.00
191_E195_A2.5221.00
199_E239_A2.5081.00
194_R200_M2.4531.00
325_K329_E2.4261.00
243_A248_N2.2061.00
41_G49_K2.1571.00
22_E25_S2.1541.00
201_A239_A2.1301.00
242_A246_R2.0501.00
201_A236_V2.0351.00
230_A276_F2.0121.00
172_K231_E1.9851.00
238_D242_A1.9771.00
231_E277_F1.9351.00
36_G319_H1.9281.00
60_N204_T1.9161.00
25_S44_T1.8791.00
73_A106_E1.8611.00
191_E194_R1.8611.00
31_L319_H1.8531.00
251_I295_A1.8481.00
48_D196_K1.8471.00
51_N248_N1.8171.00
115_I119_M1.8081.00
284_I288_F1.8041.00
249_R295_A1.7971.00
30_S49_K1.7891.00
26_C164_L1.7821.00
169_Y182_G1.7601.00
319_H322_N1.7501.00
65_P162_R1.7491.00
72_K105_A1.7401.00
24_S186_D1.7281.00
90_R128_E1.7251.00
61_T175_A1.7051.00
149_L153_I1.6771.00
118_T130_E1.6761.00
233_P236_V1.6661.00
146_H156_P1.6491.00
244_K294_D1.6301.00
101_P107_L1.6101.00
43_F297_V1.6081.00
47_L196_K1.6021.00
265_A292_V1.6021.00
41_G48_D1.6001.00
106_E116_N1.5931.00
252_A258_V1.5841.00
70_G107_L1.5781.00
252_A261_L1.5721.00
80_V95_I1.5691.00
58_F200_M1.5691.00
60_N171_E1.5661.00
199_E242_A1.5441.00
31_L323_A1.5431.00
234_Q275_P1.5311.00
240_V273_I1.5291.00
315_A323_A1.5251.00
290_Y313_A1.5151.00
215_V309_M1.5101.00
62_R163_E1.5101.00
252_A293_V1.5071.00
30_S344_T1.4811.00
27_R330_E1.4741.00
87_D90_R1.4641.00
237_V273_I1.4581.00
67_R79_E1.4531.00
54_D249_R1.4511.00
57_V201_A1.4501.00
155_R337_Y1.4481.00
295_A344_T1.4471.00
136_S139_D1.4421.00
51_N249_R1.4411.00
199_E243_A1.4401.00
326_A329_E1.4361.00
3_V220_I1.4311.00
236_V239_A1.4301.00
60_N172_K1.4291.00
82_V91_I1.4161.00
227_S281_Q1.4151.00
17_H153_I1.4141.00
308_I320_T1.4141.00
69_F146_H1.4071.00
50_L198_V1.4051.00
84_R279_D1.4011.00
225_M306_T1.3941.00
258_V293_V1.3921.00
125_A129_V1.3901.00
51_N196_K1.3671.00
123_H127_F1.3631.00
232_V264_A1.3601.00
14_L328_V1.3551.00
28_L340_A1.3511.00
55_L239_A1.3501.00
266_Q288_F1.3391.00
90_R130_E1.3381.00
326_A330_E1.3331.00
47_L192_K1.3240.99
33_G314_F1.3080.99
266_Q270_N1.3070.99
217_V222_D1.2960.99
47_L193_L1.2950.99
3_V304_E1.2850.99
258_V296_L1.2810.99
263_S280_T1.2780.99
26_C43_F1.2780.99
50_L251_I1.2720.99
18_Y155_R1.2680.99
85_M138_L1.2670.99
295_A342_F1.2620.99
55_L199_E1.2550.99
48_D192_K1.2540.99
325_K328_V1.2540.99
224_I281_Q1.2540.99
31_L343_I1.2460.99
32_D39_T1.2450.99
80_V109_L1.2440.99
192_K196_K1.2380.99
8_F282_I1.2320.99
46_L189_L1.2310.99
4_T304_E1.2290.99
31_L315_A1.2290.99
326_A332_Y1.2260.99
55_L201_A1.2180.99
121_A125_A1.2160.99
32_D35_T1.2160.99
33_G344_T1.2110.99
237_V241_L1.2070.99
20_M24_S1.1930.99
30_S41_G1.1920.99
