GREMLIN Database
PYRH - Uridylate kinase
UniProt: P0A7E9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11539
Length: 241 (216)
Sequences: 11403 (6629)
Seq/√Len: 451.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_A178_D4.0631.00
11_R50_Q3.8131.00
228_R233_E2.8631.00
39_Q98_A2.4431.00
101_N130_R2.4421.00
42_K100_V2.3851.00
169_G183_M2.3801.00
153_G161_V2.3051.00
42_K46_E2.2901.00
104_L107_A2.1721.00
160_V216_R2.1631.00
52_G156_I2.0711.00
105_M109_P2.0701.00
100_V131_V2.0531.00
103_R110_L2.0411.00
168_D219_N1.9901.00
42_K98_A1.9261.00
35_D98_A1.9231.00
92_R102_A1.9061.00
10_K159_D1.8661.00
20_A220_M1.8641.00
104_L110_L1.8641.00
105_M110_L1.8621.00
190_S209_R1.8581.00
107_A110_L1.8291.00
104_L109_P1.8271.00
59_N62_R1.8231.00
111_N114_C1.8221.00
162_L218_F1.7871.00
172_T182_T1.7771.00
172_T178_D1.7751.00
168_D222_K1.7331.00
59_N63_G1.7151.00
45_V100_V1.7141.00
18_G61_F1.6721.00
35_D97_R1.6601.00
106_S110_L1.6451.00
36_R39_Q1.6121.00
173_A180_T1.6091.00
174_D177_K1.6051.00
45_V129_N1.6041.00
75_V78_H1.5911.00
154_I213_L1.5821.00
43_E227_R1.5761.00
227_R231_M1.5661.00
83_A87_N1.5091.00
165_T217_V1.5031.00
111_N115_D1.5021.00
45_V50_Q1.4901.00
134_L152_R1.4141.00
192_V205_F1.4101.00
166_K176_A1.3941.00
38_A94_A1.3931.00
123_I127_R1.3811.00
40_E224_G1.3781.00
216_R229_V1.3771.00
113_V116_S1.3741.00
43_E223_P1.3721.00
14_L41_I1.3581.00
208_A215_I1.3551.00
154_I211_H1.3431.00
168_D171_F1.3301.00
150_C208_A1.3281.00
104_L108_I1.3221.00
150_C161_V1.3201.00
125_L130_R1.3181.00
112_G115_D1.3131.00
172_T184_Y1.3091.00
95_L102_A1.2951.00
106_S109_P1.2761.00
35_D94_A1.2751.00
43_E46_E1.2691.00
122_A134_L1.2661.00
11_R123_I1.2601.00
13_L158_A1.2591.00
103_R106_S1.2581.00
76_G80_G1.2421.00
36_R40_E1.2391.00
103_R107_A1.2371.00
114_C117_Y1.2311.00
33_I36_R1.2261.00
58_G61_F1.2171.00
84_T87_N1.2061.00
37_M91_M1.2051.00
12_I49_I1.2021.00
94_A98_A1.1971.00
50_Q127_R1.1951.00
60_L63_G1.1891.00
45_V131_V1.1701.00
85_V88_G1.1581.00
121_E125_L1.1551.00
219_N222_K1.1431.00
95_L100_V1.1341.00
60_L141_P1.1331.00
124_S127_R1.1141.00
218_F225_A1.1041.00
10_K49_I1.0981.00
35_D39_Q1.0941.00
191_E194_E1.0901.00
226_L229_V1.0901.00
47_L231_M1.0901.00
103_R109_P1.0881.00
41_I53_V1.0811.00
171_F175_P1.0731.00
222_K225_A1.0641.00
227_R230_V1.0611.00
191_E195_K1.0601.00
96_H101_N1.0591.00
124_S128_N1.0571.00
43_E47_L1.0501.00
40_E223_P1.0471.00
206_T210_D1.0421.00
222_K228_R1.0401.00
170_V187_L1.0351.00
157_E211_H1.0291.00
39_Q42_K1.0251.00
81_M84_T1.0231.00
225_A228_R1.0171.00
82_L86_M1.0091.00
19_E22_Q1.0091.00
119_W157_E0.9991.00
52_G126_L0.9861.00
149_A161_V0.9841.00
65_G68_K0.9841.00
105_M125_L0.9821.00
74_V78_H0.9771.00
168_D183_M0.9741.00
50_Q129_N0.9621.00
218_F229_V0.9551.00
83_A86_M0.9541.00
34_L94_A0.9521.00
119_W123_I0.9491.00
84_T88_G0.9481.00
112_G116_S0.9471.00
78_H82_L0.9421.00
121_E124_S0.9381.00
33_I221_N0.9321.00
23_G32_S0.9271.00
172_T181_A0.9261.00
66_L70_G0.9201.00
184_Y187_L0.9201.00
44_L47_L0.9151.00
32_S35_D0.9071.00
19_E166_K0.9061.00
38_A95_L0.9051.00
65_G69_A0.9011.00
171_F181_A0.9001.00
162_L216_R0.9001.00
125_L132_V0.8991.00
175_P181_A0.8831.00
173_A181_A0.8831.00
188_T191_E0.8771.00
64_A68_K0.8761.00
39_Q43_E0.8721.00
134_L156_I0.8691.00
183_M219_N0.8641.00
112_G117_Y0.8611.00
52_G134_L0.8591.00
64_A67_A0.8581.00
41_I131_V0.8541.00
92_R96_H0.8541.00
105_M108_I0.8431.00
83_A88_G0.8401.00
45_V51_V0.8391.00
147_S207_L0.8321.00
111_N116_S0.8301.00
34_L91_M0.8281.00
150_C207_L0.8271.00
44_L162_L0.8241.00
