GREMLIN Database
PYRE - Orotate phosphoribosyltransferase
UniProt: P0A7E3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10808
Length: 213 (189)
Sequences: 3123 (1724)
Seq/√Len: 125.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_Q185_K4.4101.00
24_T30_K4.1211.00
22_E30_K3.9321.00
119_R146_T3.6281.00
140_I145_A3.5161.00
152_I180_S2.9831.00
51_R84_A2.5951.00
57_L121_M2.5921.00
6_R193_E2.5491.00
201_L205_K2.3471.00
137_M176_C2.1721.00
10_E194_K2.1621.00
138_E142_A2.0081.00
78_A95_Y1.9861.00
68_F96_C1.9561.00
19_K23_F1.9191.00
159_R163_E1.8851.00
54_A85_L1.8471.00
138_E174_Y1.8331.00
149_G179_I1.7981.00
101_E104_D1.7931.00
157_Q183_T1.7751.00
119_R148_A1.7301.00
50_G80_T1.6871.00
127_I178_V1.6761.00
192_E205_K1.6761.00
80_T83_V1.6491.00
141_Q176_C1.6401.00
63_E119_R1.6391.00
40_F49_L1.6311.00
115_A145_A1.6241.00
11_F48_L1.6101.00
202_A205_K1.5991.00
47_A84_A1.5981.00
192_E201_L1.5971.00
198_A202_A1.5941.00
56_A179_I1.5761.00
149_G177_K1.5701.00
10_E14_S1.5451.00
35_F154_L1.5131.00
110_N139_I1.5041.00
163_E173_D1.4941.00
141_Q146_T1.4841.00
183_T186_D1.4821.00
47_A92_D1.4691.00
66_L96_C1.4651.00
44_R92_D1.4401.00
133_I150_V1.4351.00
71_A75_I1.4211.00
122_L133_I1.4081.00
138_E141_Q1.4021.00
192_E198_A1.4011.00
164_I172_R1.4001.00
65_D119_R1.3981.00
79_T95_Y1.3881.00
25_L31_S1.3751.00
64_F121_M1.3661.00
15_K45_D1.3601.00
57_L151_L1.3581.00
7_Q48_L1.3231.00
55_E59_D1.2971.00
60_S179_I1.2761.00
184_L204_V1.2731.00
98_N139_I1.2611.00
29_R158_E1.2571.00
110_N142_A1.2511.00
53_Y151_L1.2491.00
124_D127_I1.2481.00
11_F14_S1.2461.00
65_D118_G1.2160.99
159_R162_G1.2090.99
127_I160_G1.2080.99
202_A206_A1.2030.99
26_K104_D1.2000.99
9_I182_I1.1840.99
134_R174_Y1.1820.99
122_L137_M1.1800.99
52_F181_I1.1760.99
137_M141_Q1.1720.99
52_F55_E1.1580.99
5_Q183_T1.1380.99
203_A206_A1.1130.99
122_L147_L1.1100.99
150_V176_C1.0950.99
61_G179_I1.0810.99
85_L92_D1.0650.98
22_E32_P1.0610.98
81_T123_V1.0590.98
47_A51_R1.0410.98
134_R173_D1.0310.98
189_A192_E1.0280.98
33_Y184_L1.0270.98
200_H203_A1.0220.98
82_A94_P1.0120.98
11_F45_D1.0100.98
190_Y193_E1.0100.98
39_L114_S1.0090.98
73_K76_P1.0070.98
127_I152_I0.9980.98
50_G81_T0.9910.98
147_L176_C0.9870.98
122_L140_I0.9700.97
161_R172_R0.9670.97
5_Q186_D0.9650.97
132_A137_M0.9460.97
164_I173_D0.9460.97
6_R189_A0.9450.97
102_A110_N0.9430.97
19_K107_E0.9420.97
141_Q174_Y0.9290.96
50_G84_A0.9280.96
53_Y81_T0.9230.96
96_C145_A0.9080.96
7_Q10_E0.9060.96
50_G83_V0.9000.96
54_A81_T0.8970.96
27_S128_T0.8790.95
154_L187_L0.8620.95
20_F33_Y0.8620.95
12_A17_V0.8590.94
7_Q11_F0.8590.94
75_I97_F0.8580.94
26_K105_H0.8540.94
60_S177_K0.8470.94
9_I191_L0.8360.94
51_R55_E0.8310.93
96_C115_A0.8300.93
10_E190_Y0.8280.93
67_L78_A0.8270.93
64_F93_L0.8150.93
104_D142_A0.8080.92
155_D159_R0.8050.92
136_S139_I0.8030.92
70_P73_K0.8020.92
153_S181_I0.7970.92
36_N109_G0.7910.92
131_T135_E0.7900.92
115_A140_I0.7850.91
124_D133_I0.7850.91
160_G164_I0.7830.91
25_L128_T0.7830.91
162_G172_R0.7810.91
66_L145_A0.7810.91
141_Q147_L0.7800.91
17_V40_F0.7770.91
74_G97_F0.7750.91
57_L81_T0.7750.91
62_I65_D0.7670.90
189_A193_E0.7670.90