315_A320_T1.1910.99
203_V232_V1.1880.99
29_L326_A1.1810.99
240_V292_V1.1800.99
62_R170_S1.1710.99
97_A100_A1.1670.99
199_E246_R1.1660.99
241_L272_L1.1640.99
51_N54_D1.1570.99
84_R92_L1.1560.99
221_E285_Y1.1410.98
230_A260_S1.1380.98
312_S317_Y1.1340.98
2_R219_T1.1310.98
24_S44_T1.1280.98
237_V275_P1.1220.98
320_T343_I1.1140.98
3_V217_V1.1110.98
86_L90_R1.1030.98
31_L320_T1.0920.98
46_L297_V1.0870.98
239_A243_A1.0820.98
243_A246_R1.0780.98
57_V261_L1.0770.98
192_K195_A1.0700.98
127_F131_F1.0650.98
263_S278_D1.0640.98
20_M25_S1.0620.98
55_L248_N1.0610.98
115_I118_T1.0600.98
174_G206_H1.0600.98
80_V107_L1.0510.97
229_Y279_D1.0440.97
161_D337_Y1.0390.97
245_A272_L1.0360.97
168_V190_L1.0330.97
68_L82_V1.0290.97
5_D317_Y1.0270.97
311_V320_T1.0270.97
187_E191_E1.0270.97
244_K292_V1.0260.97
203_V260_S1.0240.97
58_F190_L1.0180.97
266_Q274_E1.0170.97
260_S264_A1.0120.97
93_A129_V1.0040.97
314_F343_I0.9930.96
273_I292_V0.9930.96
322_N326_A0.9910.96
62_R173_P0.9880.96
32_D37_A0.9840.96
240_V250_V0.9840.96
251_I342_F0.9800.96
190_L200_M0.9760.96
189_L297_V0.9740.96
2_R5_D0.9730.96
106_E118_T0.9650.96
187_E194_R0.9600.96
244_K247_G0.9570.95
253_V297_V0.9570.95
2_R218_D0.9560.95
199_E248_N0.9530.95
33_G36_G0.9520.95
261_L293_V0.9500.95
8_F308_I0.9470.95
125_A131_F0.9460.95
64_I173_P0.9460.95
94_H126_L0.9320.95
220_I285_Y0.9320.95
91_I137_V0.9290.95
123_H128_E0.9250.95
31_L38_L0.9230.94
302_L335_F0.9090.94
288_F291_K0.9090.94
266_Q291_K0.9050.94
24_S189_L0.9020.94
123_H129_V0.9010.94
94_H209_A0.8990.94
83_E94_H0.8940.93
72_K76_G0.8900.93
296_L311_V0.8900.93
110_G144_I0.8880.93
4_T7_S0.8870.93
43_F185_F0.8870.93
188_P192_K0.8840.93
3_V221_E0.8810.93
81_L147_M0.8790.93
322_N325_K0.8780.93
126_L129_V0.8740.93
121_A127_F0.8730.93
18_Y160_A0.8710.93
40_H330_E0.8660.92
167_T182_G0.8610.92
73_A108_L0.8600.92
83_E209_A0.8590.92
50_L56_L0.8560.92
116_N132_N0.8520.92
86_L128_E0.8520.92
17_H154_D0.8500.92
37_A319_H0.8470.92
123_H131_F0.8410.91
171_E202_F0.8300.91
236_V240_V0.8290.91
117_A131_F0.8230.90
207_V256_T0.8220.90
118_T132_N0.8190.90
142_N173_P0.8180.90
316_G319_H0.8140.90
45_D49_K0.8120.90
95_I101_P0.8120.90
45_D48_D0.8080.89
3_V219_T0.8030.89
120_T125_A0.7980.89
120_T128_E0.7950.89
122_R129_V0.7930.89
52_P196_K0.7910.88
3_V7_S0.7880.88
223_H306_T0.7860.88
46_L50_L0.7830.88
35_T319_H0.7810.88
124_G127_F0.7810.88
38_L326_A0.7800.88
25_S42_T0.7790.88
122_R127_F0.7790.88
328_V331_K0.7760.88
47_L189_L0.7700.87
202_F236_V0.7690.87
159_D162_R0.7690.87
27_R331_K0.7660.87
