GREMLIN Database
PYRI - Aspartate carbamoyltransferase regulatory chain
UniProt: P0A7F3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10811
Length: 153 (139)
Sequences: 760 (466)
Seq/√Len: 39.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_T70_Q3.7861.00
101_E130_R3.0131.00
45_G48_L3.0071.00
14_R87_D2.9481.00
26_G57_D2.8341.00
25_I28_K2.7191.00
87_D92_V2.6521.00
126_A139_K2.5991.00
29_L59_I2.5231.00
104_D124_S2.4411.00
65_F87_D2.4411.00
30_L57_D2.4131.00
124_S139_K2.3531.00
76_L103_I2.3471.00
39_D55_R2.2431.00
104_D122_S2.2361.00
32_L74_L2.0540.99
34_K37_E1.8420.98
24_Q57_D1.8270.98
128_R144_E1.8050.98
102_R124_S1.7310.97
36_T116_S1.6990.97
107_L136_L1.6790.96
96_R130_R1.6340.96
105_N122_S1.6270.96
22_P78_A1.6100.95
33_F70_Q1.5960.95
99_L135_A1.5800.95
129_K133_D1.5680.95
76_L145_F1.5180.94
57_D82_T1.5090.93
16_T64_T1.4840.93
102_R139_K1.4540.92
117_H123_S1.4070.91
12_I65_F1.3780.90
12_I17_V1.3590.89
101_E104_D1.3210.88
12_I86_I1.3180.88
127_V136_L1.3090.87
14_R29_L1.2970.87
84_N105_N1.2620.85
128_R137_K1.2540.85
29_L145_F1.2490.85
48_L57_D1.2370.84
11_A48_L1.2030.82
78_A81_A1.2000.82
43_T58_L1.1390.79
29_L77_Y1.1110.77
40_Q63_N1.1090.77
79_P134_I1.0910.76
18_I83_V1.0830.75
17_V21_I1.0820.75
129_K135_A1.0800.75
57_D62_E1.0590.74
9_V43_T1.0580.73
116_S123_S1.0560.73
34_K93_G1.0520.73
118_A123_S1.0380.72
32_L91_V1.0340.72
49_P86_I1.0310.72
43_T48_L1.0310.72
12_I30_L1.0300.71
14_R145_F1.0170.70
55_R92_V1.0140.70
13_K95_S1.0070.70
9_V49_P0.9960.69
9_V84_N0.9930.69
65_F85_R0.9930.69
74_L81_A0.9860.68
85_R93_G0.9840.68
65_F77_Y0.9780.67
43_T143_K0.9780.67
13_K88_N0.9690.67
53_M80_Q0.9670.67
69_D88_N0.9550.66
68_E108_V0.9550.66
17_V86_I0.9310.64
89_Y120_P0.9240.63
87_D93_G0.9180.62
26_G35_L0.9160.62
74_L97_P0.9120.62
31_S36_T0.9090.62
47_N55_R0.9070.62
30_L46_L0.8800.59
12_I46_L0.8590.57
11_A45_G0.8580.57
14_R79_P0.8560.57
30_L81_A0.8550.57
63_N142_E0.8390.56
29_L71_V0.8370.55
105_N124_S0.8370.55
98_S130_R0.8350.55
24_Q100_P0.8330.55
108_V117_H0.8240.54
9_V45_G0.8210.54
86_I91_V0.8170.54
101_E127_V0.8160.53
30_L89_Y0.8140.53
17_V42_I0.8140.53
29_L35_L0.8120.53
61_I102_R0.8120.53
92_V98_S0.8100.53
106_V128_R0.7940.51
28_K91_V0.7920.51
23_A86_I0.7900.51
30_L78_A0.7870.51
30_L44_I0.7800.50
44_I135_A0.7790.50
46_L57_D0.7700.49
79_P96_R0.7680.49
7_L145_F0.7680.49
10_E78_A0.7620.49
51_G61_I0.7620.49
8_Q110_P0.7530.48
63_N87_D0.7480.47
96_R101_E0.7480.47
18_I46_L0.7410.47
75_A119_E0.7400.47
70_Q89_Y0.7380.46
86_I95_S0.7370.46
116_S146_S0.7320.46
10_E46_L0.7240.45
26_G30_L0.7230.45
84_N107_L0.7160.44
31_S146_S0.7150.44
67_S110_P0.7130.44
24_Q77_Y0.7110.44
110_P145_F0.7070.44
23_A57_D0.7070.44
103_I130_R0.7020.43
68_E71_V0.6980.43
73_Q106_V0.6960.43
113_N142_E0.6950.42
12_I41_R0.6930.42
88_N102_R0.6910.42
24_Q82_T0.6890.42
28_K75_A0.6850.42
49_P121_V0.6840.41
80_Q96_R0.6830.41
32_L77_Y0.6820.41
35_L119_E0.6810.41
86_I90_E0.6780.41
47_N84_N0.6730.41
7_L48_L0.6700.40
7_L41_R0.6700.40
128_R142_E0.6620.40
97_P139_K0.6620.40
11_A53_M0.6560.39
31_S122_S0.6490.38
42_I59_I0.6460.38
33_F77_Y0.6450.38
13_K89_Y0.6450.38
99_L134_I0.6360.37
11_A91_V0.6270.37
69_D73_Q0.6250.36
29_L130_R0.6240.36
50_S60_K0.6240.36
63_N104_D0.6220.36
113_N117_H0.6190.36
81_A133_D0.6160.36
76_L105_N0.6070.35
26_G82_T0.6070.35
41_R47_N0.6060.35
91_V108_V0.6040.35
41_R62_E0.5960.34
83_V97_P0.5940.34
116_S128_R0.5880.33
68_E107_L0.5870.33
21_I112_S0.5870.33
34_K133_D0.5810.33
121_V144_E0.5800.33
77_Y128_R0.5760.32
34_K96_R0.5730.32
68_E86_I0.5700.32
28_K68_E0.5650.31
35_L43_T0.5650.31
39_D51_G0.5650.31
52_E112_S0.5640.31
33_F60_K0.5590.31
76_L120_P0.5590.31
44_I144_E0.5590.31
65_F83_V0.5580.31
63_N91_V0.5570.31
47_N50_S0.5560.31
11_A90_E0.5560.31
61_I112_S0.5550.31
70_Q91_V0.5550.31
47_N60_K0.5500.30
38_T44_I0.5480.30
99_L110_P0.5460.30
30_L123_S0.5450.30
7_L52_E0.5430.30
49_P79_P0.5420.30
74_L117_H0.5420.30
64_T83_V0.5410.30
53_M89_Y0.5400.30
18_I73_Q0.5270.29
33_F112_S0.5230.28
11_A73_Q0.5230.28
98_S102_R0.5190.28
45_G89_Y0.5160.28
42_I126_A0.5150.28
39_D130_R0.5100.27
40_Q55_R0.5090.27
98_S142_E0.5070.27
24_Q89_Y0.5070.27
138_C141_C0.5020.27
12_I26_G0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fyyB 2 0.9673 100 0.043 Contact Map
1pg5B 2 0.9281 100 0.058 Contact Map
2be7D 2 0.8758 100 0.063 Contact Map
2ywwA 2 0.9281 100 0.074 Contact Map
2jrrA 1 0.3595 62.7 0.935 Contact Map
1dl6A 1 0.3137 31.3 0.947 Contact Map
2jvmA 1 0.4641 26.5 0.948 Contact Map
2eluA 1 0.1765 25.5 0.949 Contact Map
3uk3C 1 0.1176 15.9 0.953 Contact Map
2drpA 1 0.3464 15.7 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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