82_A95_Y0.7660.90
14_S194_K0.7650.90
124_D136_S0.7610.90
26_K131_T0.7610.90
135_E138_E0.7570.90
51_R54_A0.7560.90
42_T92_D0.7540.90
47_A83_V0.7500.89
98_N140_I0.7480.89
121_M149_G0.7390.89
55_E58_V0.7350.88
53_Y181_I0.7350.88
200_H204_V0.7340.88
55_E195_P0.7290.88
102_A108_G0.7250.88
193_E199_E0.7230.88
40_F77_I0.7220.88
78_A123_V0.7210.87
5_Q182_I0.7200.87
190_Y194_K0.7160.87
54_A58_V0.7120.87
152_I178_V0.7100.87
71_A74_G0.7060.86
199_E202_A0.7050.86
18_L33_Y0.6980.86
69_G78_A0.6980.86
5_Q10_E0.6970.86
96_C111_L0.6970.86
151_L179_I0.6870.85
172_R177_K0.6850.85
17_V39_L0.6800.84
40_F153_S0.6790.84
97_F124_D0.6770.84
56_A60_S0.6760.84
180_S183_T0.6740.84
194_K198_A0.6730.84
77_I123_V0.6730.84
67_L123_V0.6720.84
62_I149_G0.6700.83
11_F52_F0.6690.83
118_G144_G0.6690.83
96_C140_I0.6650.83
57_L64_F0.6640.83
54_A84_A0.6640.83
19_K70_P0.6600.82
49_L181_I0.6600.82
184_L188_I0.6580.82
155_D183_T0.6570.82
41_N80_T0.6550.82
68_F136_S0.6530.82
141_Q175_N0.6530.82
80_T84_A0.6500.81
50_G54_A0.6450.81
58_V85_L0.6410.81
148_A177_K0.6410.81
35_F126_V0.6370.80
8_F49_L0.6260.79
5_Q8_F0.6250.79
117_Q146_T0.6240.79
12_A40_F0.6200.78
95_Y112_V0.6190.78
105_H108_G0.6190.78
188_I195_P0.6170.78
103_K106_G0.6160.78
18_L35_F0.6150.78
196_E200_H0.6130.78
76_P79_T0.6050.77
85_L93_L0.6040.77
164_I178_V0.6010.76
198_A201_L0.6010.76
47_A80_T0.5980.76
15_K39_L0.5970.76
50_G77_I0.5960.76
49_L153_S0.5950.75
64_F67_L0.5940.75
122_L176_C0.5940.75
16_Q114_S0.5930.75
70_P136_S0.5930.75
172_R175_N0.5930.75
101_E135_E0.5930.75
72_Y97_F0.5900.75
16_Q196_E0.5880.75
26_K70_P0.5840.74
48_L51_R0.5800.74
163_E172_R0.5780.73
43_G94_P0.5780.73
97_F112_V0.5750.73
193_E196_E0.5740.73
13_L19_K0.5730.73
73_K98_N0.5720.73
16_Q19_K0.5720.73
192_E199_E0.5710.72
11_F15_K0.5690.72
142_A146_T0.5690.72
193_E201_L0.5690.72
182_I186_D0.5680.72
26_K72_Y0.5670.72
126_V154_L0.5660.72
188_I201_L0.5660.72
19_K39_L0.5600.71
25_L204_V0.5590.71
199_E203_A0.5570.71
126_V158_E0.5560.71
124_D152_I0.5520.70
25_L156_R0.5460.69
194_K200_H0.5460.69
81_T104_D0.5430.69
13_L27_S0.5420.69
36_N70_P0.5420.69
66_L115_A0.5410.68
132_A136_S0.5400.68
158_E207_Y0.5390.68
199_E206_A0.5380.68
79_T83_V0.5370.68
56_A59_D0.5360.68
195_P198_A0.5340.67
186_D189_A0.5330.67
72_Y100_K0.5330.67
120_V140_I0.5290.67
109_G112_V0.5260.66
71_A136_S0.5240.66
193_E205_K0.5240.66
24_T27_S0.5240.66
70_P158_E0.5180.65
72_Y98_N0.5130.64
53_Y77_I0.5120.64
159_R164_I0.5100.64
115_A120_V0.5090.64
72_Y101_E0.5070.63
104_D135_E0.5070.63
155_D162_G0.5070.63
192_E200_H0.5010.63
67_L81_T0.5010.63
34_F38_G0.5000.62
42_T96_C0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n2lA 4 0.9624 100 0.296 Contact Map
1lh0A 2 1 100 0.32 Contact Map
3mjdA 2 0.9624 100 0.322 Contact Map
2ps1A 2 0.9953 100 0.365 Contact Map
3qw4B 4 0.8873 100 0.371 Contact Map
3m3hA 2 0.8826 100 0.416 Contact Map
2wnsA 2 0.9249 100 0.419 Contact Map
4fymA 4 0.8685 100 0.425 Contact Map
4ohcA 5 0.939 100 0.44 Contact Map
3dezA 2 0.8967 100 0.44 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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