125_A128_E0.7660.87
318_Q322_N0.7600.86
188_P191_E0.7600.86
39_T49_K0.7560.86
81_L176_V0.7560.86
82_V137_V0.7530.86
6_F309_M0.7490.86
126_L131_F0.7490.86
229_Y277_F0.7480.86
69_F77_K0.7480.86
328_V335_F0.7470.85
193_L200_M0.7410.85
20_M333_R0.7370.85
76_G97_A0.7350.85
232_V260_S0.7350.85
189_L340_A0.7330.84
169_Y257_S0.7330.84
242_A245_A0.7310.84
318_Q321_M0.7310.84
22_E188_P0.7310.84
215_V306_T0.7300.84
14_L27_R0.7260.84
296_L314_F0.7230.84
31_L341_M0.7220.83
155_R161_D0.7180.83
67_R81_L0.7170.83
177_A180_T0.7170.83
122_R125_A0.7140.83
4_T218_D0.7120.83
250_V292_V0.7100.82
266_Q272_L0.7080.82
122_R126_L0.7070.82
213_Q216_R0.7010.82
78_I97_A0.6990.81
235_D238_D0.6970.81
159_D337_Y0.6950.81
55_L240_V0.6950.81
30_S39_T0.6920.81
182_G257_S0.6910.81
2_R6_F0.6900.81
243_A250_V0.6900.81
317_Y320_T0.6890.81
203_V236_V0.6890.81
106_E132_N0.6890.81
321_M325_K0.6890.81
38_L323_A0.6880.80
138_L142_N0.6870.80
38_L322_N0.6840.80
193_L198_V0.6840.80
215_V223_H0.6830.80
27_R328_V0.6830.80
56_L251_I0.6830.80
306_T309_M0.6830.80
176_V209_A0.6810.80
308_I312_S0.6780.79
170_S173_P0.6780.79
29_L38_L0.6730.79
95_I129_V0.6730.79
80_V129_V0.6700.79
29_L323_A0.6700.79
53_G243_A0.6700.79
76_G100_A0.6700.79
3_V306_T0.6690.79
21_P160_A0.6690.79
49_K342_F0.6670.78
91_I97_A0.6650.78
111_D114_S0.6640.78
174_G204_T0.6630.78
177_A336_S0.6580.77
135_R139_D0.6570.77
138_L173_P0.6570.77
180_T336_S0.6570.77
140_I144_I0.6560.77
103_P120_T0.6530.77
121_A124_G0.6490.76
265_A291_K0.6450.76
131_F137_V0.6440.76
297_V342_F0.6440.76
83_E176_V0.6430.76
235_D239_A0.6420.76
225_M283_F0.6420.76
21_P164_L0.6400.75
266_Q281_Q0.6390.75
227_S279_D0.6380.75
194_R202_F0.6370.75
163_E170_S0.6360.75
12_E154_D0.6320.75
249_R294_D0.6310.74
32_D344_T0.6310.74
71_R77_K0.6290.74
95_I127_F0.6290.74
238_D241_L0.6280.74
62_R166_Q0.6280.74
190_L193_L0.6270.74
12_E17_H0.6240.74
26_C333_R0.6230.74
73_A116_N0.6230.74
209_A306_T0.6220.73
46_L342_F0.6210.73
70_G109_L0.6210.73
97_A101_P0.6210.73
255_T296_L0.6200.73
315_A343_I0.6140.72
139_D143_S0.6140.72
296_L310_L0.6130.72
85_M91_I0.6130.72
123_H126_L0.6130.72
269_K289_Q0.6120.72
315_A319_H0.6120.72
76_G98_S0.6100.72
30_S342_F0.6090.72
54_D198_V0.6070.72
8_F328_V0.6070.72
264_A273_I0.6060.71
266_Q269_K0.6050.71
42_T45_D0.6020.71
293_V314_F0.6020.71
31_L36_G0.6010.71
289_Q325_K0.6010.71
108_L116_N0.6000.71
101_P105_A0.6000.71
232_V236_V0.5990.71
120_T127_F0.5990.71
120_T124_G0.5960.70
155_R159_D0.5960.70
230_A278_D0.5940.70
149_L175_A0.5930.70
89_K130_E0.5920.70
36_G322_N0.5910.70