64_A71_M0.8151.00
171_F183_M0.8131.00
184_Y195_K0.8131.00
209_R215_I0.8081.00
94_A97_R0.8051.00
173_A177_K0.8021.00
161_V208_A0.8011.00
65_G70_G0.7981.00
44_L49_I0.7961.00
39_Q223_P0.7801.00
120_A124_S0.7781.00
14_L44_L0.7781.00
42_K45_V0.7781.00
123_I157_E0.7781.00
16_L53_V0.7771.00
41_I95_L0.7761.00
153_G213_L0.7751.00
82_L85_V0.7731.00
189_Y205_F0.7731.00
80_G83_A0.7711.00
43_E224_G0.7701.00
135_S139_G0.7701.00
170_V217_V0.7561.00
78_H81_M0.7521.00
103_R108_I0.7521.00
42_K131_V0.7351.00
130_R133_I0.7321.00
36_R220_M0.7291.00
67_A71_M0.7271.00
203_A207_L0.7271.00
170_V184_Y0.7261.00
115_D119_W0.7231.00
19_E58_G0.7231.00
173_A179_P0.7221.00
164_A218_F0.7211.00
136_A140_N0.7201.00
80_G87_N0.7191.00
203_A206_T0.7181.00
16_L20_A0.7171.00
224_G228_R0.7171.00
196_E209_R0.7161.00
42_K95_L0.7151.00
14_L162_L0.7121.00
125_L128_N0.7111.00
147_S203_A0.7061.00
152_R156_I0.7061.00
190_S194_E0.7041.00
88_G91_M0.7041.00
160_V214_P0.7001.00
44_L230_V0.6981.00
66_L71_M0.6931.00
208_A213_L0.6871.00
77_D80_G0.6841.00
135_S141_P0.6761.00
135_S138_T0.6751.00
137_G140_N0.6721.00
185_E226_L0.6721.00
114_C118_S0.6721.00
93_D97_R0.6681.00
122_A126_L0.6671.00
189_Y192_V0.6641.00
41_I51_V0.6631.00
93_D96_H0.6621.00
168_D224_G0.6601.00
16_L21_L0.6561.00
194_E206_T0.6521.00
166_K221_N0.6501.00
162_L226_L0.6471.00
77_D81_M0.6461.00
59_N198_K0.6461.00
207_L211_H0.6441.00
160_V229_V0.6420.99
81_M138_T0.6370.99
57_G83_A0.6370.99
23_G33_I0.6350.99
81_M86_M0.6340.99
63_G67_A0.6330.99
44_L51_V0.6320.99
228_R231_M0.6310.99
115_D118_S0.6250.99
224_G227_R0.6240.99
11_R159_D0.6220.99
80_G84_T0.6200.99
65_G71_M0.6170.99
81_M87_N0.6160.99
36_R223_P0.6070.99
12_I160_V0.6040.99
89_L92_R0.6030.99
95_L98_A0.6030.99
81_M85_V0.5990.99
40_E43_E0.5980.99
177_K198_K0.5950.99
38_A98_A0.5950.99
40_E222_K0.5900.99
163_K166_K0.5890.99
39_Q97_R0.5870.99
46_E100_V0.5840.99
138_T142_F0.5830.99
68_K72_N0.5830.99
64_A69_A0.5810.99
226_L230_V0.5790.99
75_V81_M0.5770.99
189_Y193_L0.5730.99
141_P144_T0.5680.99
64_A70_G0.5640.99
58_G63_G0.5640.99
58_G62_R0.5630.99
109_P115_D0.5610.99
47_L227_R0.5600.99
138_T141_P0.5600.99
139_G142_F0.5570.99
171_F174_D0.5560.99
154_I207_L0.5540.99
66_L69_A0.5540.99
64_A72_N0.5530.98
86_M90_A0.5520.98
78_H124_S0.5520.98
52_G152_R0.5510.98
96_H102_A0.5460.98
104_L117_Y0.5440.98
114_C119_W0.5430.98
49_I159_D0.5410.98
200_M204_A0.5400.98
34_L38_A0.5400.98
118_S121_E0.5400.98
37_M41_I0.5370.98
117_Y121_E0.5310.98
200_M215_I0.5310.98
193_L202_L0.5260.98
33_I37_M0.5250.98
186_Q231_M0.5240.98
170_V202_L0.5230.98
67_A70_G0.5230.98
126_L132_V0.5220.98
178_D181_A0.5200.98
75_V79_M0.5200.98
101_N129_N0.5180.98
40_E220_M0.5160.98
108_I112_G0.5150.98
11_R14_L0.5150.98
78_H86_M0.5150.98
74_V137_G0.5140.98
140_N144_T0.5130.98
165_T215_I0.5120.98
131_V134_L0.5120.98
78_H85_V0.5100.97
38_A42_K0.5070.97
14_L164_A0.5060.97
136_A141_P0.5060.97
125_L129_N0.5040.97
52_G158_A0.5020.97
95_L131_V0.5020.97
204_A208_A0.5020.97
19_E165_T0.5000.97
16_L40_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a1fA 5 0.9502 100 0.277 Contact Map
3ab4A 7 0.9004 100 0.28 Contact Map
1ybdA 5 0.9793 100 0.283 Contact Map
3l76A 2 0.9212 100 0.287 Contact Map
3nwyA 5 0.9793 100 0.289 Contact Map
2jjxA 5 0.9751 100 0.292 Contact Map
2va1A 5 0.9959 100 0.293 Contact Map
3ek6A 5 0.9876 100 0.294 Contact Map
3c1mA 3 0.9295 100 0.303 Contact Map
1z9dA 5 0.9751 100 0.309 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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