177_A211_T0.5910.70
194_R199_E0.5900.69
252_A257_S0.5900.69
147_M162_R0.5900.69
314_F317_Y0.5890.69
240_V265_A0.5870.69
282_I308_I0.5870.69
283_F309_M0.5840.69
226_H335_F0.5830.69
128_E131_F0.5820.68
176_V337_Y0.5820.68
37_A322_N0.5810.68
189_L193_L0.5810.68
78_I101_P0.5770.68
265_A270_N0.5760.68
220_I309_M0.5750.67
69_F78_I0.5750.67
80_V93_A0.5720.67
22_E164_L0.5700.67
225_M280_T0.5700.67
40_H285_Y0.5680.67
56_L297_V0.5670.66
114_S119_M0.5640.66
112_D143_S0.5630.66
319_H323_A0.5630.66
71_R108_L0.5620.66
146_H162_R0.5580.65
56_L253_V0.5570.65
60_N233_P0.5570.65
91_I186_D0.5560.65
233_P237_V0.5560.65
270_N274_E0.5540.65
264_A278_D0.5540.65
3_V222_D0.5520.64
320_T323_A0.5510.64
162_R337_Y0.5500.64
108_L112_D0.5500.64
53_G248_N0.5490.64
41_G47_L0.5470.64
232_V240_V0.5440.63
201_A233_P0.5440.63
16_A333_R0.5430.63
135_R143_S0.5390.63
147_M282_I0.5380.62
269_K272_L0.5370.62
24_S188_P0.5370.62
3_V218_D0.5370.62
53_G193_L0.5360.62
10_L15_I0.5360.62
260_S276_F0.5320.62
20_M26_C0.5310.61
187_E190_L0.5290.61
55_L236_V0.5290.61
319_H344_T0.5270.61
211_T336_S0.5270.61
109_L117_A0.5260.61
232_V263_S0.5260.61
308_I328_V0.5250.61
169_Y190_L0.5240.60
17_H149_L0.5240.60
108_L143_S0.5240.60
49_K344_T0.5240.60
95_I98_S0.5240.60
69_F79_E0.5240.60
116_N119_M0.5230.60
142_N162_R0.5230.60
76_G101_P0.5220.60
127_F130_E0.5220.60
68_L141_L0.5220.60
218_D221_E0.5210.60
295_A314_F0.5210.60
60_N175_A0.5210.60
264_A276_F0.5200.60
207_V211_T0.5200.60
258_V308_I0.5180.60
76_G99_K0.5170.59
49_K52_P0.5170.59
177_A212_F0.5160.59
65_P147_M0.5140.59
312_S315_A0.5120.59
6_F221_E0.5120.59
203_V257_S0.5110.58
44_T47_L0.5110.58
41_G332_Y0.5090.58
193_L196_K0.5090.58
32_D319_H0.5090.58
153_I335_F0.5090.58
263_S266_Q0.5090.58
56_L198_V0.5090.58
308_I321_M0.5070.58
244_K248_N0.5060.58
26_C290_Y0.5060.58
242_A248_N0.5050.58
269_K291_K0.5050.58
283_F306_T0.5050.58
55_L246_R0.5040.57
114_S118_T0.5040.57
180_T212_F0.5030.57
42_T297_V0.5030.57
190_L202_F0.5020.57
123_H130_E0.5010.57
183_L207_V0.5010.57
53_G198_V0.5010.57
233_P239_A0.5010.57
72_K75_G0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yy3A 1 0.8764 100 0.032 Contact Map
1wdiA 1 0.8006 100 0.039 Contact Map
1vkyA 2 0.7949 100 0.041 Contact Map
1ds1A 1 0.3006 30.3 0.978 Contact Map
4uu5A 1 0.191 25 0.979 Contact Map
2wbqA 1 0.2528 21.4 0.98 Contact Map
4xrpA 2 0.6994 19.2 0.98 Contact Map
2k32A 1 0.323 17.8 0.98 Contact Map
1oihA 3 0.2556 16.6 0.981 Contact Map
1earA 2 0.3989 16 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.